MeSH term | MeSH ID | Detail |
---|---|---|
Adenocarcinoma | D000230 | 166 associated lipids |
Abnormalities, Drug-Induced | D000014 | 10 associated lipids |
Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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DANKE RJ and TILLMAN AD | EFFECT OF GOSSYPOL AND HEXAHOMOSERINE ON PERFORMANCE OF RATS FED PURIFIED DIETS WITH AND WITHOUT LYSINE. | 1965 | J. Anim. Sci. | pmid:14296177 |
CASADY RB et al. | FURTHER STUDIES OF DEGOSSYPOLIZED COTTONSEED MEAL AS A SOURCE OF PLANT PROTEIN IN RABBIT FEEDS. | 1965 | J Am Oil Chem Soc | pmid:14328364 |
Klaasen GH | [Gossypol, properties and occurrence]. | 1965 | Pharm Weekbl | pmid:5321432 |
VERMEL EM and KRUGLYAK SA | ANTITUMOR ACTIVITY OF GOSSYPOL IN EXPERIMENTS ON TRANSPLANTABLE TUMORS. | 1965 Jan-Feb | Fed Proc Transl Suppl | pmid:14275562 |
Sharma MP et al. | Effects of levels of protein and gossypol, and length of feeding period on the accumulation of gossypol in tissues of swine. | 1966 | J. Nutr. | pmid:5931188 |
Muzaffaruddin M and Saxena ER | Physicochemical studies on the composition and stability of metal-gossypol complexes. I. Fe+++ gossypol complex. | 1966 | J Am Oil Chem Soc | pmid:5939582 |
Clawson AJ and Smith FH | Effect of dietary iron on gossypol toxicity and on residues of gossypil in porcine liver. | 1966 | J. Nutr. | pmid:5950205 |
Myers BD and Throneberry GO | Effect of gossypol on some oxidative respiratory enzymes. | 1966 | Plant Physiol. | pmid:4287149 |
Ghittino P et al. | Experimental dietary hepatoma in rainbow trout. The role of cottonseed meals and other diets. | 1967 | Cancro | pmid:4303305 |
Braham JE et al. | Effect of gossypol on the iron-binding capacity of serum in swine. | 1967 | J. Nutr. | pmid:6052995 |
Roehm JN et al. | Accumulation and elimination of dietary gossypol in the organs of rainbow trout. | 1967 | J. Nutr. | pmid:6054742 |
Smith FH | Determination of gossypol in leaves and flower buds of Gossypium. | 1967 | J Am Oil Chem Soc | pmid:6041387 |
Margalith P | Inhibitory effect of gossypol on microorganisms. | 1967 | Appl Microbiol | pmid:6049314 |
Braham JE et al. | Effect of calcium and gossypol on the performance of swine and on certain enzymes and other blood constituents. | 1967 | J. Nutr. | pmid:6018252 |
Sinnhuber RO et al. | Dietary factors and hepatoma in rainbow trout (Salmo gairdneri). II. Cocarcinogenes by cyclopropenoid fatty acids and the effect of gossypol and altered lipids on aflatoxin-induced liver cancer. | 1968 | J. Natl. Cancer Inst. | pmid:4178161 |
Albrecht JE et al. | Effects of high gossypol cottonseed meal on the electrocardiogram of swine. | 1968 | J. Anim. Sci. | pmid:5744268 |
Vichkanova SA and Goriunova LV | [Study of virulicidal effect of gossypol in vitro]. | 1968 | Antibiotiki | pmid:4974209 |
Lyman CM et al. | Metabolism of gossypol in the chick. | 1969 | J Am Oil Chem Soc | pmid:5779540 |
Baugher WL and Campbell TC | Gossypol detoxication by fungi. | 1969 | Science | pmid:5786644 |
Cottonseed meal and tumors. | 1969 | Nutr. Rev. | pmid:4311090 |