Udoh P et al. |
Histopathological and biochemical effects of gossypol acetate on pituitary-gonadal axis of male albino rats. |
1992 |
Contraception |
pmid:1623720
|
Udoh P and Patil DR |
Effects of gossypol acetate on pituitary-adrenal axis in male albino rats. |
1992 |
Contraception |
pmid:1324828
|
Srivastava A et al. |
Studies on mechanism(s) of antifertility action of gossypol in rat and hamster. |
1989 |
Contraception |
pmid:2469550
|
Moore GD et al. |
Inhibition of sperm migration, fertilization and implantation in rats by precoital intrauterine administration of gossypol or nonoxynol-9. |
1988 |
Contraception |
pmid:2835205
|
Lan ZJ et al. |
Effects of multiglycosides of Tripterygium wilfordii (GTW) on rat fertility and Leydig and Sertoli cells. |
1992 |
Contraception |
pmid:1511610
|
Duo X et al. |
Clinical safety of long-term administration of gossypol in 32 cases. |
1988 |
Contraception |
pmid:3370987
|
Pearce S et al. |
Inhibition by gossypol of cyclic AMP production in mouse Leydig cells. |
1986 |
Contraception |
pmid:3030630
|
Tang F et al. |
Inhibition of catechol-O-methyltransferase by gossypol: the effect of plasma proteins. |
1982 |
Contraception |
pmid:7160182
|
Giridharan N et al. |
Inhibition of rat testis LDH-X activity by gossypol. |
1982 |
Contraception |
pmid:7168954
|
Meng GD et al. |
Follow-up of men in the recovery period immediately after the cessation of gossypol treatment. |
1988 |
Contraception |
pmid:3131064
|
Bourinbaiar AS and Lee-Huang S |
Comparative in vitro study of contraceptive agents with anti-HIV activity: gramicidin, nonoxynol-9, and gossypol. |
1994 |
Contraception |
pmid:7511493
|
Tanphaichitr N and Fitzgerald LM |
Adverse effects of gossypol analogs on TM4 cell mitochondrial function. |
1989 |
Contraception |
pmid:2752754
|
Tanphaichitr N et al. |
Inhibitory effects of gossypol analogs on human sperm motility. |
1989 |
Contraception |
pmid:2752755
|
Waller DP et al. |
In vitjro spermicidal activity of gossypol. |
1980 |
Contraception |
pmid:7449381
|
Teng CS |
Biological activity in the repopulating rat spermatocyte after the withdrawal of gossypol treatment. V. Inhibition and recovery of microtubular dynein. |
1995 |
Contraception |
pmid:7628207
|
Coutinho EM et al. |
Gossypol blood levels and inhibition of spermatogenesis in men taking gossypol as a contraceptive. A multicenter, international, dose-finding study. |
2000 |
Contraception |
pmid:10745071
|
Wichmann K et al. |
Studies on structure-activity relationship of gossypol, gossypol ethers and three naphthaldehydes in the inhibition of spermatozoal metabolism. |
1986 |
Contraception |
pmid:3757514
|
Paz GF and Homonnai ZT |
Effect of the antifertility agent, gossypol acetic acid, on the metabolism and testosterone secretion of isolated rat interstitial cells in vitro. |
1984 |
Contraception |
pmid:6467943
|
Johansen RL and Misra HP |
Effects of gossypol on the hepatic drug metabolizing system in rats. |
1990 |
Contraception |
pmid:2083490
|
Lin YC et al. |
Effect of gossypol on spermatozoal lactate dehydrogenase-X (LDH-X) in male rats. |
1987 |
Contraception |
pmid:3447817
|
Kim IC et al. |
Comparative in vitro spermicidal effects of (+/-)-gossypol, (+)-gossypol, (-)-gossypol and gossypolone. |
1984 |
Contraception |
pmid:6509980
|
Tso WW and Lee CS |
Gossypol uncoupling of respiratory chain and oxidative phosphorylation in ejaculated boar spermatozoa. |
1982 |
Contraception |
pmid:6889482
|
Cui GH et al. |
A combined regimen of gossypol plus methyltestosterone and ethinylestradiol as a contraceptive induces germ cell apoptosis and expression of its related genes in rats. |
2004 |
Contraception |
pmid:15451339
|
Kalla NR et al. |
Involvement of prostaglandin in the antifertility effects of gossypol. |
1986 |
Contraception |
pmid:3465506
|
Lin YC et al. |
Effect of gossypol on thyroid hormones in young female rats. |
1990 |
Contraception |
pmid:2335106
|
Kanwar U et al. |
Gossypol-induced inhibition of glucose uptake in human ejaculated spermatozoa may be mediated by lipid peroxidation. |
1990 |
Contraception |
pmid:2272185
|
Teng CS |
Reversible changes in the content of cellular and microtubular tubulin in spermatogenic cells after gossypol treatment. |
1997 |
Contraception |
pmid:9115008
|
Kanwar U et al. |
Gossypol inhibition of Ca++ uptake and Ca++-ATPase in human ejaculated spermatozoal plasma membrane vesicles. |
1989 |
Contraception |
pmid:2541968
|
Chongthammakun S et al. |
Effects of gossypol on human and monkey sperm motility in vitro. |
1986 |
Contraception |
pmid:3791997
|
Teng CS |
Reversible changes in the content of cellular and microtubular tubulin in spermatogenic cells after gossypol treatment. |
1997 |
Contraception |
pmid:9013060
|
Wu D and Reidenberg MM |
Effect of potassium deficiency and gossypol on urinary N-acetyl-beta-glucosaminidase excretion in the rat. |
1993 |
Contraception |
pmid:8275698
|
Teng CS |
Biological activity in the repopulating rat spermatocyte after the withdrawal of gossypol treatment. IV. The activity for the modification of core histones. |
1993 |
Contraception |
pmid:8403913
|
Polsky B et al. |
Inactivation of human immunodeficiency virus in vitro by gossypol. |
1989 |
Contraception |
pmid:2473865
|
Nwoha PU |
The blood constituents of gossypol-treated, protein-malnourished Wistar rats. |
1995 |
Contraception |
pmid:8605784
|
Teng CS and Vilagrasa X |
Biphasic c-Myc protein expression during gossypol-induced apoptosis in rat spermatocytes. |
1998 |
Contraception |
pmid:9589839
|
Teng CS |
c-fos protein expression in apoptotic rat spermatocytes induced by gossypol. |
1998 |
Contraception |
pmid:9649921
|
Teng CS et al. |
Biological activity in the repopulating rat spermatocyte after the withdrawal of gossypol treatment. VI. Alteration in nuclear factors for interaction with histone gene promoter. |
1995 |
Contraception |
pmid:8536450
|
Sufi SB et al. |
Inhibition by (+) and (-) isomers of gossypol of testosterone release from mouse Leydig cells in vitro. |
1985 |
Contraception |
pmid:3987277
|
Donaldson A et al. |
Inhibition by gossypol of testosterone production by mouse Leydig cells in vitro. |
1985 |
Contraception |
pmid:3987278
|
Wong PY et al. |
Gossypol does not affect testicular fluid secretion in rats. |
1984 |
Contraception |
pmid:6744863
|
Wang Y et al. |
Antifertility effect of polyvinylpyrrolidone-gossypol and gossypol in male rats. |
1985 |
Contraception |
pmid:4092462
|
Wong PY et al. |
Lack of an effect of gossypol on the epididymis of the rat. |
1983 |
Contraception |
pmid:6851567
|
Pearce S et al. |
The viability of mouse Leydig cells in vitro following incubation with gossypol. |
1985 |
Contraception |
pmid:4085245
|
Giridharan N et al. |
Dose and time related changes in LDH-X activity, epididymal carnitine levels and fertility, in gossypol-treated male rats. |
1987 |
Contraception |
pmid:3568662
|
Gu Y and Anderson NO |
Effects of gossypol on the estrous cycle and ovarian weight in the rat. |
1985 |
Contraception |
pmid:4085249
|
Anuja MN et al. |
Spermatotoxicity of a protein isolated from the root of Achyranthes aspera: a comparative study with gossypol. |
2010 |
Contraception |
pmid:20851234
|
Coutinho EM and Melo JF |
Clinical experience with gossypol in non-Chinese men: a follow-up. |
1988 |
Contraception |
pmid:3286112
|
Velez de la Calle JF and Bujan L |
[Male contraception]. |
1995 |
Contracept Fertil Sex |
pmid:7613573
|
Trischitta F and Faggio C |
Gossypol affects ion transport in the isolated intestine of the seawater adapted eel, Anguilla anguilla. |
2008 |
Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. |
pmid:18606239
|
MartÃnez F |
The antifertility agent, gossypol, changes several mitochondrial functions in the presence of Mg2+. |
1992 |
Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. |
pmid:1360378
|
MartÃnez F et al. |
The antifertility agent, gossypol, releases calcium from rat liver mitochondria. |
1993 |
Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. |
pmid:8097449
|
Kim HL et al. |
Accumulation of gossypol enantiomers in ovine tissues. |
1996 |
Comp. Biochem. Physiol. B, Biochem. Mol. Biol. |
pmid:8653593
|
Prakash O and Khan F |
Development of method for three-point data estimation and SVR-QSAR model to screen anti cancer leads. |
2013 |
Comb. Chem. High Throughput Screen. |
pmid:23410041
|
Wu DF et al. |
Pharmacokinetics of (+/-)-, (+)-, and (-)-gossypol in humans and dogs. |
1986 |
Clin. Pharmacol. Ther. |
pmid:3709025
|
Zhang M et al. |
Differential growth inhibition and induction of apoptosis by gossypol between HCT116 and HCT116/Bax(-/-) colorectal cancer cells. |
2007 |
Clin. Exp. Pharmacol. Physiol. |
pmid:17250644
|
Chang JS et al. |
Upregulation of Fas/Fas ligand-mediated apoptosis by gossypol in an immortalized human alveolar lung cancer cell line. |
2004 |
Clin. Exp. Pharmacol. Physiol. |
pmid:15554914
|
Jiang J et al. |
Gossypol inhibits growth, invasiveness, and angiogenesis in human prostate cancer cells by modulating NF-κB/AP-1 dependent- and independent-signaling. |
2012 |
Clin. Exp. Metastasis |
pmid:22167622
|
Sheriff DS et al. |
Effect of gossypol on the activity of erythrocyte Na+-K+ ATPase activity in vitro. |
1987 |
Clin. Chem. |
pmid:3026686
|
Oliver CL et al. |
In vitro effects of the BH3 mimetic, (-)-gossypol, on head and neck squamous cell carcinoma cells. |
2004 |
Clin. Cancer Res. |
pmid:15570010
|
Kang MH and Reynolds CP |
Bcl-2 inhibitors: targeting mitochondrial apoptotic pathways in cancer therapy. |
2009 |
Clin. Cancer Res. |
pmid:19228717
|
Liu G et al. |
An open-label, multicenter, phase I/II study of single-agent AT-101 in men with castrate-resistant prostate cancer. |
2009 |
Clin. Cancer Res. |
pmid:19366825
|
Henderson J et al. |
Occupation-related male infertility: a review. |
1986 |
Clin Reprod Fertil |
pmid:3527400
|
Pond GR et al. |
Neutropenia as a potential pharmacodynamic marker for docetaxel-based chemotherapy in men with metastatic castration-resistant prostate cancer. |
2012 |
Clin Genitourin Cancer |
pmid:23000202
|
Stein MN et al. |
A Phase II Study of AT-101 to Overcome Bcl-2--Mediated Resistance to Androgen Deprivation Therapy in Patients With Newly Diagnosed Castration-Sensitive Metastatic Prostate Cancer. |
2016 |
Clin Genitourin Cancer |
pmid:26476589
|
Hall C et al. |
Bcl-2 family of proteins as therapeutic targets in genitourinary neoplasms. |
2013 |
Clin Genitourin Cancer |
pmid:23083798
|
Bassenge E et al. |
Abluminal release and asymmetrical response of the rabbit arterial wall to endothelium-derived relaxing factor. |
1987 |
Circ. Res. |
pmid:3117407
|
Dowd MK |
Preparation of enantiomeric gossypol by crystallization. |
2003 |
Chirality |
pmid:12774287
|
Freedman TB et al. |
Determination of the absolute configuration and solution conformation of gossypol by vibrational circular dichroism. |
2003 |
Chirality |
pmid:12520512
|
Xiao B and Wang M |
Birth control techniques in China. |
1983 |
China Popul Newsl |
pmid:12312957
|
Han S |
New progress in research on contraceptive technology. |
1986 |
China Popul Newsl |
pmid:12268508
|
Ye W et al. |
Effect of intra-vas deferens injection of gossypol-polylactic acid on fertility and spermatogenesis in rats. |
1993 |
Chin. Med. Sci. J. |
pmid:8274715
|
Chang Q et al. |
Drug synergistic antifertility effect of combined administration of low-dose gossypol with steroid hormones in rats. |
2011 |
Chin. Med. J. |
pmid:21740776
|
|
Gossypol--a new antifertility agent for males. |
1978 |
Chin. Med. J. |
pmid:104833
|
Tong SM et al. |
Human antifertility effect of gossypol cytologic observation of semen. |
1982 |
Chin. Med. J. |
pmid:6216077
|
Zhang Y et al. |
Estrogen and progestin cytosol receptor concentrations in patients with endometriosis and their changes after gossypol therapy. |
1996 |
Chin. Med. J. |
pmid:9275362
|
Qian SZ et al. |
Gossypol related hypokalemia. Clinicopharmacologic studies. |
1980 |
Chin. Med. J. |
pmid:6772395
|
Cheng JS et al. |
Effect of gossypol on intracellular Ca2+ regulation in human hepatoma cells. |
2003 |
Chin J Physiol |
pmid:14672280
|
Zhang SD et al. |
Isochamaejasmin induces apoptosis in leukemia cells through inhibiting Bcl-2 family proteins. |
2015 |
Chin J Nat Med |
pmid:26412425
|
Hu ZY et al. |
Apogossypolone targets mitochondria and light enhances its anticancer activity by stimulating generation of singlet oxygen and reactive oxygen species. |
2011 |
Chin J Cancer |
pmid:21192843
|
Kilburn KH et al. |
Two patterns for bronchial damage from inhaled materials. |
1974 |
Chest |
pmid:4819236
|
ADAMS R et al. |
Gossypol, a pigment of cottonseed. |
1960 |
Chem. Rev. |
pmid:13681414
|
Wood AB et al. |
Conformation and hydrogen bonding of gossypol. |
1969 |
Chem. Ind. |
pmid:5357782
|
Lu H and Liu GT |
Effect of dibenzo[a,c]cyclooctene lignans isolated from Fructus schizandrae on lipid peroxidation and anti-oxidative enzyme activity. |
1991 |
Chem. Biol. Interact. |
pmid:1849050
|
Bhatia C et al. |
Towards a systematic analysis of human short-chain dehydrogenases/reductases (SDR): Ligand identification and structure-activity relationships. |
2015 |
Chem. Biol. Interact. |
pmid:25526675
|
Hockenbery D |
Breaking down tumor defenses. |
2004 |
Chem. Biol. |
pmid:15123233
|
Becattini B et al. |
Rational design and real time, in-cell detection of the proapoptotic activity of a novel compound targeting Bcl-X(L). |
2004 |
Chem. Biol. |
pmid:15123268
|
Havránek F |
[Gossypol, a new contraceptive agent for men]. |
1979 |
Cesk Gynekol |
pmid:116775
|
Leyman A et al. |
The absence of expression of the three isoenzymes of the inositol 1,4,5-trisphosphate 3-kinase does not prevent the formation of inositol pentakisphosphate and hexakisphosphate in mouse embryonic fibroblasts. |
2007 |
Cell. Signal. |
pmid:17355905
|
Ionov M et al. |
The interaction of PVP complexes of gossypol and its derivatives with an artificial membrane lipid matrix. |
2010 |
Cell. Mol. Biol. Lett. |
pmid:19936629
|
Bozek SA et al. |
Scanning electron microscopic study of spermatozoa from gossypol-treated rats. |
1981 |
Cell Tissue Res. |
pmid:7273120
|
Nadakavukaren MJ et al. |
Effect of gossypol on the ultrastructure of rat spermatozoa. |
1979 |
Cell Tissue Res. |
pmid:535032
|
Goff DJ et al. |
A Pan-BCL2 inhibitor renders bone-marrow-resident human leukemia stem cells sensitive to tyrosine kinase inhibition. |
2013 |
Cell Stem Cell |
pmid:23333150
|
Yuan Y et al. |
Gossypol and an HMT G9a inhibitor act in synergy to induce cell death in pancreatic cancer cells. |
2013 |
Cell Death Dis |
pmid:23807219
|
Cheng P et al. |
The novel BH-3 mimetic apogossypolone induces Beclin-1- and ROS-mediated autophagy in human hepatocellular carcinoma [corrected] cells. |
2013 |
Cell Death Dis |
pmid:23392177
|
Li G et al. |
RhoA/ROCK/PTEN signaling is involved in AT-101-mediated apoptosis in human leukemia cells in vitro and in vivo. |
2014 |
Cell Death Dis |
pmid:24434521
|
Wolter KG et al. |
Therapeutic window for melanoma treatment provided by selective effects of the proteasome on Bcl-2 proteins. |
2007 |
Cell Death Differ. |
pmid:17541428
|
Varadarajan S et al. |
A novel cellular stress response characterised by a rapid reorganisation of membranes of the endoplasmic reticulum. |
2012 |
Cell Death Differ. |
pmid:22955944
|
Goldsmith KC et al. |
BH3 response profiles from neuroblastoma mitochondria predict activity of small molecule Bcl-2 family antagonists. |
2010 |
Cell Death Differ. |
pmid:19893570
|
Lian J et al. |
A natural BH3 mimetic induces autophagy in apoptosis-resistant prostate cancer via modulating Bcl-2-Beclin1 interaction at endoplasmic reticulum. |
2011 |
Cell Death Differ. |
pmid:20577262
|
Hutchinson RW et al. |
Induction of c-fos, and cytochrome c oxidase subunits I and II by gossypol acetic acid in rat liver cells. |
1998 |
Cell Biol. Toxicol. |
pmid:9879931
|