| MeSH term | MeSH ID | Detail |
|---|---|---|
| Abnormalities, Drug-Induced | D000014 | 10 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
| Cattle Diseases | D002418 | 24 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Endometriosis | D004715 | 29 associated lipids |
| Genital Neoplasms, Male | D005834 | 3 associated lipids |
Gossypol
Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
Cross Reference
Introduction
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Gossypol?
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Mol. Cancer Ther. (4)
- Proc. Natl. Acad. Sci. U.S.A. (3)
- Am. J. Physiol. Lung Cell Mol. Physiol. (2)
- Others (13)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Gossypol
PubChem Associated disorders and diseases
What pathways are associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Gossypol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Gossypol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Gossypol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Gossypol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Gossypol?
Xenograft Model
Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Gossypol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Chang MC et al. | Effects of Gossypol on the fertility of male rats, hamsters and rabbits. | 1980 | Contraception | pmid:7428357 |
| Shepu X et al. | Antispermatogenic effect of gossypol on the germinal epithelium of the rat testes. A cytological, autoradiographical and ultrastructural observation. | 1980 | Sci. Sin. | pmid:7403840 |
| Muratov MM et al. | [Hygienic evaluation of acetate fabric dyed with technical grade gossypol]. | 1980 | Gig Sanit | pmid:7372107 |
| Abidov MM et al. | [Effect of the immunodepressive preparation, batriden, on the course of experimental allergic dermatitis]. | 1980 | Vestn Dermatol Venerol | pmid:7376717 |
| Pösö H et al. | Gossypol, a powerful inhibitor of human spermatozoal metabolism. | 1980 | Lancet | pmid:6103251 |
| Gossypol as an oral contraceptive for men. | 1980 | J Med Soc N J | pmid:6928215 | |
| Qian SZ et al. | Gossypol related hypokalemia. Clinicopharmacologic studies. | 1980 | Chin. Med. J. | pmid:6772395 |
| Tang XC et al. | [Comparative studies on the absorption, distribution and excretion of 14C-gossypol in four species of animals (author's transl)]. | 1980 | Yao Xue Xue Bao | pmid:6779501 |
| Gossypol--a new antifertility agent for males. | 1979 | Gynecol. Obstet. Invest. | pmid:393575 | |
| Colman N et al. | Non-mutagenicity of gossypol in the Salmonella/mammalian-microsome plate assay. | 1979 | Environ Mutagen | pmid:399915 |
| Qian SZ et al. | [The potassium-depleting effect of gossypol on isolated rabbit heart and it's possible mechanism (author's transl)]. | 1979 | Yao Xue Xue Bao | pmid:506710 |
| de Buckle TS et al. | Two food applications of cottonseed flours and meals. | 1979 | J Am Oil Chem Soc | pmid:583421 |
| Wang YE et al. | [Studies o the anti-fertility actions of cotton seed meal and gossypol (author's transl)]. | 1979 | Yao Xue Xue Bao | pmid:583588 |
| Chen ZC et al. | [The influence of gossypol on the potassium metabolism of rats and the effect of some possible contributing factors (low-K and low-MG intake) (author's transl)]. | 1979 | Yao Xue Xue Bao | pmid:532653 |
| Nadakavukaren MJ et al. | Effect of gossypol on the ultrastructure of rat spermatozoa. | 1979 | Cell Tissue Res. | pmid:535032 |
| de Peyster A and Wang YY | Gossypol--proposed contraceptive for men passes the Ames test. | 1979 | N. Engl. J. Med. | pmid:450009 |
| Havránek F | [Gossypol, a new contraceptive agent for men]. | 1979 | Cesk Gynekol | pmid:116775 |
| Khadzhibaev GS et al. | [Interferonogenic activity of gossypol, a low-molecular substance]. | 1978 | Antibiotiki | pmid:206198 |
| Aver'ianov AA and Merzliak MN | [Chemiluminescence during oxidation of gossipol by peroxidase]. | 1978 | Biokhimiia | pmid:214169 |
| Alford BB and Onley K | The minimum cottonseed protein required for nitrogen balance in women. | 1978 | J. Nutr. | pmid:580097 |
| Cherry JP et al. | Potential for improving cottonseed quality by genetic and agronomic practices. | 1978 | Adv. Exp. Med. Biol. | pmid:581532 |
| Gossypol--a new antifertility agent for males. | 1978 | Chin. Med. J. | pmid:104833 | |
| Jones LA and Smith FH | Effect of bound gossypol and amino acid supplementation of glandless cottonseed meal on the growth of weanling rats. | 1977 | J. Anim. Sci. | pmid:576596 |
| Jones LA and Smith FH | Effect of gossypol on the removal of nitrogen and amino acids from feed in digestion by the rat. | 1977 | J. Anim. Sci. | pmid:576597 |
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| Broderick GA | Effect of processing on protein utilization by ruminants. | 1977 | Adv. Exp. Med. Biol. | pmid:906927 |
| Couch JR and Thomas MC | A comparison of chemical methods for the determination of available lysine in various proteins. | 1976 Sep-Oct | J. Agric. Food Chem. | pmid:989491 |
| El-Nockrashy AS et al. | Biochemical changes in cottonseed during development and maturity. | 1976 | Nahrung | pmid:989153 |
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| Kulagin VI and Butov IuS | [Treatment of plantal warts in children]. | 1976 | Vestn Dermatol Venerol | pmid:997868 |
| Roberts R | Protein products and hulls for animal foods. | 1976 | J Am Oil Chem Soc | pmid:932385 |
| Skripkin IuK et al. | [Treatment of viral skin diseases with Soviet-made antiviral drugs]. | 1976 | Vestn Dermatol Venerol | pmid:1023645 |
| Tone JN and Jensen DR | The accumulation pattern of ingested gossypol in selected organs of the rat. | 1976 | Experientia | pmid:1253913 |
| Abou-Donia MB | Physiological effects and metabolism of gossypol. | 1976 | Residue Rev | pmid:778955 |
| El-Nockrashy AS et al. | Cottonseed colour fixed pigments. Part I. Selectivity of hexane isomers. | 1976 | Nahrung | pmid:989152 |
| Herman DL and Smith FH | Effect of free gossypol on tissue uptake of iron by everted segments of rat duodenum. | 1975 May-Jun | J. Agric. Food Chem. | pmid:1151001 |
| Jones LA and Smith FH | Effect of free and bound gossypol on the absorption of L-]14-C]lysine, L-[14-C]methionine, and L-[14-C]valine from the rat small intestine. | 1975 Jul-Aug | J. Agric. Food Chem. | pmid:1141508 |
| Damaty SM and Hudson BJ | Preparation of low-gossypol cottonseed flour. | 1975 | J. Sci. Food Agric. | pmid:1172995 |
| Clawson AJ et al. | Unextracted cottonseed in diets for monogastric animals. I. The effect of ferrous sulfate and calcium hydroxide in reducing gossypol toxicity. | 1975 | J. Anim. Sci. | pmid:1173579 |
| Bressani R et al. | [Effect of free gossypol of different cottonseed flours on the growth of rats and levels of free lysin and free gossypol in animal organs, muscle and serum]. | 1975 | Arch Latinoam Nutr | pmid:1174302 |
| Braham JE and Bressani R | Effect of different levels of gossypol on transaminase activity, on nonessential to essential amino acid ratio, and on iron and nitrogen retention in rats. | 1975 | J. Nutr. | pmid:1117346 |
| Damaty S and Hudson BJ | A secondary interaction between gossypol and cottonseed protein. | 1975 | Proc Nutr Soc | pmid:1187618 |
| Jolad SD et al. | Tumor-inhibitory agent from Montezuma speciosissima (Malvaceae). | 1975 | J Pharm Sci | pmid:1195125 |
| Abou-Donia MB and Dieckert JW | Metabolic fate of gossypol: the metabolism of [14-C]gossypol in swine. | 1975 | Toxicol. Appl. Pharmacol. | pmid:1129787 |
| Dorsett PH et al. | Letter: Antiviral activity of gossypol and apogossypol. | 1975 | J Pharm Sci | pmid:1133739 |
| Aripov UA et al. | [Immunodepressive properties of the drug "Batriden" in experiments on parabionts]. | 1975 | Dokl. Akad. Nauk SSSR | pmid:1140070 |
| Pandey SN and Thejappa N | Study on relationship between oil, protein, and gossypol in cottonseed kernels. | 1975 | J Am Oil Chem Soc | pmid:1242138 |
| Krylov VF | [Treatment of patients with influenza]. | 1975 | Ter. Arkh. | pmid:52894 |
| Tone JN and Jensen DR | Hematological effects of injected gossypol and iron in rats. | 1974 Jan-Feb | J. Agric. Food Chem. | pmid:4811630 |
| Abou-Donia MB and Dieckert JW | Gossypol: uncoupling of respiratory chain and oxidative phosphorylation. | 1974 | Life Sci. | pmid:4277086 |
| Pirogov AI et al. | [Postoperative bronchopleural complications in the combined treatment of lung cancer]. | 1974 | Vopr Onkol | pmid:4211564 |
| Abou-Donia MB and Dieckert JW | Urinary and biliary excretion of 14C-gossypol in swine. | 1974 | J. Nutr. | pmid:4830281 |
| Skutches CL et al. | Effect of dietary free gossypol on blood components and tissue iron in swine and rats. | 1974 | J. Nutr. | pmid:4816926 |
| Kilburn KH et al. | Two patterns for bronchial damage from inhaled materials. | 1974 | Chest | pmid:4819236 |
| Smith FH | Preparation of 14C-gossypol by incorporation of acetate-1-14C and acetate-2-14C by biosynthesis. | 1974 | J Am Oil Chem Soc | pmid:4415176 |
| Skutches CL and Smith FH | Effect of phenobarbital on the level of gossypol in the liver and the effect of gossypol and phenobarbital on liver microsomal O-demethylation and lipid peroxidation activities in the rat. | 1974 | J. Nutr. | pmid:4430931 |
| Abou-Donia MB et al. | Gossypol: antagonistic effect on toxicity of insecticides to Spodoptera littoralis. | 1974 | Experientia | pmid:4435119 |
| Skutches CL and Smith FH | Metabolism of gossypol, biosynthesized from methyl-14C-and carboxyl-14 C-labeled sodium acetate, in rat. | 1974 | J Am Oil Chem Soc | pmid:4479245 |
| el-Nockrashy AS et al. | Biochemical changes in cottonseed during germination. | 1974 | Nahrung | pmid:4365683 |
| Mayorga H et al. | [Extraction and precipitation of cottonseed protein by the wet method]. | 1973 | Arch Latinoam Nutr | pmid:4801265 |
| Lee J | The inheritance of gossypol level in Gossypium. II. Inheritance of seed gosypol in two trains of cultivated Gossypoium barbadense L. | 1973 | Genetics | pmid:4769299 |
| Ogot JO | The performance of pigs in Kenya fed cottonseed meal in mixtures of concentrate supplements. | 1973 | Bull Epizoot Dis Afr | pmid:4808120 |
| Finlay TH et al. | Mechanism of the gossypol inactivation of pepsinogen. | 1973 | J. Biol. Chem. | pmid:4718749 |
| Skutches CL et al. | Effect of intravenous gossypol injection on iron ultilization in swine. | 1973 | J. Nutr. | pmid:4705271 |
| Herman DL and Smith FH | Effect of bound gossypol on the absorption of iron by rats. | 1973 | J. Nutr. | pmid:4705274 |
| Smith FH | Effect of gossypol bound to cottonseed protein on growth of weanling rats. | 1972 Jul-Aug | J. Agric. Food Chem. | pmid:5068584 |
| Fishbein L | Natural non-nutrient substances in the food chain. | 1972 | Sci. Total Environ. | pmid:4121147 |
| Albrecht JE et al. | Rate of depletion and route of elimination of intravenously injected gossypol in swine. | 1972 | J. Anim. Sci. | pmid:5085300 |
| Kornegay ET et al. | Fungal-treated cottonseed meal for swine. | 1972 | J. Nutr. | pmid:4678034 |
| Wong RC et al. | Studies on the nature of the inhibition by gossypol of the transformation of pepsinogen to pepsin. | 1972 | J. Biol. Chem. | pmid:4551945 |
| Fedeli E and Jacini G | Lipid composition of vegetable oils. | 1971 | Adv. Lipid Res. | pmid:4942102 |
| Berg LR and Lawrence WW | Cottonseed meal, dehydrated grass and ascorbic acid as dietary factors preventing toxicity of vanadium for the chick. | 1971 | Poult. Sci. | pmid:5109894 |
| Albrecht JE et al. | Effect of initial weight and days on feed on the accumulation of gossypol in pig livers. | 1971 | J. Anim. Sci. | pmid:5546881 |
| Abou-Donia MB and Dieckert JW | Gossypol: subcellular localization and stimulation of rat liver microsomal oxidases. | 1971 | Toxicol. Appl. Pharmacol. | pmid:4998823 |
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| Meksongsee LA et al. | The in vivo effect of gossypol on cytochrome oxidase, succinoxidase, and succinic dehydrogenase in animal tissues. | 1970 Sep-Oct | J. Agric. Food Chem. | pmid:4319770 |
| Heinstein PF et al. | Biosynthesis of gossypol. Incorporation of mevalonate-2-14C and isoprenyl pyrophosphates. | 1970 | J. Biol. Chem. | pmid:4318479 |
| Tanksley TD et al. | Inhibition of pepsinogen activation by gossypol. | 1970 | J. Biol. Chem. | pmid:4922043 |
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| Fry KE | Some factors affecting the Hill reaction activity in cotton chloroplasts. | 1970 | Plant Physiol. | pmid:5427116 |
| Tone JN and Jensen DR | Effect of ingested gossypol on the growth performance of rats. | 1970 | Experientia | pmid:5478639 |
| Abou-Donia MB et al. | Metabolic fate of gossypol: the metabolism of 14C-gossypol in rats. | 1970 | Lipids | pmid:5484207 |
| Smith FH and Clawson AJ | The effects of dietary gossypol on animals. | 1970 | J Am Oil Chem Soc | pmid:5487114 |
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| Graham GG et al. | Dietary protein quality in infants and children. II. Metabolic studies with cottonseed flour. | 1969 | Am. J. Clin. Nutr. | pmid:5819114 |
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| Sinnhuber RO et al. | Dietary factors and hepatoma in rainbow trout (Salmo gairdneri). II. Cocarcinogenes by cyclopropenoid fatty acids and the effect of gossypol and altered lipids on aflatoxin-induced liver cancer. | 1968 | J. Natl. Cancer Inst. | pmid:4178161 |
| Albrecht JE et al. | Effects of high gossypol cottonseed meal on the electrocardiogram of swine. | 1968 | J. Anim. Sci. | pmid:5744268 |
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