Lei X et al. |
Gossypol induces Bax/Bak-independent activation of apoptosis and cytochrome c release via a conformational change in Bcl-2. |
2006 |
FASEB J. |
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Stipanovic RD et al. |
Ratios of (+)- and (-)-gossypol in leaves, stems, and roots of selected accessions of Gossypium hirsutum var. marie galante (Watt) Hutchinson. |
2006 |
J. Agric. Food Chem. |
pmid:16506812
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Yang G et al. |
Molecular cloning and characterization of a novel lactate dehydrogenase gene from Clonorchis sinensis. |
2006 |
Parasitol. Res. |
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Price CP et al. |
Dissecting the behavior of a promiscuous solvate former. |
2006 |
Angew. Chem. Int. Ed. Engl. |
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Wang G et al. |
Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins. |
2006 |
J. Med. Chem. |
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Cleverley J |
American Society of Clinical Oncology--42nd annual meeting. Poster presentations on leukemia and cytotoxic chemotherapy. 2-6 June 2006, Atlanta, GA, USA. |
2006 |
IDrugs |
pmid:16871453
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Shen YL et al. |
Determinations of the inclusion complex between gossypol and beta-cyclodextrin. |
2006 |
Spectrochim Acta A Mol Biomol Spectrosc |
pmid:16877036
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Yeow WS et al. |
Gossypol, a phytochemical with BH3-mimetic property, sensitizes cultured thoracic cancer cells to Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand. |
2006 |
J. Thorac. Cardiovasc. Surg. |
pmid:17140955
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de Andrade SF et al. |
Epididymis-specific pathologic disorders in rats exposed to gossypol from weaning through puberty. |
2006 |
Toxicol Pathol |
pmid:17162530
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Sunilkumar G et al. |
Engineering cottonseed for use in human nutrition by tissue-specific reduction of toxic gossypol. |
2006 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:17110445
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Przybylski P et al. |
1H- and 13C-NMR, FTIR, UV-VIS, ESI-MS, and PM5 studies as well as emission properties of a new Schiff base of gossypol with 5-methoxytryptamine and a new hydrazone of gossypol with dansylhydrazine. |
2006 |
Biopolymers |
pmid:16538663
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Akinola OB et al. |
Proteinaceous diet inhibits gossypol-induced spermatotoxicity. |
2006 Jul-Sep |
Eur J Histochem |
pmid:16920644
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Huang YW et al. |
Molecular mechanisms of (-)-gossypol-induced apoptosis in human prostate cancer cells. |
2006 May-Jun |
Anticancer Res. |
pmid:16827126
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Huang YW et al. |
Effects of serum on (-)-gossypol-suppressed growth in human prostate cancer cells. |
2006 Sep-Oct |
Anticancer Res. |
pmid:17094491
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Meng Y et al. |
(-)Gossypol and its combination with imatinib induce apoptosis in human chronic myeloid leukemic cells. |
2007 |
Leuk. Lymphoma |
pmid:17926190
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Mao YB et al. |
Silencing a cotton bollworm P450 monooxygenase gene by plant-mediated RNAi impairs larval tolerance of gossypol. |
2007 |
Nat. Biotechnol. |
pmid:17982444
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Lordelo MM et al. |
Relative toxicity of gossypol enantiomers in laying and broiler breeder hens. |
2007 |
Poult. Sci. |
pmid:17297172
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Zhang M et al. |
Differential growth inhibition and induction of apoptosis by gossypol between HCT116 and HCT116/Bax(-/-) colorectal cancer cells. |
2007 |
Clin. Exp. Pharmacol. Physiol. |
pmid:17250644
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Leyman A et al. |
The absence of expression of the three isoenzymes of the inositol 1,4,5-trisphosphate 3-kinase does not prevent the formation of inositol pentakisphosphate and hexakisphosphate in mouse embryonic fibroblasts. |
2007 |
Cell. Signal. |
pmid:17355905
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Costantino A et al. |
Current status and future perspectives in male contraception. |
2007 |
Minerva Ginecol |
pmid:17576406
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Tang G et al. |
Structure-based design of flavonoid compounds as a new class of small-molecule inhibitors of the anti-apoptotic Bcl-2 proteins. |
2007 |
J. Med. Chem. |
pmid:17552510
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Ko CH et al. |
Gossypol reduction of tumor growth through ROS-dependent mitochondria pathway in human colorectal carcinoma cells. |
2007 |
Int. J. Cancer |
pmid:17597109
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Wolter KG et al. |
Therapeutic window for melanoma treatment provided by selective effects of the proteasome on Bcl-2 proteins. |
2007 |
Cell Death Differ. |
pmid:17541428
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Kasten-Pisula U et al. |
Radiosensitization of tumour cell lines by the polyphenol Gossypol results from depressed double-strand break repair and not from enhanced apoptosis. |
2007 |
Radiother Oncol |
pmid:17521756
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Feng BY et al. |
A high-throughput screen for aggregation-based inhibition in a large compound library. |
2007 |
J. Med. Chem. |
pmid:17447748
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Badawy SZ et al. |
Gossypol inhibits proliferation of endometrioma cells in culture. |
2007 |
Asian J. Androl. |
pmid:17486280
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Orth RG et al. |
Determining larval host plant use by a polyphagous lepidopteran through analysis of adult moths for plant secondary metabolites. |
2007 |
J. Chem. Ecol. |
pmid:17492366
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Choi SR et al. |
Design, synthesis, and biological evaluation of Plasmodium falciparum lactate dehydrogenase inhibitors. |
2007 |
J. Med. Chem. |
pmid:17636950
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Loberg RD et al. |
In vivo evaluation of AT-101 (R-(-)-gossypol acetic acid) in androgen-independent growth of VCaP prostate cancer cells in combination with surgical castration. |
2007 |
Neoplasia |
pmid:18084610
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Turco E et al. |
The in vitro effect of gossypol and its interaction with salts on conidial germination and viability of Fusarium oxysporum sp. vasinfectum isolates. |
2007 |
J. Appl. Microbiol. |
pmid:18045422
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Akinola OB et al. |
Spermatoprotective activity of the leaf extract of Psidium guajava Linn. |
2007 |
Niger Postgrad Med J |
pmid:18163132
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Gerasimidis K et al. |
Preparation of an edible cottonseed protein concentrate and evaluation of its functional properties. |
2007 |
Int J Food Sci Nutr |
pmid:17710592
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Carruthers NJ et al. |
Gossypol inhibits calcineurin phosphatase activity at multiple sites. |
2007 |
Eur. J. Pharmacol. |
pmid:17141216
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Liu F et al. |
Pharmacophore identification of KSP inhibitors. |
2007 |
Bioorg. Med. Chem. Lett. |
pmid:17095225
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Zhang M et al. |
Gossypol induces apoptosis in human PC-3 prostate cancer cells by modulating caspase-dependent and caspase-independent cell death pathways. |
2007 |
Life Sci. |
pmid:17156797
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Song JJ et al. |
Evidence for two modes of development of acquired tumor necrosis factor-related apoptosis-inducing ligand resistance. Involvement of Bcl-xL. |
2007 |
J. Biol. Chem. |
pmid:17110373
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Development of selective inhibitors for anti-apoptotic Bcl-2 proteins from BHI-1. |
2007 |
Bioorg. Med. Chem. |
pmid:17227711
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Lv G et al. |
[The effect of gossypol, praziquantel and artemether on recombinant lactate dehydrogenase from Schistosoma japonicum]. |
2007 |
Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi |
pmid:18441994
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Denisov AY et al. |
Heat-induced dimerization of BCL-xL through alpha-helix swapping. |
2007 |
Biochemistry |
pmid:17223694
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Makkar HP et al. |
Plant secondary metabolites. |
2007 |
Methods Mol. Biol. |
pmid:19238775
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Ye W et al. |
Modulation of multidrug resistance gene expression in human breast cancer cells by (-)-gossypol-enriched cottonseed oil. |
2007 Jan-Feb |
Anticancer Res. |
pmid:17352222
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Cui G et al. |
Gossypol with methyltestosterone and ethinylestradiol male does not affect rat spermatogonial stem cell differentiation. |
2007 Mar-Apr |
Arch. Androl. |
pmid:17453689
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Meng Y et al. |
Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa. |
2008 |
Mol. Cancer Ther. |
pmid:18645028
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Brozic P et al. |
Inhibitors of 17beta-hydroxysteroid dehydrogenase type 1. |
2008 |
Curr. Med. Chem. |
pmid:18220769
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Ojha P et al. |
Rat testicular germ cell type(s) targeted by anti-spermatogenic agents in vivo and their recovery on withdrawal of treatment--a flow cytometric study. |
2008 |
Anim. Reprod. Sci. |
pmid:17207942
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Balakrishnan K et al. |
Gossypol, a BH3 mimetic, induces apoptosis in chronic lymphocytic leukemia cells. |
2008 |
Blood |
pmid:18566329
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Wang X et al. |
Bioactivities of gossypol, 6-methoxygossypol, and 6,6'-dimethoxygossypol. |
2008 |
J. Agric. Food Chem. |
pmid:18517219
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Johnson PW |
New targets for lymphoma treatment. |
2008 |
Ann. Oncol. |
pmid:18519406
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Mi JX et al. |
Synergistic antitumoral activity and induction of apoptosis by novel pan Bcl-2 proteins inhibitor apogossypolone with adriamycin in human hepatocellular carcinoma. |
2008 |
Acta Pharmacol. Sin. |
pmid:19026166
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Stipanovic RD et al. |
Effect of racemic, (+)- and (-)-gossypol on survival and development of Heliothis virescens larvae. |
2008 |
Environ. Entomol. |
pmid:19036185
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