| MeSH term | MeSH ID | Detail |
|---|---|---|
| Chemical and Drug Induced Liver Injury | D056486 | 39 associated lipids |
| Endometriosis | D004715 | 29 associated lipids |
| Uterine Neoplasms | D014594 | 18 associated lipids |
| Proteinuria | D011507 | 30 associated lipids |
| Genital Neoplasms, Male | D005834 | 3 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
| Neuroblastoma | D009447 | 66 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Protein Deficiency | D011488 | 5 associated lipids |
| Leukemia, Experimental | D007942 | 42 associated lipids |
Gossypol
Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
Cross Reference
Introduction
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Gossypol?
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Mol. Cancer Ther. (4)
- Proc. Natl. Acad. Sci. U.S.A. (3)
- Am. J. Physiol. Lung Cell Mol. Physiol. (2)
- Others (13)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Gossypol
PubChem Associated disorders and diseases
What pathways are associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Gossypol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Gossypol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Gossypol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Gossypol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Gossypol?
Xenograft Model
Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Gossypol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kaur S | Effect of gossypol on the concentration of sodium and potassium in the rat epididymis. | 1989 | Int. J. Androl. | pmid:2807585 |
| Molderings GJ et al. | Characterization of an endothelial 5-hydroxytryptamine (5-HT) receptor mediating relaxation of the porcine coronary artery. | 1989 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:2812041 |
| Tanphaichitr N et al. | Inhibitory effects of gossypol analogs on human sperm motility. | 1989 | Contraception | pmid:2752755 |
| Laughton MJ et al. | Antioxidant and pro-oxidant actions of the plant phenolics quercetin, gossypol and myricetin. Effects on lipid peroxidation, hydroxyl radical generation and bleomycin-dependent damage to DNA. | 1989 | Biochem. Pharmacol. | pmid:2476132 |
| Rikihisa Y and Lin YC | Effect of gossypol on the thyroid in young rats. | 1989 | J. Comp. Pathol. | pmid:2760274 |
| Strøm-Hansen T et al. | Interaction of gossypol with amino acids and peptides as a model of enzyme inhibition. | 1989 | Int. J. Pept. Protein Res. | pmid:2599770 |
| D'Orleans-Juste P et al. | Pharmacology of endothelin-1 in isolated vessels: effect of nicardipine, methylene blue, hemoglobin, and gossypol. | 1989 | J. Cardiovasc. Pharmacol. | pmid:2473306 |
| Polsky B et al. | Inactivation of human immunodeficiency virus in vitro by gossypol. | 1989 | Contraception | pmid:2473865 |
| Zhang SF et al. | Biological activity in the repopulating rat spermatocyte after the withdrawal of gossypol treatment: I. The activity for DNA synthesis. | 1989 | Contraception | pmid:2758843 |
| Ye BK et al. | Biological activity in the repopulating rat spermatocyte after the withdrawal of gossypol treatment: II. The activity for the synthesis of cellular and nuclear basic proteins. | 1989 | Contraception | pmid:2758844 |
| Grankvist K | Gossypol-induced free radical toxicity to isolated islet cells. | 1989 | Int. J. Biochem. | pmid:2684701 |
| Wu YW et al. | An in vitro and in vivo study of antitumor effects of gossypol on human SW-13 adrenocortical carcinoma. | 1989 | Cancer Res. | pmid:2736516 |
| Wang JM et al. | The entry of gossypol across the blood-testis barrier in rats. | 1989 | Contraception | pmid:2721201 |
| Amanov N et al. | [Intestinal microbial ecology and its modulation under the influence of immunodepressants]. | 1989 | Antibiot. Khimioter. | pmid:2802878 |
| Nakamura M et al. | Metabolism of round spermatids in the rat: effect of gossypol on the glucose transport. | 1988 Sep-Oct | Andrologia | pmid:3207199 |
| Ershov FI et al. | [Interferonogenic activity of low-molecular compounds of plant origin]. | 1988 Nov-Dec | Vopr. Virusol. | pmid:2470203 |
| Wang JM et al. | The correlation between the gossypol contents in blood plasma, rete testis fluid, and cauda epididymal fluid following chronic treatment with gossypol in rats. | 1988 Nov-Dec | J. Androl. | pmid:3215825 |
| Zakhidov ST et al. | [Clastogenic action of gossypol on spermatogenic cells in rats studied by counting micronuclei]. | 1988 May-Jun | Izv Akad Nauk SSSR Biol | pmid:3411013 |
| Tazulakhova EB et al. | [Effect of low-molecular interferon inducers in experimental hepatitis in mice]. | 1988 Mar-Apr | Vopr. Virusol. | pmid:2457987 |
| Tanphaichitr N et al. | Differential effects of (+) and (-) gossypol enantiomers on mitochondrial function and proliferation of cultured TM4 cells. | 1988 Jul-Aug | J. Androl. | pmid:3182397 |
| Den Boer PJ and Grootegoed JA | Differential effects of (+)- and (-)-gossypol enantiomers on LDH-C4 activity of hamster spermatogenic epithelium in vitro. | 1988 | J. Reprod. Fertil. | pmid:3411560 |
| Zhou SW | [Clinical experience with a gossypol-releasing IUD]. | 1988 | Zhonghua Fu Chan Ke Za Zhi | pmid:3058417 |
| Kaur P et al. | Effect of gossypol on testes & epididymis of albino rats. | 1988 | Indian J. Med. Res. | pmid:3169891 |
| Jones LA | Gossypol toxicosis. | 1988 | Am. J. Vet. Res. | pmid:3178038 |
| Jones LA | Gossypol toxicosis. | 1988 | J. Am. Vet. Med. Assoc. | pmid:3182379 |
| Janero DR and Burghardt B | Protection of rat myocardial phospholipid against peroxidative injury through superoxide-(xanthine oxidase)-dependent, iron-promoted Fenton chemistry by the male contraceptive gossypol. | 1988 | Biochem. Pharmacol. | pmid:2840914 |
| Busse R et al. | Vasomotor activity of diadenosine triphosphate and diadenosine tetraphosphate in isolated arteries. | 1988 | Am. J. Physiol. | pmid:3364587 |
| Eid JE et al. | Gossypol-induced death of African trypanosomes. | 1988 | Exp. Parasitol. | pmid:3366212 |
| Othman MA and Abou-Donia MB | Pharmacokinetic profile of (+/-)-gossypol in male Sprague-Dawley rats following single intravenous and oral and subchronic oral administration. | 1988 | Proc. Soc. Exp. Biol. Med. | pmid:3368474 |
| International Symposium on Gossypol Research for Fertility Regulation. Wuhan, China, 15-17 October 1986. Representative papers. | 1988 | Contraception | pmid:3370985 | |
| Liu GZ et al. | Effects of K salt or a potassium blocker on gossypol-related hypokalemia. | 1988 | Contraception | pmid:3370986 |
| Frick J et al. | Clinical microdose study of gossypol: effect on sperm motility and renal function. | 1988 | Contraception | pmid:3370988 |
| Drayer DE and Reidenberg MM | Gossypol and Na+, K+ ATPase from human erythrocytes. | 1988 | Contraception | pmid:2848657 |
| Xue SP et al. | Evaluation of the renal tubulo-toxic effect of gossypol by urinary protein analysis with SDS-polyacrylamide gel electrophoresis. | 1988 | Contraception | pmid:3370989 |
| Beaudoin AR | A developmental toxicity evaluation of gossypol. | 1988 | Contraception | pmid:3370993 |
| Baba Y | [Effect of HCG administration in the gossypol-treated male rats]. | 1988 | Hinyokika Kiyo | pmid:3135706 |
| Best RG and McKenzie WH | Variable sister-chromatid exchange response in human lymphocytes exposed in vitro to gossypol acetic acid. | 1988 | Mutat. Res. | pmid:3173390 |
| Dou SJ and Fu YF | [Effects of gossypol acetic acid on heart mitochondrial membranes ATPase]. | 1988 | Zhongguo Yao Li Xue Bao | pmid:2975138 |
| Bajpai PK and Benghuzzi HA | Ceramic systems for long-term delivery of chemicals and biologicals. | 1988 | J. Biomed. Mater. Res. | pmid:3235459 |
| Den Boer PJ and Grootegoed JA | Mechanism of action of (-)gossypol on ATP production in isolated hamster spermatids. | 1988 | J. Reprod. Fertil. | pmid:3411559 |
| Ohuchi K et al. | Inhibition by gossypol of tumor promoter-induced arachidonic acid metabolism in rat peritoneal macrophages. | 1988 | Biochim. Biophys. Acta | pmid:3136806 |
| Bender HS et al. | A histopathologic study of the effects of gossypol on the female rat. | 1988 | Contraception | pmid:3197423 |
| Dudel C and Förstermann U | Gossypol attenuates selectively the blood pressure lowering effect of endothelium-dependent vasodilators in the rabbit in vivo. | 1988 | Eur. J. Pharmacol. | pmid:2450761 |
| Bugeja V et al. | Primary mitochondrial activity of gossypol in yeast and mammalian cells. | 1988 | Biochem. Pharmacol. | pmid:2461202 |
| Wong YC and Tam CC | A structural and cytochemical study of the effects of gossypol on the epithelial cells of the guinea-pig seminal vesicle. | 1988 | J. Reprod. Fertil. | pmid:3199385 |
| Kainz V et al. | The effect of gossypol acetic acid on the different stages of the spermatogenic cycle in the rat. | 1988 | Int. J. Androl. | pmid:3215704 |
| Ahmed AA et al. | Gossypol as anti-fertility agent in female rats. | 1988 | Arch Exp Veterinarmed | pmid:3219036 |
| Han ZY | [Relationship between eating cotton-seed oil and blood potassium levels]. | 1988 | Zhonghua Yu Fang Yi Xue Za Zhi | pmid:3219964 |
| Placzek R et al. | Effect of ace-inhibitors, calmodulin antagonists, acetylcholine receptor blocking, and alpha receptor blocking agents on motility of human sperm. | 1988 | Arch. Androl. | pmid:2903725 |
| Wu YW et al. | [Ultrastructural studies on sodium and potassium ion active transport in the rat epididymis]. | 1988 | Shi Yan Sheng Wu Xue Bao | pmid:2849267 |