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Long-term clinical remission of a patient with chronic lymphocytic leukemia using alternative treatment option: cottonseed oil (gossypol). |
2008 |
Phytomedicine |
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Reproductive toxicologic effects of gossypol on male rabbits: biochemical, enzymatic, and electrolytic properties of seminal plasma. |
2008 |
Fertil. Steril. |
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2008 |
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Comparison of pharmacokinetic and metabolic profiling among gossypol, apogossypol and apogossypol hexaacetate. |
2008 |
Cancer Chemother. Pharmacol. |
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2008 |
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2008 |
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2008 |
Environ. Entomol. |
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Gossypol suppresses NF-kappaB activity and NF-kappaB-related gene expression in human leukemia U937 cells. |
2008 |
Cancer Lett. |
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Combining HPLC-PDA-MS-SPE-NMR with circular dichroism for complete natural product characterization in crude extracts: levorotatory gossypol in Thespesia danis. |
2008 |
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Targeting Bcl-2 family members with the BH3 mimetic AT-101 markedly enhances the therapeutic effects of chemotherapeutic agents in in vitro and in vivo models of B-cell lymphoma. |
2008 |
Blood |
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CP/MAS spectroscopy in the determination of the tautomeric forms of gossypol, its Schiff bases and hydrazones in the solid state. |
2008 |
Magn Reson Chem |
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[Male antifertility drugs and cell apoptosis]. |
2008 |
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2008 |
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Preclinical studies of Apogossypolone: a new nonpeptidic pan small-molecule inhibitor of Bcl-2, Bcl-XL and Mcl-1 proteins in Follicular Small Cleaved Cell Lymphoma model. |
2008 |
Mol. Cancer |
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Anti-oxidant treatment enhances anti-tumor cytotoxicity of (-)-gossypol. |
2008 |
Cancer Biol. Ther. |
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HPLC preparation of the chiral forms of 6-methoxy-gossypol and 6,6'-dimethoxy-gossypol. |
2008 |
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. |
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Rat testicular germ cell type(s) targeted by anti-spermatogenic agents in vivo and their recovery on withdrawal of treatment--a flow cytometric study. |
2008 |
Anim. Reprod. Sci. |
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Gossypol, a BH3 mimetic, induces apoptosis in chronic lymphocytic leukemia cells. |
2008 |
Blood |
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2008 |
J. Agric. Food Chem. |
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[Determination of gossypol in feeds by HPLC]. |
2008 |
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Apogossypolone, a nonpeptidic small molecule inhibitor targeting Bcl-2 family proteins, effectively inhibits growth of diffuse large cell lymphoma cells in vitro and in vivo. |
2008 |
Cancer Biol. Ther. |
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Gossypol suppresses telomerase activity in human leukemia cells via regulating hTERT. |
2008 |
FEBS Lett. |
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Molecular structures and stability constants of gossypol and its aza-derivative complexes with silver(I) cations studied by potentiometric, ESI MS, NMR, and AM1d semiempirical methods. |
2008 |
J Phys Chem A |
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Cytotoxic and antibacterial sesquiterpenes from Thespesia populnea. |
2008 |
J. Nat. Prod. |
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Gossypol repressed the gap junctional intercellular communication between Sertoli cells by decreasing the expression of Connexin43. |
2008 |
Toxicol In Vitro |
pmid:18706992
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Gossypol affects ion transport in the isolated intestine of the seawater adapted eel, Anguilla anguilla. |
2008 |
Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. |
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Regulation of antiapoptotic MCL-1 function by gossypol: mechanistic insights from in vitro reconstituted systems. |
2008 |
Biochem. Pharmacol. |
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2008 |
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Cinnamyl-3,4-dihydroxy-alpha-cyanocinnamate and nordihydroguaiaretic acid inhibit human Kv1.5 currents independently of lipoxygenase. |
2008 |
Eur. J. Pharmacol. |
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ApoG2 inhibits antiapoptotic Bcl-2 family proteins and induces mitochondria-dependent apoptosis in human lymphoma U937 cells. |
2008 |
Anticancer Drugs |
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2008 |
Bioorg. Med. Chem. Lett. |
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Synergistic antitumoral activity and induction of apoptosis by novel pan Bcl-2 proteins inhibitor apogossypolone with adriamycin in human hepatocellular carcinoma. |
2008 |
Acta Pharmacol. Sin. |
pmid:19026166
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Effect of racemic, (+)- and (-)-gossypol on survival and development of Heliothis virescens larvae. |
2008 |
Environ. Entomol. |
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-(-)Gossypol promotes the apoptosis of bladder cancer cells in vitro. |
2008 Nov-Dec |
Pharmacol. Res. |
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N-Nitrosodimethylamine changes the expression of glutathione S-transferase in the liver of male mice: The role of antioxidants. |
2008 Nov-Dec |
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2008 Sep-Oct |
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2009 |
Cancer Lett. |
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J. Cell. Physiol. |
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Bcl-2 inhibitors: targeting mitochondrial apoptotic pathways in cancer therapy. |
2009 |
Clin. Cancer Res. |
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2009 |
Zhongguo Shi Yan Xue Ye Xue Za Zhi |
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Efficacy of signal pathway inhibitors alone and in combination with Cisplatin varies between human non-small cell lung cancer lines. |
2009 |
J. Surg. Res. |
pmid:19084241
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The (+)- and (-)-gossypols potently inhibit human and rat 11beta-hydroxysteroid dehydrogenase type 2. |
2009 |
J. Steroid Biochem. Mol. Biol. |
pmid:19150652
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Total and percent atropisomers of gossypol and gossypol-6-methyl ether in seeds from pima cottons and accessions of Gossypium barbadense L. |
2009 |
J. Agric. Food Chem. |
pmid:19113939
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Chiral gossypol derivatives: evaluation of their anticancer activity and molecular modeling. |
2009 |
Eur J Med Chem |
pmid:19447525
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Apogossypolone inhibits cell growth by inducing cell cycle arrest in U937 cells. |
2009 |
Oncol. Rep. |
pmid:19513523
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Gossypol inhibits the growth of MAT-LyLu prostate cancer cells by modulation of TGFbeta/Akt signaling. |
2009 |
Int. J. Mol. Med. |
pmid:19513537
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Synthesis, crystal structures and antibacterial activity studies of aza-derivatives of phytoalexin from cotton plant--gossypol. |
2009 |
Eur J Med Chem |
pmid:19577825
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Apogossypol derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins. |
2009 |
J. Med. Chem. |
pmid:19555126
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Mcl1 downregulation sensitizes neuroblastoma to cytotoxic chemotherapy and small molecule Bcl2-family antagonists. |
2009 |
Cancer Biol. Ther. |
pmid:19556859
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