Hsiao WT et al. |
Involvement of Smac, p53, and caspase pathways in induction of apoptosis by gossypol in human retinoblastoma cells. |
2012 |
Mol. Vis. |
pmid:22876131
|
Balakrishnan K et al. |
Bax and Bak are required for apogossypolone, a BH3-mimetic, induced apoptosis in chronic lymphocytic leukemia cells. |
2013 |
Leuk. Lymphoma |
pmid:22866921
|
Zheng DK et al. |
[Studies on the resolution of racemic gossypol. IV. Use of threo (-) or (+)-1-(p-nitrophenyl)-1,3-dihydroxypropylamine-2 as the resolving agent]. |
1990 |
Yao Xue Xue Bao |
pmid:2284968
|
Si YK et al. |
[Studies on the resolution of racemic gossypol. III. Study on the chemical and physical properties of the amino condensates of gossypol]. |
1990 |
Yao Xue Xue Bao |
pmid:2284967
|
Zheng DK et al. |
[Studies on the resolution of racemic gossypol. II. By chiral alpha-methylphenethylamine and alpha-methylbenzylamine]. |
1990 |
Yao Xue Xue Bao |
pmid:2284966
|
Cuéllar A et al. |
Cholesterol side-chain cleavage and 11 beta-hydroxylation are inhibited by gossypol in adrenal cortex mitochondria. |
1990 |
J. Steroid Biochem. Mol. Biol. |
pmid:2278843
|
Sun P et al. |
Action of db-cAMP on the bystander effect and chemosensitivity through connexin 43 and Bcl-2-mediated pathways in medulloblastoma cells. |
2012 |
Oncol. Rep. |
pmid:22766741
|
Li HQ et al. |
Structure-based design of rhodanine-based acylsulfonamide derivatives as antagonists of the anti-apoptotic Bcl-2 protein. |
2012 |
Bioorg. Med. Chem. |
pmid:22739087
|
Ignatova M et al. |
Quaternized chitosan-coated nanofibrous materials containing gossypol: preparation by electrospinning, characterization and antiproliferative activity towards HeLa cells. |
2012 |
Int J Pharm |
pmid:22728261
|
Kanwar U et al. |
Gossypol-induced inhibition of glucose uptake in human ejaculated spermatozoa may be mediated by lipid peroxidation. |
1990 |
Contraception |
pmid:2272185
|
|
|
|
|
pmid:22711315
|
Singh SK and Rath SK |
Histologic changes in the mouse testis after treatment with gossypol tetra-acetic acid. |
1990 |
Arch. Histol. Cytol. |
pmid:2268474
|
Rovai LE et al. |
Effect of gossypol on trypomastigotes and amastigotes of Trypanosoma cruzi. |
1990 Jul-Aug |
J. Protozool. |
pmid:2258832
|
El-Mokadem MY et al. |
Alleviation of reproductive toxicity of gossypol using selenium supplementation in rams. |
2012 |
J. Anim. Sci. |
pmid:22585803
|
Zubair H et al. |
Apogossypolone, derivative of gossypol, mobilizes endogenous copper in human peripheral lymphocytes leading to oxidative DNA breakage. |
2012 |
Eur J Pharm Sci |
pmid:22554693
|
Pond GR et al. |
Efficacy of docetaxel-based chemotherapy following ketoconazole in metastatic castration-resistant prostate cancer: implications for prior therapy in clinical trials. |
2013 |
Urol. Oncol. |
pmid:22552048
|
Zhang YS et al. |
Gossypol exhibits a strong influence towards UDP-glucuronosyltransferase (UGT) 1A1, 1A9 and 2B7-mediated metabolism of xenobiotics and endogenous substances. |
2012 |
Molecules |
pmid:22543504
|
Cheng W et al. |
[Effects of gossypol acetate on apoptosis in primary cultured cells from patients with lymphoid leukemia and its synergy with dexamethasone]. |
2012 |
Zhongguo Shi Yan Xue Ye Xue Za Zhi |
pmid:22541072
|
Nair IN and Bhiwgade DA |
Effect of gossypol on pituitary reproductive axis: ultrastructural and biochemical studies. |
1990 |
Indian J. Exp. Biol. |
pmid:2253964
|
Mazumder S et al. |
Mcl-1 Phosphorylation defines ABT-737 resistance that can be overcome by increased NOXA expression in leukemic B cells. |
2012 |
Cancer Res. |
pmid:22525702
|
Tao XY et al. |
Gossypol-enhanced P450 gene pool contributes to cotton bollworm tolerance to a pyrethroid insecticide. |
2012 |
Mol. Ecol. |
pmid:22515600
|
Lin H et al. |
A validated HPLC assay for the determination of R-(-)-gossypol in human plasma and its application in clinical pharmacokinetic studies. |
2012 |
J Pharm Biomed Anal |
pmid:22483642
|
Billard C |
Development of Noxa-like BH3 mimetics for apoptosis-based therapeutic strategy in chronic lymphocytic leukemia. |
2012 |
Mol. Cancer Res. |
pmid:22466256
|
An T et al. |
Amino acid derivatives of the (-) enantiomer of gossypol are effective fusion inhibitors of human immunodeficiency virus type 1. |
2012 |
Antiviral Res. |
pmid:22426469
|
Bodur C and Basaga H |
Bcl-2 inhibitors: emerging drugs in cancer therapy. |
2012 |
Curr. Med. Chem. |
pmid:22414090
|
Kisim A et al. |
Pretreatment with AT-101 enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis of breast cancer cells by inducing death receptors 4 and 5 protein levels. |
2012 |
J. Cancer Res. Clin. Oncol. |
pmid:22411600
|
Kerr LA |
Incidence and management of poisonings in livestock. |
1990 |
Vet Hum Toxicol |
pmid:2238452
|
Wagner TA et al. |
Hemigossypol, a constituent in developing glanded cottonseed (Gossypium hirsutum). |
2012 |
J. Agric. Food Chem. |
pmid:22369216
|
Mellon JE et al. |
Inhibitory effects of gossypol, gossypolone, and apogossypolone on a collection of economically important filamentous fungi. |
2012 |
J. Agric. Food Chem. |
pmid:22324794
|
Yang J et al. |
Synthesis and antiviral activities of novel gossypol derivatives. |
2012 |
Bioorg. Med. Chem. Lett. |
pmid:22226654
|
Swan MA et al. |
Electron microscopic observations on the effect of gossypol on rat cauda epididymis. |
1990 |
Z Mikrosk Anat Forsch |
pmid:2220026
|
Lian J et al. |
Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation. |
2012 |
Mol. Cancer Ther. |
pmid:22188816
|
Masood A et al. |
Downregulation of BCL2 by AT-101 enhances the antileukaemic effect of lenalidomide both by an immune dependant and independent manner. |
2012 |
Br. J. Haematol. |
pmid:22171982
|
Chien CC et al. |
The role of COX-2/PGE2 in gossypol-induced apoptosis of colorectal carcinoma cells. |
2012 |
J. Cell. Physiol. |
pmid:22170686
|
Jiang J et al. |
Gossypol inhibits growth, invasiveness, and angiogenesis in human prostate cancer cells by modulating NF-κB/AP-1 dependent- and independent-signaling. |
2012 |
Clin. Exp. Metastasis |
pmid:22167622
|
Imai A et al. |
Metronomic dosing of BH3 mimetic small molecule yields robust antiangiogenic and antitumor effects. |
2012 |
Cancer Res. |
pmid:22158856
|
Zhou DR et al. |
[Gossypol decreases the expression of connexin 43 in Sertoli cells]. |
2011 |
Zhonghua Nan Ke Xue |
pmid:22141269
|
Semon B |
Dietary intake of cottonseed toxins is hypothesized to be a partial cause of Alzheimer's disorder. |
2012 |
Med. Hypotheses |
pmid:22136946
|
Sonpavde G et al. |
Randomized phase II trial of docetaxel plus prednisone in combination with placebo or AT-101, an oral small molecule Bcl-2 family antagonist, as first-line therapy for metastatic castration-resistant prostate cancer. |
2012 |
Ann. Oncol. |
pmid:22112969
|
Celorio-Mancera Mde L et al. |
Transcriptional responses underlying the hormetic and detrimental effects of the plant secondary metabolite gossypol on the generalist herbivore Helicoverpa armigera. |
2011 |
BMC Genomics |
pmid:22111916
|
Huang HF and Wang M |
[Effects of gossypol acetate, progesterone, danazol and GnRH-A (gonadotropin release hormone-A) on the DNA-synthesis of human endometrial cell in vitro]. |
1990 |
Zhong Xi Yi Jie He Za Zhi |
pmid:2208435
|
Jaroszewski JW et al. |
Action of gossypol and rhodamine 123 on wild type and multidrug-resistant MCF-7 human breast cancer cells: 31P nuclear magnetic resonance and toxicity studies. |
1990 |
Cancer Res. |
pmid:2208159
|
Ilkevych NS et al. |
Vibrational spectra, structure and antioxidant activity of gossypol imine derivatives. |
2012 |
Spectrochim Acta A Mol Biomol Spectrosc |
pmid:22078080
|
Wang Y et al. |
Small molecule inhibition of the steroid receptor coactivators, SRC-3 and SRC-1. |
2011 |
Mol. Endocrinol. |
pmid:22053001
|
Hu W et al. |
Proapoptotic protein Smac mediates apoptosis in cisplatin-resistant ovarian cancer cells when treated with the anti-tumor agent AT101. |
2012 |
J. Biol. Chem. |
pmid:22052903
|
Yang X et al. |
Identification and proteomic analysis of a novel gossypol-degrading fungal strain. |
2012 |
J. Sci. Food Agric. |
pmid:22002592
|
Benz CC et al. |
Biochemical correlates of the antitumor and antimitochondrial properties of gossypol enantiomers. |
1990 |
Mol. Pharmacol. |
pmid:2193225
|
Baggstrom MQ et al. |
A phase II study of AT-101 (Gossypol) in chemotherapy-sensitive recurrent extensive-stage small cell lung cancer. |
2011 |
J Thorac Oncol |
pmid:21918390
|
Rathore KS et al. |
Ultra-low gossypol cottonseed: generational stability of the seed-specific, RNAi-mediated phenotype and resumption of terpenoid profile following seed germination. |
2012 |
Plant Biotechnol. J. |
pmid:21902797
|
Grando SA et al. |
Clinical and laboratory evaluation of hemocarboadsorption in autoimmune bullous dermatoses. |
1990 |
Int J Artif Organs |
pmid:2189836
|