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Gossypol toxicity from cottonseed products. |
2014 |
ScientificWorldJournal |
pmid:24895646
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Qian C et al. |
Identification of a novel potential antitumor activity of gossypol as an APE1/Ref-1 inhibitor. |
2014 |
Drug Des Devel Ther |
pmid:24872679
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Kaza N et al. |
BNIP3 regulates AT101 [(-)-gossypol] induced death in malignant peripheral nerve sheath tumor cells. |
2014 |
PLoS ONE |
pmid:24824755
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Mellon JE et al. |
Growth inhibitory effects of gossypol and related compounds on fungal cotton root pathogens. |
2014 |
Lett. Appl. Microbiol. |
pmid:24713043
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Cho H et al. |
Polymeric micelles for apoptosis-targeted optical imaging of cancer and intraoperative surgical guidance. |
2014 |
PLoS ONE |
pmid:24587157
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Sonpavde G et al. |
Radiographic progression by Prostate Cancer Working Group (PCWG)-2 criteria as an intermediate endpoint for drug development in metastatic castration-resistant prostate cancer. |
2014 |
BJU Int. |
pmid:24298897
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Ignatova M et al. |
Quaternized chitosan-coated nanofibrous implants loaded with gossypol prepared by electrospinning and their efficacy against Graffi myeloid tumor. |
2014 |
J Biomater Sci Polym Ed |
pmid:24236801
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Paulus A et al. |
The investigational agent MLN2238 induces apoptosis and is cytotoxic to CLL cells in vitro, as a single agent and in combination with other drugs. |
2014 |
Br. J. Haematol. |
pmid:24467634
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Jang GH and Lee M |
BH3-mimetic gossypol-induced autophagic cell death in mutant BRAF melanoma cells with high expression of p21Cip¹.). |
2014 |
Life Sci. |
pmid:24625733
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Li G et al. |
RhoA/ROCK/PTEN signaling is involved in AT-101-mediated apoptosis in human leukemia cells in vitro and in vivo. |
2014 |
Cell Death Dis |
pmid:24434521
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Mei H et al. |
Autophagy inhibition enhances pan-Bcl-2 inhibitor AT-101-induced apoptosis in non-small cell lung cancer. |
2014 |
Neoplasma |
pmid:24299314
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Spijkers-Hagelstein JA et al. |
Glucocorticoid sensitisation in Mixed Lineage Leukaemia-rearranged acute lymphoblastic leukaemia by the pan-BCL-2 family inhibitors gossypol and AT-101. |
2014 |
Eur. J. Cancer |
pmid:24703900
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Sorokina EV et al. |
[Influence of immunovac-VP-4 therapy on innate immunity effectors in patients with darier erythema annulare centrifugum]. |
2013 Nov-Dec |
Zh. Mikrobiol. Epidemiol. Immunobiol. |
pmid:24605681
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Lin YL et al. |
Synergistic combination of small molecule inhibitor and RNA interference against antiapoptotic Bcl-2 protein in head and neck cancer cells. |
2013 |
Mol. Pharm. |
pmid:23734725
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Pond GR et al. |
Efficacy of docetaxel-based chemotherapy following ketoconazole in metastatic castration-resistant prostate cancer: implications for prior therapy in clinical trials. |
2013 |
Urol. Oncol. |
pmid:22552048
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Balakrishnan K et al. |
Bax and Bak are required for apogossypolone, a BH3-mimetic, induced apoptosis in chronic lymphocytic leukemia cells. |
2013 |
Leuk. Lymphoma |
pmid:22866921
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Pridgeon JW et al. |
Attempt to develop live attenuated bacterial vaccines by selecting resistance to gossypol, proflavine hemisulfate, novobiocin, or ciprofloxacin. |
2013 |
Vaccine |
pmid:23499519
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Hamdy R et al. |
Synthesis and evaluation of 3-(benzylthio)-5-(1H-indol-3-yl)-1,2,4-triazol-4-amines as Bcl-2 inhibitory anticancer agents. |
2013 |
Bioorg. Med. Chem. Lett. |
pmid:23474389
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Yuan Y et al. |
Gossypol and an HMT G9a inhibitor act in synergy to induce cell death in pancreatic cancer cells. |
2013 |
Cell Death Dis |
pmid:23807219
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Deng S et al. |
Gossypol acetic acid induces apoptosis in RAW264.7 cells via a caspase-dependent mitochondrial signaling pathway. |
2013 |
J. Vet. Sci. |
pmid:23820203
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Zhan YH et al. |
Growth inhibition and apoptosis induction of human umbilical vein endothelial cells by apogossypolone. |
2013 |
Asian Pac. J. Cancer Prev. |
pmid:23679275
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Mellon JE et al. |
Effects of temperature and medium composition on inhibitory activities of gossypol-related compounds against aflatoxigenic fungi. |
2013 |
J. Appl. Microbiol. |
pmid:23594138
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Cho H et al. |
Poly(ethylene glycol)-block-poly(ε-caprolactone) micelles for combination drug delivery: evaluation of paclitaxel, cyclopamine and gossypol in intraperitoneal xenograft models of ovarian cancer. |
2013 |
J Control Release |
pmid:23246471
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Ahn JH et al. |
Defective autophagy in multidrug resistant cells may lead to growth inhibition by BH3-mimetic gossypol. |
2013 |
J. Cell. Physiol. |
pmid:23254564
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Zhang Z et al. |
Novel soluble myeloid cell leukemia sequence 1 (Mcl-1) inhibitor (E,E)-2-(benzylaminocarbonyl)-3-styrylacrylonitrile (4g) developed using a fragment-based approach. |
2013 |
Eur J Med Chem |
pmid:23220642
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Xin J et al. |
ApoG2 as the most potent gossypol derivatives inhibits cell growth and induces apoptosis on gastric cancer cells. |
2013 |
Biomed. Pharmacother. |
pmid:23201009
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Song T et al. |
3-Thiomorpholin-8-oxo-8H-acenaphtho [1,2-b] pyrrole-9-carbonitrile (S1) derivatives as pan-Bcl-2-inhibitors of Bcl-2, Bcl-xL and Mcl-1. |
2013 |
Bioorg. Med. Chem. |
pmid:23206987
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Cheng P et al. |
The novel BH-3 mimetic apogossypolone induces Beclin-1- and ROS-mediated autophagy in human hepatocellular carcinoma [corrected] cells. |
2013 |
Cell Death Dis |
pmid:23392177
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Ni Z et al. |
Natural Bcl-2 inhibitor (-)- gossypol induces protective autophagy via reactive oxygen species-high mobility group box 1 pathway in Burkitt lymphoma. |
2013 |
Leuk. Lymphoma |
pmid:23398207
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Huo M et al. |
Suppression of LPS-induced inflammatory responses by gossypol in RAW 264.7 cells and mouse models. |
2013 |
Int. Immunopharmacol. |
pmid:23352443
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Goff DJ et al. |
A Pan-BCL2 inhibitor renders bone-marrow-resident human leukemia stem cells sensitive to tyrosine kinase inhibition. |
2013 |
Cell Stem Cell |
pmid:23333150
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Anderson MA et al. |
BH3 mimetic therapy: an emerging and promising approach to treating chronic lymphocytic leukemia. |
2013 |
Leuk. Lymphoma |
pmid:23339446
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Kannan A et al. |
Effect of feeding of calcium hydroxide-treated or vitamin E-supplemented cottonseed meal on plasma gossypol levels, blood parameters, and performance of Bikaneri lambs. |
2013 |
Trop Anim Health Prod |
pmid:23345064
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Ansari N et al. |
Quantitative 3D cell-based assay performed with cellular spheroids and fluorescence microscopy. |
2013 |
Methods Cell Biol. |
pmid:23317907
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Senarisoy M et al. |
Gossypol interferes with both type I and type II topoisomerase activities without generating strand breaks. |
2013 |
Cell Biochem. Biophys. |
pmid:23161103
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Hall C et al. |
Bcl-2 family of proteins as therapeutic targets in genitourinary neoplasms. |
2013 |
Clin Genitourin Cancer |
pmid:23083798
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Palle SR et al. |
RNAi-mediated Ultra-low gossypol cottonseed trait: performance of transgenic lines under field conditions. |
2013 |
Plant Biotechnol. J. |
pmid:23078138
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Zelaya CA et al. |
Di(phenylpropylamino)gossypol: a derivative of the dimeric natural product gossypol. |
2013 |
Acta Crystallogr C |
pmid:23579723
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Lin J et al. |
Induction of apoptosis and antitumor effects of a small molecule inhibitor of Bcl-2 and Bcl-xl, gossypol acetate, in multiple myeloma in vitro and in vivo. |
2013 |
Oncol. Rep. |
pmid:23708869
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Zhou M et al. |
Metabolic engineering of gossypol in cotton. |
2013 |
Appl. Microbiol. Biotechnol. |
pmid:23775273
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Song B et al. |
Gossypol suppresses mouse T lymphocytes via inhibition of NFκB, NFAT and AP-1 pathways. |
2013 |
Immunopharmacol Immunotoxicol |
pmid:23981004
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Billard C |
BH3 mimetics: status of the field and new developments. |
2013 |
Mol. Cancer Ther. |
pmid:23974697
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Guo JY et al. |
Effects of high-gossypol cotton on the development and reproduction of Bemisia tabaci (Hemiptera: Aleyrodidae) MEAM1 cryptic species. |
2013 |
J. Econ. Entomol. |
pmid:23865205
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Zhang Z et al. |
Design and application of a rigid quinazolone scaffold based on two-face Bim α-helix mimicking. |
2013 |
Eur J Med Chem |
pmid:24095762
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Karaca B et al. |
Combination of AT-101/cisplatin overcomes chemoresistance by inducing apoptosis and modulating epigenetics in human ovarian cancer cells. |
2013 |
Mol. Biol. Rep. |
pmid:23269627
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Soderquist R et al. |
Gossypol overcomes stroma-mediated resistance to the BCL2 inhibitor ABT-737 in chronic lymphocytic leukemia cells ex vivo. |
2013 |
Leukemia |
pmid:23640104
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Granchi C et al. |
Small-molecule inhibitors of human LDH5. |
2013 |
Future Med Chem |
pmid:24175747
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Zhang Z et al. |
Fragment-based design, synthesis, and biological evaluation of N-substituted-5-(4-isopropylthiophenol)-2-hydroxynicotinamide derivatives as novel Mcl-1 inhibitors. |
2013 |
Eur J Med Chem |
pmid:23314054
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Zhong S et al. |
(-)-Gossypol-enriched cottonseed oil inhibits proliferation and adipogenesis of human breast pre-adipocytes. |
2013 |
Anticancer Res. |
pmid:23482766
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Varadarajan S et al. |
Sabutoclax (BI97C1) and BI112D1, putative inhibitors of MCL-1, induce mitochondrial fragmentation either upstream of or independent of apoptosis. |
2013 |
Neoplasia |
pmid:23633928
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