Gossypol

Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.

Cross Reference

Introduction

To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Gossypol?

Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Gossypol

MeSH term MeSH ID Detail
Hematologic Neoplasms D019337 4 associated lipids
Darier Disease D007644 2 associated lipids
Endometrial Neoplasms D016889 30 associated lipids
Trypanosomiasis, African D014353 5 associated lipids
Retinoblastoma D012175 12 associated lipids
Lymphoma, B-Cell D016393 24 associated lipids
Carcinoma, Mucoepidermoid D018277 3 associated lipids
Lung Injury D055370 14 associated lipids
Retinal Neoplasms D019572 3 associated lipids
Prostatic Neoplasms, Castration-Resistant D064129 3 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Gossypol

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Gossypol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Gossypol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Gossypol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Gossypol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Gossypol?

Xenograft Model

Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).

Transgenic Model

Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Gossypol

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Per page 10 20 50 100 | Total 1511
Authors Title Published Journal PubMed Link
Han HL [Gossypol treatment for menopausal functional bleeding, myoma of uterus and endometriosis--preliminary report (author's transl)]. 1980 Zhongguo Yi Xue Ke Xue Yuan Xue Bao pmid:6451316
Hamasaki Y et al. [Rat basophilic leukemia-1 cell possesses 12-lipoxygenase and 5-lipoxygenase activities which are specifically inhibited by gossypol acetic acid]. 1984 Arerugi pmid:6442854
Ma XN et al. [Effect of gossypol acetic acid on testosterone, LH and FSH levels of male rats]. 1983 Yao Xue Xue Bao pmid:6433647
Weinbauer GF et al. The endocrine status of gossypol - treated male rats. 1983 Andrologia pmid:6421193
Kennedy WP et al. Gossypol inhibition of acrosin and proacrosin, and oocyte penetration by human spermatozoa. 1983 Biol. Reprod. pmid:6416323
Prasad MR and Diczfalusy E New contraceptives for men. What are the prospects? 1983 Int. J. Androl. pmid:6413430
Wichmann K et al. Effect of gossypol on the motility and metabolism of human spermatozoa. 1983 J. Reprod. Fertil. pmid:6411909
Huang TH [The effect of gossypol acetate on the function of rRNA gene and acrocentric chromosome association in human cells]. 1983 Zhonghua Yi Xue Za Zhi pmid:6407739
Qian SZ and Wang ZG Gossypol: a potential antifertility agent for males. 1984 Annu. Rev. Pharmacol. Toxicol. pmid:6375548
Gerez de Burgos NM et al. Inhibition by gossypol of oxidoreductases from Trypanosoma cruzi. 1984 Biochem. Pharmacol. pmid:6370265
Aitken RJ New techniques in contraception: gossypol, vaccines and GnRH analogues. 1983 Proc Annu Symp Eugen Soc pmid:6366784
Blanco A et al. Effect of gossypol upon motility and ultrastructure of Trypanosoma cruzi. 1983 J. Protozool. pmid:6363678
Gombe S A review of the current status in male contraceptive studies. 1983 East Afr Med J pmid:6354690
Pathak HK et al. Gossypol, ouabain and vanadate on the isolated perfused rat kidney and Na, K-ATPase. 1984 Zhongguo Yao Li Xue Bao pmid:6326465
de Peyster A et al. Oxygen radical formation induced by gossypol in rat liver microsomes and human sperm. 1984 Biochem. Biophys. Res. Commun. pmid:6322752
Jackson H and Schnieden H Aspects of male reproductive pharmacology and toxicology. 1982 Jan-Mar Rev Pure Appl Pharmacol Sci pmid:6291102
Shu HD et al. [Effects of gossypol acetate on neuromuscular transmission (author's transl)]. 1982 Zhongguo Yao Li Xue Bao pmid:6283787
Wichmann K et al. Inhibiting herpes simplex virus type 2 infection in human epithelial cells by gossypol, a potent spermicidal and contraceptive agent. 1982 Am. J. Obstet. Gynecol. pmid:6277198
Ridley AJ and Blasco L Testosterone and gossypol effects on human sperm motility. 1981 Fertil. Steril. pmid:6273239
Bi XF et al. The effect of gossypol on ATPase activity of the kidney. 1981 Sci. Sin. pmid:6266011