Gossypol

Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.

Cross Reference

Introduction

To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Gossypol?

Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Gossypol

MeSH term MeSH ID Detail
Leukemia, Lymphocytic, Chronic, B-Cell D015451 25 associated lipids
Neoplasms, Hormone-Dependent D009376 23 associated lipids
Leiomyoma D007889 8 associated lipids
Nutrition Disorders D009748 6 associated lipids
Swine Diseases D013553 16 associated lipids
Pemphigoid, Bullous D010391 8 associated lipids
Infertility, Female D007247 5 associated lipids
Micronuclei, Chromosome-Defective D048629 33 associated lipids
Carcinoma, Non-Small-Cell Lung D002289 72 associated lipids
Acute Lung Injury D055371 33 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Gossypol

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Gossypol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Gossypol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Gossypol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Gossypol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Gossypol?

Xenograft Model

Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).

Transgenic Model

Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Gossypol

Download all related citations
Per page 10 20 50 100 | Total 1511
Authors Title Published Journal PubMed Link
Berg LR and Lawrence WW Cottonseed meal, dehydrated grass and ascorbic acid as dietary factors preventing toxicity of vanadium for the chick. 1971 Poult. Sci. pmid:5109894
Fishbein L Natural non-nutrient substances in the food chain. 1972 Sci. Total Environ. pmid:4121147
Albrecht JE et al. Rate of depletion and route of elimination of intravenously injected gossypol in swine. 1972 J. Anim. Sci. pmid:5085300
Kornegay ET et al. Fungal-treated cottonseed meal for swine. 1972 J. Nutr. pmid:4678034
Wong RC et al. Studies on the nature of the inhibition by gossypol of the transformation of pepsinogen to pepsin. 1972 J. Biol. Chem. pmid:4551945
Smith FH Effect of gossypol bound to cottonseed protein on growth of weanling rats. 1972 Jul-Aug J. Agric. Food Chem. pmid:5068584
Mayorga H et al. [Extraction and precipitation of cottonseed protein by the wet method]. 1973 Arch Latinoam Nutr pmid:4801265
Lee J The inheritance of gossypol level in Gossypium. II. Inheritance of seed gosypol in two trains of cultivated Gossypoium barbadense L. 1973 Genetics pmid:4769299
Ogot JO The performance of pigs in Kenya fed cottonseed meal in mixtures of concentrate supplements. 1973 Bull Epizoot Dis Afr pmid:4808120
Finlay TH et al. Mechanism of the gossypol inactivation of pepsinogen. 1973 J. Biol. Chem. pmid:4718749
Skutches CL et al. Effect of intravenous gossypol injection on iron ultilization in swine. 1973 J. Nutr. pmid:4705271
Herman DL and Smith FH Effect of bound gossypol on the absorption of iron by rats. 1973 J. Nutr. pmid:4705274
Abou-Donia MB and Dieckert JW Gossypol: uncoupling of respiratory chain and oxidative phosphorylation. 1974 Life Sci. pmid:4277086
Pirogov AI et al. [Postoperative bronchopleural complications in the combined treatment of lung cancer]. 1974 Vopr Onkol pmid:4211564
Abou-Donia MB and Dieckert JW Urinary and biliary excretion of 14C-gossypol in swine. 1974 J. Nutr. pmid:4830281
Smith FH Preparation of 14C-gossypol by incorporation of acetate-1-14C and acetate-2-14C by biosynthesis. 1974 J Am Oil Chem Soc pmid:4415176
Skutches CL and Smith FH Effect of phenobarbital on the level of gossypol in the liver and the effect of gossypol and phenobarbital on liver microsomal O-demethylation and lipid peroxidation activities in the rat. 1974 J. Nutr. pmid:4430931
Abou-Donia MB et al. Gossypol: antagonistic effect on toxicity of insecticides to Spodoptera littoralis. 1974 Experientia pmid:4435119
Skutches CL and Smith FH Metabolism of gossypol, biosynthesized from methyl-14C-and carboxyl-14 C-labeled sodium acetate, in rat. 1974 J Am Oil Chem Soc pmid:4479245
el-Nockrashy AS et al. Biochemical changes in cottonseed during germination. 1974 Nahrung pmid:4365683