Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
---|
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Gossypol--a new antifertility agent for males. | 1979 | Gynecol. Obstet. Invest. | pmid:393575 | |
Colman N et al. | Non-mutagenicity of gossypol in the Salmonella/mammalian-microsome plate assay. | 1979 | Environ Mutagen | pmid:399915 |
Qian SZ et al. | [The potassium-depleting effect of gossypol on isolated rabbit heart and it's possible mechanism (author's transl)]. | 1979 | Yao Xue Xue Bao | pmid:506710 |
Lindsey TO et al. | Physiological responses of lactating cows to gossypol from cottonseed meal rations. | 1980 | J. Dairy Sci. | pmid:7189761 |
Chang MC et al. | Effects of Gossypol on the fertility of male rats, hamsters and rabbits. | 1980 | Contraception | pmid:7428357 |
Shepu X et al. | Antispermatogenic effect of gossypol on the germinal epithelium of the rat testes. A cytological, autoradiographical and ultrastructural observation. | 1980 | Sci. Sin. | pmid:7403840 |
Muratov MM et al. | [Hygienic evaluation of acetate fabric dyed with technical grade gossypol]. | 1980 | Gig Sanit | pmid:7372107 |
Abidov MM et al. | [Effect of the immunodepressive preparation, batriden, on the course of experimental allergic dermatitis]. | 1980 | Vestn Dermatol Venerol | pmid:7376717 |
Coulson PB et al. | Short term metabolic effects of the anti-fertility agent, gossypol, on various reproductive organs of male mice. | 1980 | Int. J. Androl. | pmid:7440012 |
Cheng KF et al. | Endometrial changes after administration of gossypol for menorrhagia. | 1980 | Am. J. Obstet. Gynecol. | pmid:7446637 |
Waller DP et al. | In vitjro spermicidal activity of gossypol. | 1980 | Contraception | pmid:7449381 |
Sang GW et al. | [Chronic toxicity of gossypol and the relationship to its metabolic fate in dogs and monkeys (author's transl)]. | 1980 | Zhongguo Yao Li Xue Bao | pmid:6461173 |
Han HL | [Gossypol treatment for menopausal functional bleeding, myoma of uterus and endometriosis--preliminary report (author's transl)]. | 1980 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:6451316 |
Pösö H et al. | Gossypol, a powerful inhibitor of human spermatozoal metabolism. | 1980 | Lancet | pmid:6103251 |
Gossypol as an oral contraceptive for men. | 1980 | J Med Soc N J | pmid:6928215 | |
Qian SZ et al. | Gossypol related hypokalemia. Clinicopharmacologic studies. | 1980 | Chin. Med. J. | pmid:6772395 |
Tang XC et al. | [Comparative studies on the absorption, distribution and excretion of 14C-gossypol in four species of animals (author's transl)]. | 1980 | Yao Xue Xue Bao | pmid:6779501 |
Labzo SS et al. | [Stimulation of interferon formation by natural and synthetic inducers in cultures of human tonsil cells]. | 1980 Jan-Feb | Vopr. Virusol. | pmid:6158181 |
Vagabov RM et al. | [Comparative study of the effectiveness of the interferon inducers, poly(I) : poly(C) and GSS (gossypol-beta-aminoethylsodium sulfate), in combination with a specific vaccine in experimental infection with the human acute encephalomyelitis virus]. | 1980 May-Jun | Vopr. Virusol. | pmid:7434726 |
Wen W | China invents male birth control pill. | 1980 Spring-Summer | Am. J. Chin. Med. | pmid:7395797 |
Maugh TH | Male "pill" blocks sperm enzyme. | 1981 | Science | pmid:7193910 |
Lin T et al. | Gossypol inhibits testicular steroidogenesis. | 1981 | Fertil. Steril. | pmid:7194804 |
Jacobs HS | Contraception in the future. | 1981 | Proc Annu Symp Eugen Soc | pmid:7050975 |
Ye YX et al. | [The effect of gossypol on the incorporation of H3-thymidine in the liver, testis and small intestine of experimental animals (author's transl)]. | 1981 | Yao Xue Xue Bao | pmid:7246187 |
Tso WW and Lee CS | Effect of gossypol on boar spermatozoa in vitro. | 1981 | Arch. Androl. | pmid:7271366 |
Bozek SA et al. | Scanning electron microscopic study of spermatozoa from gossypol-treated rats. | 1981 | Cell Tissue Res. | pmid:7273120 |
Hahn DW et al. | Antifertility and endocrine activities of gossypol in rodents. | 1981 | Contraception | pmid:7273769 |
Waller DP et al. | Antifertility effects of gossypol and its impurities on male hamsters. | 1981 | Contraception | pmid:7285581 |
Sakesena SK et al. | Gossypol: its toxicological and endocrinological effects in male rabbits. | 1981 | Contraception | pmid:7297071 |
Lawrence SV | Gossypol: a potential male contraceptive? | 1981 | Am Pharm | pmid:7304423 |
Tso WW and Lee CS | Variations of gossypol sensitivity in boar spermatozoal electron transport chain segments. | 1981 | Contraception | pmid:7318437 |
Liu YX | [The effect of gossypol acetate on the content of the sex steroid hormone in endometrium (author's transl)]. | 1981 | Zhonghua Fu Chan Ke Za Zhi | pmid:7327032 |
[A preliminary study on gossypol used in gynecology and its mechanism of action (author's transl)]. | 1981 | Zhonghua Fu Chan Ke Za Zhi | pmid:7327033 | |
Zhou SW | [Clinical use of gossypol in gynecology (author's transl)]. | 1981 | Zhonghua Fu Chan Ke Za Zhi | pmid:7327034 |
El-Sebae AH et al. | Gossypol as an inducer or inhibitor in Spodoptera littoralis larvae. | 1981 | J Environ Sci Health B | pmid:6454717 |
Liang DC et al. | [Studies on distribution of 14C-gossypol in subcellular fractions of rat testes and site of gossypol action (author's transl)]. | 1981 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:6459173 |
Bi XF et al. | [Preliminary study on gossypol in causing hypokalemia (author's transl)]. | 1981 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:6459178 |
Shi QX et al. | [Analysis on exfoliated cells in human semen after oral administrations of gossypol acetic acid (author's transl)]. | 1981 | Zhongguo Yao Li Xue Bao | pmid:6462027 |
Bi XF et al. | The effect of gossypol on ATPase activity of the kidney. | 1981 | Sci. Sin. | pmid:6266011 |
Ridley AJ and Blasco L | Testosterone and gossypol effects on human sperm motility. | 1981 | Fertil. Steril. | pmid:6273239 |
Wu YM et al. | Effects of gossypol on pituitary-ovarian endocrine function, ovulation and fertility in female hamsters. | 1981 | Contraception | pmid:6796329 |
Hei LS | [Electron-microscopic observations on bioptic testicular tissue of cancerous patients after oral administration of gossypol (author's transl)]. | 1981 | Zhonghua Yi Xue Za Zhi | pmid:6804060 |
El'chits SV et al. | [Glucoamylase immobilization on silochrome using gossypol]. | 1981 Jan-Feb | Ukr. Biokhim. Zh. | pmid:6259793 |
Liu GZ | Clinical study of gossypol as a male contraceptive. | 1981 Jul-Sep | Reproduccion | pmid:6793420 |
Kalla NR and Vasudev M | Studies on the male antifertility agent-gossypol acetic acid. II. Effect of gossypol acetic acid on the motility and ATPase activity of human spermatozoa. | 1981 Mar-Apr | Andrologia | pmid:6454365 |
Kalla NR et al. | Studies on the male antifertility agent--gossypol acetic acid. III. Effect of gossypol acetic acid on rat testis. | 1981 May-Jun | Andrologia | pmid:6455943 |
Cameron SM et al. | Vaginal spermicidal activity of gossypol in the Macaca arctoides. | 1982 | Fertil. Steril. | pmid:7060775 |
Oko R and Hrudka F | Segmental aplasia of the mitochondrial sheath and sequelae induced by gossypol in rat spermatozoa. | 1982 | Biol. Reprod. | pmid:7066454 |
Jiang DH and Xue H | [Monoanilinogossypol--the impurity possibly present in gossypol (author's transl)]. | 1982 | Yao Xue Xue Bao | pmid:7102321 |
Tso WW and Lee CS | Lactate dehydrogenase-X: an isozyme particularly sensitive to gossypol inhibition. | 1982 | Int. J. Androl. | pmid:7107034 |
Hoffer AP | Ultrastructural studies of spermatozoa and the epithelial lining of the epididymis and vas deferens in rats treated with gossypol. | 1982 | Arch. Androl. | pmid:7114955 |
Shandilya L et al. | Effects of gossypol on reproductive and endocrine functions of male cynomolgus monkeys (Macaca fascicularis). | 1982 | Biol. Reprod. | pmid:7115850 |
Tso WW and Lee CS | Potassium leakage: not the cause of gossypol induced anti-motility in spermatozoa. | 1982 | Int. J. Androl. | pmid:7118270 |
Saksena SK and Salmonsen RA | Antifertility effects of gossypol in male hamsters. | 1982 | Fertil. Steril. | pmid:7075801 |
Jensen DR et al. | Deposition pattern of the antifertility agent, gossypol, in selected organs of male rats. | 1982 | Toxicology | pmid:7135404 |
Zhou LF et al. | [Further observations on the effect of prolonged administration of gossypol acetic acid to rats]. | 1982 | Yao Xue Xue Bao | pmid:7136708 |
Lee CY et al. | Enzyme inactivation and inhibition by gossypol. | 1982 | Mol. Cell. Biochem. | pmid:7144742 |
Tang F et al. | Inhibition of catechol-O-methyltransferase by gossypol: the effect of plasma proteins. | 1982 | Contraception | pmid:7160182 |
Giridharan N et al. | Inhibition of rat testis LDH-X activity by gossypol. | 1982 | Contraception | pmid:7168954 |
Majumdar SK et al. | Gossypol--an effective male contraceptive was not mutagenic in sperm head abnormality assay in mice. | 1982 | Can. J. Genet. Cytol. | pmid:7182060 |
Lei HP | [Review and prospect of gossypol research (author's transl)]. | 1982 | Yao Xue Xue Bao | pmid:7090820 |
Chang CC et al. | Studies on gossypol. I. Toxicity, antifertility, and endocrine analyses in male rats. | 1982 | Int. J. Fertil. | pmid:6131039 |
Ke YB and Tso WW | Variations of gossypol susceptibility in rat spermatozoa during spermatogenesis. | 1982 | Int. J. Fertil. | pmid:6122656 |
Tso WW and Lee CS | Gossypol uncoupling of respiratory chain and oxidative phosphorylation in ejaculated boar spermatozoa. | 1982 | Contraception | pmid:6889482 |
Allamiiarova SA and Abidov MM | [Effect of the immunosuppressive agent batridene on contact allergic dermatitis induced by 2,4-dinitrochlorobenzene]. | 1982 | Vestn Dermatol Venerol | pmid:6979837 |
Wang WH | [Antagonistic effect of Smilax sp. on gossypol toxicity (author's transl)]. | 1982 | Zhong Yao Tong Bao | pmid:6212150 |
Shandilya LN and Clarkson TB | Hypolipidemic effects of gossypol in cynomolgus monkeys (Macaca fascicularis). | 1982 | Lipids | pmid:6952061 |
Sun YB et al. | [Effect of gossypol on potassium excretion of male rats]. | 1982 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:6216008 |
Tso WW and Lee CS | Cottonseed oil as a vaginal contraceptive. | 1982 | Arch. Androl. | pmid:6895984 |
Tong SM et al. | Human antifertility effect of gossypol cytologic observation of semen. | 1982 | Chin. Med. J. | pmid:6216077 |
Sotelo A et al. | Infertility in male rats induced by diets containing whole cottonseed flour. | 1982 | J. Nutr. | pmid:6897076 |
Tso WW et al. | Effect of gossypol on boar spermatozoal adenosine triphosphate metabolism. | 1982 | Arch. Androl. | pmid:6219642 |
Han ML | [Clinical observation of the gossypol treatment of endometriosis and uterine myoma and the location of the pharmacological action]. | 1982 | Zhong Xi Yi Jie He Za Zhi | pmid:6219819 |
Wichmann K et al. | Inhibiting herpes simplex virus type 2 infection in human epithelial cells by gossypol, a potent spermicidal and contraceptive agent. | 1982 | Am. J. Obstet. Gynecol. | pmid:6277198 |
Shu HD et al. | [Effects of gossypol acetate on neuromuscular transmission (author's transl)]. | 1982 | Zhongguo Yao Li Xue Bao | pmid:6283787 |
Male fertility and its regulation: expanded abstracts. International symposium, Maui, Hawaii, October 9-15, 1982. | 1982 | Arch. Androl. | pmid:6812518 | |
Hoshiai H et al. | Gossypol as oral contraceptive for male: trial case report. | 1982 | Tohoku J. Exp. Med. | pmid:6818716 |
Tso WW and Lee CS | Gossypol: an effective acrosin blocker. | 1982 | Arch. Androl. | pmid:6803693 |
Montamat EE et al. | Inhibitory action of gossypol on enzymes and growth of Trypanosoma cruzi. | 1982 | Science | pmid:6750791 |
Johnsen O et al. | Gossypol; a potent inhibitor of human sperm acrosomal proteinase. | 1982 | Int. J. Androl. | pmid:6761275 |
Majumdar SK et al. | Mutagenic evaluation of two male contraceptives: 5-thio-d-glucose and gossypol acetic acid. | 1982 Jan-Feb | J. Hered. | pmid:7040540 |
Jackson H and Schnieden H | Aspects of male reproductive pharmacology and toxicology. | 1982 Jan-Mar | Rev Pure Appl Pharmacol Sci | pmid:6291102 |
Weinbauer GF et al. | Antifertility efficacy of gossypol acetic acid in male rats. | 1982 May-Jun | Andrologia | pmid:7114507 |
Kalla NR et al. | Studies on the male antifertility agent--gossypol acetic acid. V. Effect of gossypol acetic acid on the fertility of male rats. | 1982 Nov-Dec | Andrologia | pmid:7165122 |
Harper MJ | Fertility control. | 1982 Oct-Dec | Med Res Rev | pmid:6757597 |
Moshchik KV et al. | [Treatment of genital herpes with levamisole in combination with megasine]. | 1982 Sep-Oct | Vopr. Virusol. | pmid:7147912 |
Huang TH | [The effect of gossypol acetate on the function of rRNA gene and acrocentric chromosome association in human cells]. | 1983 | Zhonghua Yi Xue Za Zhi | pmid:6407739 |
Olgiati KL and Toscano WA | Kinetics of gossypol inhibition of bovine lactate dehydrogenase X. | 1983 | Biochem. Biophys. Res. Commun. | pmid:6615526 |
Huang GZ et al. | [Etiological study of the burning sensation disease]. | 1983 | Acta Acad Med Wuhan | pmid:6621973 |
Xue SP et al. | Subcellular site of antispermatogenic effect of gossypol and its possible molecular mechanism of action. | 1983 | Sci. Sin., Ser. B, Chem. Biol. Agric. Med. Earth Sci. | pmid:6623054 |
Ratsula K et al. | Vaginal contraception with gossypol: a clinical study. | 1983 | Contraception | pmid:6684533 |
Wong SM et al. | 14C-gossypol: optimum conditions for synthesis by cotton seedlings. | 1983 | Yao Xue Xue Bao | pmid:6687973 |
El-Nahry FI et al. | Detoxification and nutritional evaluation of solvent extracted Egyptian cottonseed meal. | 1983 | Nahrung | pmid:6688656 |
Herrera J et al. | Cottonseed flour effects on androgen testicular content and serum levels in rats. | 1983 | Arch. Androl. | pmid:6688944 |
Stephens DT et al. | Mechanism of inhibition by gossypol of glycolysis and motility of monkey spermatozoa in vitro. | 1983 | J. Reprod. Fertil. | pmid:6631812 |
Gu ZP et al. | Morphological changes in the testes and epididymides of rats after gossypol. | 1983 | Zhongguo Yao Li Xue Bao | pmid:6223497 |
Xu Y et al. | [Antagonism of antifertility effect of gossypol by aspirin]. | 1983 | Zhongguo Yao Li Xue Bao | pmid:6225300 |
Qian SZ et al. | Antispermatogenic activity of gossypol in rats on low-potassium diet. | 1983 | Zhongguo Yao Li Xue Bao | pmid:6228118 |
Eliasson R and Virji N | Effects of gossypol acetic acid on the activity of LDH-C4 from human and rabbit spermatozoa. | 1983 | Int. J. Androl. | pmid:6840877 |
Tsui YC et al. | The effect of the male contraceptive agent Gossypol on human lymphocytes in vitro: traditional chromosome breakage, micronuclei, sister chromatid exchange, and cell kinetics. | 1983 | J. Med. Genet. | pmid:6842561 |