Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Gombe S | A review of the current status in male contraceptive studies. | 1983 | East Afr Med J | pmid:6354690 |
Blanco A et al. | Effect of gossypol upon motility and ultrastructure of Trypanosoma cruzi. | 1983 | J. Protozool. | pmid:6363678 |
Xiao B and Wang M | Birth control techniques in China. | 1983 | China Popul Newsl | pmid:12312957 |
Ma XN et al. | [Effect of gossypol acetic acid on testosterone, LH and FSH levels of male rats]. | 1983 | Yao Xue Xue Bao | pmid:6433647 |
Hong SK et al. | Effects of gossypol on PAH transport in the rabbit kidney slice. | 1983 | Toxicol. Appl. Pharmacol. | pmid:6140776 |
Stephens DT et al. | Mechanism of inhibition by gossypol of glycolysis and motility of monkey spermatozoa in vitro. | 1983 | J. Reprod. Fertil. | pmid:6631812 |
Lei HP | [Prospect of gossypol as a contraceptive agents for men]. | 1983 | Yao Xue Xue Bao | pmid:6637482 |
Shi QX and Friend DS | Gossypol-induced inhibition of guinea pig sperm capacitation in vitro. | 1983 | Biol. Reprod. | pmid:6640034 |
Manmade A et al. | Gossypol. Synthesis and in vitro spermicidal activity of isomeric hemigossypol derivatives. | 1983 | Experientia | pmid:6641903 |
Posinovec J | [Gossypol - the newest agent for the prevention of male fertility]. | 1983 | Lijec Vjesn | pmid:6888153 |
Xu Y et al. | [Antagonism of antifertility effect of gossypol by aspirin]. | 1983 | Zhongguo Yao Li Xue Bao | pmid:6225300 |
Qian SZ et al. | Antispermatogenic activity of gossypol in rats on low-potassium diet. | 1983 | Zhongguo Yao Li Xue Bao | pmid:6228118 |
Fei RR et al. | [Effects of gossypol on rat testicular mitochondria]. | 1983 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:6228314 |
Chen XM et al. | [Effects of gossypol on lactate dehydrogenase isoenzyme-X in human spermatozoa]. | 1983 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:6228315 |
Cao J and Liu GZ | [Reversibility of azoospermia following gossypol withdrawal]. | 1983 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:6228316 |
Wang MZ | [High performance liquid chromatographic analysis of gossypol]. | 1983 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:6228325 |
Wichmann K et al. | Effect of gossypol on the motility and metabolism of human spermatozoa. | 1983 | J. Reprod. Fertil. | pmid:6411909 |
Tsui YC et al. | The effect of the male contraceptive agent Gossypol on human lymphocytes in vitro: traditional chromosome breakage, micronuclei, sister chromatid exchange, and cell kinetics. | 1983 | J. Med. Genet. | pmid:6842561 |
Wong PY et al. | Lack of an effect of gossypol on the epididymis of the rat. | 1983 | Contraception | pmid:6851567 |
Floridi A et al. | The effect of the association of Gossypol and Lonidamine on the energy metabolism of Ehrlich ascites tumor cells. | 1983 | Exp. Mol. Pathol. | pmid:6852206 |
Vander Jagt DL et al. | Regulation of the glutathione S-transferase activity of bilirubin transport protein (ligandin) from human liver. Enzymic memory involving protein-protein interactions. | 1983 | J. Biol. Chem. | pmid:6853539 |
Hoffer AP | Effects of gossypol on the seminiferous epithelium in the rat: a light and electron microscope study. | 1983 | Biol. Reprod. | pmid:6860736 |
Royer RE and Vander Jagt DL | Gossypol binds to a high-affinity binding site on human serum albumin. | 1983 | FEBS Lett. | pmid:6862017 |
Aitken RJ et al. | An analysis of the direct effects of gossypol on human spermatozoa. | 1983 | Int. J. Androl. | pmid:6862672 |
Rovan E et al. | Ultrastructural analysis of rat testes after gossypol acetic acid (GAA) treatment. | 1983 | Urol. Res. | pmid:6868221 |
Moshchik KV et al. | [Treatment of genital herpes with levamisole in combination with megasine]. | 1982 Sep-Oct | Vopr. Virusol. | pmid:7147912 |
Harper MJ | Fertility control. | 1982 Oct-Dec | Med Res Rev | pmid:6757597 |
Kalla NR et al. | Studies on the male antifertility agent--gossypol acetic acid. V. Effect of gossypol acetic acid on the fertility of male rats. | 1982 Nov-Dec | Andrologia | pmid:7165122 |
Weinbauer GF et al. | Antifertility efficacy of gossypol acetic acid in male rats. | 1982 May-Jun | Andrologia | pmid:7114507 |
Jackson H and Schnieden H | Aspects of male reproductive pharmacology and toxicology. | 1982 Jan-Mar | Rev Pure Appl Pharmacol Sci | pmid:6291102 |
Majumdar SK et al. | Mutagenic evaluation of two male contraceptives: 5-thio-d-glucose and gossypol acetic acid. | 1982 Jan-Feb | J. Hered. | pmid:7040540 |
Cameron SM et al. | Vaginal spermicidal activity of gossypol in the Macaca arctoides. | 1982 | Fertil. Steril. | pmid:7060775 |
Oko R and Hrudka F | Segmental aplasia of the mitochondrial sheath and sequelae induced by gossypol in rat spermatozoa. | 1982 | Biol. Reprod. | pmid:7066454 |
Jiang DH and Xue H | [Monoanilinogossypol--the impurity possibly present in gossypol (author's transl)]. | 1982 | Yao Xue Xue Bao | pmid:7102321 |
Tso WW and Lee CS | Lactate dehydrogenase-X: an isozyme particularly sensitive to gossypol inhibition. | 1982 | Int. J. Androl. | pmid:7107034 |
Hoffer AP | Ultrastructural studies of spermatozoa and the epithelial lining of the epididymis and vas deferens in rats treated with gossypol. | 1982 | Arch. Androl. | pmid:7114955 |
Lei HP | [Review and prospect of gossypol research (author's transl)]. | 1982 | Yao Xue Xue Bao | pmid:7090820 |
Ke YB and Tso WW | Variations of gossypol susceptibility in rat spermatozoa during spermatogenesis. | 1982 | Int. J. Fertil. | pmid:6122656 |
Wang WH | [Antagonistic effect of Smilax sp. on gossypol toxicity (author's transl)]. | 1982 | Zhong Yao Tong Bao | pmid:6212150 |
Sun YB et al. | [Effect of gossypol on potassium excretion of male rats]. | 1982 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:6216008 |
Tso WW and Lee CS | Cottonseed oil as a vaginal contraceptive. | 1982 | Arch. Androl. | pmid:6895984 |
Tong SM et al. | Human antifertility effect of gossypol cytologic observation of semen. | 1982 | Chin. Med. J. | pmid:6216077 |
Sotelo A et al. | Infertility in male rats induced by diets containing whole cottonseed flour. | 1982 | J. Nutr. | pmid:6897076 |
Tso WW et al. | Effect of gossypol on boar spermatozoal adenosine triphosphate metabolism. | 1982 | Arch. Androl. | pmid:6219642 |
Han ML | [Clinical observation of the gossypol treatment of endometriosis and uterine myoma and the location of the pharmacological action]. | 1982 | Zhong Xi Yi Jie He Za Zhi | pmid:6219819 |
Wichmann K et al. | Inhibiting herpes simplex virus type 2 infection in human epithelial cells by gossypol, a potent spermicidal and contraceptive agent. | 1982 | Am. J. Obstet. Gynecol. | pmid:6277198 |
Shu HD et al. | [Effects of gossypol acetate on neuromuscular transmission (author's transl)]. | 1982 | Zhongguo Yao Li Xue Bao | pmid:6283787 |
Male fertility and its regulation: expanded abstracts. International symposium, Maui, Hawaii, October 9-15, 1982. | 1982 | Arch. Androl. | pmid:6812518 | |
Hoshiai H et al. | Gossypol as oral contraceptive for male: trial case report. | 1982 | Tohoku J. Exp. Med. | pmid:6818716 |
Tso WW and Lee CS | Gossypol: an effective acrosin blocker. | 1982 | Arch. Androl. | pmid:6803693 |