| MeSH term | MeSH ID | Detail |
|---|---|---|
| Leukemia, Biphenotypic, Acute | D015456 | 2 associated lipids |
| Lymphoma, B-Cell | D016393 | 24 associated lipids |
| Lymphoma, Large B-Cell, Diffuse | D016403 | 13 associated lipids |
| Endometrial Neoplasms | D016889 | 30 associated lipids |
| Carcinoma, Mucoepidermoid | D018277 | 3 associated lipids |
| Hematologic Neoplasms | D019337 | 4 associated lipids |
| Retinal Neoplasms | D019572 | 3 associated lipids |
| Micronuclei, Chromosome-Defective | D048629 | 33 associated lipids |
| Lung Injury | D055370 | 14 associated lipids |
| Acute Lung Injury | D055371 | 33 associated lipids |
Gossypol
Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
Cross Reference
Introduction
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Gossypol?
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Mol. Cancer Ther. (4)
- Proc. Natl. Acad. Sci. U.S.A. (3)
- Am. J. Physiol. Lung Cell Mol. Physiol. (2)
- Others (13)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Gossypol
PubChem Associated disorders and diseases
What pathways are associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Gossypol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Gossypol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Gossypol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Gossypol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Gossypol?
Xenograft Model
Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Gossypol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Skripkin IuK et al. | [Treatment of viral skin diseases with Soviet-made antiviral drugs]. | 1976 | Vestn Dermatol Venerol | pmid:1023645 |
| Pridgeon JW et al. | Attempt to develop live attenuated bacterial vaccines by selecting resistance to gossypol, proflavine hemisulfate, novobiocin, or ciprofloxacin. | 2013 | Vaccine | pmid:23499519 |
| Rovan E et al. | Effect of gossypol on bull spermatozoa in vitro. | 1984 | Urol. Res. | pmid:6485187 |
| Rovan E et al. | Ultrastructural analysis of rat testes after gossypol acetic acid (GAA) treatment. | 1983 | Urol. Res. | pmid:6868221 |
| Pond GR et al. | Efficacy of docetaxel-based chemotherapy following ketoconazole in metastatic castration-resistant prostate cancer: implications for prior therapy in clinical trials. | 2013 | Urol. Oncol. | pmid:22552048 |
| Kogan P and Wald M | Male contraception: history and development. | 2014 | Urol. Clin. North Am. | pmid:24286773 |
| El'chits SV et al. | [Glucoamylase immobilization on silochrome using gossypol]. | 1981 Jan-Feb | Ukr. Biokhim. Zh. | pmid:6259793 |
| Ruppel A and Shi YE | Schistosoma mansoni: effect of gossypol on infections in mice. | 1988 | Trop. Med. Parasitol. | pmid:3140355 |
| Fombad RB and Bryant MJ | Effects of cottonseed cake-based diets supplemented with blood meal, alone or with lysine, on the growth of pigs. | 2004 | Trop Anim Health Prod | pmid:15241972 |
| Fombad RB and Bryant MJ | An evaluation of the use of cottonseed cake in the diet of growing pigs. | 2004 | Trop Anim Health Prod | pmid:15080544 |
| Kannan A et al. | Effect of feeding of calcium hydroxide-treated or vitamin E-supplemented cottonseed meal on plasma gossypol levels, blood parameters, and performance of Bikaneri lambs. | 2013 | Trop Anim Health Prod | pmid:23345064 |
| Lima Pde M et al. | Methane emission of Santa Inês sheep fed cottonseed by-products containing different levels of gossypol. | 2014 | Trop Anim Health Prod | pmid:24132456 |
| Mao YB et al. | Cotton plants expressing CYP6AE14 double-stranded RNA show enhanced resistance to bollworms. | 2011 | Transgenic Res. | pmid:20953975 |
| Gonzalez-Garza MT et al. | High susceptibility of five axenic Entamoeba histolytica strains to gossypol. | 1989 Jul-Aug | Trans. R. Soc. Trop. Med. Hyg. | pmid:2559507 |
| Monsees TK et al. | Influence of gossypol on the secretory function of cultured rat sertoli cells. | 1998 | Toxicon | pmid:9655644 |
| Zhang WJ et al. | Optimization of process parameters for reduction of gossypol levels in cottonseed meal by Candida tropicalis ZD-3 during solid substrate fermentation. | 2006 | Toxicon | pmid:16846625 |
| Manabe S et al. | Zone-specific hepatotoxicity of gossypol in perfused rat liver. | 1991 | Toxicon | pmid:1926180 |
| Cheng JS et al. | Gossypol, a component in cottonseed, induced increases in cytosolic Ca2+ levels in Chang liver cells. | 2002 | Toxicon | pmid:12076637 |
| GÃ¥fvels M et al. | Toxic effects of the antifertility agent gossypol in male rats. | 1984 | Toxicology | pmid:6485000 |
| Zbidah M et al. | Gossypol-induced suicidal erythrocyte death. | 2012 | Toxicology | pmid:23041711 |