| MeSH term | MeSH ID | Detail |
|---|---|---|
| Leukemia, Lymphocytic, Chronic, B-Cell | D015451 | 25 associated lipids |
| Neoplasms, Hormone-Dependent | D009376 | 23 associated lipids |
| Leiomyoma | D007889 | 8 associated lipids |
| Nutrition Disorders | D009748 | 6 associated lipids |
| Swine Diseases | D013553 | 16 associated lipids |
| Pemphigoid, Bullous | D010391 | 8 associated lipids |
| Infertility, Female | D007247 | 5 associated lipids |
| Micronuclei, Chromosome-Defective | D048629 | 33 associated lipids |
| Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
| Acute Lung Injury | D055371 | 33 associated lipids |
Gossypol
Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
Cross Reference
Introduction
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Gossypol?
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Gossypol
PubChem Associated disorders and diseases
What pathways are associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Gossypol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Gossypol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Gossypol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Gossypol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Gossypol?
Xenograft Model
Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Gossypol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Li XX et al. | [Spermicidal effects in vitro of gossypol acetic acid-povidone coprecipitate]. | 1986 | Zhongguo Yao Li Xue Bao | pmid:2954422 |
| Wu DF and Yu YW | Superoxide free radical formation stimulated by (+/-), (+), (-) gossypol in rat liver and kidney microsomes. | 1986 | Proc Chin Acad Med Sci Peking Union Med Coll | pmid:2827151 |
| Pearce S et al. | Site of gossypol inhibition of steroidogenesis in purified mouse Leydig cells. | 1986 | J. Steroid Biochem. | pmid:3025516 |
| Radloff RJ et al. | Antiviral activities of gossypol and its derivatives against herpes simplex virus type II. | 1986 | Pharmacol Res Commun | pmid:3025895 |
| Morris ID | Gossypol: a male contraceptive with potential? | 1986 | IRCS J Med Sci | pmid:12280996 |
| Reyes J et al. | Membrane actions of male contraceptive gossypol tautomers. | 1986 | Biochim. Biophys. Acta | pmid:3778905 |
| Wang JM et al. | Electrolyte composition of rete testis fluid and cauda epididymal plasma and spermatozoa from rats following gossypol treatment. | 1986 Jan-Feb | Andrologia | pmid:3954086 |
| Ahluwalia B et al. | Morphologic and endocrine changes in the reproductive organs in rats implanted with gossypol acetate pellet in the testis. | 1986 Jul-Aug | J. Androl. | pmid:3745012 |
| Kalla NR et al. | Studies on the male antifertility agent gossypol acetic acid. VII. Effect of motility stimulated factors on the revival of human spermatozoal motility after gossypol treatment in vitro. | 1986 Jul-Aug | Andrologia | pmid:3019180 |
| Karpovich LG et al. | [Indices of lymphocyte functional activity in patients with recurrent cutaneous-genital herpes during treatment with a herpes vaccine]. | 1986 Mar-Apr | Vopr. Virusol. | pmid:3014750 |
| Sakhibov AD et al. | [Mechanism of Na,K-ATPase inhibition with gossypol and megasin]. | 1986 May-Jun | Vopr. Med. Khim. | pmid:3014735 |
| Pelletier RM and Friend DS | Sertoli cell junctional complexes in gossypol-treated neonatal and adult guinea pigs. | 1986 May-Jun | J. Androl. | pmid:3721997 |
| Ershov FI et al. | [A new interferon inducer active via peroral administration]. | 1986 May-Jun | Vopr. Virusol. | pmid:2429451 |
| Stephens DT et al. | Kinetic characterization of the inhibition of purified cynomolgus monkey lactate dehydrogenase isozymes by gossypol. | 1986 Nov-Dec | J. Androl. | pmid:3793617 |
| Su SY and Liu Y | Electron microscopic observation of gossypol effects on gastrocnemius muscles in laboratory animals. | 1987 | Proc Chin Acad Med Sci Peking Union Med Coll | pmid:2827153 |
| Sheriff DS et al. | Effect of gossypol on the activity of erythrocyte Na+-K+ ATPase activity in vitro. | 1987 | Clin. Chem. | pmid:3026686 |
| Baram N et al. | Inactivation of intestinal brush-border enzymes by gossypol. | 1987 | Agric. Biol. Chem. | pmid:12283503 |
| Ye YX et al. | Direct actions of gossypol on cardiac muscle. | 1987 | Eur. J. Pharmacol. | pmid:3036543 |
| Bassenge E et al. | Abluminal release and asymmetrical response of the rabbit arterial wall to endothelium-derived relaxing factor. | 1987 | Circ. Res. | pmid:3117407 |
| Tung DS et al. | Effect of long term gossypol treatment on human testicular structure. | 1987 | Adv Contracept Deliv Syst | pmid:12314752 |
| Russell DH et al. | Prolactin-dependent mitogenesis in Nb 2 node lymphoma cells: effects of immunosuppressive cyclopeptides. | 1987 | J. Immunol. | pmid:3097147 |
| Ye YX et al. | Cardiodepressant actions of the orally active male contraceptive, gossypol, in guinea-pig heart muscle. | 1987 | Eur. J. Pharmacol. | pmid:3691653 |
| Benz C et al. | Lactic dehydrogenase isozymes, 31P magnetic resonance spectroscopy, and in vitro antimitochondrial tumor toxicity with gossypol and rhodamine-123. | 1987 | J. Clin. Invest. | pmid:3805280 |
| Cooke E et al. | Diacylglycerol kinase inhibitor, R59022, potentiates neutrophil oxidase activation by Ca2+-dependent stimuli. Evidence for two separate but convergent pathways. | 1987 | Biochem. Pharmacol. | pmid:2823820 |
| Lin YC et al. | Effect of gossypol on spermatozoal lactate dehydrogenase-X (LDH-X) in male rats. | 1987 | Contraception | pmid:3447817 |
| Liu GZ et al. | Effect of K salt and K sparing agent in preventing gossypol-induced hypokalemia. | 1987 | Proc Chin Acad Med Sci Peking Union Med Coll | pmid:3423005 |
| Cheng JX et al. | Effect of gossypol(+/-, +, -) on Leydig cells of rat in vitro. | 1987 | Proc Chin Acad Med Sci Peking Union Med Coll | pmid:3423013 |
| Alheid U et al. | Endothelium-derived relaxing factor from cultured human endothelial cells inhibits aggregation of human platelets. | 1987 | Thromb. Res. | pmid:3499684 |
| Guo ZM et al. | [Synthesis of mono-aldehyde gossypol and its analogues]. | 1987 | Yao Xue Xue Bao | pmid:3450164 |
| Zhou RH and Lin XD | [Isolation of (-)-gossypol from natural plant]. | 1987 | Yao Xue Xue Bao | pmid:3450165 |
| Xu Y et al. | [The effect of combined use of gossypol and tripterygium wilfordii on the fertility of male rats]. | 1987 | Yao Xue Xue Bao | pmid:3452960 |
| Dhaliwal MK et al. | Cytogenetic analysis of a gossypol-induced murine myxosarcoma. | 1987 | J. Natl. Cancer Inst. | pmid:3473256 |
| Baccetti B et al. | Action of gossypol on rat germinal cells. II. The acrosome. | 1987 | Gamete Res | pmid:3506897 |
| Kim I et al. | Inhibition of lactate dehydrogenase-X by imino-derivatives of gossypol:structure activity relationship. | 1987 | Contraception | pmid:3608484 |
| Huang L et al. | Resolution of racemic gossypol. | 1987 | J Ethnopharmacol | pmid:3626591 |
| Wang NG et al. | Effect of (-)- and (+)-gossypol on fertility in male rats. | 1987 | J Ethnopharmacol | pmid:3626592 |
| Yao KQ et al. | Effect of (+/-)-, (+)- and (-)-gossypol on the lactate dehydrogenase-X activity of rat testis. | 1987 | J Ethnopharmacol | pmid:3626593 |
| Chen QQ et al. | Comparative study on the metabolism of optical gossypol in rats. | 1987 | J Ethnopharmacol | pmid:3626594 |
| Liu GZ et al. | Clinical trial of gossypol as a male contraceptive drug. Part I. Efficacy study. | 1987 | Fertil. Steril. | pmid:3305087 |
| Liu GZ and Lyle KC | Clinical trial of gossypol as a male contraceptive drug. Part II. Hypokalemia study. | 1987 | Fertil. Steril. | pmid:3305088 |
| Yu YW | Probing into the mechanism of action, metabolism and toxicity of gossypol by studying its (+)- and (-)-stereoisomers. | 1987 | J Ethnopharmacol | pmid:3306161 |
| Liu GZ et al. | Experiences with gossypol as a male pill. | 1987 | Am. J. Obstet. Gynecol. | pmid:3314523 |
| Lei HP | Future research priorities of gossypol in the field of fertility regulation. | 1987 | Proc Chin Acad Med Sci Peking Union Med Coll | pmid:3321051 |
| Alheid U et al. | Selective inhibition by gossypol of endothelium-dependent relaxations augments relaxations to glyceryl trinitrate in rabbit coeliac artery. | 1987 | Br. J. Pharmacol. | pmid:2444300 |
| Förstermann U et al. | Endothelium-derived relaxing factor is likely to modulate the tone of resistance arteries in rabbit hindlimb in vivo. | 1987 | J. Pharmacol. Exp. Ther. | pmid:2447263 |
| Touvay C et al. | Gossypol: a potent inhibitor of PAF-acether- and leukotriene-induced contractions of guinea-pig lung parenchyma strips. | 1987 | J. Pharm. Pharmacol. | pmid:2886603 |
| Mülsch A et al. | Stimulation of soluble guanylate cyclase by endothelium-derived relaxing factor from cultured endothelial cells. | 1987 | Eur. J. Pharmacol. | pmid:2884122 |
| Pohl U et al. | Selective inhibition of endothelium-dependent dilation in resistance-sized vessels in vivo. | 1987 | Am. J. Physiol. | pmid:2887120 |
| Giridharan N et al. | Dose and time related changes in LDH-X activity, epididymal carnitine levels and fertility, in gossypol-treated male rats. | 1987 | Contraception | pmid:3568662 |
| YU TW | [Ultrastructural study of the testis in 22 persons based on the effect of gossypol]. | 1987 | Zhonghua Bing Li Xue Za Zhi | pmid:2957085 |