| MeSH term | MeSH ID | Detail |
|---|---|---|
| Leukemia, Lymphocytic, Chronic, B-Cell | D015451 | 25 associated lipids |
| Neoplasms, Hormone-Dependent | D009376 | 23 associated lipids |
| Leiomyoma | D007889 | 8 associated lipids |
| Nutrition Disorders | D009748 | 6 associated lipids |
| Swine Diseases | D013553 | 16 associated lipids |
| Pemphigoid, Bullous | D010391 | 8 associated lipids |
| Infertility, Female | D007247 | 5 associated lipids |
| Micronuclei, Chromosome-Defective | D048629 | 33 associated lipids |
| Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
| Acute Lung Injury | D055371 | 33 associated lipids |
Gossypol
Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
Cross Reference
Introduction
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Gossypol?
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Gossypol
PubChem Associated disorders and diseases
What pathways are associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Gossypol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Gossypol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Gossypol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Gossypol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Gossypol?
Xenograft Model
Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Gossypol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Weinbauer GF et al. | The endocrine status of gossypol - treated male rats. | 1983 | Andrologia | pmid:6421193 |
| Wang JM et al. | Electrolyte composition of rete testis fluid and cauda epididymal plasma and spermatozoa from rats following gossypol treatment. | 1986 Jan-Feb | Andrologia | pmid:3954086 |
| Ikeda M | Inhibition kinetics of NAD-linked enzymes by gossypol acetic acid. | 1990 Sep-Oct | Andrologia | pmid:2073051 |
| Levinsky H et al. | Inhibition of sialyl transferase activity by gossypol acetic acid in human seminal plasma. | 1991 Mar-Apr | Andrologia | pmid:1952122 |
| Nakamura M et al. | Metabolism of round spermatids in the rat: effect of gossypol on the glucose transport. | 1988 Sep-Oct | Andrologia | pmid:3207199 |
| Rikihisa Y et al. | Histopathologic changes of uterus following gossypol treatment during early pregnancy in rats. | 1985 | Anat. Rec. | pmid:4073564 |
| Admasu A and Chandravanshi BS | Spectrophotometric determination of total gossypol in cottonseeds and cottonseed meals. | 1984 | Anal. Chem. | pmid:6546479 |
| Schmidt JH and Wells R | Recovery of soluble proteins from glanded cotton tissues with amines. | 1986 | Anal. Biochem. | pmid:3706729 |
| Meyer R et al. | Identification and quantification of gossypol in cotton by using packed micro-tips columns in combination with HPLC. | 2004 | Anal Bioanal Chem | pmid:15372136 |
| Jones LA | Gossypol toxicosis. | 1988 | Am. J. Vet. Res. | pmid:3178038 |
| Morgan S et al. | Clinical, clinicopathologic, pathologic, and toxicologic alterations associated with gossypol toxicosis in feeder lambs. | 1988 | Am. J. Vet. Res. | pmid:3377308 |
| Gupta GS and Syal N | Newly exposed immunochemically cross-reactive epitopes in sperm-specific LDH after glucosylation and gossypol interaction. | 2000 | Am. J. Reprod. Immunol. | pmid:11125794 |
| Pérez A et al. | Endofacial competitive inhibition of the glucose transporter 1 activity by gossypol. | 2009 | Am. J. Physiol., Cell Physiol. | pmid:19386788 |
| Kottmann RM et al. | Pharmacologic inhibition of lactate production prevents myofibroblast differentiation. | 2015 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:26408551 |
| Judge JL et al. | Ionizing radiation induces myofibroblast differentiation via lactate dehydrogenase. | 2015 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:26254422 |
| Hill MA et al. | Cyclooxygenase inhibition potentiates myogenic activity in skeletal muscle arterioles. | 1990 | Am. J. Physiol. | pmid:2105665 |
| Reyes J et al. | A bioenergetic model of gossypol action: effects of gossypol on adult rat spermatogenic cells. | 1988 | Am. J. Physiol. | pmid:3354654 |
| Hasegawa K et al. | Angiotensin II-induced endothelium-dependent relaxation of fowl aorta. | 1993 | Am. J. Physiol. | pmid:8498599 |
| Radermacher J et al. | Endothelium-derived relaxing factor influences renal vascular resistance. | 1990 | Am. J. Physiol. | pmid:2115741 |
| Reyes J and Benos DJ | Specificity of gossypol uncoupling: a comparative study of liver and spermatogenic cells. | 1988 | Am. J. Physiol. | pmid:3354655 |