Gossypol

Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.

Cross Reference

Introduction

To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Gossypol?

Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Gossypol

MeSH term MeSH ID Detail
Hematologic Neoplasms D019337 4 associated lipids
Darier Disease D007644 2 associated lipids
Endometrial Neoplasms D016889 30 associated lipids
Trypanosomiasis, African D014353 5 associated lipids
Retinoblastoma D012175 12 associated lipids
Lymphoma, B-Cell D016393 24 associated lipids
Carcinoma, Mucoepidermoid D018277 3 associated lipids
Lung Injury D055370 14 associated lipids
Retinal Neoplasms D019572 3 associated lipids
Prostatic Neoplasms, Castration-Resistant D064129 3 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Gossypol

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.

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Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Gossypol?

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Location Cross reference Weighted score Related literatures
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What functions are associated with Gossypol?


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Function Cross reference Weighted score Related literatures

What lipids are associated with Gossypol?

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Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Gossypol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Gossypol?

Xenograft Model

Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).

Transgenic Model

Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Gossypol

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Per page 10 20 50 100 | Total 1511
Authors Title Published Journal PubMed Link
Skutches CL et al. Effect of dietary free gossypol on blood components and tissue iron in swine and rats. 1974 J. Nutr. pmid:4816926
Kilburn KH et al. Two patterns for bronchial damage from inhaled materials. 1974 Chest pmid:4819236
Tone JN and Jensen DR Hematological effects of injected gossypol and iron in rats. 1974 Jan-Feb J. Agric. Food Chem. pmid:4811630
Damaty SM and Hudson BJ Preparation of low-gossypol cottonseed flour. 1975 J. Sci. Food Agric. pmid:1172995
Clawson AJ et al. Unextracted cottonseed in diets for monogastric animals. I. The effect of ferrous sulfate and calcium hydroxide in reducing gossypol toxicity. 1975 J. Anim. Sci. pmid:1173579
Bressani R et al. [Effect of free gossypol of different cottonseed flours on the growth of rats and levels of free lysin and free gossypol in animal organs, muscle and serum]. 1975 Arch Latinoam Nutr pmid:1174302
Braham JE and Bressani R Effect of different levels of gossypol on transaminase activity, on nonessential to essential amino acid ratio, and on iron and nitrogen retention in rats. 1975 J. Nutr. pmid:1117346
Damaty S and Hudson BJ A secondary interaction between gossypol and cottonseed protein. 1975 Proc Nutr Soc pmid:1187618
Jolad SD et al. Tumor-inhibitory agent from Montezuma speciosissima (Malvaceae). 1975 J Pharm Sci pmid:1195125
Abou-Donia MB and Dieckert JW Metabolic fate of gossypol: the metabolism of [14-C]gossypol in swine. 1975 Toxicol. Appl. Pharmacol. pmid:1129787
Dorsett PH et al. Letter: Antiviral activity of gossypol and apogossypol. 1975 J Pharm Sci pmid:1133739
Aripov UA et al. [Immunodepressive properties of the drug "Batriden" in experiments on parabionts]. 1975 Dokl. Akad. Nauk SSSR pmid:1140070
Pandey SN and Thejappa N Study on relationship between oil, protein, and gossypol in cottonseed kernels. 1975 J Am Oil Chem Soc pmid:1242138
Krylov VF [Treatment of patients with influenza]. 1975 Ter. Arkh. pmid:52894
Jones LA and Smith FH Effect of free and bound gossypol on the absorption of L-]14-C]lysine, L-[14-C]methionine, and L-[14-C]valine from the rat small intestine. 1975 Jul-Aug J. Agric. Food Chem. pmid:1141508
Herman DL and Smith FH Effect of free gossypol on tissue uptake of iron by everted segments of rat duodenum. 1975 May-Jun J. Agric. Food Chem. pmid:1151001
El-Nockrashy AS et al. Biochemical changes in cottonseed during development and maturity. 1976 Nahrung pmid:989153
El-DIN S and Aboul-Ela S Fish meal supplementation of chick starting rations containing cottonseed cake. 1976 Beitr Trop Landwirtsch Veterinarmed pmid:990100
Tone JN and Jensen DR The accumulation pattern of ingested gossypol in selected organs of the rat. 1976 Experientia pmid:1253913
Abou-Donia MB Physiological effects and metabolism of gossypol. 1976 Residue Rev pmid:778955