Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Velasquez-Pereira J et al. | Effects of gossypol from cottonseed meal and dietary vitamin E on the reproductive characteristics of superovulated beef heifers. | 2002 | J. Anim. Sci. | pmid:12350026 |
Jones LA and Smith FH | Effect of gossypol on the removal of nitrogen and amino acids from feed in digestion by the rat. | 1977 | J. Anim. Sci. | pmid:576597 |
Clawson AJ et al. | Unextracted cottonseed in diets for monogastric animals. I. The effect of ferrous sulfate and calcium hydroxide in reducing gossypol toxicity. | 1975 | J. Anim. Sci. | pmid:1173579 |
DANKE RJ and TILLMAN AD | EFFECT OF GOSSYPOL AND HEXAHOMOSERINE ON PERFORMANCE OF RATS FED PURIFIED DIETS WITH AND WITHOUT LYSINE. | 1965 | J. Anim. Sci. | pmid:14296177 |
Willard ST et al. | Effects of free gossypol in the diet of pregnant and postpartum Brahman cows on calf development and cow performance. | 1995 | J. Anim. Sci. | pmid:7601784 |
Albrecht JE et al. | Rate of depletion and route of elimination of intravenously injected gossypol in swine. | 1972 | J. Anim. Sci. | pmid:5085300 |
Luginbuhl JM et al. | Effect of level of whole cottonseed on intake, digestibility, and performance of growing male goats fed hay-based diets. | 2000 | J. Anim. Sci. | pmid:10875652 |
Albrecht JE et al. | Effect of initial weight and days on feed on the accumulation of gossypol in pig livers. | 1971 | J. Anim. Sci. | pmid:5546881 |
Buitrago JA et al. | Effects of dietary iron on gossypol accumulation in and elimination from porcine liver. | 1970 | J. Anim. Sci. | pmid:5520345 |
Chan WK et al. | Effects of alpha-tocopherol on metmyoglobin formation and reduction in beef from cattle fed soybean or cottonseed meal diets. | 1998 | J. Anim. Sci. | pmid:9621948 |
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GALLUP WD et al. | Comparative effect on vitamin A metabolism in sheep of urea, soybean oil meal and cottonseed meal as sources of protein. | 1951 | J. Anim. Sci. | pmid:14814051 |
PARHAM AP et al. | The influence of solvent extracted and hydraulic processed cottonseed meals upon performance and level of plasma carotene, vitamin A, and fat in the blood of wintering beef cows. | 1950 | J. Anim. Sci. | pmid:14794574 |
Randel RD et al. | Effects of gossypol and cottonseed products on reproduction of mammals. | 1992 | J. Anim. Sci. | pmid:1526930 |
El-Mokadem MY et al. | Alleviation of reproductive toxicity of gossypol using selenium supplementation in rams. | 2012 | J. Anim. Sci. | pmid:22585803 |
Husby FM and Kroening GH | Energy value of cottonseed meal for swine. | 1971 | J. Anim. Sci. | pmid:5171308 |
Chase CC et al. | Growth and reproductive development in Brahman bulls fed diets containing gossypol. | 1994 | J. Anim. Sci. | pmid:8157529 |
Gray ML et al. | Effects of dietary gossypol consumption on metabolic homeostasis and reproductive endocrine function in beef heifers and cows. | 1993 | J. Anim. Sci. | pmid:8270527 |
Velasquez-Pereira J et al. | Effects on performance, tissue integrity, and metabolism of vitamin E supplementation for beef heifers fed a diet that contains gossypol. | 1998 | J. Anim. Sci. | pmid:9856398 |
Velasquez-Pereira J et al. | Reproductive effects of feeding gossypol and vitamin E to bulls. | 1998 | J. Anim. Sci. | pmid:9856400 |
Blom JH et al. | Reproductive efficiency and maternal-offspring transfer of gossypol in rainbow trout (Oncorhynchus mykiss) fed diets containing cottonseed meal. | 2001 | J. Anim. Sci. | pmid:11424691 |
Price WD et al. | Naturally occurring toxins in feedstuffs: Center for Veterinary Medicine Perspective. | 1993 | J. Anim. Sci. | pmid:8407668 |
RUEGAMER WR and POLING CE | Rat feeding tests with milk obtained from cows fed toxic cottonseed meal. | 1950 | J. Anim. Sci. | pmid:15415370 |
Terry BJ et al. | Inhibition of herpes simplex virus type 1 DNA polymerase by the natural product oosporein. | 1992 | J. Antibiot. | pmid:1556024 |
Turco E et al. | The in vitro effect of gossypol and its interaction with salts on conidial germination and viability of Fusarium oxysporum sp. vasinfectum isolates. | 2007 | J. Appl. Microbiol. | pmid:18045422 |
Yildirim-Aksoy M et al. | In vitro inhibitory effect of gossypol from gossypol-acetic acid, and (+)- and (-)-isomers of gossypol on the growth of Edwardsiella ictaluri. | 2004 | J. Appl. Microbiol. | pmid:15186445 |
Mellon JE et al. | Effects of temperature and medium composition on inhibitory activities of gossypol-related compounds against aflatoxigenic fungi. | 2013 | J. Appl. Microbiol. | pmid:23594138 |
FOSTER JW and WOODRUFF HB | Microbiological aspects of penicillin; cottonseed meal as a substitute for corn steep liquor in penicillin production. | 1946 | J. Bacteriol. | pmid:21064711 |
Wang H et al. | Inhibition of calcineurin by quercetin in vitro and in Jurkat cells. | 2010 | J. Biochem. | pmid:19880376 |
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Zaidi R and Hadi SM | Strand scission in DNA by gossypol and Cu(II): role of Cu(I) and oxygen-free radicals. | 1992 | J. Biochem. Toxicol. | pmid:1293310 |
Heinstein PF et al. | Biosynthesis of gossypol. Incorporation of mevalonate-2-14C and isoprenyl pyrophosphates. | 1970 | J. Biol. Chem. | pmid:4318479 |
Tanksley TD et al. | Inhibition of pepsinogen activation by gossypol. | 1970 | J. Biol. Chem. | pmid:4922043 |
HEINSTEIN PF et al. | Biosynthesis of C-14-labeled gossypol. | 1962 | J. Biol. Chem. | pmid:13906099 |
Song JJ et al. | Evidence for two modes of development of acquired tumor necrosis factor-related apoptosis-inducing ligand resistance. Involvement of Bcl-xL. | 2007 | J. Biol. Chem. | pmid:17110373 |
Wong RC et al. | Studies on the nature of the inhibition by gossypol of the transformation of pepsinogen to pepsin. | 1972 | J. Biol. Chem. | pmid:4551945 |
Finlay TH et al. | Mechanism of the gossypol inactivation of pepsinogen. | 1973 | J. Biol. Chem. | pmid:4718749 |
HOFFPAUIR CL and GUTHRIE JD | The use of aminized and phosphorylated cotton fabrics as ion exchange materials in the preparation of oil seed proteins. | 1949 | J. Biol. Chem. | pmid:18112104 |
Sung B et al. | Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL. | 2010 | J. Biol. Chem. | pmid:20837473 |
Soubeyrand S et al. | Purification of a novel phospholipase A2 from bovine seminal plasma. | 1997 | J. Biol. Chem. | pmid:8995251 |
Baumgrass R et al. | Reversible inhibition of calcineurin by the polyphenolic aldehyde gossypol. | 2001 | J. Biol. Chem. | pmid:11598106 |
Reyes J et al. | Molecular mechanisms of gossypol action on lipid membranes. | 1984 | J. Biol. Chem. | pmid:6746663 |
Gao P et al. | The Bcl-2 homology domain 3 mimetic gossypol induces both Beclin 1-dependent and Beclin 1-independent cytoprotective autophagy in cancer cells. | 2010 | J. Biol. Chem. | pmid:20529838 |
Soderquist RS et al. | Gossypol increases expression of the pro-apoptotic BH3-only protein NOXA through a novel mechanism involving phospholipase A2, cytoplasmic calcium, and endoplasmic reticulum stress. | 2014 | J. Biol. Chem. | pmid:24778183 |
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Hu W et al. | Proapoptotic protein Smac mediates apoptosis in cisplatin-resistant ovarian cancer cells when treated with the anti-tumor agent AT101. | 2012 | J. Biol. Chem. | pmid:22052903 |
Bajpai PK and Benghuzzi HA | Ceramic systems for long-term delivery of chemicals and biologicals. | 1988 | J. Biomed. Mater. Res. | pmid:3235459 |
Cai Y et al. | An optimized gossypol high-performance liquid chromatography assay and its application in evaluation of different gland genotypes of cotton. | 2004 | J. Biosci. | pmid:15286405 |
Kisim A et al. | Pretreatment with AT-101 enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis of breast cancer cells by inducing death receptors 4 and 5 protein levels. | 2012 | J. Cancer Res. Clin. Oncol. | pmid:22411600 |
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