| MeSH term | MeSH ID | Detail |
|---|---|---|
| Edema | D004487 | 152 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Testicular Diseases | D013733 | 15 associated lipids |
| Lymphoma, Large B-Cell, Diffuse | D016403 | 13 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Abnormalities, Drug-Induced | D000014 | 10 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Leukemia P388 | D007941 | 43 associated lipids |
Gossypol
Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
Cross Reference
Introduction
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Gossypol?
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Mol. Cancer Ther. (4)
- Proc. Natl. Acad. Sci. U.S.A. (3)
- Am. J. Physiol. Lung Cell Mol. Physiol. (2)
- Others (13)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Gossypol
PubChem Associated disorders and diseases
What pathways are associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Gossypol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Gossypol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Gossypol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Gossypol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Gossypol?
Xenograft Model
Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Gossypol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Zheng YH et al. | [Effect of gossypol acetic acid on hCG-stimulated progesterone production of dissociated rat luteal cells]. | 1991 | Yao Xue Xue Bao | pmid:1668561 |
| Zheng DK et al. | [Studies on the resolution of racemic gossypol. II. By chiral alpha-methylphenethylamine and alpha-methylbenzylamine]. | 1990 | Yao Xue Xue Bao | pmid:2284966 |
| Si YK et al. | [Studies on the resolution of racemic gossypol. III. Study on the chemical and physical properties of the amino condensates of gossypol]. | 1990 | Yao Xue Xue Bao | pmid:2284967 |
| Han SD et al. | [Study on quality of gossypol recrystalized from chloroform]. | 1989 | Yao Xue Xue Bao | pmid:2609986 |
| Deng HL et al. | [The subcellular distribution and covalent binding of 3H-(+) and 3H-(-) gossypol in the main tissues of rats]. | 1989 | Yao Xue Xue Bao | pmid:2618689 |
| Wu GP et al. | [Synthesis and antifertility actions of gossypol derivatives and phenol aldehydes]. | 1989 | Yao Xue Xue Bao | pmid:2618691 |
| Yuan XB et al. | [Study on polymorphism of gossypol by infrared spectrophotometry and X-ray diffraction]. | 1991 | Yao Xue Xue Bao | pmid:1950572 |
| Wong YK and Li JH | [Quantum pharmacological investigations of gossypol and some simple aromatic compounds]. | 1986 | Yao Xue Xue Bao | pmid:3728037 |
| Jiang DH et al. | [The comparison of some properties of gossypol recrystallized from different solvents]. | 1986 | Yao Xue Xue Bao | pmid:3811948 |
| Guo ZM et al. | [Synthesis of mono-aldehyde gossypol and its analogues]. | 1987 | Yao Xue Xue Bao | pmid:3450164 |
| Zhou RH and Lin XD | [Isolation of (-)-gossypol from natural plant]. | 1987 | Yao Xue Xue Bao | pmid:3450165 |
| Wu DF et al. | [Determination of (+)- and (-)-gossypol in human plasma using high performance liquid chromatography with pre-column chemical derivatization]. | 1988 | Yao Xue Xue Bao | pmid:3256191 |
| Wang YE et al. | [Studies o the anti-fertility actions of cotton seed meal and gossypol (author's transl)]. | 1979 | Yao Xue Xue Bao | pmid:583588 |
| Chen ZC et al. | [The influence of gossypol on the potassium metabolism of rats and the effect of some possible contributing factors (low-K and low-MG intake) (author's transl)]. | 1979 | Yao Xue Xue Bao | pmid:532653 |
| Lei HQ and Xu YX | [Effects of gossypol acetic acid on transport and development of fertilized eggs in rats]. | 1990 | Yao Xue Xue Bao | pmid:2082677 |
| Xu Y et al. | [Intratesticular subcapsular assay, a simple method for the preliminary screening of male contraceptives]. | 1993 | Yao Xue Xue Bao | pmid:8010008 |
| Jiang DH and Xue H | [Monoanilinogossypol--the impurity possibly present in gossypol (author's transl)]. | 1982 | Yao Xue Xue Bao | pmid:7102321 |
| Zhou LF et al. | [Further observations on the effect of prolonged administration of gossypol acetic acid to rats]. | 1982 | Yao Xue Xue Bao | pmid:7136708 |
| Ma XN et al. | [Effect of gossypol acetic acid on testosterone, LH and FSH levels of male rats]. | 1983 | Yao Xue Xue Bao | pmid:6433647 |
| Wang NG et al. | [Antisteroidal and antigonadotrophic effects of gossypol acetic acid in rats]. | 1984 | Yao Xue Xue Bao | pmid:6464763 |
| Lei HP | [Prospect of gossypol as a contraceptive agents for men]. | 1983 | Yao Xue Xue Bao | pmid:6637482 |
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| Yang B et al. | [The effects of gossypol on rat luteal cells, human decidual cells and cytotrophoblasts]. | 1997 | Yao Xue Xue Bao | pmid:11596304 |
| Tang Y et al. | [Progress in small-molecule inhibitors of Bcl-2 family proteins]. | 2008 | Yao Xue Xue Bao | pmid:18819468 |
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