| MeSH term | MeSH ID | Detail |
|---|---|---|
| Acute Lung Injury | D055371 | 33 associated lipids |
| Chemical and Drug Induced Liver Injury | D056486 | 39 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Leukemia, Experimental | D007942 | 42 associated lipids |
| Leukemia P388 | D007941 | 43 associated lipids |
| Neuroblastoma | D009447 | 66 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
Gossypol
Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
Cross Reference
Introduction
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Gossypol?
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Mol. Cancer Ther. (4)
- Proc. Natl. Acad. Sci. U.S.A. (3)
- Am. J. Physiol. Lung Cell Mol. Physiol. (2)
- Others (13)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Gossypol
PubChem Associated disorders and diseases
What pathways are associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Gossypol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Gossypol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Gossypol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Gossypol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Gossypol?
Xenograft Model
Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Gossypol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Li XX et al. | [Spermicidal effects in vitro of gossypol acetic acid-povidone coprecipitate]. | 1986 | Zhongguo Yao Li Xue Bao | pmid:2954422 |
| Zhuang LZ et al. | Comparison of sensitivities of rat spermatozoa, Sertoli and Leydig cells to gossypol acetic acid in vitro by the LD50. | 1986 | Zhongguo Yao Li Xue Bao | pmid:2955650 |
| Pearce S et al. | Site of gossypol inhibition of steroidogenesis in purified mouse Leydig cells. | 1986 | J. Steroid Biochem. | pmid:3025516 |
| Radloff RJ et al. | Antiviral activities of gossypol and its derivatives against herpes simplex virus type II. | 1986 | Pharmacol Res Commun | pmid:3025895 |
| Robinson JM et al. | Gossypol-induced damage to mitochondria of transformed Sertoli cells. | 1986 | Am. J. Pathol. | pmid:3026188 |
| Morris ID | Gossypol: a male contraceptive with potential? | 1986 | IRCS J Med Sci | pmid:12280996 |
| Tan FQ | [Gossypol acetate users]. | 1986 | Shengzhi Yu Biyun | pmid:12267917 |
| Han S | New progress in research on contraceptive technology. | 1986 | China Popul Newsl | pmid:12268508 |
| Tam SC | Acute hypokalemic effect of gossypol. | 1986 | Can. J. Physiol. Pharmacol. | pmid:3768796 |
| Whaley KJ et al. | Monkey lactate dehydrogenase-C4 as a model for the interaction of enzymes with gossypol. | 1986 | Contraception | pmid:3769483 |
| Hu F et al. | Gossypol effects on cultured normal and malignant melanocytes. | 1986 | In Vitro Cell. Dev. Biol. | pmid:3771439 |
| Reyes J et al. | Membrane actions of male contraceptive gossypol tautomers. | 1986 | Biochim. Biophys. Acta | pmid:3778905 |
| Rosenberg LJ et al. | Inhibition of DNA polymerase alpha by gossypol. | 1986 | Biochim. Biophys. Acta | pmid:3697356 |
| Morris ID et al. | Inhibition of testicular LDH-X from laboratory animals and man by gossypol and its isomers. | 1986 | J. Reprod. Fertil. | pmid:3735252 |
| Hadley MA and Burgos MH | Gossypol injected in the rat epididymal fat pad inhibits epididymal sperm motility. | 1986 | Microsc Electron Biol Celular | pmid:3587061 |
| Fody EP and Walker EM | Effects of drugs on the male and female reproductive systems. | 1985 Nov-Dec | Ann. Clin. Lab. Sci. | pmid:4062226 |
| Kim IC et al. | Inhibition of LDH-X by gossypol optical isomers. | 1985 Nov-Dec | J. Androl. | pmid:4077725 |
| Sadykov AS et al. | [Effect of gossypol on spermatogenesis and fertility in man and mammals]. | 1985 Jul-Aug | Ontogenez | pmid:3900844 |
| Shi QX and Friend DS | Effect of gossypol acetate on guinea pig epididymal spermatozoa in vivo and their susceptibility to capacitation in vitro. | 1985 Jan-Feb | J. Androl. | pmid:3972719 |
| Zhang JB et al. | [Comparison of the action of racemic (+/-) and optically active (-and+) gossypols on HeLa cells]. | 1985 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:2938762 |
| Zheng DK et al. | Resolution of racemic gossypol. | 1985 | J. Chem. Soc. Chem. Commun. | pmid:12340526 |
| Gonzales-garza MT et al. | Cytotoxic effects of gossypol and vitamin E on human and rat lymphocytes and spermatozoa. | 1985 | Nutr Rep Int | pmid:12340733 |
| Haspel HC et al. | Effect of gossypol on erythrocyte membrane function: specific inhibition of inorganic anion exchange and interaction with band 3. | 1985 | J. Pharmacol. Exp. Ther. | pmid:4032282 |
| Kimura K et al. | Inhibition by gossypol of phospholipid-sensitive Ca2+-dependent protein kinase from pig testis. | 1985 | Biochim. Biophys. Acta | pmid:3157405 |
| Berry CN et al. | Gossypol is a potent inhibitor of the NAD+-dependent dehydrogenase responsible for the inactivation of prostaglandins. | 1985 | Zhongguo Yao Li Xue Bao | pmid:3158161 |
| Li FY et al. | [The antiandrogen effect of gossypol and its influence on androgen receptor]. | 1985 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:3158419 |
| Wang YF | [Late effect of gossypol treatment in gynecological diseases--a clinical study of 72 cases]. | 1985 | Zhong Xi Yi Jie He Za Zhi | pmid:3158438 |
| Wang MZ et al. | [Determination of gossypol with high performance liquid chromatography]. | 1985 | Yao Xue Xue Bao | pmid:3834747 |
| Vongsorasak L and Svasti J | Inhibition of liquefaction and protein degradation in human semen by gossypol. | 1985 | Int. J. Androl. | pmid:3835162 |
| Rikihisa Y et al. | Histopathologic changes of uterus following gossypol treatment during early pregnancy in rats. | 1985 | Anat. Rec. | pmid:4073564 |
| Krasil'nikov OV et al. | [Dependence of the protonophore and channel-forming capacity of gossypol on the pH]. | 1985 | Dokl. Akad. Nauk SSSR | pmid:2408838 |
| Kainz P et al. | The in vivo effect of gossypol on macromolecular synthesis in rat testis. | 1985 | Contraception | pmid:2419026 |
| Hamasaki Y and Tai HH | Gossypol, a potent inhibitor of arachidonate 5- and 12-lipoxygenases. | 1985 | Biochim. Biophys. Acta | pmid:3919771 |
| Donaldson A et al. | Inhibition by gossypol of testosterone production by mouse Leydig cells in vitro. | 1985 | Contraception | pmid:3987278 |
| Rao PN et al. | Antitumor effects of gossypol on murine tumors. | 1985 | Cancer Chemother. Pharmacol. | pmid:4006045 |
| Lin YC et al. | Gossypol in female fertility control: ovum implantation and early pregnancy inhibited in rats. | 1985 | Life Sci. | pmid:4010468 |
| Wang Y et al. | Antifertility effect of polyvinylpyrrolidone-gossypol and gossypol in male rats. | 1985 | Contraception | pmid:4092462 |
| Wu YW et al. | Effect of gossypol on the potential difference of rat seminiferous tubules. | 1985 | Sci. Sin., Ser. B, Chem. Biol. Agric. Med. Earth Sci. | pmid:4012264 |
| Lagerlöf RK and Tone JN | The effect of gossypol acetic acid on female reproduction. | 1985 | Drug Chem Toxicol | pmid:4092619 |
| Maliwal BP et al. | Spectroscopic study of the interaction of gossypol with bovine serum albumin. | 1985 | Int. J. Pept. Protein Res. | pmid:4019021 |
| Liang JC and Ye WS | Clastogenicity of a male contraceptive, gossypol, in mammalian cell cultures with and without the metabolic activation by S9 mix. | 1985 | Environ. Res. | pmid:3967635 |
| Vainio P et al. | Hydrolysis of phospholipid monolayers by human spermatozoa. Inhibition by male contraceptive gossypol. | 1985 | Biochim. Biophys. Acta | pmid:3978108 |
| Beaudoin AR | The embryotoxicity of gossypol. | 1985 | Teratology | pmid:4049283 |
| Gao H et al. | [Primary observations on distal renal tubule acidosis in 177 cases caused by gossypol intoxication]. | 1985 | Zhonghua Nei Ke Za Zhi | pmid:4053804 |
| Wang MZ et al. | High-performance liquid chromatography with electrochemical detection of gossypol in human plasma. | 1985 | J. Chromatogr. | pmid:4066879 |
| Wang WH et al. | [Influence of salicylaldehyde and its analogs on the antispermatogenic effect of gossypol]. | 1985 | Yao Xue Xue Bao | pmid:4083027 |
| Pearce S et al. | The viability of mouse Leydig cells in vitro following incubation with gossypol. | 1985 | Contraception | pmid:4085245 |
| Gu Y and Anderson NO | Effects of gossypol on the estrous cycle and ovarian weight in the rat. | 1985 | Contraception | pmid:4085249 |
| Patton CS et al. | Heart failure caused by gossypol poisoning in two dogs. | 1985 | J. Am. Vet. Med. Assoc. | pmid:4086371 |
| Ding LA et al. | [Hepatoma initiating and promoting effects of gossypol]. | 1985 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:2986867 |