| MeSH term | MeSH ID | Detail |
|---|---|---|
| Leukemia, Lymphocytic, Chronic, B-Cell | D015451 | 25 associated lipids |
| Neoplasms, Hormone-Dependent | D009376 | 23 associated lipids |
| Leiomyoma | D007889 | 8 associated lipids |
| Nutrition Disorders | D009748 | 6 associated lipids |
| Swine Diseases | D013553 | 16 associated lipids |
| Pemphigoid, Bullous | D010391 | 8 associated lipids |
| Infertility, Female | D007247 | 5 associated lipids |
| Micronuclei, Chromosome-Defective | D048629 | 33 associated lipids |
| Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
| Acute Lung Injury | D055371 | 33 associated lipids |
Gossypol
Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
Cross Reference
Introduction
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Gossypol?
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Mol. Cancer Ther. (4)
- Proc. Natl. Acad. Sci. U.S.A. (3)
- Am. J. Physiol. Lung Cell Mol. Physiol. (2)
- Others (13)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Gossypol
PubChem Associated disorders and diseases
What pathways are associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Gossypol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Gossypol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Gossypol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Gossypol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Gossypol?
Xenograft Model
Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Gossypol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Cameron SM et al. | Vaginal spermicidal activity of gossypol in the Macaca arctoides. | 1982 | Fertil. Steril. | pmid:7060775 |
| Lei HP | [Review and prospect of gossypol research (author's transl)]. | 1982 | Yao Xue Xue Bao | pmid:7090820 |
| Ke YB and Tso WW | Variations of gossypol susceptibility in rat spermatozoa during spermatogenesis. | 1982 | Int. J. Fertil. | pmid:6122656 |
| Wang WH | [Antagonistic effect of Smilax sp. on gossypol toxicity (author's transl)]. | 1982 | Zhong Yao Tong Bao | pmid:6212150 |
| Shandilya LN and Clarkson TB | Hypolipidemic effects of gossypol in cynomolgus monkeys (Macaca fascicularis). | 1982 | Lipids | pmid:6952061 |
| Sun YB et al. | [Effect of gossypol on potassium excretion of male rats]. | 1982 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:6216008 |
| Tso WW and Lee CS | Cottonseed oil as a vaginal contraceptive. | 1982 | Arch. Androl. | pmid:6895984 |
| Tong SM et al. | Human antifertility effect of gossypol cytologic observation of semen. | 1982 | Chin. Med. J. | pmid:6216077 |
| Sotelo A et al. | Infertility in male rats induced by diets containing whole cottonseed flour. | 1982 | J. Nutr. | pmid:6897076 |
| Tso WW et al. | Effect of gossypol on boar spermatozoal adenosine triphosphate metabolism. | 1982 | Arch. Androl. | pmid:6219642 |
| Wichmann K et al. | Inhibiting herpes simplex virus type 2 infection in human epithelial cells by gossypol, a potent spermicidal and contraceptive agent. | 1982 | Am. J. Obstet. Gynecol. | pmid:6277198 |
| Shu HD et al. | [Effects of gossypol acetate on neuromuscular transmission (author's transl)]. | 1982 | Zhongguo Yao Li Xue Bao | pmid:6283787 |
| Male fertility and its regulation: expanded abstracts. International symposium, Maui, Hawaii, October 9-15, 1982. | 1982 | Arch. Androl. | pmid:6812518 | |
| Hoshiai H et al. | Gossypol as oral contraceptive for male: trial case report. | 1982 | Tohoku J. Exp. Med. | pmid:6818716 |
| Tso WW and Lee CS | Gossypol: an effective acrosin blocker. | 1982 | Arch. Androl. | pmid:6803693 |
| Kalla NR et al. | Studies on the male antifertility agent--gossypol acetic acid. III. Effect of gossypol acetic acid on rat testis. | 1981 May-Jun | Andrologia | pmid:6455943 |
| Kalla NR and Vasudev M | Studies on the male antifertility agent-gossypol acetic acid. II. Effect of gossypol acetic acid on the motility and ATPase activity of human spermatozoa. | 1981 Mar-Apr | Andrologia | pmid:6454365 |
| Liu GZ | Clinical study of gossypol as a male contraceptive. | 1981 Jul-Sep | Reproduccion | pmid:6793420 |
| El'chits SV et al. | [Glucoamylase immobilization on silochrome using gossypol]. | 1981 Jan-Feb | Ukr. Biokhim. Zh. | pmid:6259793 |
| Maugh TH | Male "pill" blocks sperm enzyme. | 1981 | Science | pmid:7193910 |
| Lin T et al. | Gossypol inhibits testicular steroidogenesis. | 1981 | Fertil. Steril. | pmid:7194804 |
| Jacobs HS | Contraception in the future. | 1981 | Proc Annu Symp Eugen Soc | pmid:7050975 |
| Ye YX et al. | [The effect of gossypol on the incorporation of H3-thymidine in the liver, testis and small intestine of experimental animals (author's transl)]. | 1981 | Yao Xue Xue Bao | pmid:7246187 |
| Tso WW and Lee CS | Effect of gossypol on boar spermatozoa in vitro. | 1981 | Arch. Androl. | pmid:7271366 |
| Bozek SA et al. | Scanning electron microscopic study of spermatozoa from gossypol-treated rats. | 1981 | Cell Tissue Res. | pmid:7273120 |
| Hahn DW et al. | Antifertility and endocrine activities of gossypol in rodents. | 1981 | Contraception | pmid:7273769 |
| Waller DP et al. | Antifertility effects of gossypol and its impurities on male hamsters. | 1981 | Contraception | pmid:7285581 |
| Sakesena SK et al. | Gossypol: its toxicological and endocrinological effects in male rabbits. | 1981 | Contraception | pmid:7297071 |
| Lawrence SV | Gossypol: a potential male contraceptive? | 1981 | Am Pharm | pmid:7304423 |
| Tso WW and Lee CS | Variations of gossypol sensitivity in boar spermatozoal electron transport chain segments. | 1981 | Contraception | pmid:7318437 |
| Liu YX | [The effect of gossypol acetate on the content of the sex steroid hormone in endometrium (author's transl)]. | 1981 | Zhonghua Fu Chan Ke Za Zhi | pmid:7327032 |
| [A preliminary study on gossypol used in gynecology and its mechanism of action (author's transl)]. | 1981 | Zhonghua Fu Chan Ke Za Zhi | pmid:7327033 | |
| Zhou SW | [Clinical use of gossypol in gynecology (author's transl)]. | 1981 | Zhonghua Fu Chan Ke Za Zhi | pmid:7327034 |
| El-Sebae AH et al. | Gossypol as an inducer or inhibitor in Spodoptera littoralis larvae. | 1981 | J Environ Sci Health B | pmid:6454717 |
| Liang DC et al. | [Studies on distribution of 14C-gossypol in subcellular fractions of rat testes and site of gossypol action (author's transl)]. | 1981 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:6459173 |
| Bi XF et al. | [Preliminary study on gossypol in causing hypokalemia (author's transl)]. | 1981 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:6459178 |
| Shi QX et al. | [Analysis on exfoliated cells in human semen after oral administrations of gossypol acetic acid (author's transl)]. | 1981 | Zhongguo Yao Li Xue Bao | pmid:6462027 |
| Bi XF et al. | The effect of gossypol on ATPase activity of the kidney. | 1981 | Sci. Sin. | pmid:6266011 |
| Ridley AJ and Blasco L | Testosterone and gossypol effects on human sperm motility. | 1981 | Fertil. Steril. | pmid:6273239 |
| Wu YM et al. | Effects of gossypol on pituitary-ovarian endocrine function, ovulation and fertility in female hamsters. | 1981 | Contraception | pmid:6796329 |
| Hei LS | [Electron-microscopic observations on bioptic testicular tissue of cancerous patients after oral administration of gossypol (author's transl)]. | 1981 | Zhonghua Yi Xue Za Zhi | pmid:6804060 |
| Wen W | China invents male birth control pill. | 1980 Spring-Summer | Am. J. Chin. Med. | pmid:7395797 |
| Vagabov RM et al. | [Comparative study of the effectiveness of the interferon inducers, poly(I) : poly(C) and GSS (gossypol-beta-aminoethylsodium sulfate), in combination with a specific vaccine in experimental infection with the human acute encephalomyelitis virus]. | 1980 May-Jun | Vopr. Virusol. | pmid:7434726 |
| Labzo SS et al. | [Stimulation of interferon formation by natural and synthetic inducers in cultures of human tonsil cells]. | 1980 Jan-Feb | Vopr. Virusol. | pmid:6158181 |
| Shepu X et al. | Antispermatogenic effect of gossypol on the germinal epithelium of the rat testes. A cytological, autoradiographical and ultrastructural observation. | 1980 | Sci. Sin. | pmid:7403840 |
| Muratov MM et al. | [Hygienic evaluation of acetate fabric dyed with technical grade gossypol]. | 1980 | Gig Sanit | pmid:7372107 |
| Abidov MM et al. | [Effect of the immunodepressive preparation, batriden, on the course of experimental allergic dermatitis]. | 1980 | Vestn Dermatol Venerol | pmid:7376717 |
| Coulson PB et al. | Short term metabolic effects of the anti-fertility agent, gossypol, on various reproductive organs of male mice. | 1980 | Int. J. Androl. | pmid:7440012 |
| Sang GW et al. | [Chronic toxicity of gossypol and the relationship to its metabolic fate in dogs and monkeys (author's transl)]. | 1980 | Zhongguo Yao Li Xue Bao | pmid:6461173 |
| Tang XC et al. | [Comparative studies on the absorption, distribution and excretion of 14C-gossypol in four species of animals (author's transl)]. | 1980 | Yao Xue Xue Bao | pmid:6779501 |