| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hematologic Neoplasms | D019337 | 4 associated lipids |
| Darier Disease | D007644 | 2 associated lipids |
| Endometrial Neoplasms | D016889 | 30 associated lipids |
| Trypanosomiasis, African | D014353 | 5 associated lipids |
| Retinoblastoma | D012175 | 12 associated lipids |
| Lymphoma, B-Cell | D016393 | 24 associated lipids |
| Carcinoma, Mucoepidermoid | D018277 | 3 associated lipids |
| Lung Injury | D055370 | 14 associated lipids |
| Retinal Neoplasms | D019572 | 3 associated lipids |
| Prostatic Neoplasms, Castration-Resistant | D064129 | 3 associated lipids |
Gossypol
Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
Cross Reference
Introduction
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Gossypol?
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Mol. Cancer Ther. (4)
- Proc. Natl. Acad. Sci. U.S.A. (3)
- Am. J. Physiol. Lung Cell Mol. Physiol. (2)
- Others (13)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Gossypol
PubChem Associated disorders and diseases
What pathways are associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Gossypol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Gossypol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Gossypol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Gossypol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Gossypol?
Xenograft Model
Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Gossypol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Schmidt K et al. | EDRF-formation increases cGMP-levels in cultured endothelial cells. | 1990 | Adv. Second Messenger Phosphoprotein Res. | pmid:1976336 |
| Jaroszewski JW et al. | Action of gossypol and rhodamine 123 on wild type and multidrug-resistant MCF-7 human breast cancer cells: 31P nuclear magnetic resonance and toxicity studies. | 1990 | Cancer Res. | pmid:2208159 |
| Huang HF and Wang M | [Effects of gossypol acetate, progesterone, danazol and GnRH-A (gonadotropin release hormone-A) on the DNA-synthesis of human endometrial cell in vitro]. | 1990 | Zhong Xi Yi Jie He Za Zhi | pmid:2208435 |
| Swan MA et al. | Electron microscopic observations on the effect of gossypol on rat cauda epididymis. | 1990 | Z Mikrosk Anat Forsch | pmid:2220026 |
| Grando SA et al. | Clinical and laboratory evaluation of hemocarboadsorption in autoimmune bullous dermatoses. | 1990 | Int J Artif Organs | pmid:2189836 |
| Benz CC et al. | Biochemical correlates of the antitumor and antimitochondrial properties of gossypol enantiomers. | 1990 | Mol. Pharmacol. | pmid:2193225 |
| Junco M et al. | Substrate-dependent inhibition of protein kinase C by specific inhibitors. | 1990 | FEBS Lett. | pmid:2332048 |
| Wang WH et al. | [Antifertility actions of gossypol derivatives and analogues]. | 1990 | Zhongguo Yao Li Xue Bao | pmid:2088004 |
| Morgan SE | Gossypol residues in organ meats vs thresholds of toxicity. | 1990 | Vet Hum Toxicol | pmid:2092408 |
| Lu Q | [Comparative studies on antifertility mechanism and toxicology of Tripterygium wilfordii monomer T4 and gossypol]. | 1990 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:2151263 |
| Zhong CQ et al. | Study on sperm function in men long after cessation of gossypol treatment. | 1990 | Contraception | pmid:2113849 |
| Kunesch N et al. | [Preparation of derivatives of the aldehydic functions of gossypol]. | 1990 | Ann Pharm Fr | pmid:2082795 |
| Johansen RL and Misra HP | Effects of gossypol on the hepatic drug metabolizing system in rats. | 1990 | Contraception | pmid:2083490 |
| Huang T et al. | Gossypol-induced alterations of aminophospholipid composition in human sperm. | 1990 | Proc Chin Acad Med Sci Peking Union Med Coll | pmid:2371261 |
| Zheng DK et al. | [Studies on the resolution of racemic gossypol. II. By chiral alpha-methylphenethylamine and alpha-methylbenzylamine]. | 1990 | Yao Xue Xue Bao | pmid:2284966 |
| Si YK et al. | [Studies on the resolution of racemic gossypol. III. Study on the chemical and physical properties of the amino condensates of gossypol]. | 1990 | Yao Xue Xue Bao | pmid:2284967 |
| Zheng DK et al. | [Studies on the resolution of racemic gossypol. IV. Use of threo (-) or (+)-1-(p-nitrophenyl)-1,3-dihydroxypropylamine-2 as the resolving agent]. | 1990 | Yao Xue Xue Bao | pmid:2284968 |
| Nair IN and Bhiwgade DA | Effect of gossypol on pituitary reproductive axis: ultrastructural and biochemical studies. | 1990 | Indian J. Exp. Biol. | pmid:2253964 |
| Lohiya NK et al. | Limitations in developing gossypol acetic acid as a male contraceptive. | 1990 | Contraception | pmid:2347196 |
| Chatterjee TK and Bhatnagar RK | Ca2(+)-dependent, ATP-induced conversion of the [3H]hemicholinium-3 binding sites from high- to low-affinity states in rat striatum: effect of protein kinase inhibitors on this affinity conversion and synaptosomal choline transport. | 1990 | J. Neurochem. | pmid:2324736 |
| Neild TO et al. | Vasodilatation of arterioles by acetylcholine released from single neurones in the guinea-pig submucosal plexus. | 1990 | J. Physiol. (Lond.) | pmid:2324984 |
| Warner TD | Simultaneous perfusion of rat isolated superior mesenteric arterial and venous beds: comparison of their vasoconstrictor and vasodilator responses to agonists. | 1990 | Br. J. Pharmacol. | pmid:2328405 |
| Wu DF and Reidenberg MM | Stereoselective interaction between gossypol and rat plasma. | 1990 | Contraception | pmid:2335102 |
| Lin YC et al. | Effect of gossypol on thyroid hormones in young female rats. | 1990 | Contraception | pmid:2335106 |
| Dézsi L et al. | Regulation of femoral vascular resistance by adenine nucleotides via endothelial and smooth muscle receptors. | 1990 | Acta Physiol Hung | pmid:2339604 |
| Aletor VA and Onibi OE | Use of oyster shell as calcium supplement. Part 1. Effect on the utilization of gossypol-containing cotton seed cake by the chicken. | 1990 | Nahrung | pmid:2388684 |
| Aletor VA and Aturamu OA | Use of oyster shell as calcium supplement. Part 2. An assessment of the responses of hepatic and serum enzymes, relative organ weights, and bone mineralization in the broiler chicken fed gossypol-containing cottonseed cake supplemented with oyster shell. | 1990 | Nahrung | pmid:2388685 |
| Messiha FS | Gossypol modulation of mouse heart and liver lactate dehydrogenase isoenzymes as a function of gender. | 1990 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:2396051 |
| Singh SK and Rath SK | Histologic changes in the mouse testis after treatment with gossypol tetra-acetic acid. | 1990 | Arch. Histol. Cytol. | pmid:2268474 |
| Kanwar U et al. | Gossypol-induced inhibition of glucose uptake in human ejaculated spermatozoa may be mediated by lipid peroxidation. | 1990 | Contraception | pmid:2272185 |
| Cuéllar A et al. | Cholesterol side-chain cleavage and 11 beta-hydroxylation are inhibited by gossypol in adrenal cortex mitochondria. | 1990 | J. Steroid Biochem. Mol. Biol. | pmid:2278843 |
| Ye YX et al. | The modulation of gap junctional communication by gossypol in various mammalian cell lines in vitro. | 1990 | Fundam Appl Toxicol | pmid:2361580 |
| Pelosin JM et al. | Differential inhibition of protein kinase C subtypes. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2363714 |
| Kerr LA | Incidence and management of poisonings in livestock. | 1990 | Vet Hum Toxicol | pmid:2238452 |
| Gu ZP et al. | Relationship between hormone profiles and the restoration of spermatogenesis in men treated with gossypol. | 1990 | Int. J. Androl. | pmid:2117586 |
| Burton GA et al. | Cyclic GMP release and vasodilatation induced by EDRF and atrial natriuretic factor in the isolated perfused kidney of the rat. | 1990 | Br. J. Pharmacol. | pmid:2158376 |
| Gu Y et al. | Inhibitory effect of gossypol on steroidogenic pathways in cultured bovine luteal cells. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2162666 |
| Porat O | Effects of gossypol on the motility of mammalian sperm. | 1990 | Mol. Reprod. Dev. | pmid:2183832 |
| Radermacher J et al. | Endothelium-derived relaxing factor influences renal vascular resistance. | 1990 | Am. J. Physiol. | pmid:2115741 |
| Vyas RK et al. | Early events in rat testis after gossypol administration. | 1990 Jan-Feb | Acta Eur. Fertil. | pmid:2150145 |
| Kalla NR et al. | Response of mice testis to gossypol acetic acid. | 1990 Jan-Feb | Acta Eur. Fertil. | pmid:2075791 |
| Kalla NR et al. | Effect of gossypol on domestic fowl, Gallus domesticus. | 1990 Jan-Feb | Acta Eur. Fertil. | pmid:2075792 |
| Vyas RK et al. | Recovery of normal testis function and sperm motility after cessation of gossypol treatment in hamster. | 1990 Jan-Feb | Acta Eur. Fertil. | pmid:2075793 |
| Kalla NR | Gossypol. | 1990 Jan-Feb | Acta Eur. Fertil. | pmid:2075794 |
| Kalla NR et al. | Response of hamster to the antifertility effect of gossypol. | 1990 Jan-Feb | Acta Eur. Fertil. | pmid:1706127 |
| Ranga A et al. | Effect of gossypol on the fertility of male rats. | 1990 Jan-Feb | Acta Eur. Fertil. | pmid:1706128 |
| Rovai LE et al. | Effect of gossypol on trypomastigotes and amastigotes of Trypanosoma cruzi. | 1990 Jul-Aug | J. Protozool. | pmid:2258832 |
| Leal-Garza CH et al. | [Frequency of sister chromatid exchange in mice treated with gossypol]. | 1990 Jul-Sep | Arch Invest Med (Mex) | pmid:2131768 |
| Kalla NR and Sud S | Distribution of gossypol. | 1990 Mar-Apr | Acta Eur. Fertil. | pmid:2087941 |
| Kalla NR et al. | 65Zn incorporation in the male reproductive organs following gossypol treatment. | 1990 Mar-Apr | Acta Eur. Fertil. | pmid:2087942 |
| Kalla NR et al. | Effect of gossypol on rats maintained on protein deficient and low potassium diets. | 1990 Mar-Apr | Acta Eur. Fertil. | pmid:2087943 |
| Kalla NR et al. | Spermatogenic events in rat and mice following intratesticular administration of optical isomers of gossypol. | 1990 Mar-Apr | Acta Eur. Fertil. | pmid:2087944 |
| Vyas RK and Kalla NR | Effect of optical isomers of gossypol on mammalian spermatozoa: an in vitro study. | 1990 Mar-Apr | Acta Eur. Fertil. | pmid:2087945 |
| Frick J and Kalla NR | Clinical studies with gossypol. Current status. | 1990 Mar-Apr | Acta Eur. Fertil. | pmid:2087946 |
| Botsoglou NA and Kufidis DC | Determination of total gossypol in cottonseed and cottonseed meals by derivative UV spectrophotometry. | 1990 May-Jun | J Assoc Off Anal Chem | pmid:2376551 |
| Ikeda M | Inhibition kinetics of NAD-linked enzymes by gossypol acetic acid. | 1990 Sep-Oct | Andrologia | pmid:2073051 |
| Bertrand V and Belleville J | Effect of refeeding diets containing cottonseed flour with traces of gossypol on rat liver and testis. | 1991 | Br. J. Nutr. | pmid:1760445 |
| Gu Y et al. | Gossypolone suppresses progesterone synthesis in bovine luteal cells. | 1991 | J. Steroid Biochem. Mol. Biol. | pmid:2064986 |
| Taylor GT et al. | Search for a male contraceptive: the effect of gossypol on sexual motivation and epididymal sperm. | 1991 | J Med | pmid:2072049 |
| Kono H et al. | Effects of progesterone and gossypol on monoamine oxidase activity in human term placental explant. | 1991 | Tohoku J. Exp. Med. | pmid:2048118 |
| Lin YC et al. | Gossypol pharmacokinetics in mid-lactation Brown Swiss dairy cows. | 1991 | Vet. Res. Commun. | pmid:1771762 |
| Jinsart W et al. | Inhibition of wheat embryo calcium-dependent protein kinase and avian myosin light chain kinase by flavonoids and related compounds. | 1991 | Biol. Chem. Hoppe-Seyler | pmid:1772594 |
| Wang YX and Chen ZX | [A possible mechanism of gossypol-induced hypokalemia and its relation to gossypol dose]. | 1991 | Shengzhi Yu Biyun | pmid:12317367 |
| Thomas KD et al. | Effects of an aqueous extract of cotton seed (Gossypium barbadense Linn.) on adult male rats. | 1991 | Adv Contracept | pmid:1776560 |
| Benz CC et al. | Gossypol effects on endothelial cells and tumor blood flow. | 1991 | Life Sci. | pmid:1875793 |
| Nikokyris P et al. | Effects of gossypol content of cottonseed cake on blood constituents in growing-fattening lambs. | 1991 | J. Dairy Sci. | pmid:1787198 |
| Gonzalez-Garza T et al. | In vitro evaluation of gossypol as potential antiamoebic drug. | 1991 | Proc. West. Pharmacol. Soc. | pmid:1788315 |
| Lu H and Liu GT | Effect of dibenzo[a,c]cyclooctene lignans isolated from Fructus schizandrae on lipid peroxidation and anti-oxidative enzyme activity. | 1991 | Chem. Biol. Interact. | pmid:1849050 |
| Messiha FS | Behavioral and metabolic interaction between gossypol and ethanol. | 1991 | Toxicol. Lett. | pmid:1853362 |
| Kono H et al. | Gossypol effects on monoamine oxidase (MAO) activity in several organs of term rats. | 1991 | Tohoku J. Exp. Med. | pmid:2063399 |
| Barraza ML et al. | Iron sulfate and feed pelleting to detoxify free gossypol in cottonseed diets for dairy cattle. | 1991 | J. Dairy Sci. | pmid:1744276 |
| Mazumder B et al. | Effect of chlorpromazine and gossypol on Ca(2+)-ATPase activity in the microsomal membranes of rat testes. | 1991 | Indian J. Biochem. Biophys. | pmid:1831790 |
| Sang GW et al. | Inhibitory effects of gossypol on corticosteroid 11-beta-hydroxysteroid dehydrogenase from guinea pig kidney: a possible mechanism for causing hypokalemia. | 1991 | J. Steroid Biochem. Mol. Biol. | pmid:1888675 |
| Royer RE et al. | Inhibition of human immunodeficiency virus type I replication by derivatives of gossypol. | 1991 | Pharmacol. Res. | pmid:1805194 |
| Murohara T et al. | Age related attenuation of the endothelium dependent relaxation to noradrenaline in isolated pig coronary arteries. | 1991 | Cardiovasc. Res. | pmid:1806231 |
| Sagach VF and Kindybaliuk AM | [The role of the endothelium in the development of functional hyperemia of the skeletal muscles]. | 1991 | Biull Eksp Biol Med | pmid:1810472 |
| Gu Y and Lin YC | Suppression of adrenocorticotropic hormone (ACTH)-induced corticosterone secretion in cultured rat adrenocortical cells by gossypol and gossypolone. | 1991 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:1647048 |
| Wu YW et al. | Inhibitory effects of gossypol on adrenal function. | 1991 | Acta Endocrinol. | pmid:1648853 |
| Zheng YH et al. | [Effect of gossypol acetic acid on hCG-stimulated progesterone production of dissociated rat luteal cells]. | 1991 | Yao Xue Xue Bao | pmid:1668561 |
| Moore SA et al. | Brain microvessel 12-hydroxyeicosatetraenoic acid is the (S) enantiomer and is lipoxygenase derived. | 1991 | J. Neurochem. | pmid:1907312 |
| Yuan XB et al. | [Study on polymorphism of gossypol by infrared spectrophotometry and X-ray diffraction]. | 1991 | Yao Xue Xue Bao | pmid:1950572 |
| Pohl U and Lamontagne D | Impaired tissue perfusion after inhibition of endothelium-derived nitric oxide. | 1991 | Basic Res. Cardiol. | pmid:1953621 |
| Deck LM et al. | Gossypol and derivatives: a new class of aldose reductase inhibitors. | 1991 | J. Med. Chem. | pmid:1956050 |
| Chadha S et al. | Alterations and reversibility of the effects of gossypol acetic acid on the intestinal uptake of end product nutrients in normal and protein calorie-malnourished male rats. | 1991 | Ann. Nutr. Metab. | pmid:1905512 |
| Majumdar SK et al. | Genotoxic effects of gossypol acetic acid on cultured murine erythroleukemia cells. | 1991 | Environ. Mol. Mutagen. | pmid:1915316 |
| Abe K et al. | Phosphorylation of coagulation factor II by phospholipid/Ca(2+)-dependent protein kinase (protein kinase C). | 1991 | Biochem. Biophys. Res. Commun. | pmid:2039497 |
| Manabe S et al. | Zone-specific hepatotoxicity of gossypol in perfused rat liver. | 1991 | Toxicon | pmid:1926180 |
| Messiha FS | Effect of gossypol on kinetics of mouse liver alcohol and aldehyde dehydrogenase. | 1991 | Gen. Pharmacol. | pmid:1936890 |
| Ford JM et al. | Modulation of resistance to alkylating agents in cancer cell by gossypol enantiomers. | 1991 | Cancer Lett. | pmid:2004358 |
| SaÄitkulov AM et al. | [Relation between interferon-inducing activity of natural interferon inducers and their chemical structure]. | 1991 | Antibiot. Khimioter. | pmid:1719947 |
| Kramer RY et al. | The effect of cottonseed components on testicular development in pubescent rams. | 1991 | Vet Hum Toxicol | pmid:2017859 |
| Barak D et al. | Structural investigation of protein kinase C inhibitors. | 1991 | J Mol Struct | pmid:11538178 |
| Nakamura M et al. | Presence of a 16 kd protein in human seminal plasma counteracts the effects of the anti-fertility agent, gossypol. | 1991 | Hum. Reprod. | pmid:1939555 |
| Botsoglou NA | High-performance liquid chromatographic method for the determination of free gossypol in chicken liver. | 1991 | J. Chromatogr. | pmid:1783672 |
| Posevaia TA et al. | [The role of herpetic infection in epithelial dysplasias of the cervix uteri and a trial of their treatment with antiherpetic preparations]. | 1991 Jan-Feb | Vopr. Virusol. | pmid:1650068 |
| Thomas M et al. | Effects of gossypol on the cell cycle phases in T-47D human breast cancer cells. | 1991 Jul-Aug | Anticancer Res. | pmid:1746904 |
| Levinsky H et al. | Inhibition of sialyl transferase activity by gossypol acetic acid in human seminal plasma. | 1991 Mar-Apr | Andrologia | pmid:1952122 |
| Woolley RJ | Contraception--a look forward, Part II: Mifepristone and gossypol. | 1991 Mar-Apr | J Am Board Fam Pract | pmid:1823560 |
| Zaidi R and Hadi SM | Complexes involving gossypol, DNA and Cu(II). | 1992 | Biochem. Int. | pmid:1290468 |
| Zaidi R and Hadi SM | Strand scission in DNA by gossypol and Cu(II): role of Cu(I) and oxygen-free radicals. | 1992 | J. Biochem. Toxicol. | pmid:1293310 |