MeSH term | MeSH ID | Detail |
---|---|---|
Chemical and Drug Induced Liver Injury | D056486 | 39 associated lipids |
Prostatic Neoplasms, Castration-Resistant | D064129 | 3 associated lipids |
Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Ilkevych NS et al. | Vibrational spectra, structure and antioxidant activity of gossypol imine derivatives. | 2012 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:22078080 |
Shen YL et al. | Study on structure and characterization of inclusion complex of gossypol/beta cyclodextrin. | 2005 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:15741097 |
Shen YL et al. | Determinations of the inclusion complex between gossypol and beta-cyclodextrin. | 2006 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:16877036 |
Krylov VF | [Treatment of patients with influenza]. | 1975 | Ter. Arkh. | pmid:52894 |
Tareeva IE et al. | [Treatment of chronic glomerulonephritis with cytostatics]. | 1989 | Ter. Arkh. | pmid:2799726 |
Nayak BN and Buttar HS | Induction of sister chromatid exchanges and chromosome damage by gossypol in bone marrow cells of mice. | 1986 | Teratog., Carcinog. Mutagen. | pmid:2874644 |
Beaudoin AR | The embryotoxicity of gossypol. | 1985 | Teratology | pmid:4049283 |
Hassan ME et al. | Reversibility of the reproductive toxicity of gossypol in peripubertal bulls. | 2004 | Theriogenology | pmid:15037004 |
Chenoweth PJ et al. | Characterization of gossypol-induced sperm abnormalities in bulls. | 2000 | Theriogenology | pmid:10798496 |
Alheid U et al. | Endothelium-derived relaxing factor from cultured human endothelial cells inhibits aggregation of human platelets. | 1987 | Thromb. Res. | pmid:3499684 |
Balci A et al. | Gossypol induced apoptosis in the human promyelocytic leukemia cell line HL 60. | 1999 | Tohoku J. Exp. Med. | pmid:10622208 |
Kono H et al. | Effects of progesterone and gossypol on monoamine oxidase activity in human term placental explant. | 1991 | Tohoku J. Exp. Med. | pmid:2048118 |
Kono H et al. | Gossypol effects on monoamine oxidase (MAO) activity in several organs of term rats. | 1991 | Tohoku J. Exp. Med. | pmid:2063399 |
Zavos PM and Zarmakoupis-Zavos PN | The inhibitory effects of gossypol on human sperm motility characteristics: possible modes of reversibility of those effects. | 1996 | Tohoku J. Exp. Med. | pmid:8888505 |
Hoshiai H et al. | Gossypol as oral contraceptive for male: trial case report. | 1982 | Tohoku J. Exp. Med. | pmid:6818716 |
Zhou DR et al. | Gossypol repressed the gap junctional intercellular communication between Sertoli cells by decreasing the expression of Connexin43. | 2008 | Toxicol In Vitro | pmid:18706992 |
de Andrade SF et al. | Epididymis-specific pathologic disorders in rats exposed to gossypol from weaning through puberty. | 2006 | Toxicol Pathol | pmid:17162530 |
Abou-Donia MB and Dieckert JW | Metabolic fate of gossypol: the metabolism of [14-C]gossypol in swine. | 1975 | Toxicol. Appl. Pharmacol. | pmid:1129787 |
Hong SK et al. | Effects of gossypol on PAH transport in the rabbit kidney slice. | 1983 | Toxicol. Appl. Pharmacol. | pmid:6140776 |
Abou-Donia MB and Dieckert JW | Gossypol: subcellular localization and stimulation of rat liver microsomal oxidases. | 1971 | Toxicol. Appl. Pharmacol. | pmid:4998823 |