Mishra PJ et al. |
Integrated Genomics Identifies miR-32/MCL-1 Pathway as a Critical Driver of Melanomagenesis: Implications for miR-Replacement and Combination Therapy. |
2016 |
PLoS ONE |
pmid:27846237
|
Zhao R et al. |
AT-101 enhances gefitinib sensitivity in non-small cell lung cancer with EGFR T790M mutations. |
2016 |
BMC Cancer |
pmid:27431492
|
Zubair H et al. |
Mobilization of Intracellular Copper by Gossypol and Apogossypolone Leads to Reactive Oxygen Species-Mediated Cell Death: Putative Anticancer Mechanism. |
2016 |
Int J Mol Sci |
pmid:27331811
|
Ma D et al. |
Genetic basis for glandular trichome formation in cotton. |
2016 |
Nat Commun |
pmid:26795254
|
Zhang J et al. |
Breeding Potential of Introgression Lines Developed from Interspecific Crossing between Upland Cotton (Gossypium hirsutum) and Gossypium barbadense: Heterosis, Combining Ability and Genetic Effects. |
2016 |
PLoS ONE |
pmid:26730964
|
Antonietti P et al. |
AT-101 simultaneously triggers apoptosis and a cytoprotective type of autophagy irrespective of expression levels and the subcellular localization of Bcl-xL and Bcl-2 in MCF7 cells. |
2016 |
Biochim. Biophys. Acta |
pmid:26721623
|
Stein MN et al. |
A Phase II Study of AT-101 to Overcome Bcl-2--Mediated Resistance to Androgen Deprivation Therapy in Patients With Newly Diagnosed Castration-Sensitive Metastatic Prostate Cancer. |
2016 |
Clin Genitourin Cancer |
pmid:26476589
|
Baoleri X et al. |
Combination of L-gossypol and low-concentration doxorubicin induces apoptosis in human synovial sarcoma cells. |
2015 |
Mol Med Rep |
pmid:26238307
|
Li K et al. |
Mulberry-like dual-drug complicated nanocarriers assembled with apogossypolone amphiphilic starch micelles and doxorubicin hyaluronic acid nanoparticles for tumor combination and targeted therapy. |
2015 |
Biomaterials |
pmid:25477180
|
Quinn BA et al. |
Pancreatic Cancer Combination Therapy Using a BH3 Mimetic and a Synthetic Tetracycline. |
2015 |
Cancer Res. |
pmid:26032425
|
Zhang SD et al. |
Isochamaejasmin induces apoptosis in leukemia cells through inhibiting Bcl-2 family proteins. |
2015 |
Chin J Nat Med |
pmid:26412425
|
Bhatia C et al. |
Towards a systematic analysis of human short-chain dehydrogenases/reductases (SDR): Ligand identification and structure-activity relationships. |
2015 |
Chem. Biol. Interact. |
pmid:25526675
|
Câmara AC et al. |
Toxicity of Gossypol from Cottonseed Cake to Sheep Ovarian Follicles. |
2015 |
PLoS ONE |
pmid:26600470
|
Gong Y et al. |
Valproic Acid Enhances the Anti-tumor Effect of (-)-gossypol to Burkitt Lymphoma Namalwa Cells. |
2015 |
Biomed. Environ. Sci. |
pmid:26582100
|
Wu Y et al. |
Influence of gossypol acetic acid on the growth of human adenoid cystic carcinoma ACC-M cells and the expression of DNA methyltransferase 1. |
2015 |
Genet. Mol. Res. |
pmid:26535659
|
Zhao GX et al. |
The BH3-mimetic gossypol and noncytotoxic doses of valproic acid induce apoptosis by suppressing cyclin-A2/Akt/FOXO3a signaling. |
2015 |
Oncotarget |
pmid:26517515
|
Kottmann RM et al. |
Pharmacologic inhibition of lactate production prevents myofibroblast differentiation. |
2015 |
Am. J. Physiol. Lung Cell Mol. Physiol. |
pmid:26408551
|
Judge JL et al. |
Ionizing radiation induces myofibroblast differentiation via lactate dehydrogenase. |
2015 |
Am. J. Physiol. Lung Cell Mol. Physiol. |
pmid:26254422
|
Tomoda K et al. |
Examination of Gossypol-Pluronic Micelles as Potential Radiosensitizers. |
2015 |
AAPS J |
pmid:26246329
|
Santana AT et al. |
Mechanisms involved in reproductive damage caused by gossypol in rats and protective effects of vitamin E. |
2015 |
Biol. Res. |
pmid:26227499
|
Zerp SF et al. |
Targeting anti-apoptotic Bcl-2 by AT-101 to increase radiation efficacy: data from in vitro and clinical pharmacokinetic studies in head and neck cancer. |
2015 |
Radiat Oncol |
pmid:26223311
|
Ren T et al. |
Small-molecule BH3 mimetic and pan-Bcl-2 inhibitor AT-101 enhances the antitumor efficacy of cisplatin through inhibition of APE1 repair and redox activity in non-small-cell lung cancer. |
2015 |
Drug Des Devel Ther |
pmid:26089640
|
He Z et al. |
Chemical Composition of Defatted Cottonseed and Soy Meal Products. |
2015 |
PLoS ONE |
pmid:26079931
|
Wang Q et al. |
Salt Stress Effects on Secondary Metabolites of Cotton in Relation to Gene Expression Responsible for Aphid Development. |
2015 |
PLoS ONE |
pmid:26061875
|
Pan R et al. |
Inhibition of Mcl-1 with the pan-Bcl-2 family inhibitor (-)BI97D6 overcomes ABT-737 resistance in acute myeloid leukemia. |
2015 |
Blood |
pmid:26045609
|
Maji S et al. |
Mcl-1 is an important therapeutic target for oral squamous cell carcinomas. |
2015 |
Oncotarget |
pmid:26009874
|
Lan L et al. |
Natural product (-)-gossypol inhibits colon cancer cell growth by targeting RNA-binding protein Musashi-1. |
2015 |
Mol Oncol |
pmid:25933687
|
Sarkar S et al. |
Therapy of prostate cancer using a novel cancer terminator virus and a small molecule BH-3 mimetic. |
2015 |
Oncotarget |
pmid:25926554
|
Mani J et al. |
Chemoresistance is associated with increased cytoprotective autophagy and diminished apoptosis in bladder cancer cells treated with the BH3 mimetic (-)-Gossypol (AT-101). |
2015 |
BMC Cancer |
pmid:25885284
|
Zeng QF et al. |
The response of meat ducks from 15 to 35 d of age to gossypol from cottonseed meal. |
2015 |
Poult. Sci. |
pmid:25834247
|
Hanus J et al. |
Gossypol Acetic Acid Prevents Oxidative Stress-Induced Retinal Pigment Epithelial Necrosis by Regulating the FoxO3/Sestrin2 Pathway. |
2015 |
Mol. Cell. Biol. |
pmid:25802279
|
Zhan W et al. |
Inhibitory activity of apogossypol in human prostate cancer in vitro and in vivo. |
2015 |
Mol Med Rep |
pmid:25672487
|
Zhang H et al. |
Canonical Wnt signaling acts synergistically on BMP9-induced osteo/odontoblastic differentiation of stem cells of dental apical papilla (SCAPs). |
2015 |
Biomaterials |
pmid:25468367
|
Sorokina EV et al. |
[Features of dynamics of sera cytokines in patients with erythema multiforme during immunotherapy]. |
2014 Jan-Feb |
Zh. Mikrobiol. Epidemiol. Immunobiol. |
pmid:24738292
|
Gawande ND et al. |
Molecular screening of insecticides with sigma glutathione S-transferases (GST) in cotton aphid Aphis gossypii using docking. |
2014 |
Bioinformation |
pmid:25512683
|
Ren T et al. |
Sequential treatment with AT-101 enhances cisplatin chemosensitivity in human non-small cell lung cancer cells through inhibition of apurinic/apyrimidinic endonuclease 1-activated IL-6/STAT3 signaling pathway. |
2014 |
Drug Des Devel Ther |
pmid:25548514
|
Gadelha IC et al. |
Gossypol promotes degeneration of ovarian follicles in rats. |
2014 |
ScientificWorldJournal |
pmid:25540815
|
Jarzabek MA et al. |
Interrogation of gossypol therapy in glioblastoma implementing cell line and patient-derived tumour models. |
2014 |
Br. J. Cancer |
pmid:25375271
|
Sadahira K et al. |
Gossypol induces apoptosis in multiple myeloma cells by inhibition of interleukin-6 signaling and Bcl-2/Mcl-1 pathway. |
2014 |
Int. J. Oncol. |
pmid:25231749
|
Xu R et al. |
Proteomic analysis of gossypol induces necrosis in multiple myeloma cells. |
2014 |
Biomed Res Int |
pmid:25197664
|
Jin L et al. |
Phosphoproteomic analysis of gossypol-induced apoptosis in ovarian cancer cell line, HOC1a. |
2014 |
Biomed Res Int |
pmid:25180175
|
Zhang X et al. |
Apogossypolone inhibits the proliferation of LNCaP cells in vitro and in vivo. |
2014 |
Mol Med Rep |
pmid:25060748
|
Gadelha IC et al. |
Gossypol toxicity from cottonseed products. |
2014 |
ScientificWorldJournal |
pmid:24895646
|
Kogan P and Wald M |
Male contraception: history and development. |
2014 |
Urol. Clin. North Am. |
pmid:24286773
|
Qian C et al. |
Identification of a novel potential antitumor activity of gossypol as an APE1/Ref-1 inhibitor. |
2014 |
Drug Des Devel Ther |
pmid:24872679
|
Paulus A et al. |
AT-101 downregulates BCL2 and MCL1 and potentiates the cytotoxic effects of lenalidomide and dexamethasone in preclinical models of multiple myeloma and Waldenström macroglobulinaemia. |
2014 |
Br. J. Haematol. |
pmid:24236538
|
Kaza N et al. |
BNIP3 regulates AT101 [(-)-gossypol] induced death in malignant peripheral nerve sheath tumor cells. |
2014 |
PLoS ONE |
pmid:24824755
|
Keshmiri-Neghab H and Goliaei B |
Therapeutic potential of gossypol: an overview. |
2014 |
Pharm Biol |
pmid:24073600
|
Mellon JE et al. |
Growth inhibitory effects of gossypol and related compounds on fungal cotton root pathogens. |
2014 |
Lett. Appl. Microbiol. |
pmid:24713043
|
Cho H et al. |
Polymeric micelles for apoptosis-targeted optical imaging of cancer and intraoperative surgical guidance. |
2014 |
PLoS ONE |
pmid:24587157
|
Sonpavde G et al. |
Radiographic progression by Prostate Cancer Working Group (PCWG)-2 criteria as an intermediate endpoint for drug development in metastatic castration-resistant prostate cancer. |
2014 |
BJU Int. |
pmid:24298897
|
Soderquist RS et al. |
Gossypol increases expression of the pro-apoptotic BH3-only protein NOXA through a novel mechanism involving phospholipase A2, cytoplasmic calcium, and endoplasmic reticulum stress. |
2014 |
J. Biol. Chem. |
pmid:24778183
|
Zeng QF et al. |
Effects of dietary gossypol concentration on growth performance, blood profiles, and hepatic histopathology in meat ducks. |
2014 |
Poult. Sci. |
pmid:24902707
|
Anderson MA et al. |
Targeting BCL2 for the treatment of lymphoid malignancies. |
2014 |
Semin. Hematol. |
pmid:25048785
|
Schelman WR et al. |
A phase I study of AT-101 with cisplatin and etoposide in patients with advanced solid tumors with an expanded cohort in extensive-stage small cell lung cancer. |
2014 |
Invest New Drugs |
pmid:23860642
|
Lima Pde M et al. |
Methane emission of Santa Inês sheep fed cottonseed by-products containing different levels of gossypol. |
2014 |
Trop Anim Health Prod |
pmid:24132456
|
Ignatova M et al. |
Quaternized chitosan-coated nanofibrous implants loaded with gossypol prepared by electrospinning and their efficacy against Graffi myeloid tumor. |
2014 |
J Biomater Sci Polym Ed |
pmid:24236801
|
Paulus A et al. |
The investigational agent MLN2238 induces apoptosis and is cytotoxic to CLL cells in vitro, as a single agent and in combination with other drugs. |
2014 |
Br. J. Haematol. |
pmid:24467634
|
Jang GH and Lee M |
BH3-mimetic gossypol-induced autophagic cell death in mutant BRAF melanoma cells with high expression of p21Cip¹.). |
2014 |
Life Sci. |
pmid:24625733
|
Li G et al. |
RhoA/ROCK/PTEN signaling is involved in AT-101-mediated apoptosis in human leukemia cells in vitro and in vivo. |
2014 |
Cell Death Dis |
pmid:24434521
|
Mei H et al. |
Autophagy inhibition enhances pan-Bcl-2 inhibitor AT-101-induced apoptosis in non-small cell lung cancer. |
2014 |
Neoplasma |
pmid:24299314
|
Spijkers-Hagelstein JA et al. |
Glucocorticoid sensitisation in Mixed Lineage Leukaemia-rearranged acute lymphoblastic leukaemia by the pan-BCL-2 family inhibitors gossypol and AT-101. |
2014 |
Eur. J. Cancer |
pmid:24703900
|
Sorokina EV et al. |
[Influence of immunovac-VP-4 therapy on innate immunity effectors in patients with darier erythema annulare centrifugum]. |
2013 Nov-Dec |
Zh. Mikrobiol. Epidemiol. Immunobiol. |
pmid:24605681
|
Gao W et al. |
Proteomic and virus-induced gene silencing (VIGS) Analyses reveal that gossypol, brassinosteroids, and jasmonic acid contribute to the resistance of cotton to Verticillium dahliae. |
2013 |
Mol. Cell Proteomics |
pmid:24019146
|
Balakrishnan K et al. |
Bax and Bak are required for apogossypolone, a BH3-mimetic, induced apoptosis in chronic lymphocytic leukemia cells. |
2013 |
Leuk. Lymphoma |
pmid:22866921
|
Fonseca NB et al. |
Effectiveness of albumin-conjugated gossypol as an immunogen to prevent gossypol-associated acute hepatotoxicity in rats. |
2013 |
Food Chem. Toxicol. |
pmid:23485613
|
Prakash O and Khan F |
Development of method for three-point data estimation and SVR-QSAR model to screen anti cancer leads. |
2013 |
Comb. Chem. High Throughput Screen. |
pmid:23410041
|
Varadarajan S et al. |
Endoplasmic reticulum membrane reorganization is regulated by ionic homeostasis. |
2013 |
PLoS ONE |
pmid:23457590
|
Mao YB et al. |
Cysteine protease enhances plant-mediated bollworm RNA interference. |
2013 |
Plant Mol. Biol. |
pmid:23460027
|
El-Nassan HB |
Advances in the discovery of kinesin spindle protein (Eg5) inhibitors as antitumor agents. |
2013 |
Eur J Med Chem |
pmid:23434636
|
Liu Z et al. |
Protective effect of gossypol on lipopolysaccharide-induced acute lung injury in mice. |
2013 |
Inflamm. Res. |
pmid:23435932
|
Pridgeon JW et al. |
Attempt to develop live attenuated bacterial vaccines by selecting resistance to gossypol, proflavine hemisulfate, novobiocin, or ciprofloxacin. |
2013 |
Vaccine |
pmid:23499519
|
Xin J et al. |
ApoG2 as the most potent gossypol derivatives inhibits cell growth and induces apoptosis on gastric cancer cells. |
2013 |
Biomed. Pharmacother. |
pmid:23201009
|
Song T et al. |
3-Thiomorpholin-8-oxo-8H-acenaphtho [1,2-b] pyrrole-9-carbonitrile (S1) derivatives as pan-Bcl-2-inhibitors of Bcl-2, Bcl-xL and Mcl-1. |
2013 |
Bioorg. Med. Chem. |
pmid:23206987
|
Cheng P et al. |
The novel BH-3 mimetic apogossypolone induces Beclin-1- and ROS-mediated autophagy in human hepatocellular carcinoma [corrected] cells. |
2013 |
Cell Death Dis |
pmid:23392177
|
Ni Z et al. |
Natural Bcl-2 inhibitor (-)- gossypol induces protective autophagy via reactive oxygen species-high mobility group box 1 pathway in Burkitt lymphoma. |
2013 |
Leuk. Lymphoma |
pmid:23398207
|
Huo M et al. |
Suppression of LPS-induced inflammatory responses by gossypol in RAW 264.7 cells and mouse models. |
2013 |
Int. Immunopharmacol. |
pmid:23352443
|
Goff DJ et al. |
A Pan-BCL2 inhibitor renders bone-marrow-resident human leukemia stem cells sensitive to tyrosine kinase inhibition. |
2013 |
Cell Stem Cell |
pmid:23333150
|
Anderson MA et al. |
BH3 mimetic therapy: an emerging and promising approach to treating chronic lymphocytic leukemia. |
2013 |
Leuk. Lymphoma |
pmid:23339446
|
Kannan A et al. |
Effect of feeding of calcium hydroxide-treated or vitamin E-supplemented cottonseed meal on plasma gossypol levels, blood parameters, and performance of Bikaneri lambs. |
2013 |
Trop Anim Health Prod |
pmid:23345064
|
Ansari N et al. |
Quantitative 3D cell-based assay performed with cellular spheroids and fluorescence microscopy. |
2013 |
Methods Cell Biol. |
pmid:23317907
|
Senarisoy M et al. |
Gossypol interferes with both type I and type II topoisomerase activities without generating strand breaks. |
2013 |
Cell Biochem. Biophys. |
pmid:23161103
|
Hall C et al. |
Bcl-2 family of proteins as therapeutic targets in genitourinary neoplasms. |
2013 |
Clin Genitourin Cancer |
pmid:23083798
|
Palle SR et al. |
RNAi-mediated Ultra-low gossypol cottonseed trait: performance of transgenic lines under field conditions. |
2013 |
Plant Biotechnol. J. |
pmid:23078138
|
Zelaya CA et al. |
Di(phenylpropylamino)gossypol: a derivative of the dimeric natural product gossypol. |
2013 |
Acta Crystallogr C |
pmid:23579723
|
Wang J et al. |
Gossypol induces apoptosis in ovarian cancer cells through oxidative stress. |
2013 |
Mol Biosyst |
pmid:23532321
|
Yang J et al. |
Synthesis and anti-H5N1 activity of chiral gossypol derivatives and its analogs implicated by a viral entry blocking mechanism. |
2013 |
Bioorg. Med. Chem. Lett. |
pmid:23538114
|
Xin J et al. |
ApoG2 induces ER stress-dependent apoptosis in gastric cancer cells in vitro and its real-time evaluation by bioluminescence imaging in vivo. |
2013 |
Cancer Lett. |
pmid:23523614
|
Tang H et al. |
Oxidative stress induces monocyte necrosis with enrichment of cell-bound albumin and overexpression of endoplasmic reticulum and mitochondrial chaperones. |
2013 |
PLoS ONE |
pmid:23555724
|
Broderick GA et al. |
Effect of replacing soybean meal protein with protein from upland cottonseed, Pima cottonseed, or extruded Pima cottonseed on production of lactating dairy cows. |
2013 |
J. Dairy Sci. |
pmid:23462167
|
Kapoor S |
Attenuating effect of gossypol on tumor growth in systemic malignancies. |
2013 |
Cell Biochem. Biophys. |
pmid:23743711
|
Lin J et al. |
Induction of apoptosis and antitumor effects of a small molecule inhibitor of Bcl-2 and Bcl-xl, gossypol acetate, in multiple myeloma in vitro and in vivo. |
2013 |
Oncol. Rep. |
pmid:23708869
|
Karaca B et al. |
Combination of AT-101/cisplatin overcomes chemoresistance by inducing apoptosis and modulating epigenetics in human ovarian cancer cells. |
2013 |
Mol. Biol. Rep. |
pmid:23269627
|
Soderquist R et al. |
Gossypol overcomes stroma-mediated resistance to the BCL2 inhibitor ABT-737 in chronic lymphocytic leukemia cells ex vivo. |
2013 |
Leukemia |
pmid:23640104
|
Granchi C et al. |
Small-molecule inhibitors of human LDH5. |
2013 |
Future Med Chem |
pmid:24175747
|
Zhang Z et al. |
Fragment-based design, synthesis, and biological evaluation of N-substituted-5-(4-isopropylthiophenol)-2-hydroxynicotinamide derivatives as novel Mcl-1 inhibitors. |
2013 |
Eur J Med Chem |
pmid:23314054
|
Zhong S et al. |
(-)-Gossypol-enriched cottonseed oil inhibits proliferation and adipogenesis of human breast pre-adipocytes. |
2013 |
Anticancer Res. |
pmid:23482766
|
Varadarajan S et al. |
Sabutoclax (BI97C1) and BI112D1, putative inhibitors of MCL-1, induce mitochondrial fragmentation either upstream of or independent of apoptosis. |
2013 |
Neoplasia |
pmid:23633928
|
Sokolova TM et al. |
Ridostin induces transcription of a wide spectrum of interferon genes in human cells. |
2013 |
Bull. Exp. Biol. Med. |
pmid:24319751
|
Jiao X et al. |
Comparative transcriptomic analysis of developing cotton cotyledons and embryo axis. |
2013 |
PLoS ONE |
pmid:23977137
|