MeSH term | MeSH ID | Detail |
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Lung Neoplasms | D008175 | 171 associated lipids |
Body Weight | D001835 | 333 associated lipids |
Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Gray ML et al. | Effects of dietary gossypol consumption on metabolic homeostasis and reproductive endocrine function in beef heifers and cows. | 1993 | J. Anim. Sci. | pmid:8270527 |
Zhang SC et al. | [The adverse effects of the preparations of the active principles of Chinese herbal drugs]. | 1993 | Zhongguo Zhong Yao Za Zhi | pmid:8267848 |
Hu YF et al. | Gossypol inhibits basal and estrogen-stimulated DNA synthesis in human breast carcinoma cells. | 1993 | Life Sci. | pmid:8255144 |
Li H and He X | [The effects of optical isomers of gossypol on Sertoli cells in vitro]. | 1993 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:8242829 |
Fornés MW et al. | Sperm motility loss induced by gossypol: relation with OH. scavengers, motile stimulators and malondialdehyde production. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8216260 |
Cowart CL et al. | The effects of cyclic adenosine monophosphate, forskolin, and theophylline on motility parameters in gossypol-treated human sperm. | 1994 | Fertil. Steril. | pmid:8174733 |
East NE et al. | Apparent gossypol-induced toxicosis in adult dairy goats. | 1994 | J. Am. Vet. Med. Assoc. | pmid:8163423 |
Chase CC et al. | Growth and reproductive development in Brahman bulls fed diets containing gossypol. | 1994 | J. Anim. Sci. | pmid:8157529 |
MartÃnez F et al. | The antifertility agent, gossypol, releases calcium from rat liver mitochondria. | 1993 | Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. | pmid:8097449 |
González-Garza MT et al. | Differential effects of the (+)- and (-)-gossypol enantiomers upon Entamoeba histolytica axenic cultures. | 1993 | J. Pharm. Pharmacol. | pmid:8095532 |
Lin YC et al. | Inhibition of in vitro fertilization and early embryonic development in hamsters by gossypol. | 1994 | Life Sci. | pmid:8090055 |
Zhang YW et al. | [Estrogen and progesterone cytosol receptor concentrations in patients with endometriosis and their changes after gossypol therapy]. | 1994 | Zhonghua Fu Chan Ke Za Zhi | pmid:8082445 |
Bansode FW | Genotoxic effects of gossypol acetate on the ovary of Rhinopoma kinneari wroughton (Microchiroptera: Mammalia). | 1994 | Contraception | pmid:8070265 |
Tuhácková Z | Staurosporine and gossypol are inhibitors of the function of peptide elongation factor 1 alpha from rabbit reticulocytes. | 1994 | Biochem. Mol. Biol. Int. | pmid:8032322 |
Prusoff W et al. | Empirical and rational approaches for development of inhibitors of the human immunodeficiency virus--HIV-1. | 1993 | Pharmacol. Ther. | pmid:8022862 |
Xu Y et al. | [Intratesticular subcapsular assay, a simple method for the preliminary screening of male contraceptives]. | 1993 | Yao Xue Xue Bao | pmid:8010008 |
Huang HF and Wang M | [Effects of gossypol acetate, danazol, progesterone and GnRH-A on estrogen and progesterone receptors of human endometrial cells]. | 1994 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:8000225 |
Zakhidov ST et al. | [The modifying cytogenetic effects of gossypol and its derivatives]. | 1994 Jul-Aug | Izv. Akad. Nauk. Ser. Biol. | pmid:7987209 |
Hu YF et al. | Presence of antitumor activities in the milk collected from gossypol-treated dairy cows. | 1994 | Cancer Lett. | pmid:7954365 |
Lebedev VG et al. | [Effect of kagocel on the postradiation recovery of the hematopoiesis and immune status in mice exposed to ionizing radiation in sublethal dosage]. | 1994 Jul-Oct | Radiats Biol Radioecol | pmid:7951886 |