Gossypol

Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.

Cross Reference

Introduction

To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Gossypol?

Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Gossypol

MeSH term MeSH ID Detail
Chemical and Drug Induced Liver Injury D056486 39 associated lipids
Prostatic Neoplasms, Castration-Resistant D064129 3 associated lipids
Per page 10 20 50 100 | Total 52

PubChem Associated disorders and diseases

What pathways are associated with Gossypol

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
Loading... please refresh the page if content is not showing up.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Gossypol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Gossypol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Gossypol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Gossypol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Gossypol?

Xenograft Model

Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).

Transgenic Model

Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with Gossypol

Download all related citations
Per page 10 20 50 100 | Total 1511
Authors Title Published Journal PubMed Link
Gray ML et al. Effects of dietary gossypol consumption on metabolic homeostasis and reproductive endocrine function in beef heifers and cows. 1993 J. Anim. Sci. pmid:8270527
Zhang SC et al. [The adverse effects of the preparations of the active principles of Chinese herbal drugs]. 1993 Zhongguo Zhong Yao Za Zhi pmid:8267848
Hu YF et al. Gossypol inhibits basal and estrogen-stimulated DNA synthesis in human breast carcinoma cells. 1993 Life Sci. pmid:8255144
Li H and He X [The effects of optical isomers of gossypol on Sertoli cells in vitro]. 1993 Zhongguo Yi Xue Ke Xue Yuan Xue Bao pmid:8242829
Fornés MW et al. Sperm motility loss induced by gossypol: relation with OH. scavengers, motile stimulators and malondialdehyde production. 1993 Biochem. Biophys. Res. Commun. pmid:8216260
Cowart CL et al. The effects of cyclic adenosine monophosphate, forskolin, and theophylline on motility parameters in gossypol-treated human sperm. 1994 Fertil. Steril. pmid:8174733
East NE et al. Apparent gossypol-induced toxicosis in adult dairy goats. 1994 J. Am. Vet. Med. Assoc. pmid:8163423
Chase CC et al. Growth and reproductive development in Brahman bulls fed diets containing gossypol. 1994 J. Anim. Sci. pmid:8157529
Martínez F et al. The antifertility agent, gossypol, releases calcium from rat liver mitochondria. 1993 Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. pmid:8097449
González-Garza MT et al. Differential effects of the (+)- and (-)-gossypol enantiomers upon Entamoeba histolytica axenic cultures. 1993 J. Pharm. Pharmacol. pmid:8095532
Lin YC et al. Inhibition of in vitro fertilization and early embryonic development in hamsters by gossypol. 1994 Life Sci. pmid:8090055
Zhang YW et al. [Estrogen and progesterone cytosol receptor concentrations in patients with endometriosis and their changes after gossypol therapy]. 1994 Zhonghua Fu Chan Ke Za Zhi pmid:8082445
Bansode FW Genotoxic effects of gossypol acetate on the ovary of Rhinopoma kinneari wroughton (Microchiroptera: Mammalia). 1994 Contraception pmid:8070265
Tuhácková Z Staurosporine and gossypol are inhibitors of the function of peptide elongation factor 1 alpha from rabbit reticulocytes. 1994 Biochem. Mol. Biol. Int. pmid:8032322
Prusoff W et al. Empirical and rational approaches for development of inhibitors of the human immunodeficiency virus--HIV-1. 1993 Pharmacol. Ther. pmid:8022862
Xu Y et al. [Intratesticular subcapsular assay, a simple method for the preliminary screening of male contraceptives]. 1993 Yao Xue Xue Bao pmid:8010008
Huang HF and Wang M [Effects of gossypol acetate, danazol, progesterone and GnRH-A on estrogen and progesterone receptors of human endometrial cells]. 1994 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:8000225
Zakhidov ST et al. [The modifying cytogenetic effects of gossypol and its derivatives]. 1994 Jul-Aug Izv. Akad. Nauk. Ser. Biol. pmid:7987209
Hu YF et al. Presence of antitumor activities in the milk collected from gossypol-treated dairy cows. 1994 Cancer Lett. pmid:7954365
Lebedev VG et al. [Effect of kagocel on the postradiation recovery of the hematopoiesis and immune status in mice exposed to ionizing radiation in sublethal dosage]. 1994 Jul-Oct Radiats Biol Radioecol pmid:7951886