Gossypol

Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.

Cross Reference

Introduction

To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Gossypol?

Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Gossypol

MeSH term MeSH ID Detail
Leukemia, Lymphocytic, Chronic, B-Cell D015451 25 associated lipids
Neoplasms, Hormone-Dependent D009376 23 associated lipids
Leiomyoma D007889 8 associated lipids
Nutrition Disorders D009748 6 associated lipids
Swine Diseases D013553 16 associated lipids
Pemphigoid, Bullous D010391 8 associated lipids
Infertility, Female D007247 5 associated lipids
Micronuclei, Chromosome-Defective D048629 33 associated lipids
Carcinoma, Non-Small-Cell Lung D002289 72 associated lipids
Acute Lung Injury D055371 33 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Gossypol

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Gossypol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Gossypol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Gossypol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Gossypol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Gossypol?

Xenograft Model

Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).

Transgenic Model

Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Gossypol

Download all related citations
Per page 10 20 50 100 | Total 1511
Authors Title Published Journal PubMed Link
DANKE RJ and TILLMAN AD EFFECT OF GOSSYPOL AND HEXAHOMOSERINE ON PERFORMANCE OF RATS FED PURIFIED DIETS WITH AND WITHOUT LYSINE. 1965 J. Anim. Sci. pmid:14296177
CASADY RB et al. FURTHER STUDIES OF DEGOSSYPOLIZED COTTONSEED MEAL AS A SOURCE OF PLANT PROTEIN IN RABBIT FEEDS. 1965 J Am Oil Chem Soc pmid:14328364
Klaasen GH [Gossypol, properties and occurrence]. 1965 Pharm Weekbl pmid:5321432
VERMEL EM and KRUGLYAK SA ANTITUMOR ACTIVITY OF GOSSYPOL IN EXPERIMENTS ON TRANSPLANTABLE TUMORS. 1965 Jan-Feb Fed Proc Transl Suppl pmid:14275562
Sharma MP et al. Effects of levels of protein and gossypol, and length of feeding period on the accumulation of gossypol in tissues of swine. 1966 J. Nutr. pmid:5931188
Muzaffaruddin M and Saxena ER Physicochemical studies on the composition and stability of metal-gossypol complexes. I. Fe+++ gossypol complex. 1966 J Am Oil Chem Soc pmid:5939582
Clawson AJ and Smith FH Effect of dietary iron on gossypol toxicity and on residues of gossypil in porcine liver. 1966 J. Nutr. pmid:5950205
Myers BD and Throneberry GO Effect of gossypol on some oxidative respiratory enzymes. 1966 Plant Physiol. pmid:4287149
Ghittino P et al. Experimental dietary hepatoma in rainbow trout. The role of cottonseed meals and other diets. 1967 Cancro pmid:4303305
Braham JE et al. Effect of gossypol on the iron-binding capacity of serum in swine. 1967 J. Nutr. pmid:6052995
Roehm JN et al. Accumulation and elimination of dietary gossypol in the organs of rainbow trout. 1967 J. Nutr. pmid:6054742
Smith FH Determination of gossypol in leaves and flower buds of Gossypium. 1967 J Am Oil Chem Soc pmid:6041387
Margalith P Inhibitory effect of gossypol on microorganisms. 1967 Appl Microbiol pmid:6049314
Braham JE et al. Effect of calcium and gossypol on the performance of swine and on certain enzymes and other blood constituents. 1967 J. Nutr. pmid:6018252
Sinnhuber RO et al. Dietary factors and hepatoma in rainbow trout (Salmo gairdneri). II. Cocarcinogenes by cyclopropenoid fatty acids and the effect of gossypol and altered lipids on aflatoxin-induced liver cancer. 1968 J. Natl. Cancer Inst. pmid:4178161
Albrecht JE et al. Effects of high gossypol cottonseed meal on the electrocardiogram of swine. 1968 J. Anim. Sci. pmid:5744268
Vichkanova SA and Goriunova LV [Study of virulicidal effect of gossypol in vitro]. 1968 Antibiotiki pmid:4974209
Lyman CM et al. Metabolism of gossypol in the chick. 1969 J Am Oil Chem Soc pmid:5779540
Baugher WL and Campbell TC Gossypol detoxication by fungi. 1969 Science pmid:5786644
Graham GG et al. Dietary protein quality in infants and children. II. Metabolic studies with cottonseed flour. 1969 Am. J. Clin. Nutr. pmid:5819114