Gossypol

Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.

Cross Reference

Introduction

To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Gossypol?

Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Gossypol

MeSH term MeSH ID Detail
Leukemia, Lymphocytic, Chronic, B-Cell D015451 25 associated lipids
Neoplasms, Hormone-Dependent D009376 23 associated lipids
Leiomyoma D007889 8 associated lipids
Nutrition Disorders D009748 6 associated lipids
Swine Diseases D013553 16 associated lipids
Pemphigoid, Bullous D010391 8 associated lipids
Infertility, Female D007247 5 associated lipids
Micronuclei, Chromosome-Defective D048629 33 associated lipids
Carcinoma, Non-Small-Cell Lung D002289 72 associated lipids
Acute Lung Injury D055371 33 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Gossypol

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Gossypol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Gossypol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Gossypol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Gossypol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Gossypol?

Xenograft Model

Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).

Transgenic Model

Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Gossypol

Download all related citations
Per page 10 20 50 100 | Total 1511
Authors Title Published Journal PubMed Link
Li K et al. Mulberry-like dual-drug complicated nanocarriers assembled with apogossypolone amphiphilic starch micelles and doxorubicin hyaluronic acid nanoparticles for tumor combination and targeted therapy. 2015 Biomaterials pmid:25477180
Zhang SD et al. Isochamaejasmin induces apoptosis in leukemia cells through inhibiting Bcl-2 family proteins. 2015 Chin J Nat Med pmid:26412425
Bhatia C et al. Towards a systematic analysis of human short-chain dehydrogenases/reductases (SDR): Ligand identification and structure-activity relationships. 2015 Chem. Biol. Interact. pmid:25526675
Câmara AC et al. Toxicity of Gossypol from Cottonseed Cake to Sheep Ovarian Follicles. 2015 PLoS ONE pmid:26600470
Gong Y et al. Valproic Acid Enhances the Anti-tumor Effect of (-)-gossypol to Burkitt Lymphoma Namalwa Cells. 2015 Biomed. Environ. Sci. pmid:26582100
Wu Y et al. Influence of gossypol acetic acid on the growth of human adenoid cystic carcinoma ACC-M cells and the expression of DNA methyltransferase 1. 2015 Genet. Mol. Res. pmid:26535659
Zhao GX et al. The BH3-mimetic gossypol and noncytotoxic doses of valproic acid induce apoptosis by suppressing cyclin-A2/Akt/FOXO3a signaling. 2015 Oncotarget pmid:26517515
Kottmann RM et al. Pharmacologic inhibition of lactate production prevents myofibroblast differentiation. 2015 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:26408551
Judge JL et al. Ionizing radiation induces myofibroblast differentiation via lactate dehydrogenase. 2015 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:26254422
Tomoda K et al. Examination of Gossypol-Pluronic Micelles as Potential Radiosensitizers. 2015 AAPS J pmid:26246329
Hanus J et al. Gossypol Acetic Acid Prevents Oxidative Stress-Induced Retinal Pigment Epithelial Necrosis by Regulating the FoxO3/Sestrin2 Pathway. 2015 Mol. Cell. Biol. pmid:25802279
Zhan W et al. Inhibitory activity of apogossypol in human prostate cancer in vitro and in vivo. 2015 Mol Med Rep pmid:25672487
Zhang H et al. Canonical Wnt signaling acts synergistically on BMP9-induced osteo/odontoblastic differentiation of stem cells of dental apical papilla (SCAPs). 2015 Biomaterials pmid:25468367
Sorokina EV et al. [Features of dynamics of sera cytokines in patients with erythema multiforme during immunotherapy]. 2014 Jan-Feb Zh. Mikrobiol. Epidemiol. Immunobiol. pmid:24738292
Ren T et al. Sequential treatment with AT-101 enhances cisplatin chemosensitivity in human non-small cell lung cancer cells through inhibition of apurinic/apyrimidinic endonuclease 1-activated IL-6/STAT3 signaling pathway. 2014 Drug Des Devel Ther pmid:25548514
Kogan P and Wald M Male contraception: history and development. 2014 Urol. Clin. North Am. pmid:24286773
Paulus A et al. AT-101 downregulates BCL2 and MCL1 and potentiates the cytotoxic effects of lenalidomide and dexamethasone in preclinical models of multiple myeloma and Waldenström macroglobulinaemia. 2014 Br. J. Haematol. pmid:24236538
Keshmiri-Neghab H and Goliaei B Therapeutic potential of gossypol: an overview. 2014 Pharm Biol pmid:24073600
Soderquist RS et al. Gossypol increases expression of the pro-apoptotic BH3-only protein NOXA through a novel mechanism involving phospholipase A2, cytoplasmic calcium, and endoplasmic reticulum stress. 2014 J. Biol. Chem. pmid:24778183
Zeng QF et al. Effects of dietary gossypol concentration on growth performance, blood profiles, and hepatic histopathology in meat ducks. 2014 Poult. Sci. pmid:24902707