Gossypol
Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
Cross Reference
Introduction
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Gossypol?
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Mol. Cancer Ther. (4)
- Proc. Natl. Acad. Sci. U.S.A. (3)
- Am. J. Physiol. Lung Cell Mol. Physiol. (2)
- Others (13)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Gossypol
PubChem Associated disorders and diseases
What pathways are associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Gossypol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
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What functions are associated with Gossypol?
Related references are published most in these journals:
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What lipids are associated with Gossypol?
Related references are published most in these journals:
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What genes are associated with Gossypol?
Related references are published most in these journals:
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What common seen animal models are associated with Gossypol?
Xenograft Model
Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Related references are published most in these journals:
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NCBI Entrez Crosslinks
All references with Gossypol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Pearce S et al. | The viability of mouse Leydig cells in vitro following incubation with gossypol. | 1985 | Contraception | pmid:4085245 |
| Gu Y and Anderson NO | Effects of gossypol on the estrous cycle and ovarian weight in the rat. | 1985 | Contraception | pmid:4085249 |
| Patton CS et al. | Heart failure caused by gossypol poisoning in two dogs. | 1985 | J. Am. Vet. Med. Assoc. | pmid:4086371 |
| Wang Y et al. | Antifertility effect of polyvinylpyrrolidone-gossypol and gossypol in male rats. | 1985 | Contraception | pmid:4092462 |
| Lagerlöf RK and Tone JN | The effect of gossypol acetic acid on female reproduction. | 1985 | Drug Chem Toxicol | pmid:4092619 |
| Fishbein L | Natural non-nutrient substances in the food chain. | 1972 | Sci. Total Environ. | pmid:4121147 |
| Sinnhuber RO et al. | Dietary factors and hepatoma in rainbow trout (Salmo gairdneri). II. Cocarcinogenes by cyclopropenoid fatty acids and the effect of gossypol and altered lipids on aflatoxin-induced liver cancer. | 1968 | J. Natl. Cancer Inst. | pmid:4178161 |
| Pirogov AI et al. | [Postoperative bronchopleural complications in the combined treatment of lung cancer]. | 1974 | Vopr Onkol | pmid:4211564 |
| Abou-Donia MB and Dieckert JW | Gossypol: uncoupling of respiratory chain and oxidative phosphorylation. | 1974 | Life Sci. | pmid:4277086 |
| Myers BD and Throneberry GO | Effect of gossypol on some oxidative respiratory enzymes. | 1966 | Plant Physiol. | pmid:4287149 |
| Ghittino P et al. | Experimental dietary hepatoma in rainbow trout. The role of cottonseed meals and other diets. | 1967 | Cancro | pmid:4303305 |
| Cottonseed meal and tumors. | 1969 | Nutr. Rev. | pmid:4311090 | |
| Heinstein PF et al. | Biosynthesis of gossypol. Incorporation of mevalonate-2-14C and isoprenyl pyrophosphates. | 1970 | J. Biol. Chem. | pmid:4318479 |
| Meksongsee LA et al. | The in vivo effect of gossypol on cytochrome oxidase, succinoxidase, and succinic dehydrogenase in animal tissues. | 1970 Sep-Oct | J. Agric. Food Chem. | pmid:4319770 |
| el-Nockrashy AS et al. | Biochemical changes in cottonseed during germination. | 1974 | Nahrung | pmid:4365683 |
| Smith FH | Preparation of 14C-gossypol by incorporation of acetate-1-14C and acetate-2-14C by biosynthesis. | 1974 | J Am Oil Chem Soc | pmid:4415176 |
| Skutches CL and Smith FH | Effect of phenobarbital on the level of gossypol in the liver and the effect of gossypol and phenobarbital on liver microsomal O-demethylation and lipid peroxidation activities in the rat. | 1974 | J. Nutr. | pmid:4430931 |
| Abou-Donia MB et al. | Gossypol: antagonistic effect on toxicity of insecticides to Spodoptera littoralis. | 1974 | Experientia | pmid:4435119 |
| Skutches CL and Smith FH | Metabolism of gossypol, biosynthesized from methyl-14C-and carboxyl-14 C-labeled sodium acetate, in rat. | 1974 | J Am Oil Chem Soc | pmid:4479245 |
| de Peyster A and Wang YY | Gossypol--proposed contraceptive for men passes the Ames test. | 1979 | N. Engl. J. Med. | pmid:450009 |
| Wong RC et al. | Studies on the nature of the inhibition by gossypol of the transformation of pepsinogen to pepsin. | 1972 | J. Biol. Chem. | pmid:4551945 |
| Kornegay ET et al. | Fungal-treated cottonseed meal for swine. | 1972 | J. Nutr. | pmid:4678034 |
| Skutches CL et al. | Effect of intravenous gossypol injection on iron ultilization in swine. | 1973 | J. Nutr. | pmid:4705271 |
| Herman DL and Smith FH | Effect of bound gossypol on the absorption of iron by rats. | 1973 | J. Nutr. | pmid:4705274 |
| Finlay TH et al. | Mechanism of the gossypol inactivation of pepsinogen. | 1973 | J. Biol. Chem. | pmid:4718749 |
| Lee J | The inheritance of gossypol level in Gossypium. II. Inheritance of seed gosypol in two trains of cultivated Gossypoium barbadense L. | 1973 | Genetics | pmid:4769299 |
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| Ogot JO | The performance of pigs in Kenya fed cottonseed meal in mixtures of concentrate supplements. | 1973 | Bull Epizoot Dis Afr | pmid:4808120 |
| Tone JN and Jensen DR | Hematological effects of injected gossypol and iron in rats. | 1974 Jan-Feb | J. Agric. Food Chem. | pmid:4811630 |
| Skutches CL et al. | Effect of dietary free gossypol on blood components and tissue iron in swine and rats. | 1974 | J. Nutr. | pmid:4816926 |
| Kilburn KH et al. | Two patterns for bronchial damage from inhaled materials. | 1974 | Chest | pmid:4819236 |
| Abou-Donia MB and Dieckert JW | Urinary and biliary excretion of 14C-gossypol in swine. | 1974 | J. Nutr. | pmid:4830281 |
| Tanksley TD et al. | Inhibition of pepsinogen activation by gossypol. | 1970 | J. Biol. Chem. | pmid:4922043 |
| Fedeli E and Jacini G | Lipid composition of vegetable oils. | 1971 | Adv. Lipid Res. | pmid:4942102 |
| Vichkanova SA and Goriunova LV | [Study of virulicidal effect of gossypol in vitro]. | 1968 | Antibiotiki | pmid:4974209 |
| Abou-Donia MB and Dieckert JW | Gossypol: subcellular localization and stimulation of rat liver microsomal oxidases. | 1971 | Toxicol. Appl. Pharmacol. | pmid:4998823 |
| Qian SZ et al. | [The potassium-depleting effect of gossypol on isolated rabbit heart and it's possible mechanism (author's transl)]. | 1979 | Yao Xue Xue Bao | pmid:506710 |
| Smith FH | Effect of gossypol bound to cottonseed protein on growth of weanling rats. | 1972 Jul-Aug | J. Agric. Food Chem. | pmid:5068584 |
| Albrecht JE et al. | Rate of depletion and route of elimination of intravenously injected gossypol in swine. | 1972 | J. Anim. Sci. | pmid:5085300 |
| Berg LR and Lawrence WW | Cottonseed meal, dehydrated grass and ascorbic acid as dietary factors preventing toxicity of vanadium for the chick. | 1971 | Poult. Sci. | pmid:5109894 |
| Husby FM and Kroening GH | Energy value of cottonseed meal for swine. | 1971 | J. Anim. Sci. | pmid:5171308 |
| Dunbar CE and Herman RL | Visceral granuloma in brook trout (Salvelinus fontinalis). | 1971 | J. Nutr. | pmid:5171403 |
| Braham JE et al. | [Gossypol absorption in rats and in pigs]. | 1971 | Arch Latinoam Nutr | pmid:5172839 |
| Rolz C et al. | [Method of wet concentration of protein of cotton seed cake processed by screw press]. | 1971 | Arch Latinoam Nutr | pmid:5172841 |
| Krylov VF | [Treatment of patients with influenza]. | 1975 | Ter. Arkh. | pmid:52894 |
| Klaasen GH | [Gossypol, properties and occurrence]. | 1965 | Pharm Weekbl | pmid:5321432 |
| Chen ZC et al. | [The influence of gossypol on the potassium metabolism of rats and the effect of some possible contributing factors (low-K and low-MG intake) (author's transl)]. | 1979 | Yao Xue Xue Bao | pmid:532653 |
| Nadakavukaren MJ et al. | Effect of gossypol on the ultrastructure of rat spermatozoa. | 1979 | Cell Tissue Res. | pmid:535032 |
| Wood AB et al. | Conformation and hydrogen bonding of gossypol. | 1969 | Chem. Ind. | pmid:5357782 |
| Goriunova LV and Vichkanova SA | [Study of antiviral effect of gossypol on chick embryo model]. | 1969 Sep-Oct | Farmakol Toksikol | pmid:5364687 |
| Fry KE | Some factors affecting the Hill reaction activity in cotton chloroplasts. | 1970 | Plant Physiol. | pmid:5427116 |
| Mauron J | [Chemical behavior of proteins at the time of preparation of nutrients and their biological effects]. | 1970 | Int Z Vitaminforsch | pmid:5451301 |
| Tone JN and Jensen DR | Effect of ingested gossypol on the growth performance of rats. | 1970 | Experientia | pmid:5478639 |
| Abou-Donia MB et al. | Metabolic fate of gossypol: the metabolism of 14C-gossypol in rats. | 1970 | Lipids | pmid:5484207 |
| Smith FH and Clawson AJ | The effects of dietary gossypol on animals. | 1970 | J Am Oil Chem Soc | pmid:5487114 |
| Vichkanova SA et al. | [Antiviral properties of gossypol in experimental influenza pneumonia]. | 1970 | Antibiotiki | pmid:5501368 |
| Buitrago JA et al. | Effects of dietary iron on gossypol accumulation in and elimination from porcine liver. | 1970 | J. Anim. Sci. | pmid:5520345 |
| Albrecht JE et al. | Effect of initial weight and days on feed on the accumulation of gossypol in pig livers. | 1971 | J. Anim. Sci. | pmid:5546881 |
| Albrecht JE et al. | Effects of high gossypol cottonseed meal on the electrocardiogram of swine. | 1968 | J. Anim. Sci. | pmid:5744268 |
| Jones LA and Smith FH | Effect of bound gossypol and amino acid supplementation of glandless cottonseed meal on the growth of weanling rats. | 1977 | J. Anim. Sci. | pmid:576596 |
| Jones LA and Smith FH | Effect of gossypol on the removal of nitrogen and amino acids from feed in digestion by the rat. | 1977 | J. Anim. Sci. | pmid:576597 |
| Lyman CM et al. | Metabolism of gossypol in the chick. | 1969 | J Am Oil Chem Soc | pmid:5779540 |
| Baugher WL and Campbell TC | Gossypol detoxication by fungi. | 1969 | Science | pmid:5786644 |
| Cornu A et al. | [Utilization of gossypol-free cottonseed and its by-products as human food]. | 1977 | Ann Nutr Aliment | pmid:579293 |
| Alford BB and Onley K | The minimum cottonseed protein required for nitrogen balance in women. | 1978 | J. Nutr. | pmid:580097 |
| Cherry JP et al. | Potential for improving cottonseed quality by genetic and agronomic practices. | 1978 | Adv. Exp. Med. Biol. | pmid:581532 |
| Graham GG et al. | Dietary protein quality in infants and children. II. Metabolic studies with cottonseed flour. | 1969 | Am. J. Clin. Nutr. | pmid:5819114 |
| de Buckle TS et al. | Two food applications of cottonseed flours and meals. | 1979 | J Am Oil Chem Soc | pmid:583421 |
| Wang YE et al. | [Studies o the anti-fertility actions of cotton seed meal and gossypol (author's transl)]. | 1979 | Yao Xue Xue Bao | pmid:583588 |
| Smith FH and Clawson AJ | Effect of diet on accumulation of gossypol in the organs of swine. | 1965 | J. Nutr. | pmid:5892976 |
| Danke RJ and Tillman AD | Effect of free gossypol and supplemental dietary iron on blood constituents of rats. | 1965 | J. Nutr. | pmid:5897732 |
| Sharma MP et al. | Effects of levels of protein and gossypol, and length of feeding period on the accumulation of gossypol in tissues of swine. | 1966 | J. Nutr. | pmid:5931188 |
| Muzaffaruddin M and Saxena ER | Physicochemical studies on the composition and stability of metal-gossypol complexes. I. Fe+++ gossypol complex. | 1966 | J Am Oil Chem Soc | pmid:5939582 |
| Clawson AJ and Smith FH | Effect of dietary iron on gossypol toxicity and on residues of gossypil in porcine liver. | 1966 | J. Nutr. | pmid:5950205 |
| Braham JE et al. | Effect of calcium and gossypol on the performance of swine and on certain enzymes and other blood constituents. | 1967 | J. Nutr. | pmid:6018252 |
| Smith FH | Determination of gossypol in leaves and flower buds of Gossypium. | 1967 | J Am Oil Chem Soc | pmid:6041387 |
| Margalith P | Inhibitory effect of gossypol on microorganisms. | 1967 | Appl Microbiol | pmid:6049314 |
| Braham JE et al. | Effect of gossypol on the iron-binding capacity of serum in swine. | 1967 | J. Nutr. | pmid:6052995 |
| Roehm JN et al. | Accumulation and elimination of dietary gossypol in the organs of rainbow trout. | 1967 | J. Nutr. | pmid:6054742 |
| Ali SF and El-Sewedy SM | Effect of gossypol on liver metabolic enzymes in male rats. | 1984 | Toxicol. Lett. | pmid:6084346 |
| SaÄitkulov AM et al. | [Biological characteristics of new interferon inducers created on a gossypol base]. | 1984 Nov-Dec | Vopr. Virusol. | pmid:6084903 |
| Bi XF et al. | [Effects of potassium on the inhibitory effect of gossypol on Na,K-ATPase in vitro]. | 1984 | Zhongguo Yao Li Xue Bao | pmid:6087611 |
| Olgiati KL et al. | Gossypol modulation of nucleotide metabolizing enzymes in the reproductive tract of male rats. | 1984 | Biol. Reprod. | pmid:6095938 |
| Pösö H et al. | Gossypol, a powerful inhibitor of human spermatozoal metabolism. | 1980 | Lancet | pmid:6103251 |
| Ke YB and Tso WW | Variations of gossypol susceptibility in rat spermatozoa during spermatogenesis. | 1982 | Int. J. Fertil. | pmid:6122656 |
| Chang CC et al. | Studies on gossypol. I. Toxicity, antifertility, and endocrine analyses in male rats. | 1982 | Int. J. Fertil. | pmid:6131039 |
| Hong SK et al. | Effects of gossypol on PAH transport in the rabbit kidney slice. | 1983 | Toxicol. Appl. Pharmacol. | pmid:6140776 |
| Gossypol prospects. | 1984 | Lancet | pmid:6144835 | |
| Soufir JC et al. | Epididymal effects of gossypol. | 1984 | Lancet | pmid:6145995 |
| Breitbart H et al. | Effect of gossypol-acetic acid on calcium transport and ATPase activity in plasma membranes from ram and bull spermatozoa. | 1984 | Int. J. Androl. | pmid:6151940 |
| Labzo SS et al. | [Stimulation of interferon formation by natural and synthetic inducers in cultures of human tonsil cells]. | 1980 Jan-Feb | Vopr. Virusol. | pmid:6158181 |
| Ye WS et al. | Toxicity of a male contraceptive, gossypol, in mammalian cell cultures. | 1983 | In Vitro | pmid:6185412 |
| Baker ME | Gossypol inhibits estrogen binding to rat alpha-fetoprotein. | 1984 | FEBS Lett. | pmid:6207049 |
| Wang WH | [Antagonistic effect of Smilax sp. on gossypol toxicity (author's transl)]. | 1982 | Zhong Yao Tong Bao | pmid:6212150 |
| Sun YB et al. | [Effect of gossypol on potassium excretion of male rats]. | 1982 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:6216008 |
| Tong SM et al. | Human antifertility effect of gossypol cytologic observation of semen. | 1982 | Chin. Med. J. | pmid:6216077 |
| Tso WW et al. | Effect of gossypol on boar spermatozoal adenosine triphosphate metabolism. | 1982 | Arch. Androl. | pmid:6219642 |
| Han ML | [Clinical observation of the gossypol treatment of endometriosis and uterine myoma and the location of the pharmacological action]. | 1982 | Zhong Xi Yi Jie He Za Zhi | pmid:6219819 |
| Gu ZP et al. | Morphological changes in the testes and epididymides of rats after gossypol. | 1983 | Zhongguo Yao Li Xue Bao | pmid:6223497 |
| Xu Y et al. | [Antagonism of antifertility effect of gossypol by aspirin]. | 1983 | Zhongguo Yao Li Xue Bao | pmid:6225300 |