Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Dabrowski K et al. | Effects of diets containing gossypol on reproductive capacity of rainbow trout (Oncorhynchus mykiss). | 2000 | Biol. Reprod. | pmid:10642557 |
Rinchard J et al. | Effects of gossypol on sperm viability and plasma sex steroid hormones in male sea lamprey, Petromyzon marinus. | 2000 | Toxicol. Lett. | pmid:10643862 |
Razakantoanina V et al. | Antimalarial activity of new gossypol derivatives. | 2000 | Parasitol. Res. | pmid:10952267 |
Nagalakshmi D et al. | Pathological lesions in lambs fed raw or processed cottonseed meal. | 2000 | Vet. Res. Commun. | pmid:10868552 |
Luginbuhl JM et al. | Effect of level of whole cottonseed on intake, digestibility, and performance of growing male goats fed hay-based diets. | 2000 | J. Anim. Sci. | pmid:10875652 |
Vander Jagt DL et al. | Gossypol: prototype of inhibitors targeted to dinucleotide folds. | 2000 | Curr. Med. Chem. | pmid:10702620 |
Abe Y et al. | Altered vascular response to acetylcholine in conditions of endothelial damage in the isolated perfused rat stomach. | 2000 | J. Gastroenterol. | pmid:10680663 |
Li AS et al. | DNA-breaking versus DNA-protecting activity of four phenolic compounds in vitro. | 2000 | Free Radic. Res. | pmid:11200088 |
Gu ZP et al. | Low dose gossypol for male contraception. | 2000 | Asian J. Androl. | pmid:11202417 |
Yuan YY and Shi QX | Inhibition of hamster sperm acrosomal enzyme by gossypol is closely associated with the decrease in fertilization capacity. | 2000 | Contraception | pmid:11137075 |
Matsuo M | Preference of female students for "tempe" preparations composed of glandless cottonseed and defatted soybean or corn at various ratios. | 2000 | J. Nutr. Sci. Vitaminol. | pmid:11185660 |
Brandes AA et al. | New drugs in recurrent high grade gliomas. | 2000 May-Jun | Anticancer Res. | pmid:10928126 |
Jiang J et al. | The effects of gossypol on the invasiveness of MAT-LyLu cells and MAT-LyLu cells from the metastasized lungs of MAT-LyLu-bearing Copenhagen rats. | 2000 Nov-Dec | Anticancer Res. | pmid:11205308 |
Yu Y et al. | Selective active site inhibitors of human lactate dehydrogenases A4, B4, and C4. | 2001 | Biochem. Pharmacol. | pmid:11377399 |
Baumgrass R et al. | Reversible inhibition of calcineurin by the polyphenolic aldehyde gossypol. | 2001 | J. Biol. Chem. | pmid:11598106 |
Mena H et al. | The effects of feeding varying amounts of gossypol from whole cottonseed and cottonseed meal in lactating dairy cows. | 2001 | J. Dairy Sci. | pmid:11699455 |
Dando C et al. | The kinetic properties and sensitivities to inhibitors of lactate dehydrogenases (LDH1 and LDH2) from Toxoplasma gondii: comparisons with pLDH from Plasmodium falciparum. | 2001 | Mol. Biochem. Parasitol. | pmid:11704270 |
Final report on the safety assessment of Hydrogenated Cottonseed Oil, Cottonseed (Gossypium) Oil, Cottonseed Acid, Cottonseed Glyceride, and Hydrogenated Cottonseed Glyceride. | 2001 | Int. J. Toxicol. | pmid:11558638 | |
Van Poznak C et al. | Oral gossypol in the treatment of patients with refractory metastatic breast cancer: a phase I/II clinical trial. | 2001 | Breast Cancer Res. Treat. | pmid:11510695 |
Gamboa DA et al. | Tissue distribution of gossypol enantiomers in broilers fed various cottonseed meals. | 2001 | Poult. Sci. | pmid:11469655 |
Poprawski TJ and Jones WJ | Host plant effects on activity of the mitosporic fungi Beauveria bassiana and Paecilomyces fumosoroseus against two populations of Bemisia whiteflies (Homoptera: Aleyrodidae). | 2001 | Mycopathologia | pmid:11502058 |
Kolena J et al. | Gossypol inhibits follicle-stimulating hormone- and epidermal growth factor-stimulated expansion of oocyte-cumulus complexes from porcine preovulatory follicles. | 2001 | Physiol Res | pmid:11829325 |
Dabrowski K et al. | Gossypol isomers bind specifically to blood plasma proteins and spermatozoa of rainbow trout fed diets containing cottonseed meal. | 2001 | Biochim. Biophys. Acta | pmid:11342251 |
Benson CG et al. | Improved method for the rapid determination of terpenoid aldehydes in cotton. | 2001 | J. Agric. Food Chem. | pmid:11368574 |
Blom JH et al. | Reproductive efficiency and maternal-offspring transfer of gossypol in rainbow trout (Oncorhynchus mykiss) fed diets containing cottonseed meal. | 2001 | J. Anim. Sci. | pmid:11424691 |
Henry MH et al. | The performance of broiler chicks fed diets containing extruded cottonseed meal supplemented with lysine. | 2001 | Poult. Sci. | pmid:11441843 |
Gamboa DA et al. | Use of expander cottonseed meal in broiler diets formulated on a digestible amino acid basis. | 2001 | Poult. Sci. | pmid:11441847 |
Nogueda-Torres B et al. | Trypanocidal activity of 4 isopropyl salicylaldehyde and 4-isopropyl salicylic acid on Trypanosoma cruzi. | 2001 Jan-Mar | Rev. Latinoam. Microbiol. | pmid:17061565 |
Henry MH et al. | Pathology and histopathology of gossypol toxicity in broiler chicks. | 2001 Jul-Sep | Avian Dis. | pmid:11569732 |
Velasquez-Pereira J et al. | Effects of gossypol from cottonseed meal and dietary vitamin E on the reproductive characteristics of superovulated beef heifers. | 2002 | J. Anim. Sci. | pmid:12350026 |
Puckhaber LS et al. | Toxicity of (+)- and (-)-gossypol to the plant pathogen, Rhizoctonia solani. | 2002 | J. Agric. Food Chem. | pmid:12428953 |
Przybylski P et al. | Spectroscopic studies and PM5 semiempirical calculations of new Schiff bases of gossypol with polyoxaalkylamines. | 2002 | Biopolymers | pmid:12209461 |
Jensen JT | Male contraception. | 2002 | Curr Womens Health Rep | pmid:12215306 |
Rogers GM et al. | Feeding cotton products to cattle. | 2002 | Vet. Clin. North Am. Food Anim. Pract. | pmid:12235661 |
Cui GH et al. | [Determination of gossypol in cotton root bark by HPLC]. | 2002 | Zhongguo Zhong Yao Za Zhi | pmid:12774395 |
Mego M | Telomerase inhibitors in anticancer therapy: gossypol as a potential telomerase inhibitor. | 2002 | Bratisl Lek Listy | pmid:12583508 |
Kuhn G et al. | Gossypol induces chloride secretion in rat proximal colon. | 2002 | Eur. J. Pharmacol. | pmid:12464365 |
Risco CA et al. | Effects of gossypol from cottonseed on hematological responses and plasma alpha-tocopherol concentration of dairy cows. | 2002 | J. Dairy Sci. | pmid:12512612 |
Le Blanc M et al. | An in vitro study of inhibitory activity of gossypol, a cottonseed extract, in human carcinoma cell lines. | 2002 | Pharmacol. Res. | pmid:12457630 |
Vershinina MY et al. | Regulation of cytokine mRNAs by interferon and interferon inducers. | 2002 | Russ. J. Immunol. | pmid:12687259 |
Lee KJ et al. | A mixture of cottonseed meal, soybean meal and animal byproduct mixture as a fish meal substitute: growth and tissue gossypol enantiomer in juvenile rainbow trout (Oncorhynchus mykiss). | 2002 | J Anim Physiol Anim Nutr (Berl) | pmid:15379906 |
Phillis JW et al. | Effects of immunosuppressants, calcineurin inhibition, and blockade of endoplasmic reticulum calcium channels on free fatty acid efflux from the ischemic/reperfused rat cerebral cortex. | 2002 | Brain Res. | pmid:12443975 |
Wang MS et al. | Inhibition of 11beta-hydroxysteroid dehydrogenase in guinea pig kidney by three bioflavonoids and their interactions with gossypol. | 2002 | Acta Pharmacol. Sin. | pmid:11860745 |
Schneider IC et al. | Fermentation of cottonseed and other feedstuffs in cattle rumen fluid. | 2002 | J. Agric. Food Chem. | pmid:11929282 |
Przybylski P and Brzezinski B | Spectroscopic studies and PM3 semiempirical calculations of Schiff bases of gossypol with L-amino acid methyl esters. | 2002 | Biopolymers | pmid:11842415 |
Coviella CE et al. | Plant allocation to defensive compounds: interactions between elevated CO(2) and nitrogen in transgenic cotton plants. | 2002 | J. Exp. Bot. | pmid:11807136 |
Santos JE et al. | Type of cottonseed and level of gossypol in diets of lactating dairy cows: effects on lactation performance and plasma gossypol. | 2002 | J. Dairy Sci. | pmid:12146481 |
Bai J and Shi Y | Inhibition of T-type Ca(2+) currents in mouse spermatogenic cells by gossypol, an antifertility compound. | 2002 | Eur. J. Pharmacol. | pmid:11959082 |
Coutinho EM | Gossypol: a contraceptive for men. | 2002 | Contraception | pmid:12020773 |
Lee KJ and Dabrowski K | Gossypol and gossypolone enantiomers in tissues of rainbow trout fed low and high levels of dietary cottonseed meal. | 2002 | J. Agric. Food Chem. | pmid:11982441 |