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Integrated Genomics Identifies miR-32/MCL-1 Pathway as a Critical Driver of Melanomagenesis: Implications for miR-Replacement and Combination Therapy. |
2016 |
PLoS ONE |
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Zhao R et al. |
AT-101 enhances gefitinib sensitivity in non-small cell lung cancer with EGFR T790M mutations. |
2016 |
BMC Cancer |
pmid:27431492
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Zubair H et al. |
Mobilization of Intracellular Copper by Gossypol and Apogossypolone Leads to Reactive Oxygen Species-Mediated Cell Death: Putative Anticancer Mechanism. |
2016 |
Int J Mol Sci |
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Ma D et al. |
Genetic basis for glandular trichome formation in cotton. |
2016 |
Nat Commun |
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Zhang J et al. |
Breeding Potential of Introgression Lines Developed from Interspecific Crossing between Upland Cotton (Gossypium hirsutum) and Gossypium barbadense: Heterosis, Combining Ability and Genetic Effects. |
2016 |
PLoS ONE |
pmid:26730964
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Antonietti P et al. |
AT-101 simultaneously triggers apoptosis and a cytoprotective type of autophagy irrespective of expression levels and the subcellular localization of Bcl-xL and Bcl-2 in MCF7 cells. |
2016 |
Biochim. Biophys. Acta |
pmid:26721623
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Stein MN et al. |
A Phase II Study of AT-101 to Overcome Bcl-2--Mediated Resistance to Androgen Deprivation Therapy in Patients With Newly Diagnosed Castration-Sensitive Metastatic Prostate Cancer. |
2016 |
Clin Genitourin Cancer |
pmid:26476589
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Baoleri X et al. |
Combination of L-gossypol and low-concentration doxorubicin induces apoptosis in human synovial sarcoma cells. |
2015 |
Mol Med Rep |
pmid:26238307
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Li K et al. |
Mulberry-like dual-drug complicated nanocarriers assembled with apogossypolone amphiphilic starch micelles and doxorubicin hyaluronic acid nanoparticles for tumor combination and targeted therapy. |
2015 |
Biomaterials |
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Quinn BA et al. |
Pancreatic Cancer Combination Therapy Using a BH3 Mimetic and a Synthetic Tetracycline. |
2015 |
Cancer Res. |
pmid:26032425
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Zhang SD et al. |
Isochamaejasmin induces apoptosis in leukemia cells through inhibiting Bcl-2 family proteins. |
2015 |
Chin J Nat Med |
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Towards a systematic analysis of human short-chain dehydrogenases/reductases (SDR): Ligand identification and structure-activity relationships. |
2015 |
Chem. Biol. Interact. |
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Toxicity of Gossypol from Cottonseed Cake to Sheep Ovarian Follicles. |
2015 |
PLoS ONE |
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Gong Y et al. |
Valproic Acid Enhances the Anti-tumor Effect of (-)-gossypol to Burkitt Lymphoma Namalwa Cells. |
2015 |
Biomed. Environ. Sci. |
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Wu Y et al. |
Influence of gossypol acetic acid on the growth of human adenoid cystic carcinoma ACC-M cells and the expression of DNA methyltransferase 1. |
2015 |
Genet. Mol. Res. |
pmid:26535659
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The BH3-mimetic gossypol and noncytotoxic doses of valproic acid induce apoptosis by suppressing cyclin-A2/Akt/FOXO3a signaling. |
2015 |
Oncotarget |
pmid:26517515
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Kottmann RM et al. |
Pharmacologic inhibition of lactate production prevents myofibroblast differentiation. |
2015 |
Am. J. Physiol. Lung Cell Mol. Physiol. |
pmid:26408551
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Ionizing radiation induces myofibroblast differentiation via lactate dehydrogenase. |
2015 |
Am. J. Physiol. Lung Cell Mol. Physiol. |
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Examination of Gossypol-Pluronic Micelles as Potential Radiosensitizers. |
2015 |
AAPS J |
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Mechanisms involved in reproductive damage caused by gossypol in rats and protective effects of vitamin E. |
2015 |
Biol. Res. |
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Targeting anti-apoptotic Bcl-2 by AT-101 to increase radiation efficacy: data from in vitro and clinical pharmacokinetic studies in head and neck cancer. |
2015 |
Radiat Oncol |
pmid:26223311
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Ren T et al. |
Small-molecule BH3 mimetic and pan-Bcl-2 inhibitor AT-101 enhances the antitumor efficacy of cisplatin through inhibition of APE1 repair and redox activity in non-small-cell lung cancer. |
2015 |
Drug Des Devel Ther |
pmid:26089640
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He Z et al. |
Chemical Composition of Defatted Cottonseed and Soy Meal Products. |
2015 |
PLoS ONE |
pmid:26079931
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Wang Q et al. |
Salt Stress Effects on Secondary Metabolites of Cotton in Relation to Gene Expression Responsible for Aphid Development. |
2015 |
PLoS ONE |
pmid:26061875
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Pan R et al. |
Inhibition of Mcl-1 with the pan-Bcl-2 family inhibitor (-)BI97D6 overcomes ABT-737 resistance in acute myeloid leukemia. |
2015 |
Blood |
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Maji S et al. |
Mcl-1 is an important therapeutic target for oral squamous cell carcinomas. |
2015 |
Oncotarget |
pmid:26009874
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Natural product (-)-gossypol inhibits colon cancer cell growth by targeting RNA-binding protein Musashi-1. |
2015 |
Mol Oncol |
pmid:25933687
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Sarkar S et al. |
Therapy of prostate cancer using a novel cancer terminator virus and a small molecule BH-3 mimetic. |
2015 |
Oncotarget |
pmid:25926554
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Mani J et al. |
Chemoresistance is associated with increased cytoprotective autophagy and diminished apoptosis in bladder cancer cells treated with the BH3 mimetic (-)-Gossypol (AT-101). |
2015 |
BMC Cancer |
pmid:25885284
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The response of meat ducks from 15 to 35 d of age to gossypol from cottonseed meal. |
2015 |
Poult. Sci. |
pmid:25834247
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Gossypol Acetic Acid Prevents Oxidative Stress-Induced Retinal Pigment Epithelial Necrosis by Regulating the FoxO3/Sestrin2 Pathway. |
2015 |
Mol. Cell. Biol. |
pmid:25802279
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Zhan W et al. |
Inhibitory activity of apogossypol in human prostate cancer in vitro and in vivo. |
2015 |
Mol Med Rep |
pmid:25672487
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Zhang H et al. |
Canonical Wnt signaling acts synergistically on BMP9-induced osteo/odontoblastic differentiation of stem cells of dental apical papilla (SCAPs). |
2015 |
Biomaterials |
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[Features of dynamics of sera cytokines in patients with erythema multiforme during immunotherapy]. |
2014 Jan-Feb |
Zh. Mikrobiol. Epidemiol. Immunobiol. |
pmid:24738292
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Gawande ND et al. |
Molecular screening of insecticides with sigma glutathione S-transferases (GST) in cotton aphid Aphis gossypii using docking. |
2014 |
Bioinformation |
pmid:25512683
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Ren T et al. |
Sequential treatment with AT-101 enhances cisplatin chemosensitivity in human non-small cell lung cancer cells through inhibition of apurinic/apyrimidinic endonuclease 1-activated IL-6/STAT3 signaling pathway. |
2014 |
Drug Des Devel Ther |
pmid:25548514
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Gadelha IC et al. |
Gossypol promotes degeneration of ovarian follicles in rats. |
2014 |
ScientificWorldJournal |
pmid:25540815
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Jarzabek MA et al. |
Interrogation of gossypol therapy in glioblastoma implementing cell line and patient-derived tumour models. |
2014 |
Br. J. Cancer |
pmid:25375271
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Gossypol induces apoptosis in multiple myeloma cells by inhibition of interleukin-6 signaling and Bcl-2/Mcl-1 pathway. |
2014 |
Int. J. Oncol. |
pmid:25231749
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Proteomic analysis of gossypol induces necrosis in multiple myeloma cells. |
2014 |
Biomed Res Int |
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Kogan P and Wald M |
Male contraception: history and development. |
2014 |
Urol. Clin. North Am. |
pmid:24286773
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Paulus A et al. |
AT-101 downregulates BCL2 and MCL1 and potentiates the cytotoxic effects of lenalidomide and dexamethasone in preclinical models of multiple myeloma and Waldenström macroglobulinaemia. |
2014 |
Br. J. Haematol. |
pmid:24236538
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Keshmiri-Neghab H and Goliaei B |
Therapeutic potential of gossypol: an overview. |
2014 |
Pharm Biol |
pmid:24073600
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Gossypol increases expression of the pro-apoptotic BH3-only protein NOXA through a novel mechanism involving phospholipase A2, cytoplasmic calcium, and endoplasmic reticulum stress. |
2014 |
J. Biol. Chem. |
pmid:24778183
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Effects of dietary gossypol concentration on growth performance, blood profiles, and hepatic histopathology in meat ducks. |
2014 |
Poult. Sci. |
pmid:24902707
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Targeting BCL2 for the treatment of lymphoid malignancies. |
2014 |
Semin. Hematol. |
pmid:25048785
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A phase I study of AT-101 with cisplatin and etoposide in patients with advanced solid tumors with an expanded cohort in extensive-stage small cell lung cancer. |
2014 |
Invest New Drugs |
pmid:23860642
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Lima Pde M et al. |
Methane emission of Santa Inês sheep fed cottonseed by-products containing different levels of gossypol. |
2014 |
Trop Anim Health Prod |
pmid:24132456
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Mei H et al. |
Autophagy inhibition enhances pan-Bcl-2 inhibitor AT-101-induced apoptosis in non-small cell lung cancer. |
2014 |
Neoplasma |
pmid:24299314
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Spijkers-Hagelstein JA et al. |
Glucocorticoid sensitisation in Mixed Lineage Leukaemia-rearranged acute lymphoblastic leukaemia by the pan-BCL-2 family inhibitors gossypol and AT-101. |
2014 |
Eur. J. Cancer |
pmid:24703900
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