| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Genital Neoplasms, Male | D005834 | 3 associated lipids |
| Endometriosis | D004715 | 29 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Cattle Diseases | D002418 | 24 associated lipids |
| Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
Gossypol
Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
Cross Reference
Introduction
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Gossypol?
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Mol. Cancer Ther. (4)
- Proc. Natl. Acad. Sci. U.S.A. (3)
- Am. J. Physiol. Lung Cell Mol. Physiol. (2)
- Others (13)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Gossypol
PubChem Associated disorders and diseases
What pathways are associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Gossypol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Gossypol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Gossypol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Gossypol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Gossypol?
Xenograft Model
Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Gossypol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Inoue H et al. | Profile of capsaicin-induced mouse ear oedema as neurogenic inflammatory model: comparison with arachidonic acid-induced ear oedema. | 1993 | Br. J. Pharmacol. | pmid:7508328 |
| Warner TD | Simultaneous perfusion of rat isolated superior mesenteric arterial and venous beds: comparison of their vasoconstrictor and vasodilator responses to agonists. | 1990 | Br. J. Pharmacol. | pmid:2328405 |
| Alheid U et al. | Selective inhibition by gossypol of endothelium-dependent relaxations augments relaxations to glyceryl trinitrate in rabbit coeliac artery. | 1987 | Br. J. Pharmacol. | pmid:2444300 |
| Gschwentner M et al. | Blockade of swelling-induced chloride channels by phenol derivatives. | 1996 | Br. J. Pharmacol. | pmid:8733574 |
| Burton GA et al. | Cyclic GMP release and vasodilatation induced by EDRF and atrial natriuretic factor in the isolated perfused kidney of the rat. | 1990 | Br. J. Pharmacol. | pmid:2158376 |
| Panigrahi S et al. | Effects of dietary cottonseed meal, with and without iron treatment, on laying hens. | 1989 | Br. Poult. Sci. | pmid:2819506 |
| Mandal AB et al. | Comparison of broiler chicken performance when fed diets containing meals of Bollgard II hybrid cotton containing Cry-X gene (Cry1Ac and Cry2ab gene), parental line or commercial cotton. | 2004 | Br. Poult. Sci. | pmid:15623220 |
| Phillis JW et al. | Effects of immunosuppressants, calcineurin inhibition, and blockade of endoplasmic reticulum calcium channels on free fatty acid efflux from the ischemic/reperfused rat cerebral cortex. | 2002 | Brain Res. | pmid:12443975 |
| Mego M | Telomerase inhibitors in anticancer therapy: gossypol as a potential telomerase inhibitor. | 2002 | Bratisl Lek Listy | pmid:12583508 |
| Medeiros YS et al. | Gossypol affects the responsiveness of isolated rat myometrium and vas deferens. | 1989 | Braz. J. Med. Biol. Res. | pmid:2638200 |
| Van Poznak C et al. | Oral gossypol in the treatment of patients with refractory metastatic breast cancer: a phase I/II clinical trial. | 2001 | Breast Cancer Res. Treat. | pmid:11510695 |
| Ogot JO | The performance of pigs in Kenya fed cottonseed meal in mixtures of concentrate supplements. | 1973 | Bull Epizoot Dis Afr | pmid:4808120 |
| Sokolova TM et al. | Ridostin induces transcription of a wide spectrum of interferon genes in human cells. | 2013 | Bull. Exp. Biol. Med. | pmid:24319751 |
| Waites GM | Male fertility regulation: recent advances. | 1986 | Bull. World Health Organ. | pmid:3091279 |
| Majumdar SK et al. | Gossypol--an effective male contraceptive was not mutagenic in sperm head abnormality assay in mice. | 1982 | Can. J. Genet. Cytol. | pmid:7182060 |
| Tam SC | Acute hypokalemic effect of gossypol. | 1986 | Can. J. Physiol. Pharmacol. | pmid:3768796 |
| Li ZM et al. | Synergistic cytotoxicity of Bcl-xL inhibitor, gossypol and chemotherapeutic agents in non-Hodgkin's lymphoma cells. | 2008 | Cancer Biol. Ther. | pmid:17938578 |
| Sikora MJ et al. | Anti-oxidant treatment enhances anti-tumor cytotoxicity of (-)-gossypol. | 2008 | Cancer Biol. Ther. | pmid:18376141 |
| Sun Y et al. | Apogossypolone, a nonpeptidic small molecule inhibitor targeting Bcl-2 family proteins, effectively inhibits growth of diffuse large cell lymphoma cells in vitro and in vivo. | 2008 | Cancer Biol. Ther. | pmid:18769131 |
| Lestini BJ et al. | Mcl1 downregulation sensitizes neuroblastoma to cytotoxic chemotherapy and small molecule Bcl2-family antagonists. | 2009 | Cancer Biol. Ther. | pmid:19556859 |