Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Qian SZ et al. | Antispermatogenic activity of gossypol in rats on low-potassium diet. | 1983 | Zhongguo Yao Li Xue Bao | pmid:6228118 |
Fei RR et al. | [Effects of gossypol on rat testicular mitochondria]. | 1983 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:6228314 |
Chen XM et al. | [Effects of gossypol on lactate dehydrogenase isoenzyme-X in human spermatozoa]. | 1983 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:6228315 |
Cao J and Liu GZ | [Reversibility of azoospermia following gossypol withdrawal]. | 1983 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:6228316 |
Wang MZ | [High performance liquid chromatographic analysis of gossypol]. | 1983 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:6228325 |
Madzhidov UV | [T-suppressors in experimental adjuvant arthritis and immunosuppression]. | 1984 | Zh. Mikrobiol. Epidemiol. Immunobiol. | pmid:6230839 |
Herrera J et al. | Modifications in the testis steroidogenic pathways in rats fed with cottonseed flour. | 1984 | Arch. Androl. | pmid:6236762 |
Wang RL et al. | [Effect of gossypol acetic acid on the induction of sister chromatid exchange of spermatogonial cell in mice]. | 1984 | Zhongguo Yao Li Xue Bao | pmid:6240903 |
Han ML et al. | [A comparative study on rapid and slow loading of gossypol in the treatment of gynecological diseases]. | 1984 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:6241066 |
Wang RL et al. | [Effect of gossypol acetic acid on induction of sister chromatid exchange of spermatogonial cell in mice]. | 1984 | Zhongguo Yao Li Xue Bao | pmid:6242220 |
El'chits SV et al. | [Glucoamylase immobilization on silochrome using gossypol]. | 1981 Jan-Feb | Ukr. Biokhim. Zh. | pmid:6259793 |
Bi XF et al. | The effect of gossypol on ATPase activity of the kidney. | 1981 | Sci. Sin. | pmid:6266011 |
Ridley AJ and Blasco L | Testosterone and gossypol effects on human sperm motility. | 1981 | Fertil. Steril. | pmid:6273239 |
Wichmann K et al. | Inhibiting herpes simplex virus type 2 infection in human epithelial cells by gossypol, a potent spermicidal and contraceptive agent. | 1982 | Am. J. Obstet. Gynecol. | pmid:6277198 |
Shu HD et al. | [Effects of gossypol acetate on neuromuscular transmission (author's transl)]. | 1982 | Zhongguo Yao Li Xue Bao | pmid:6283787 |
Jackson H and Schnieden H | Aspects of male reproductive pharmacology and toxicology. | 1982 Jan-Mar | Rev Pure Appl Pharmacol Sci | pmid:6291102 |
de Peyster A et al. | Oxygen radical formation induced by gossypol in rat liver microsomes and human sperm. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6322752 |
Pathak HK et al. | Gossypol, ouabain and vanadate on the isolated perfused rat kidney and Na, K-ATPase. | 1984 | Zhongguo Yao Li Xue Bao | pmid:6326465 |
Gombe S | A review of the current status in male contraceptive studies. | 1983 | East Afr Med J | pmid:6354690 |
Blanco A et al. | Effect of gossypol upon motility and ultrastructure of Trypanosoma cruzi. | 1983 | J. Protozool. | pmid:6363678 |
Aitken RJ | New techniques in contraception: gossypol, vaccines and GnRH analogues. | 1983 | Proc Annu Symp Eugen Soc | pmid:6366784 |
Gerez de Burgos NM et al. | Inhibition by gossypol of oxidoreductases from Trypanosoma cruzi. | 1984 | Biochem. Pharmacol. | pmid:6370265 |
Qian SZ and Wang ZG | Gossypol: a potential antifertility agent for males. | 1984 | Annu. Rev. Pharmacol. Toxicol. | pmid:6375548 |
Huang TH | [The effect of gossypol acetate on the function of rRNA gene and acrocentric chromosome association in human cells]. | 1983 | Zhonghua Yi Xue Za Zhi | pmid:6407739 |
Wichmann K et al. | Effect of gossypol on the motility and metabolism of human spermatozoa. | 1983 | J. Reprod. Fertil. | pmid:6411909 |
Prasad MR and Diczfalusy E | New contraceptives for men. What are the prospects? | 1983 | Int. J. Androl. | pmid:6413430 |
Kennedy WP et al. | Gossypol inhibition of acrosin and proacrosin, and oocyte penetration by human spermatozoa. | 1983 | Biol. Reprod. | pmid:6416323 |
Weinbauer GF et al. | The endocrine status of gossypol - treated male rats. | 1983 | Andrologia | pmid:6421193 |
Ma XN et al. | [Effect of gossypol acetic acid on testosterone, LH and FSH levels of male rats]. | 1983 | Yao Xue Xue Bao | pmid:6433647 |
Hamasaki Y et al. | [Rat basophilic leukemia-1 cell possesses 12-lipoxygenase and 5-lipoxygenase activities which are specifically inhibited by gossypol acetic acid]. | 1984 | Arerugi | pmid:6442854 |
Han HL | [Gossypol treatment for menopausal functional bleeding, myoma of uterus and endometriosis--preliminary report (author's transl)]. | 1980 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:6451316 |
Kalla NR and Vasudev M | Studies on the male antifertility agent-gossypol acetic acid. II. Effect of gossypol acetic acid on the motility and ATPase activity of human spermatozoa. | 1981 Mar-Apr | Andrologia | pmid:6454365 |
El-Sebae AH et al. | Gossypol as an inducer or inhibitor in Spodoptera littoralis larvae. | 1981 | J Environ Sci Health B | pmid:6454717 |
Kalla NR et al. | Studies on the male antifertility agent--gossypol acetic acid. III. Effect of gossypol acetic acid on rat testis. | 1981 May-Jun | Andrologia | pmid:6455943 |
Liang DC et al. | [Studies on distribution of 14C-gossypol in subcellular fractions of rat testes and site of gossypol action (author's transl)]. | 1981 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:6459173 |
Bi XF et al. | [Preliminary study on gossypol in causing hypokalemia (author's transl)]. | 1981 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:6459178 |
Sang GW et al. | [Chronic toxicity of gossypol and the relationship to its metabolic fate in dogs and monkeys (author's transl)]. | 1980 | Zhongguo Yao Li Xue Bao | pmid:6461173 |
Shi QX et al. | [Analysis on exfoliated cells in human semen after oral administrations of gossypol acetic acid (author's transl)]. | 1981 | Zhongguo Yao Li Xue Bao | pmid:6462027 |
Wang NG et al. | [Antisteroidal and antigonadotrophic effects of gossypol acetic acid in rats]. | 1984 | Yao Xue Xue Bao | pmid:6464763 |
Zu PD et al. | Electron microscopic observations of the effects of gossypol on the human endometrium. | 1984 | Am. J. Obstet. Gynecol. | pmid:6465231 |
Kalla NR et al. | Studies on the male antifertility agent gossypol acetic acid. VI. Effect of gossypol acetic acid on the fertility of bonnet monkey. Macaca radiata. | 1984 May-Jun | Andrologia | pmid:6465549 |
Whaley KJ et al. | Optically active gossypol as a circular dichroism probe of interactions with serum albumins. | 1984 | Biochim. Biophys. Acta | pmid:6466708 |
Paz GF and Homonnai ZT | Effect of the antifertility agent, gossypol acetic acid, on the metabolism and testosterone secretion of isolated rat interstitial cells in vitro. | 1984 | Contraception | pmid:6467943 |
Coutinho EM et al. | Antispermatogenic action of gossypol in men. | 1984 | Fertil. Steril. | pmid:6468676 |
Ma XN and Back DJ | Inhibition of hepatic microsomal enzymes by gossypol in the rat. | 1984 | Contraception | pmid:6478834 |
GÃ¥fvels M et al. | Toxic effects of the antifertility agent gossypol in male rats. | 1984 | Toxicology | pmid:6485000 |
Rovan E et al. | Effect of gossypol on bull spermatozoa in vitro. | 1984 | Urol. Res. | pmid:6485187 |
Jiang Y and Zhou TH | [Polarographic study on gossypol]. | 1984 | Yao Xue Xue Bao | pmid:6496091 |
Zhou LF and Lei HP | [Effect of gossypol acetic acid on the uterus and ovary]. | 1984 | Yao Xue Xue Bao | pmid:6496095 |
Tso WW | Gossypol inhibits Ehrlich ascites tumor cell proliferation. | 1984 | Cancer Lett. | pmid:6498805 |
Kim IC et al. | Comparative in vitro spermicidal effects of (+/-)-gossypol, (+)-gossypol, (-)-gossypol and gossypolone. | 1984 | Contraception | pmid:6509980 |
Reddy RM et al. | Pattern of ovarian and uterine carbohydrate metabolism during induced antiimplantation by (+)gossypol. | 1984 | Indian J. Exp. Biol. | pmid:6510968 |
Hoffer AP and Lisser SP | Recovery of normal testicular ultrastructure and sperm motility after cessation of gossypol treatment in rats. | 1984 Nov-Dec | J. Androl. | pmid:6511655 |
Kim I and Waller DP | Specific inhibition of the testicular mitochondrial respiratory chain in vitro by gossypol. | 1984 Nov-Dec | J. Androl. | pmid:6511656 |
Alarcón B et al. | Screening for new compounds with antiherpes activity. | 1984 | Antiviral Res. | pmid:6517562 |
Tanphaichitr N et al. | Direct effect of gossypol on TR-ST cells: perturbation of rhodamine 123 accumulation in mitochondria. | 1984 | Biol. Reprod. | pmid:6518226 |
Steiner M et al. | In vivo study of LDH isoenzyme activities in heart, liver and testis cytosols of gossypol-treated rats. | 1984 | Int. J. Androl. | pmid:6526516 |
Gu ZW et al. | Studies on fertility control-the formation and antifertility effect of polyvinyl-pyrolidone-gossypol complex. | 1984 | Biomater Med Devices Artif Organs | pmid:6532483 |
Engler SJ et al. | Absence of histopathology in somatic tissues of rats made infertile with gossypol. | 1984 | Arch. Androl. | pmid:6534283 |
Zhu PD | [Electron microscopic observations on the effect of gossypol on the human endometrium]. | 1984 | Zhonghua Fu Chan Ke Za Zhi | pmid:6536444 |
Bhargava SK | Semen characteristics of gossypol-treated langurs (Presbytis entellus entellus Dufresne). | 1984 | Arch. Androl. | pmid:6537746 |
Zhang ZR et al. | [High performance liquid chromatography of gossypol]. | 1984 | Yao Xue Xue Bao | pmid:6544029 |
Wang NG et al. | [Effect of gossypol acetic acid on early pregnancy in rats]. | 1984 | Yao Xue Xue Bao | pmid:6544547 |
Wang NG et al. | [Effects of (-) and (+) gossypol on the fertility of male rats]. | 1984 | Yao Xue Xue Bao | pmid:6544566 |
Admasu A and Chandravanshi BS | Spectrophotometric determination of total gossypol in cottonseeds and cottonseed meals. | 1984 | Anal. Chem. | pmid:6546479 |
Tuszynski GP and Cossu G | Differential cytotoxic effect of gossypol on human melanoma, colon carcinoma, and other tissue culture cell lines. | 1984 | Cancer Res. | pmid:6581864 |
Haspel HC et al. | Cytocidal effect of gossypol on cultured murine erythroleukemia cells is prevented by serum protein. | 1984 | J. Pharmacol. Exp. Ther. | pmid:6584595 |
Penningroth SM | Pharmacological basis of therapeutics: gossypol, an oral male contraceptive? | 1984 | J Med Soc N J | pmid:6592366 |
Tvermyr SM et al. | Glucose metabolism in rat germ cells: mechanism of action of gossypol. | 1984 | Ann. N. Y. Acad. Sci. | pmid:6598341 |
Olgiati KL and Toscano WA | Kinetics of gossypol inhibition of bovine lactate dehydrogenase X. | 1983 | Biochem. Biophys. Res. Commun. | pmid:6615526 |
Waller DP et al. | Effect of (+)-gossypol on fertility in male hamsters. | 1983 Jul-Aug | J. Androl. | pmid:6618998 |
Huang GZ et al. | [Etiological study of the burning sensation disease]. | 1983 | Acta Acad Med Wuhan | pmid:6621973 |
Xue SP et al. | Subcellular site of antispermatogenic effect of gossypol and its possible molecular mechanism of action. | 1983 | Sci. Sin., Ser. B, Chem. Biol. Agric. Med. Earth Sci. | pmid:6623054 |
Kalla NR et al. | Effect of gossypol on testicular testosterone production in vitro. | 1983 Sep-Oct | J. Androl. | pmid:6630052 |
Stephens DT et al. | Mechanism of inhibition by gossypol of glycolysis and motility of monkey spermatozoa in vitro. | 1983 | J. Reprod. Fertil. | pmid:6631812 |
Lei HP | [Prospect of gossypol as a contraceptive agents for men]. | 1983 | Yao Xue Xue Bao | pmid:6637482 |
Shi QX and Friend DS | Gossypol-induced inhibition of guinea pig sperm capacitation in vitro. | 1983 | Biol. Reprod. | pmid:6640034 |
Manmade A et al. | Gossypol. Synthesis and in vitro spermicidal activity of isomeric hemigossypol derivatives. | 1983 | Experientia | pmid:6641903 |
Ratsula K et al. | Vaginal contraception with gossypol: a clinical study. | 1983 | Contraception | pmid:6684533 |
Zhuang LZ et al. | Effects of gossypol on rat Sertoli and Leydig cells in primary culture and established cell lines. | 1983 Sep-Oct | J. Androl. | pmid:6685120 |
Wong SM et al. | 14C-gossypol: optimum conditions for synthesis by cotton seedlings. | 1983 | Yao Xue Xue Bao | pmid:6687973 |
El-Nahry FI et al. | Detoxification and nutritional evaluation of solvent extracted Egyptian cottonseed meal. | 1983 | Nahrung | pmid:6688656 |
Herrera J et al. | Cottonseed flour effects on androgen testicular content and serum levels in rats. | 1983 | Arch. Androl. | pmid:6688944 |
Wang Y and Rao PN | Effect of gossypol on DNA synthesis and cell cycle progression of mammalian cells in vitro. | 1984 | Cancer Res. | pmid:6690046 |
Hunt S and Mittwoch U | Effects of gossypol on sperm counts in two inbred strains of mice. | 1984 | J. Reprod. Fertil. | pmid:6694149 |
Floridi A et al. | The effect of gossypol and Lonidamine on electron transport in Ehrlich ascites tumor mitochondria. | 1984 | Exp. Mol. Pathol. | pmid:6705894 |
Marcelle GB et al. | Analysis of gossypol and gossypol-acetic acid by high-performance liquid chromatography. | 1984 | J Pharm Sci | pmid:6716251 |
Nordenskjöld M and Lambert B | Gossypol induces DNA strand breaks in human fibroblasts and sister chromatid exchanges in human lymphocytes in vitro. | 1984 | J. Med. Genet. | pmid:6716412 |
Tang F and Wong PY | Serum potassium and aldosterone levels in gossypol-treated rats. | 1984 | Int. J. Androl. | pmid:6724725 |
Sattayasai N et al. | High-performance liquid chromatographic determination of gossypol in plasma. | 1984 | J. Chromatogr. | pmid:6725489 |
Wang JM et al. | Effect of gossypol on testicular blood flow and testosterone production in rats. | 1984 | J. Reprod. Fertil. | pmid:6726673 |
Demoulin A | [Male contraception]. | 1984 | Rev Med Liege | pmid:6729295 |
Olgiati KL et al. | Gossypol inhibition of adenylate cyclase. | 1984 | Arch. Biochem. Biophys. | pmid:6732240 |
Hoffer AP and Hinton BT | Morphological evidence for a blood-epididymis barrier and the effects of gossypol on its integrity. | 1984 | Biol. Reprod. | pmid:6733204 |
Oko R and Hrudka F | Comparison of the effects of gossypol, estradiol-17 beta and testosterone compensation on male rat reproductive organs. | 1984 | Biol. Reprod. | pmid:6733210 |
Whaley KJ et al. | A circular dichroism study of (+) gossypol binding to proteins. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6743322 |
Wong PY et al. | Gossypol does not affect testicular fluid secretion in rats. | 1984 | Contraception | pmid:6744863 |
Reyes J et al. | Molecular mechanisms of gossypol action on lipid membranes. | 1984 | J. Biol. Chem. | pmid:6746663 |
Montamat EE et al. | Inhibitory action of gossypol on enzymes and growth of Trypanosoma cruzi. | 1982 | Science | pmid:6750791 |
Harper MJ | Fertility control. | 1982 Oct-Dec | Med Res Rev | pmid:6757597 |