Gossypol

Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.

Cross Reference

Introduction

To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Gossypol?

Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Gossypol

MeSH term MeSH ID Detail
Neovascularization, Pathologic D009389 39 associated lipids
Micronuclei, Chromosome-Defective D048629 33 associated lipids
Acute Lung Injury D055371 33 associated lipids
Proteinuria D011507 30 associated lipids
Endometrial Neoplasms D016889 30 associated lipids
Endometriosis D004715 29 associated lipids
Leukemia, Lymphocytic, Chronic, B-Cell D015451 25 associated lipids
Lymphoma, B-Cell D016393 24 associated lipids
Cattle Diseases D002418 24 associated lipids
Neoplasms, Hormone-Dependent D009376 23 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Gossypol

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Gossypol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Gossypol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Gossypol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Gossypol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Gossypol?

Xenograft Model

Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).

Transgenic Model

Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Gossypol

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Per page 10 20 50 100 | Total 1511
Authors Title Published Journal PubMed Link
Shi QX and Friend DS Gossypol-induced inhibition of guinea pig sperm capacitation in vitro. 1983 Biol. Reprod. pmid:6640034
Fei RR et al. [Effects of gossypol on rat testicular mitochondria]. 1983 Zhongguo Yi Xue Ke Xue Yuan Xue Bao pmid:6228314
Chen XM et al. [Effects of gossypol on lactate dehydrogenase isoenzyme-X in human spermatozoa]. 1983 Zhongguo Yi Xue Ke Xue Yuan Xue Bao pmid:6228315
Wichmann K et al. Effect of gossypol on the motility and metabolism of human spermatozoa. 1983 J. Reprod. Fertil. pmid:6411909
Floridi A et al. The effect of the association of Gossypol and Lonidamine on the energy metabolism of Ehrlich ascites tumor cells. 1983 Exp. Mol. Pathol. pmid:6852206
Vander Jagt DL et al. Regulation of the glutathione S-transferase activity of bilirubin transport protein (ligandin) from human liver. Enzymic memory involving protein-protein interactions. 1983 J. Biol. Chem. pmid:6853539
Waller DP et al. Effect of (+)-gossypol on fertility in male hamsters. 1983 Jul-Aug J. Androl. pmid:6618998
Weinbauer GF et al. Toxicity of gossypol at antifertility dosages in male rats: statistical analysis of lethal rates and body weight responses. 1983 May-Jun Andrologia pmid:6881556
Kalla NR et al. Effect of gossypol on testicular testosterone production in vitro. 1983 Sep-Oct J. Androl. pmid:6630052
Zhuang LZ et al. Effects of gossypol on rat Sertoli and Leydig cells in primary culture and established cell lines. 1983 Sep-Oct J. Androl. pmid:6685120
Wang NG et al. [Antisteroidal and antigonadotrophic effects of gossypol acetic acid in rats]. 1984 Yao Xue Xue Bao pmid:6464763
Zu PD et al. Electron microscopic observations of the effects of gossypol on the human endometrium. 1984 Am. J. Obstet. Gynecol. pmid:6465231
Whaley KJ et al. Optically active gossypol as a circular dichroism probe of interactions with serum albumins. 1984 Biochim. Biophys. Acta pmid:6466708
Penningroth SM Pharmacological basis of therapeutics: gossypol, an oral male contraceptive? 1984 J Med Soc N J pmid:6592366
Tvermyr SM et al. Glucose metabolism in rat germ cells: mechanism of action of gossypol. 1984 Ann. N. Y. Acad. Sci. pmid:6598341
Tuszynski GP and Cossu G Differential cytotoxic effect of gossypol on human melanoma, colon carcinoma, and other tissue culture cell lines. 1984 Cancer Res. pmid:6581864
Haspel HC et al. Cytocidal effect of gossypol on cultured murine erythroleukemia cells is prevented by serum protein. 1984 J. Pharmacol. Exp. Ther. pmid:6584595
Kim IC et al. Comparative in vitro spermicidal effects of (+/-)-gossypol, (+)-gossypol, (-)-gossypol and gossypolone. 1984 Contraception pmid:6509980
Ali SF and El-Sewedy SM Effect of gossypol on liver metabolic enzymes in male rats. 1984 Toxicol. Lett. pmid:6084346
Bi XF et al. [Effects of potassium on the inhibitory effect of gossypol on Na,K-ATPase in vitro]. 1984 Zhongguo Yao Li Xue Bao pmid:6087611