| MeSH term | MeSH ID | Detail |
|---|---|---|
| Leukemia, Biphenotypic, Acute | D015456 | 2 associated lipids |
| Lymphoma, B-Cell | D016393 | 24 associated lipids |
| Lymphoma, Large B-Cell, Diffuse | D016403 | 13 associated lipids |
| Endometrial Neoplasms | D016889 | 30 associated lipids |
| Carcinoma, Mucoepidermoid | D018277 | 3 associated lipids |
| Hematologic Neoplasms | D019337 | 4 associated lipids |
| Retinal Neoplasms | D019572 | 3 associated lipids |
| Micronuclei, Chromosome-Defective | D048629 | 33 associated lipids |
| Lung Injury | D055370 | 14 associated lipids |
| Acute Lung Injury | D055371 | 33 associated lipids |
| Chemical and Drug Induced Liver Injury | D056486 | 39 associated lipids |
| Prostatic Neoplasms, Castration-Resistant | D064129 | 3 associated lipids |
Gossypol
Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
Cross Reference
Introduction
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Gossypol?
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Gossypol
PubChem Associated disorders and diseases
What pathways are associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Gossypol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Gossypol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Gossypol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Gossypol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Gossypol?
Xenograft Model
Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Gossypol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Cheng W et al. | [Effect of gossypol acetate on proliferation and apoptosis in Raji lymphoblastoid cell line]. | 2009 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:19968063 |
| Varol U et al. | The effect of racemic gossypol and at-101 on angiogenic profile of ovcar-3 cells: a preliminary molecular framework for gossypol enantiomers. | 2009 | Exp. Oncol. | pmid:20010531 |
| Wu G et al. | Temporal allocation of metabolic tolerance in the body of beet armyworm in response to three gossypol-cotton cultivars. | 2009 | Sci. China, C, Life Sci. | pmid:20016971 |
| Wang WQ et al. | [Apoptosis of multiple myeloma cells induced by gossypol acetic acid in vitro and its mechanism]. | 2009 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:20030926 |
| Xu P et al. | Mitogenic activity of zeranol in human breast cancer cells is enhanced by leptin and suppressed by gossypol. | 2009 | Anticancer Res. | pmid:20032412 |
| Liu YX | Temperature control of spermatogenesis and prospect of male contraception. | 2010 | Front Biosci (Schol Ed) | pmid:20036980 |
| Ford JM et al. | Modulation of resistance to alkylating agents in cancer cell by gossypol enantiomers. | 1991 | Cancer Lett. | pmid:2004358 |
| Zhang XQ et al. | Inhibition of proliferation of prostate cancer cell line, PC-3, in vitro and in vivo using (-)-gossypol. | 2010 | Asian J. Androl. | pmid:20081872 |
| Volate SR et al. | Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells. | 2010 | Mol. Cancer Ther. | pmid:20124455 |
| Le A et al. | Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression. | 2010 | Proc. Natl. Acad. Sci. U.S.A. | pmid:20133848 |
| Kramer RY et al. | The effect of cottonseed components on testicular development in pubescent rams. | 1991 | Vet Hum Toxicol | pmid:2017859 |
| Roychoudhury S et al. | In vitro gossypol induced spermatozoa motility alterations in rabbits. | 2009 | J Environ Sci Health B | pmid:20183084 |
| Barelier S et al. | Fragment-based deconstruction of Bcl-xL inhibitors. | 2010 | J. Med. Chem. | pmid:20192224 |
| Priyadarshi A et al. | Structural insights into mouse anti-apoptotic Bcl-xl reveal affinity for Beclin 1 and gossypol. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20206602 |
| Reddish JM et al. | (-)-Gossypol containing hen sera and a myosin (-)-gossypol conjugate reduces the proliferation of MCF-7 cells. | 2010 | Anticancer Res. | pmid:20332451 |
| Moretti L et al. | AT-101, a pan-Bcl-2 inhibitor, leads to radiosensitization of non-small cell lung cancer. | 2010 | J Thorac Oncol | pmid:20354451 |
| Abe K et al. | Phosphorylation of coagulation factor II by phospholipid/Ca(2+)-dependent protein kinase (protein kinase C). | 1991 | Biochem. Biophys. Res. Commun. | pmid:2039497 |
| Wei J et al. | BI-97C1, an optically pure Apogossypol derivative as pan-active inhibitor of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins. | 2010 | J. Med. Chem. | pmid:20443627 |
| Kono H et al. | Effects of progesterone and gossypol on monoamine oxidase activity in human term placental explant. | 1991 | Tohoku J. Exp. Med. | pmid:2048118 |
| Fulda S | Modulation of apoptosis by natural products for cancer therapy. | 2010 | Planta Med. | pmid:20486070 |
| pmid:20496676 | ||||
| Ye W et al. | Induction of apoptosis by (-)-gossypol-enriched cottonseed oil in human breast cancer cells. | 2010 | Int. J. Mol. Med. | pmid:20514430 |
| Gao P et al. | The Bcl-2 homology domain 3 mimetic gossypol induces both Beclin 1-dependent and Beclin 1-independent cytoprotective autophagy in cancer cells. | 2010 | J. Biol. Chem. | pmid:20529838 |
| Sahin F et al. | Gossypol exerts its cytotoxic effect on HL-60 leukemic cell line via decreasing activity of protein phosphatase 2A and interacting with human telomerase reverse transcriptase activity. | 2010 | Hematology | pmid:20557672 |
| D'Cruz SC et al. | Effects of plants and plant products on the testis. | 2010 | Asian J. Androl. | pmid:20562897 |
| Lian J et al. | A natural BH3 mimetic induces autophagy in apoptosis-resistant prostate cancer via modulating Bcl-2-Beclin1 interaction at endoplasmic reticulum. | 2011 | Cell Death Differ. | pmid:20577262 |
| Voss V et al. | The pan-Bcl-2 inhibitor (-)-gossypol triggers autophagic cell death in malignant glioma. | 2010 | Mol. Cancer Res. | pmid:20587533 |
| McGregor N et al. | AT-101 (R-(-)-gossypol acetic acid) enhances the effectiveness of androgen deprivation therapy in the VCaP prostate cancer model. | 2010 | J. Cell. Biochem. | pmid:20589722 |
| Khadzhibaev GS et al. | [Interferonogenic activity of gossypol, a low-molecular substance]. | 1978 | Antibiotiki | pmid:206198 |
| Huang LH et al. | Gossypol inhibits phosphorylation of Bcl-2 in human leukemia HL-60 cells. | 2010 | Eur. J. Pharmacol. | pmid:20633548 |
| Kono H et al. | Gossypol effects on monoamine oxidase (MAO) activity in several organs of term rats. | 1991 | Tohoku J. Exp. Med. | pmid:2063399 |
| Tiliabaev KZ et al. | [Synthesis, structures, and acute toxicity of gossypol nonsymmetrical aldehyde derivatives]. | 2010 May-Jun | Bioorg. Khim. | pmid:20644599 |
| Gu Y et al. | Gossypolone suppresses progesterone synthesis in bovine luteal cells. | 1991 | J. Steroid Biochem. Mol. Biol. | pmid:2064986 |
| Zhang XQ et al. | Apogossypolone, a novel inhibitor of antiapoptotic Bcl-2 family proteins, induces autophagy of PC-3 and LNCaP prostate cancer cells in vitro. | 2010 | Asian J. Androl. | pmid:20657602 |
| Yan F et al. | A novel water-soluble gossypol derivative increases chemotherapeutic sensitivity and promotes growth inhibition in colon cancer. | 2010 | J. Med. Chem. | pmid:20684596 |
| Blevins S et al. | Effects of silymarin on gossypol toxicosis in divergent lines of chickens. | 2010 | Poult. Sci. | pmid:20709972 |
| Taylor GT et al. | Search for a male contraceptive: the effect of gossypol on sexual motivation and epididymal sperm. | 1991 | J Med | pmid:2072049 |
| Ikeda M | Inhibition kinetics of NAD-linked enzymes by gossypol acetic acid. | 1990 Sep-Oct | Andrologia | pmid:2073051 |
| Kalla NR et al. | Response of mice testis to gossypol acetic acid. | 1990 Jan-Feb | Acta Eur. Fertil. | pmid:2075791 |
| Kalla NR et al. | Effect of gossypol on domestic fowl, Gallus domesticus. | 1990 Jan-Feb | Acta Eur. Fertil. | pmid:2075792 |
| Vyas RK et al. | Recovery of normal testis function and sperm motility after cessation of gossypol treatment in hamster. | 1990 Jan-Feb | Acta Eur. Fertil. | pmid:2075793 |
| Kalla NR | Gossypol. | 1990 Jan-Feb | Acta Eur. Fertil. | pmid:2075794 |
| Heist RS et al. | Phase I/II study of AT-101 with topotecan in relapsed and refractory small cell lung cancer. | 2010 | J Thorac Oncol | pmid:20808253 |
| Lei HQ and Xu YX | [Effects of gossypol acetic acid on transport and development of fertilized eggs in rats]. | 1990 | Yao Xue Xue Bao | pmid:2082677 |
| Kunesch N et al. | [Preparation of derivatives of the aldehydic functions of gossypol]. | 1990 | Ann Pharm Fr | pmid:2082795 |
| El-Sharaky AS et al. | Spermatotoxicity, biochemical changes and histological alteration induced by gossypol in testicular and hepatic tissues of male rats. | 2010 | Food Chem. Toxicol. | pmid:20832445 |
| Johansen RL and Misra HP | Effects of gossypol on the hepatic drug metabolizing system in rats. | 1990 | Contraception | pmid:2083490 |
| Sung B et al. | Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL. | 2010 | J. Biol. Chem. | pmid:20837473 |
| Chang Q et al. | Effects of combined administration of low-dose gossypol with steroid hormones on the mitotic phase of spermatogenesis of rat. | 2010 | J Exp Zool A Ecol Genet Physiol | pmid:20839281 |
| Uzunoglu S et al. | Comparison of XTT and Alamar blue assays in the assessment of the viability of various human cancer cell lines by AT-101 (-/- gossypol). | 2010 | Toxicol. Mech. Methods | pmid:20843265 |