| MeSH term | MeSH ID | Detail |
|---|---|---|
| Leukemia, Biphenotypic, Acute | D015456 | 2 associated lipids |
| Lymphoma, B-Cell | D016393 | 24 associated lipids |
| Lymphoma, Large B-Cell, Diffuse | D016403 | 13 associated lipids |
| Endometrial Neoplasms | D016889 | 30 associated lipids |
| Carcinoma, Mucoepidermoid | D018277 | 3 associated lipids |
| Hematologic Neoplasms | D019337 | 4 associated lipids |
| Retinal Neoplasms | D019572 | 3 associated lipids |
| Micronuclei, Chromosome-Defective | D048629 | 33 associated lipids |
| Lung Injury | D055370 | 14 associated lipids |
| Acute Lung Injury | D055371 | 33 associated lipids |
| Chemical and Drug Induced Liver Injury | D056486 | 39 associated lipids |
| Prostatic Neoplasms, Castration-Resistant | D064129 | 3 associated lipids |
Gossypol
Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
Cross Reference
Introduction
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Gossypol?
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Mol. Cancer Ther. (4)
- Proc. Natl. Acad. Sci. U.S.A. (3)
- Am. J. Physiol. Lung Cell Mol. Physiol. (2)
- Others (13)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Gossypol
PubChem Associated disorders and diseases
What pathways are associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Gossypol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Gossypol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Gossypol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Gossypol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Gossypol?
Xenograft Model
Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Gossypol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Anuja MN et al. | Spermatotoxicity of a protein isolated from the root of Achyranthes aspera: a comparative study with gossypol. | 2010 | Contraception | pmid:20851234 |
| Zwitter M | Combining cytotoxic and targeted therapies for lung cancer. | 2010 | J Thorac Oncol | pmid:20871258 |
| Kalla NR and Sud S | Distribution of gossypol. | 1990 Mar-Apr | Acta Eur. Fertil. | pmid:2087941 |
| Kalla NR et al. | 65Zn incorporation in the male reproductive organs following gossypol treatment. | 1990 Mar-Apr | Acta Eur. Fertil. | pmid:2087942 |
| Kalla NR et al. | Effect of gossypol on rats maintained on protein deficient and low potassium diets. | 1990 Mar-Apr | Acta Eur. Fertil. | pmid:2087943 |
| Kalla NR et al. | Spermatogenic events in rat and mice following intratesticular administration of optical isomers of gossypol. | 1990 Mar-Apr | Acta Eur. Fertil. | pmid:2087944 |
| Vyas RK and Kalla NR | Effect of optical isomers of gossypol on mammalian spermatozoa: an in vitro study. | 1990 Mar-Apr | Acta Eur. Fertil. | pmid:2087945 |
| Frick J and Kalla NR | Clinical studies with gossypol. Current status. | 1990 Mar-Apr | Acta Eur. Fertil. | pmid:2087946 |
| Wang WH et al. | [Antifertility actions of gossypol derivatives and analogues]. | 1990 | Zhongguo Yao Li Xue Bao | pmid:2088004 |
| Morgan SE | Gossypol residues in organ meats vs thresholds of toxicity. | 1990 | Vet Hum Toxicol | pmid:2092408 |
| Vizirianakis IS et al. | Toward the development of innovative bifunctional agents to induce differentiation and to promote apoptosis in leukemia: clinical candidates and perspectives. | 2010 | J. Med. Chem. | pmid:20925433 |
| Lian J et al. | The Bcl-2-Beclin 1 interaction in (-)-gossypol-induced autophagy versus apoptosis in prostate cancer cells. | 2010 | Autophagy | pmid:20930561 |
| Mao YB et al. | Cotton plants expressing CYP6AE14 double-stranded RNA show enhanced resistance to bollworms. | 2011 | Transgenic Res. | pmid:20953975 |
| Przybylski P et al. | The influence of protonation on molecular structure and physico-chemical properties of gossypol Schiff bases. | 2010 | Org. Biomol. Chem. | pmid:20959900 |
| GRAU CR | Protein concentrates as amino acid sources for the chick; corn gluten meal, cottonseed meal and peanut meal. | 1946 | J. Nutr. | pmid:20999576 |
| VISWESWARA RAO K and VASUDEVA SARMA R | Occurrence of gossypol. | 1945 | Curr. Sci. | pmid:21007609 |
| Wei J et al. | Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins. | 2010 | J. Med. Chem. | pmid:21033669 |
| Hill MA et al. | Cyclooxygenase inhibition potentiates myogenic activity in skeletal muscle arterioles. | 1990 | Am. J. Physiol. | pmid:2105665 |
| FOSTER JW and WOODRUFF HB | Microbiological aspects of penicillin; cottonseed meal as a substitute for corn steep liquor in penicillin production. | 1946 | J. Bacteriol. | pmid:21064711 |
| Wu G et al. | Responses of three successive generations of beet armyworm, Spodoptera exigua, fed exclusively on different levels of gossypol in cotton leaves. | 2010 | J. Insect Sci. | pmid:21067414 |
| ZHU Y et al. | Involvement of Bcl-2, Src, and ERα in gossypol-mediated growth inhibition and apoptosis in human uterine leiomyoma and myometrial cells. | 2010 | Acta Pharmacol. Sin. | pmid:21102482 |
| Zhong CQ et al. | Study on sperm function in men long after cessation of gossypol treatment. | 1990 | Contraception | pmid:2113849 |
| Radermacher J et al. | Endothelium-derived relaxing factor influences renal vascular resistance. | 1990 | Am. J. Physiol. | pmid:2115741 |
| Le TT et al. | Evidence for a trianion intermediate in the metalation of 4-hydroxy-6,7-dimethoxy-8-methyl-2-naphthoic acid. Methodology and application to racemic 5,5'-didesisopropyl-5,5'-dialkylapogossypol derivatives. | 2011 | J. Org. Chem. | pmid:21174400 |
| Gu ZP et al. | Relationship between hormone profiles and the restoration of spermatogenesis in men treated with gossypol. | 1990 | Int. J. Androl. | pmid:2117586 |
| Schteingart DE et al. | Expression of anti-apoptosis genes determines the response of adrenal cancer to apoptosis-inducing chemotherapy. | 2010 | Anticancer Res. | pmid:21187456 |
| Zhong S et al. | Aromatase expression in leptin-pretreated human breast pre-adipocytes is enhanced by zeranol and suppressed by (-)-gossypol. | 2010 | Anticancer Res. | pmid:21187493 |
| Hu ZY et al. | Apogossypolone targets mitochondria and light enhances its anticancer activity by stimulating generation of singlet oxygen and reactive oxygen species. | 2011 | Chin J Cancer | pmid:21192843 |
| Moon DO et al. | Gossypol decreases tumor necrosis factor-α-induced intercellular adhesion molecule-1 expression via suppression of NF-κB activity. | 2011 | Food Chem. Toxicol. | pmid:21223991 |
| Akagunduz O et al. | Radiosensitization of hormone-refractory prostate cancer cells by gossypol treatment. | 2010 Oct-Dec | J BUON | pmid:21229643 |
| Özdoğan M et al. | Effect of gossypol on blood serum parameters and small intestinal morphology of male broilers. | 2012 | J Anim Physiol Anim Nutr (Berl) | pmid:21261752 |
| Lu Z et al. | Mirabamides E-H, HIV-inhibitory depsipeptides from the sponge Stelletta clavosa. | 2011 | J. Nat. Prod. | pmid:21280591 |
| Ready N et al. | Double-blind, placebo-controlled, randomized phase 2 study of the proapoptotic agent AT-101 plus docetaxel, in second-line non-small cell lung cancer. | 2011 | J Thorac Oncol | pmid:21289522 |
| Mellon JE et al. | Inhibitory effects of gossypol-related compounds on growth of Aspergillus flavus. | 2011 | Lett. Appl. Microbiol. | pmid:21291481 |
| Leal-Garza CH et al. | [Frequency of sister chromatid exchange in mice treated with gossypol]. | 1990 Jul-Sep | Arch Invest Med (Mex) | pmid:2131768 |
| Zhan WH et al. | [Studies on the killing effect of gamma ray irradiated peripheral blood mononuclear cells combined with (-)-gossypol on human prostate cancer LNCaP cells]. | 2010 | Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi | pmid:21319440 |
| Granchi C et al. | Discovery of N-hydroxyindole-based inhibitors of human lactate dehydrogenase isoform A (LDH-A) as starvation agents against cancer cells. | 2011 | J. Med. Chem. | pmid:21332213 |
| Li G et al. | [Effect of testosterone on the expression of CMTM family of the male spermatogenesis suppression rats]. | 2010 | Yao Xue Xue Bao | pmid:21351585 |
| Amm HM et al. | Mechanisms of drug sensitization to TRA-8, an agonistic death receptor 5 antibody, involve modulation of the intrinsic apoptotic pathway in human breast cancer cells. | 2011 | Mol. Cancer Res. | pmid:21357440 |
| Pang X et al. | (-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis. | 2011 | Mol. Cancer Ther. | pmid:21372225 |
| Aver'ianov AA and Merzliak MN | [Chemiluminescence during oxidation of gossipol by peroxidase]. | 1978 | Biokhimiia | pmid:214169 |
| Vyas RK et al. | Early events in rat testis after gossypol administration. | 1990 Jan-Feb | Acta Eur. Fertil. | pmid:2150145 |
| Guo Z et al. | [Gossypol acetic acid induces DNA double-strand breaks in human mucoepidermoid carcinoma cell MEC-1]. | 2011 | Sheng Li Xue Bao | pmid:21505732 |
| Lu Q | [Comparative studies on antifertility mechanism and toxicology of Tripterygium wilfordii monomer T4 and gossypol]. | 1990 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:2151263 |
| Ma X et al. | Environmental inhibitors of 11β-hydroxysteroid dehydrogenase type 2. | 2011 | Toxicology | pmid:21515335 |
| Dash R et al. | Apogossypol derivative BI-97C1 (Sabutoclax) targeting Mcl-1 sensitizes prostate cancer cells to mda-7/IL-24-mediated toxicity. | 2011 | Proc. Natl. Acad. Sci. U.S.A. | pmid:21555592 |
| Burton GA et al. | Cyclic GMP release and vasodilatation induced by EDRF and atrial natriuretic factor in the isolated perfused kidney of the rat. | 1990 | Br. J. Pharmacol. | pmid:2158376 |
| Gu Y et al. | Inhibitory effect of gossypol on steroidogenic pathways in cultured bovine luteal cells. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2162666 |
| Gu Y et al. | Inhibitory effect of gossypol on human chorionic gonadotropin (hCG)-induced progesterone secretion in cultured bovine luteal cells. | 1990 | Life Sci. | pmid:2168511 |
| Li H et al. | Liposomes containing (-)-gossypol-enriched cottonseed oil suppress Bcl-2 and Bcl-xL expression in breast cancer cells. | 2011 | Pharm. Res. | pmid:21710341 |