| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Cattle Diseases | D002418 | 24 associated lipids |
| Infertility, Male | D007248 | 11 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Testicular Diseases | D013733 | 15 associated lipids |
| Lymphoma, Large B-Cell, Diffuse | D016403 | 13 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Abnormalities, Drug-Induced | D000014 | 10 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Leukemia P388 | D007941 | 43 associated lipids |
Gossypol
Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
Cross Reference
Introduction
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Gossypol?
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Mol. Cancer Ther. (4)
- Proc. Natl. Acad. Sci. U.S.A. (3)
- Am. J. Physiol. Lung Cell Mol. Physiol. (2)
- Others (13)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Gossypol
PubChem Associated disorders and diseases
What pathways are associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Gossypol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Gossypol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Gossypol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Gossypol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Gossypol?
Xenograft Model
Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Gossypol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Su SY and Liu Y | Electron microscopic observation of gossypol effects on gastrocnemius muscles in laboratory animals. | 1987 | Proc Chin Acad Med Sci Peking Union Med Coll | pmid:2827153 |
| Baram N et al. | Inactivation of intestinal brush-border enzymes by gossypol. | 1987 | Agric. Biol. Chem. | pmid:12283503 |
| Bassenge E et al. | Abluminal release and asymmetrical response of the rabbit arterial wall to endothelium-derived relaxing factor. | 1987 | Circ. Res. | pmid:3117407 |
| Cooke E et al. | Diacylglycerol kinase inhibitor, R59022, potentiates neutrophil oxidase activation by Ca2+-dependent stimuli. Evidence for two separate but convergent pathways. | 1987 | Biochem. Pharmacol. | pmid:2823820 |
| Lin YC et al. | Effect of gossypol on spermatozoal lactate dehydrogenase-X (LDH-X) in male rats. | 1987 | Contraception | pmid:3447817 |
| Zhou RH and Lin XD | [Isolation of (-)-gossypol from natural plant]. | 1987 | Yao Xue Xue Bao | pmid:3450165 |
| Xu Y et al. | [The effect of combined use of gossypol and tripterygium wilfordii on the fertility of male rats]. | 1987 | Yao Xue Xue Bao | pmid:3452960 |
| Dhaliwal MK et al. | Cytogenetic analysis of a gossypol-induced murine myxosarcoma. | 1987 | J. Natl. Cancer Inst. | pmid:3473256 |
| Baccetti B et al. | Action of gossypol on rat germinal cells. II. The acrosome. | 1987 | Gamete Res | pmid:3506897 |
| Kim I et al. | Inhibition of lactate dehydrogenase-X by imino-derivatives of gossypol:structure activity relationship. | 1987 | Contraception | pmid:3608484 |
| Srivastava AK and Padmanaban G | Gossypol mediated DNA degradation. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3619941 |
| Sinha Hikim AP and Hoffer AP | Quantitative analysis of germ cells and Leydig cells in rat made infertile with gossypol. | 1987 | Contraception | pmid:3621939 |
| Etindi RN and Rillema JA | Effect of kinase C inhibitor, gossypol, on the actions of prolactin in cultured mouse mammary tissues. | 1987 | Biochim. Biophys. Acta | pmid:2434140 |
| Mülsch A et al. | Stimulation of soluble guanylate cyclase by endothelium-derived relaxing factor from cultured endothelial cells. | 1987 | Eur. J. Pharmacol. | pmid:2884122 |
| BelokrinitskiÄ DV et al. | [Indices of the immune status of recurrent herpes patients being treated with a herpes polyvaccine]. | 1987 Mar-Apr | Vopr. Virusol. | pmid:3037800 |
| Fu YF et al. | Effects of gossypol on the activity of kidney (Na+ + K+)-ATPase and the functions of erythrocyte membrane. | 1988 | Contraception | pmid:2836126 |
| White IG et al. | Studies of the mechanism of action of gossypol as a male antifertility agent. | 1988 | Contraception | pmid:2836127 |
| Meng GD et al. | Follow-up of men in the recovery period immediately after the cessation of gossypol treatment. | 1988 | Contraception | pmid:3131064 |
| Ruppel A and Shi YE | Schistosoma mansoni: effect of gossypol on infections in mice. | 1988 | Trop. Med. Parasitol. | pmid:3140355 |
| Zhong CQ | [Studies on sperm function in man long after cessation of gossypol administration]. | 1988 | Shengzhi Yu Biyun | pmid:12315492 |
| Den Boer PJ and Grootegoed JA | Differential effects of (+)- and (-)-gossypol enantiomers on LDH-C4 activity of hamster spermatogenic epithelium in vitro. | 1988 | J. Reprod. Fertil. | pmid:3411560 |
| Janero DR and Burghardt B | Protection of rat myocardial phospholipid against peroxidative injury through superoxide-(xanthine oxidase)-dependent, iron-promoted Fenton chemistry by the male contraceptive gossypol. | 1988 | Biochem. Pharmacol. | pmid:2840914 |
| Drayer DE and Reidenberg MM | Gossypol and Na+, K+ ATPase from human erythrocytes. | 1988 | Contraception | pmid:2848657 |
| Benz C et al. | Selective toxicity of gossypol against epithelial tumors and its detection by magnetic resonance spectroscopy. | 1988 | Contraception | pmid:3370994 |
| Matlin SA et al. | Large-scale resolution of gossypol enantiomers for biological evaluation. | 1988 | Contraception | pmid:3370995 |
| Zhou RH and Lin XD | Isolation of (-)-gossypol from natural plant. | 1988 | Contraception | pmid:3370996 |
| Sonenberg M et al. | Anti-fertility and other actions of gossypol analogues. | 1988 | Contraception | pmid:3370997 |
| Stumpf WE et al. | Sites of action of gossypol studied by autoradiography and enzyme histochemistry. | 1988 | Contraception | pmid:3370998 |
| Fei RR and Teng CS | The effects of gossypol on nuclear protein in rat testes. I. Reduction in the content of basic proteins in the spermiogenic cells. | 1988 | Contraception | pmid:3370999 |
| Teng CS and Fei RR | The effects of gossypol on nuclear protein in rat testes. II. The synthesis of histones and testis-specific proteins after gossypol treatment. | 1988 | Contraception | pmid:3371000 |
| Hoffer AP et al. | Antifertility, spermicidal and ultrastructural effects of gossypol and derivatives administered orally and by intratesticular injections. | 1988 | Contraception | pmid:3371001 |
| Morgan S et al. | Clinical, clinicopathologic, pathologic, and toxicologic alterations associated with gossypol toxicosis in feeder lambs. | 1988 | Am. J. Vet. Res. | pmid:3377308 |
| Hudson LM et al. | Gossypol toxicosis in a herd of beef calves. | 1988 | J. Am. Vet. Med. Assoc. | pmid:3391858 |
| Reyes J et al. | A bioenergetic model of gossypol action: effects of gossypol on adult rat spermatogenic cells. | 1988 | Am. J. Physiol. | pmid:3354654 |
| Best RG and McKenzie WH | Variable sister-chromatid exchange response in human lymphocytes exposed in vitro to gossypol acetic acid. | 1988 | Mutat. Res. | pmid:3173390 |
| Meng GD et al. | Recovery of sperm production following the cessation of gossypol treatment: a two-centre study in China. | 1988 | Int. J. Androl. | pmid:3356480 |
| Rikihisa Y and Lin YC | Ultrastructure of the testis and epididymis of Japanese quail (Coturnix coturnix japonica) administered gossypol. | 1988 | Poult. Sci. | pmid:3413024 |
| Bajpai PK and Benghuzzi HA | Ceramic systems for long-term delivery of chemicals and biologicals. | 1988 | J. Biomed. Mater. Res. | pmid:3235459 |
| Den Boer PJ and Grootegoed JA | Mechanism of action of (-)gossypol on ATP production in isolated hamster spermatids. | 1988 | J. Reprod. Fertil. | pmid:3411559 |
| Holmberg CA et al. | Pathological and toxicological studies of calves fed a high concentration cotton seed meal diet. | 1988 | Vet. Pathol. | pmid:3363792 |
| Ye XQ | [Clinical and experimental study of gossypol in the treatment of dysfunctional menorrhagia, endometriosis and fibromyoma of the uterus]. | 1988 | Zhong Xi Yi Jie He Za Zhi | pmid:3191544 |
| Rajpurohit R and Giridharan N | Failure of oral gossypol to inhibit hepatic microsomal and cytosolic drug-metabolising enzymes. | 1988 | Biochem. Pharmacol. | pmid:3202895 |
| Bender HS et al. | A histopathologic study of the effects of gossypol on the female rat. | 1988 | Contraception | pmid:3197423 |
| Dudel C and Förstermann U | Gossypol attenuates selectively the blood pressure lowering effect of endothelium-dependent vasodilators in the rabbit in vivo. | 1988 | Eur. J. Pharmacol. | pmid:2450761 |
| Radigue C et al. | Early effects of gossypol on the testis and epididymis in the rat. | 1988 | Reprod Nutr Dev | pmid:3253903 |
| Bugeja V et al. | Primary mitochondrial activity of gossypol in yeast and mammalian cells. | 1988 | Biochem. Pharmacol. | pmid:2461202 |
| Wong YC and Tam CC | A structural and cytochemical study of the effects of gossypol on the epithelial cells of the guinea-pig seminal vesicle. | 1988 | J. Reprod. Fertil. | pmid:3199385 |
| Kainz V et al. | The effect of gossypol acetic acid on the different stages of the spermatogenic cycle in the rat. | 1988 | Int. J. Androl. | pmid:3215704 |
| Wu YW et al. | [Ultrastructural studies on sodium and potassium ion active transport in the rat epididymis]. | 1988 | Shi Yan Sheng Wu Xue Bao | pmid:2849267 |
| Gonzalez-Garza MT and Said-Fernandez S | Entamoeba histolytica: potent in vitro antiamoebic effect of gossypol. | 1988 | Exp. Parasitol. | pmid:2899518 |