Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Sipkema P et al. | Does the endothelium play a role in flow-dependent constriction? A study in the isolated rabbit femoral artery. | 1989 | Blood Vessels | pmid:2641926 |
pmid:26460165 | ||||
pmid:26476415 | ||||
Stein MN et al. | A Phase II Study of AT-101 to Overcome Bcl-2--Mediated Resistance to Androgen Deprivation Therapy in Patients With Newly Diagnosed Castration-Sensitive Metastatic Prostate Cancer. | 2016 | Clin Genitourin Cancer | pmid:26476589 |
Zhao GX et al. | The BH3-mimetic gossypol and noncytotoxic doses of valproic acid induce apoptosis by suppressing cyclin-A2/Akt/FOXO3a signaling. | 2015 | Oncotarget | pmid:26517515 |
pmid:26531719 | ||||
Wu Y et al. | Influence of gossypol acetic acid on the growth of human adenoid cystic carcinoma ACC-M cells and the expression of DNA methyltransferase 1. | 2015 | Genet. Mol. Res. | pmid:26535659 |
Gong Y et al. | Valproic Acid Enhances the Anti-tumor Effect of (-)-gossypol to Burkitt Lymphoma Namalwa Cells. | 2015 | Biomed. Environ. Sci. | pmid:26582100 |
Câmara AC et al. | Toxicity of Gossypol from Cottonseed Cake to Sheep Ovarian Follicles. | 2015 | PLoS ONE | pmid:26600470 |
Morgan SE | Gossypol as a toxicant in livestock. | 1989 | Vet. Clin. North Am. Food Anim. Pract. | pmid:2667706 |
pmid:26709042 | ||||
pmid:26715260 | ||||
Antonietti P et al. | AT-101 simultaneously triggers apoptosis and a cytoprotective type of autophagy irrespective of expression levels and the subcellular localization of Bcl-xL and Bcl-2 in MCF7 cells. | 2016 | Biochim. Biophys. Acta | pmid:26721623 |
pmid:26725485 | ||||
Zhang J et al. | Breeding Potential of Introgression Lines Developed from Interspecific Crossing between Upland Cotton (Gossypium hirsutum) and Gossypium barbadense: Heterosis, Combining Ability and Genetic Effects. | 2016 | PLoS ONE | pmid:26730964 |
pmid:26765310 | ||||
Ma D et al. | Genetic basis for glandular trichome formation in cotton. | 2016 | Nat Commun | pmid:26795254 |
pmid:26803304 | ||||
Wu D | An overview of the clinical pharmacology and therapeutic potential of gossypol as a male contraceptive agent and in gynaecological disease. | 1989 | Drugs | pmid:2680434 |
Grankvist K | Gossypol-induced free radical toxicity to isolated islet cells. | 1989 | Int. J. Biochem. | pmid:2684701 |
pmid:26873292 | ||||
pmid:26883980 | ||||
pmid:27005728 | ||||
pmid:27016043 | ||||
pmid:27071859 | ||||
pmid:27074577 | ||||
pmid:27098313 | ||||
Abou-Donia MB et al. | Interspecies comparison of pharmacokinetic profile and bioavailability of (+/-)-gossypol in male Fischer-344 rats and male B6C3F mice. | 1989 | Toxicology | pmid:2711405 |
pmid:27128796 | ||||
pmid:27144437 | ||||
Wang JM et al. | The entry of gossypol across the blood-testis barrier in rats. | 1989 | Contraception | pmid:2721201 |
pmid:27225873 | ||||
Zubair H et al. | Mobilization of Intracellular Copper by Gossypol and Apogossypolone Leads to Reactive Oxygen Species-Mediated Cell Death: Putative Anticancer Mechanism. | 2016 | Int J Mol Sci | pmid:27331811 |
Wu YW et al. | An in vitro and in vivo study of antitumor effects of gossypol on human SW-13 adrenocortical carcinoma. | 1989 | Cancer Res. | pmid:2736516 |
pmid:27384481 | ||||
Zhao R et al. | AT-101 enhances gefitinib sensitivity in non-small cell lung cancer with EGFR T790M mutations. | 2016 | BMC Cancer | pmid:27431492 |
Tanphaichitr N and Fitzgerald LM | Incorporation of gossypol and formation of its protein conjugates in mouse transformed Sertoli (TM4) cells. | 1989 May-Jun | J. Androl. | pmid:2745232 |
pmid:27469129 | ||||
Druez D et al. | Effect of gossypol on the morphology, motility and metabolism of a flagellated protist, Dunaliella bioculata. | 1989 | J. Submicrosc. Cytol. Pathol. | pmid:2752364 |
Tanphaichitr N and Fitzgerald LM | Adverse effects of gossypol analogs on TM4 cell mitochondrial function. | 1989 | Contraception | pmid:2752754 |
Tanphaichitr N et al. | Inhibitory effects of gossypol analogs on human sperm motility. | 1989 | Contraception | pmid:2752755 |
Zhang SF et al. | Biological activity in the repopulating rat spermatocyte after the withdrawal of gossypol treatment: I. The activity for DNA synthesis. | 1989 | Contraception | pmid:2758843 |
Ye BK et al. | Biological activity in the repopulating rat spermatocyte after the withdrawal of gossypol treatment: II. The activity for the synthesis of cellular and nuclear basic proteins. | 1989 | Contraception | pmid:2758844 |
Rikihisa Y and Lin YC | Effect of gossypol on the thyroid in young rats. | 1989 | J. Comp. Pathol. | pmid:2760274 |
Soufir JC et al. | Gossypol-induced modifications in the microenvironment of rat epididymal spermatozoa. | 1989 | J. Reprod. Fertil. | pmid:2760873 |
pmid:27670669 | ||||
pmid:27673746 | ||||
pmid:27687846 | ||||
Haschek WM et al. | Cottonseed meal (gossypol) toxicosis in a swine herd. | 1989 | J. Am. Vet. Med. Assoc. | pmid:2777708 |
pmid:27777286 |