Gossypol

Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.

Cross Reference

Introduction

To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Gossypol?

Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Gossypol

MeSH term MeSH ID Detail
Chemical and Drug Induced Liver Injury D056486 39 associated lipids
Endometriosis D004715 29 associated lipids
Uterine Neoplasms D014594 18 associated lipids
Proteinuria D011507 30 associated lipids
Genital Neoplasms, Male D005834 3 associated lipids
Leukemia D007938 74 associated lipids
Neuroblastoma D009447 66 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Protein Deficiency D011488 5 associated lipids
Leukemia, Experimental D007942 42 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Gossypol

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Gossypol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Gossypol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Gossypol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Gossypol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Gossypol?

Xenograft Model

Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).

Transgenic Model

Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Gossypol

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Per page 10 20 50 100 | Total 1511
Authors Title Published Journal PubMed Link
Zheng YH et al. [Effect of gossypol acetic acid on hCG-stimulated progesterone production of dissociated rat luteal cells]. 1991 Yao Xue Xue Bao pmid:1668561
Zheng DK et al. [Studies on the resolution of racemic gossypol. II. By chiral alpha-methylphenethylamine and alpha-methylbenzylamine]. 1990 Yao Xue Xue Bao pmid:2284966
Si YK et al. [Studies on the resolution of racemic gossypol. III. Study on the chemical and physical properties of the amino condensates of gossypol]. 1990 Yao Xue Xue Bao pmid:2284967
Zheng DK et al. [Studies on the resolution of racemic gossypol. IV. Use of threo (-) or (+)-1-(p-nitrophenyl)-1,3-dihydroxypropylamine-2 as the resolving agent]. 1990 Yao Xue Xue Bao pmid:2284968
Han SD et al. [Study on quality of gossypol recrystalized from chloroform]. 1989 Yao Xue Xue Bao pmid:2609986
Deng HL et al. [The subcellular distribution and covalent binding of 3H-(+) and 3H-(-) gossypol in the main tissues of rats]. 1989 Yao Xue Xue Bao pmid:2618689
Wu GP et al. [Synthesis and antifertility actions of gossypol derivatives and phenol aldehydes]. 1989 Yao Xue Xue Bao pmid:2618691
Jiang DH et al. [The comparison of some properties of gossypol recrystallized from different solvents]. 1986 Yao Xue Xue Bao pmid:3811948
Wang MZ et al. [Determination of gossypol with high performance liquid chromatography]. 1985 Yao Xue Xue Bao pmid:3834747
Guo ZM et al. [Synthesis of mono-aldehyde gossypol and its analogues]. 1987 Yao Xue Xue Bao pmid:3450164
Zhou RH and Lin XD [Isolation of (-)-gossypol from natural plant]. 1987 Yao Xue Xue Bao pmid:3450165
Wu DF et al. [Determination of (+)- and (-)-gossypol in human plasma using high performance liquid chromatography with pre-column chemical derivatization]. 1988 Yao Xue Xue Bao pmid:3256191
Wang WH et al. [Influence of salicylaldehyde and its analogs on the antispermatogenic effect of gossypol]. 1985 Yao Xue Xue Bao pmid:4083027
Lei HQ and Xu YX [Effects of gossypol acetic acid on transport and development of fertilized eggs in rats]. 1990 Yao Xue Xue Bao pmid:2082677
Xu Y et al. [Intratesticular subcapsular assay, a simple method for the preliminary screening of male contraceptives]. 1993 Yao Xue Xue Bao pmid:8010008
Zhou LF et al. [Further observations on the effect of prolonged administration of gossypol acetic acid to rats]. 1982 Yao Xue Xue Bao pmid:7136708
Ma XN et al. [Effect of gossypol acetic acid on testosterone, LH and FSH levels of male rats]. 1983 Yao Xue Xue Bao pmid:6433647
Wang NG et al. [Antisteroidal and antigonadotrophic effects of gossypol acetic acid in rats]. 1984 Yao Xue Xue Bao pmid:6464763
Ye WS et al. [The antifertility effect of gossypol plus testosterone and estrogen]. 1996 Yao Xue Xue Bao pmid:9208651
Tang Y et al. [Progress in small-molecule inhibitors of Bcl-2 family proteins]. 2008 Yao Xue Xue Bao pmid:18819468