| MeSH term | MeSH ID | Detail |
|---|---|---|
| Leukemia, Biphenotypic, Acute | D015456 | 2 associated lipids |
| Lymphoma, B-Cell | D016393 | 24 associated lipids |
| Lymphoma, Large B-Cell, Diffuse | D016403 | 13 associated lipids |
| Endometrial Neoplasms | D016889 | 30 associated lipids |
| Carcinoma, Mucoepidermoid | D018277 | 3 associated lipids |
| Hematologic Neoplasms | D019337 | 4 associated lipids |
| Retinal Neoplasms | D019572 | 3 associated lipids |
| Micronuclei, Chromosome-Defective | D048629 | 33 associated lipids |
| Lung Injury | D055370 | 14 associated lipids |
| Acute Lung Injury | D055371 | 33 associated lipids |
Gossypol
Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
Cross Reference
Introduction
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Gossypol?
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Mol. Cancer Ther. (4)
- Proc. Natl. Acad. Sci. U.S.A. (3)
- Am. J. Physiol. Lung Cell Mol. Physiol. (2)
- Others (13)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Gossypol
PubChem Associated disorders and diseases
What pathways are associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Gossypol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Gossypol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Gossypol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Gossypol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Gossypol?
Xenograft Model
Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Gossypol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kalla NR et al. | Studies on the male antifertility agent--gossypol acetic acid. V. Effect of gossypol acetic acid on the fertility of male rats. | 1982 Nov-Dec | Andrologia | pmid:7165122 |
| Price CP et al. | Dissecting the behavior of a promiscuous solvate former. | 2006 | Angew. Chem. Int. Ed. Engl. | pmid:16493716 |
| Ojha P et al. | Rat testicular germ cell type(s) targeted by anti-spermatogenic agents in vivo and their recovery on withdrawal of treatment--a flow cytometric study. | 2008 | Anim. Reprod. Sci. | pmid:17207942 |
| Cornu A et al. | [Utilization of gossypol-free cottonseed and its by-products as human food]. | 1977 | Ann Nutr Aliment | pmid:579293 |
| Kunesch N et al. | [Preparation of derivatives of the aldehydic functions of gossypol]. | 1990 | Ann Pharm Fr | pmid:2082795 |
| Fody EP and Walker EM | Effects of drugs on the male and female reproductive systems. | 1985 Nov-Dec | Ann. Clin. Lab. Sci. | pmid:4062226 |
| Tvermyr SM et al. | Glucose metabolism in rat germ cells: mechanism of action of gossypol. | 1984 | Ann. N. Y. Acad. Sci. | pmid:6598341 |
| Chadha S et al. | Alterations and reversibility of the effects of gossypol acetic acid on the intestinal uptake of end product nutrients in normal and protein calorie-malnourished male rats. | 1991 | Ann. Nutr. Metab. | pmid:1905512 |
| Sonpavde G et al. | Randomized phase II trial of docetaxel plus prednisone in combination with placebo or AT-101, an oral small molecule Bcl-2 family antagonist, as first-line therapy for metastatic castration-resistant prostate cancer. | 2012 | Ann. Oncol. | pmid:22112969 |
| Johnson PW | New targets for lymphoma treatment. | 2008 | Ann. Oncol. | pmid:18519406 |
| Qian SZ and Wang ZG | Gossypol: a potential antifertility agent for males. | 1984 | Annu. Rev. Pharmacol. Toxicol. | pmid:6375548 |
| SaÄitkulov AM et al. | [Relation between interferon-inducing activity of natural interferon inducers and their chemical structure]. | 1991 | Antibiot. Khimioter. | pmid:1719947 |
| Amanov N et al. | [Intestinal microbial ecology and its modulation under the influence of immunodepressants]. | 1989 | Antibiot. Khimioter. | pmid:2802878 |
| Khadzhibaev GS et al. | [Interferonogenic activity of gossypol, a low-molecular substance]. | 1978 | Antibiotiki | pmid:206198 |
| Vichkanova SA et al. | [Antiviral properties of gossypol in experimental influenza pneumonia]. | 1970 | Antibiotiki | pmid:5501368 |
| Vichkanova SA and Goriunova LV | [Study of virulicidal effect of gossypol in vitro]. | 1968 | Antibiotiki | pmid:4974209 |
| Hedvat M et al. | Selected approaches for rational drug design and high throughput screening to identify anti-cancer molecules. | 2012 | Anticancer Agents Med Chem | pmid:22931411 |
| Shelley MD et al. | Structure-activity studies on gossypol in tumor cell lines. | 2000 | Anticancer Drugs | pmid:10831280 |
| Sun J et al. | ApoG2 inhibits antiapoptotic Bcl-2 family proteins and induces mitochondria-dependent apoptosis in human lymphoma U937 cells. | 2008 | Anticancer Drugs | pmid:18827561 |
| Huang YW et al. | Molecular mechanisms of (-)-gossypol-induced apoptosis in human prostate cancer cells. | 2006 May-Jun | Anticancer Res. | pmid:16827126 |