| MeSH term | MeSH ID | Detail |
|---|---|---|
| Leukemia, Biphenotypic, Acute | D015456 | 2 associated lipids |
| Lymphoma, B-Cell | D016393 | 24 associated lipids |
| Lymphoma, Large B-Cell, Diffuse | D016403 | 13 associated lipids |
| Endometrial Neoplasms | D016889 | 30 associated lipids |
| Carcinoma, Mucoepidermoid | D018277 | 3 associated lipids |
| Hematologic Neoplasms | D019337 | 4 associated lipids |
| Retinal Neoplasms | D019572 | 3 associated lipids |
| Micronuclei, Chromosome-Defective | D048629 | 33 associated lipids |
| Lung Injury | D055370 | 14 associated lipids |
| Acute Lung Injury | D055371 | 33 associated lipids |
Gossypol
Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
Cross Reference
Introduction
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Gossypol?
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Mol. Cancer Ther. (4)
- Proc. Natl. Acad. Sci. U.S.A. (3)
- Am. J. Physiol. Lung Cell Mol. Physiol. (2)
- Others (13)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Gossypol
PubChem Associated disorders and diseases
What pathways are associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Gossypol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Gossypol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Gossypol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Gossypol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Gossypol?
Xenograft Model
Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Gossypol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Heywood R et al. | The toxicity of gossypol to the male rat. | 1986 | Toxicology | pmid:3750328 |
| Jensen DR et al. | Deposition pattern of the antifertility agent, gossypol, in selected organs of male rats. | 1982 | Toxicology | pmid:7135404 |
| Ma X et al. | Environmental inhibitors of 11β-hydroxysteroid dehydrogenase type 2. | 2011 | Toxicology | pmid:21515335 |
| Abou-Donia MB et al. | Interspecies comparison of pharmacokinetic profile and bioavailability of (+/-)-gossypol in male Fischer-344 rats and male B6C3F mice. | 1989 | Toxicology | pmid:2711405 |
| Uzunoglu S et al. | Comparison of XTT and Alamar blue assays in the assessment of the viability of various human cancer cell lines by AT-101 (-/- gossypol). | 2010 | Toxicol. Mech. Methods | pmid:20843265 |
| Rinchard J et al. | Effects of gossypol on sperm viability and plasma sex steroid hormones in male sea lamprey, Petromyzon marinus. | 2000 | Toxicol. Lett. | pmid:10643862 |
| Quintana PJ et al. | Gossypol-induced DNA breaks in rat lymphocytes are secondary to cytotoxicity. | 2000 | Toxicol. Lett. | pmid:11033237 |
| Messiha FS | Behavioral and metabolic interaction between gossypol and ethanol. | 1991 | Toxicol. Lett. | pmid:1853362 |
| Ali SF and El-Sewedy SM | Effect of gossypol on liver metabolic enzymes in male rats. | 1984 | Toxicol. Lett. | pmid:6084346 |
| Buttar HS and Nayak BN | Cytogenetic effects of vaginally administered gossypol in murine bone marrow cells. | 1987 | Toxicol. Lett. | pmid:3660427 |
| Abou-Donia MB and Dieckert JW | Metabolic fate of gossypol: the metabolism of [14-C]gossypol in swine. | 1975 | Toxicol. Appl. Pharmacol. | pmid:1129787 |
| Hong SK et al. | Effects of gossypol on PAH transport in the rabbit kidney slice. | 1983 | Toxicol. Appl. Pharmacol. | pmid:6140776 |
| Abou-Donia MB and Dieckert JW | Gossypol: subcellular localization and stimulation of rat liver microsomal oxidases. | 1971 | Toxicol. Appl. Pharmacol. | pmid:4998823 |
| Hutchinson RW et al. | Attenuation of gossypol cytotoxicity by cyclic AMP in a rat liver cell line. | 1998 | Toxicol. Appl. Pharmacol. | pmid:9707507 |
| de Andrade SF et al. | Epididymis-specific pathologic disorders in rats exposed to gossypol from weaning through puberty. | 2006 | Toxicol Pathol | pmid:17162530 |
| Zhou DR et al. | Gossypol repressed the gap junctional intercellular communication between Sertoli cells by decreasing the expression of Connexin43. | 2008 | Toxicol In Vitro | pmid:18706992 |
| Balci A et al. | Gossypol induced apoptosis in the human promyelocytic leukemia cell line HL 60. | 1999 | Tohoku J. Exp. Med. | pmid:10622208 |
| Kono H et al. | Effects of progesterone and gossypol on monoamine oxidase activity in human term placental explant. | 1991 | Tohoku J. Exp. Med. | pmid:2048118 |
| Kono H et al. | Gossypol effects on monoamine oxidase (MAO) activity in several organs of term rats. | 1991 | Tohoku J. Exp. Med. | pmid:2063399 |
| Zavos PM and Zarmakoupis-Zavos PN | The inhibitory effects of gossypol on human sperm motility characteristics: possible modes of reversibility of those effects. | 1996 | Tohoku J. Exp. Med. | pmid:8888505 |