Gossypol

Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.

Cross Reference

Introduction

To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Gossypol?

Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Gossypol

MeSH term MeSH ID Detail
Chemical and Drug Induced Liver Injury D056486 39 associated lipids
Endometriosis D004715 29 associated lipids
Uterine Neoplasms D014594 18 associated lipids
Proteinuria D011507 30 associated lipids
Genital Neoplasms, Male D005834 3 associated lipids
Leukemia D007938 74 associated lipids
Neuroblastoma D009447 66 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Protein Deficiency D011488 5 associated lipids
Leukemia, Experimental D007942 42 associated lipids
Per page 10 20 50 100 | Total 52

PubChem Associated disorders and diseases

What pathways are associated with Gossypol

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
Loading... please refresh the page if content is not showing up.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Gossypol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Gossypol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Gossypol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Gossypol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Gossypol?

Xenograft Model

Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).

Transgenic Model

Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with Gossypol

Download all related citations
Per page 10 20 50 100 | Total 1511
Authors Title Published Journal PubMed Link
Ershov FI et al. [A new interferon inducer active via peroral administration]. 1986 May-Jun Vopr. Virusol. pmid:2429451
Ershov FI et al. [Interferonogenic activity of low-molecular compounds of plant origin]. 1988 Nov-Dec Vopr. Virusol. pmid:2470203
Labzo SS et al. [Stimulation of interferon formation by natural and synthetic inducers in cultures of human tonsil cells]. 1980 Jan-Feb Vopr. Virusol. pmid:6158181
Shi A et al. [Screening and breeding of highly-effected degrading cotton-phenol strains and study on defoxication technology and conditions]. 1998 Wei Sheng Wu Xue Bao pmid:12549423
Han J et al. [Determination of anti-nutrients in genetically modified crops]. 2004 Wei Sheng Yan Jiu pmid:15727185
Zhan WH et al. [Studies on the killing effect of gamma ray irradiated peripheral blood mononuclear cells combined with (-)-gossypol on human prostate cancer LNCaP cells]. 2010 Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi pmid:21319440
Yuan XB et al. [Study on polymorphism of gossypol by infrared spectrophotometry and X-ray diffraction]. 1991 Yao Xue Xue Bao pmid:1950572
Wong YK and Li JH [Quantum pharmacological investigations of gossypol and some simple aromatic compounds]. 1986 Yao Xue Xue Bao pmid:3728037
Wang WC et al. [Changes of serum concentrations of testosterone, LH and FSH in men taking gossypol]. 1985 Yao Xue Xue Bao pmid:3938917
Wang YE et al. [Studies o the anti-fertility actions of cotton seed meal and gossypol (author's transl)]. 1979 Yao Xue Xue Bao pmid:583588
Chen ZC et al. [The influence of gossypol on the potassium metabolism of rats and the effect of some possible contributing factors (low-K and low-MG intake) (author's transl)]. 1979 Yao Xue Xue Bao pmid:532653
Tang XC et al. [Comparative studies on the absorption, distribution and excretion of 14C-gossypol in four species of animals (author's transl)]. 1980 Yao Xue Xue Bao pmid:6779501
Jiang DH and Xue H [Monoanilinogossypol--the impurity possibly present in gossypol (author's transl)]. 1982 Yao Xue Xue Bao pmid:7102321
Zhou LF and Lei HP [Effect of gossypol acetic acid on the uterus and ovary]. 1984 Yao Xue Xue Bao pmid:6496095
Wong SM et al. 14C-gossypol: optimum conditions for synthesis by cotton seedlings. 1983 Yao Xue Xue Bao pmid:6687973
Lei HP [Prospect of gossypol as a contraceptive agents for men]. 1983 Yao Xue Xue Bao pmid:6637482
Xiao DM et al. [Comparison between the effects of (-)- and (+)-gossypol on protein kinase C and protein kinase A]. 1993 Yao Xue Xue Bao pmid:8285048
Lei HQ and Xu YX [Effects of gossypol acetic acid on the motility of rat oviduct smooth muscle]. 1993 Yao Xue Xue Bao pmid:8328273
Chen Y et al. [Effect of gossypol in combination with misoprostol on termination of early pregnancy in rats and mice]. 1997 Yao Xue Xue Bao pmid:11596197
Yang B et al. [The effects of gossypol on rat luteal cells, human decidual cells and cytotrophoblasts]. 1997 Yao Xue Xue Bao pmid:11596304