| MeSH term | MeSH ID | Detail |
|---|---|---|
| Chemical and Drug Induced Liver Injury | D056486 | 39 associated lipids |
| Endometriosis | D004715 | 29 associated lipids |
| Uterine Neoplasms | D014594 | 18 associated lipids |
| Proteinuria | D011507 | 30 associated lipids |
| Genital Neoplasms, Male | D005834 | 3 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
| Neuroblastoma | D009447 | 66 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Protein Deficiency | D011488 | 5 associated lipids |
| Leukemia, Experimental | D007942 | 42 associated lipids |
Gossypol
Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
Cross Reference
Introduction
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Gossypol?
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Gossypol
PubChem Associated disorders and diseases
What pathways are associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Gossypol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Gossypol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Gossypol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Gossypol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Gossypol?
Xenograft Model
Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Gossypol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Smith C et al. | Protection by albumin against the pro-oxidant actions of phenolic dietary components. | 1992 | Food Chem. Toxicol. | pmid:1379971 |
| Sagach VF et al. | Functional hyperemia of skeletal muscle: role of endothelium. | 1992 | J. Cardiovasc. Pharmacol. | pmid:1282960 |
| Tkachenko MN et al. | Involvement of endothelium in vasodilating effects of vintoperol. | 1992 | J. Cardiovasc. Pharmacol. | pmid:1282997 |
| Zaidi R and Hadi SM | Complexes involving gossypol, DNA and Cu(II). | 1992 | Biochem. Int. | pmid:1290468 |
| Zaidi R and Hadi SM | Strand scission in DNA by gossypol and Cu(II): role of Cu(I) and oxygen-free radicals. | 1992 | J. Biochem. Toxicol. | pmid:1293310 |
| González-Garza MT et al. | Further studies on the in vitro activity of gossypol as antiamebic agent. | 1992 | Arch. Med. Res. | pmid:1340324 |
| Lan ZJ et al. | Effects of multiglycosides of Tripterygium wilfordii (GTW) on rat fertility and Leydig and Sertoli cells. | 1992 | Contraception | pmid:1511610 |
| Jensen EC et al. | Lipoxygenase inhibitors shift the yeast/mycelium dimorphism in Ceratocystis ulmi. | 1992 | Appl. Environ. Microbiol. | pmid:1514797 |
| Stein RC et al. | A preliminary clinical study of gossypol in advanced human cancer. | 1992 | Cancer Chemother. Pharmacol. | pmid:1394805 |
| Herndon N | Looking for the "male pill". | 1992 | Netw Res Triangle Park N C | pmid:12317724 |
| Terry BJ et al. | Inhibition of herpes simplex virus type 1 DNA polymerase by the natural product oosporein. | 1992 | J. Antibiot. | pmid:1556024 |
| Knych ET | Endothelium-dependent tolerance to ethanol-induced contraction of rat aorta: effect of inhibition of EDRF action and nitric oxide synthesis. | 1992 | Alcohol. Clin. Exp. Res. | pmid:1558303 |
| Wang JM et al. | Differential binding of (+) and (-) gossypol to plasma protein and their entry into rat testis. | 1992 | J. Reprod. Fertil. | pmid:1625243 |
| Levinsky H et al. | Inhibition of sialyl transferase activity by gossypol acetic acid in human seminal plasma. | 1991 Mar-Apr | Andrologia | pmid:1952122 |
| Woolley RJ | Contraception--a look forward, Part II: Mifepristone and gossypol. | 1991 Mar-Apr | J Am Board Fam Pract | pmid:1823560 |
| Thomas M et al. | Effects of gossypol on the cell cycle phases in T-47D human breast cancer cells. | 1991 Jul-Aug | Anticancer Res. | pmid:1746904 |
| Posevaia TA et al. | [The role of herpetic infection in epithelial dysplasias of the cervix uteri and a trial of their treatment with antiherpetic preparations]. | 1991 Jan-Feb | Vopr. Virusol. | pmid:1650068 |
| Bertrand V and Belleville J | Effect of refeeding diets containing cottonseed flour with traces of gossypol on rat liver and testis. | 1991 | Br. J. Nutr. | pmid:1760445 |
| Gu Y et al. | Gossypolone suppresses progesterone synthesis in bovine luteal cells. | 1991 | J. Steroid Biochem. Mol. Biol. | pmid:2064986 |
| Kono H et al. | Effects of progesterone and gossypol on monoamine oxidase activity in human term placental explant. | 1991 | Tohoku J. Exp. Med. | pmid:2048118 |
| Lin YC et al. | Gossypol pharmacokinetics in mid-lactation Brown Swiss dairy cows. | 1991 | Vet. Res. Commun. | pmid:1771762 |
| Jinsart W et al. | Inhibition of wheat embryo calcium-dependent protein kinase and avian myosin light chain kinase by flavonoids and related compounds. | 1991 | Biol. Chem. Hoppe-Seyler | pmid:1772594 |
| Thomas KD et al. | Effects of an aqueous extract of cotton seed (Gossypium barbadense Linn.) on adult male rats. | 1991 | Adv Contracept | pmid:1776560 |
| Benz CC et al. | Gossypol effects on endothelial cells and tumor blood flow. | 1991 | Life Sci. | pmid:1875793 |
| Nikokyris P et al. | Effects of gossypol content of cottonseed cake on blood constituents in growing-fattening lambs. | 1991 | J. Dairy Sci. | pmid:1787198 |
| Gonzalez-Garza T et al. | In vitro evaluation of gossypol as potential antiamoebic drug. | 1991 | Proc. West. Pharmacol. Soc. | pmid:1788315 |
| Lu H and Liu GT | Effect of dibenzo[a,c]cyclooctene lignans isolated from Fructus schizandrae on lipid peroxidation and anti-oxidative enzyme activity. | 1991 | Chem. Biol. Interact. | pmid:1849050 |
| Messiha FS | Behavioral and metabolic interaction between gossypol and ethanol. | 1991 | Toxicol. Lett. | pmid:1853362 |
| Kono H et al. | Gossypol effects on monoamine oxidase (MAO) activity in several organs of term rats. | 1991 | Tohoku J. Exp. Med. | pmid:2063399 |
| Barraza ML et al. | Iron sulfate and feed pelleting to detoxify free gossypol in cottonseed diets for dairy cattle. | 1991 | J. Dairy Sci. | pmid:1744276 |
| Mazumder B et al. | Effect of chlorpromazine and gossypol on Ca(2+)-ATPase activity in the microsomal membranes of rat testes. | 1991 | Indian J. Biochem. Biophys. | pmid:1831790 |
| Sang GW et al. | Inhibitory effects of gossypol on corticosteroid 11-beta-hydroxysteroid dehydrogenase from guinea pig kidney: a possible mechanism for causing hypokalemia. | 1991 | J. Steroid Biochem. Mol. Biol. | pmid:1888675 |
| Royer RE et al. | Inhibition of human immunodeficiency virus type I replication by derivatives of gossypol. | 1991 | Pharmacol. Res. | pmid:1805194 |
| Murohara T et al. | Age related attenuation of the endothelium dependent relaxation to noradrenaline in isolated pig coronary arteries. | 1991 | Cardiovasc. Res. | pmid:1806231 |
| Sagach VF and Kindybaliuk AM | [The role of the endothelium in the development of functional hyperemia of the skeletal muscles]. | 1991 | Biull Eksp Biol Med | pmid:1810472 |
| Gu Y and Lin YC | Suppression of adrenocorticotropic hormone (ACTH)-induced corticosterone secretion in cultured rat adrenocortical cells by gossypol and gossypolone. | 1991 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:1647048 |
| Wu YW et al. | Inhibitory effects of gossypol on adrenal function. | 1991 | Acta Endocrinol. | pmid:1648853 |
| Zheng YH et al. | [Effect of gossypol acetic acid on hCG-stimulated progesterone production of dissociated rat luteal cells]. | 1991 | Yao Xue Xue Bao | pmid:1668561 |
| Moore SA et al. | Brain microvessel 12-hydroxyeicosatetraenoic acid is the (S) enantiomer and is lipoxygenase derived. | 1991 | J. Neurochem. | pmid:1907312 |
| Yuan XB et al. | [Study on polymorphism of gossypol by infrared spectrophotometry and X-ray diffraction]. | 1991 | Yao Xue Xue Bao | pmid:1950572 |
| Pohl U and Lamontagne D | Impaired tissue perfusion after inhibition of endothelium-derived nitric oxide. | 1991 | Basic Res. Cardiol. | pmid:1953621 |
| Deck LM et al. | Gossypol and derivatives: a new class of aldose reductase inhibitors. | 1991 | J. Med. Chem. | pmid:1956050 |
| Manabe S et al. | Zone-specific hepatotoxicity of gossypol in perfused rat liver. | 1991 | Toxicon | pmid:1926180 |
| Messiha FS | Effect of gossypol on kinetics of mouse liver alcohol and aldehyde dehydrogenase. | 1991 | Gen. Pharmacol. | pmid:1936890 |
| Ford JM et al. | Modulation of resistance to alkylating agents in cancer cell by gossypol enantiomers. | 1991 | Cancer Lett. | pmid:2004358 |
| SaÄitkulov AM et al. | [Relation between interferon-inducing activity of natural interferon inducers and their chemical structure]. | 1991 | Antibiot. Khimioter. | pmid:1719947 |
| Kramer RY et al. | The effect of cottonseed components on testicular development in pubescent rams. | 1991 | Vet Hum Toxicol | pmid:2017859 |
| Barak D et al. | Structural investigation of protein kinase C inhibitors. | 1991 | J Mol Struct | pmid:11538178 |
| Nakamura M et al. | Presence of a 16 kd protein in human seminal plasma counteracts the effects of the anti-fertility agent, gossypol. | 1991 | Hum. Reprod. | pmid:1939555 |
| Botsoglou NA | High-performance liquid chromatographic method for the determination of free gossypol in chicken liver. | 1991 | J. Chromatogr. | pmid:1783672 |