Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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pmid: | ||||
Meng YL et al. | Coordinated accumulation of (+)-delta-cadinene synthase mRNAs and gossypol in developing seeds of Gossypium hirsutum and a new member of the cad1 family from G. arboreum. | 1999 | J. Nat. Prod. | pmid:10075752 |
Shelley MD et al. | Stereo-specific cytotoxic effects of gossypol enantiomers and gossypolone in tumour cell lines. | 1999 | Cancer Lett. | pmid:10096426 |
Javed MH and Khan MA | Effect of amino acids on inhibition of lactate dehydrogenase-X by gossypol. | 1999 | Exp. Mol. Med. | pmid:10231019 |
Skripkin IuK et al. | [Treatment of viral skin diseases with Soviet-made antiviral drugs]. | 1976 | Vestn Dermatol Venerol | pmid:1023645 |
Wang MS et al. | NAD- and NADP-dependent 11 beta-hydroxysteroid dehydrogenase isoforms in guinea pig kidney with gossypol inhibition. | 1997 | Zhongguo Yao Li Xue Bao | pmid:10322899 |
Tosukhowong P et al. | Environmental distal renal tubular acidosis in Thailand: an enigma. | 1999 | Am. J. Kidney Dis. | pmid:10352213 |
Deck LM et al. | Inhibition of aldose reductase by gossypol and gossypol-related compounds. | 1999 | Adv. Exp. Med. Biol. | pmid:10352723 |
Achudume AC et al. | Experimental analysis of gossypol and chloroquine interaction in serum and in liver of rat. | 1998 | Indian J. Exp. Biol. | pmid:10356961 |
Velasquez-Pereira J et al. | Long-term effects of feeding gossypol and vitamin E to dairy calves. | 1999 | J. Dairy Sci. | pmid:10386310 |
Bernard JK et al. | Effect of coating whole cottonseed on performance of lactating dairy cows. | 1999 | J. Dairy Sci. | pmid:10386315 |
Bushunow P et al. | Gossypol treatment of recurrent adult malignant gliomas. | 1999 | J. Neurooncol. | pmid:10448875 |
Cerelli JS and Johnson L | Potential daily sperm production, Sertoli cell number, and seminiferous tubule characteristics in beef bulls fed conventional or gossypol-enriched diets. | 1999 Jul-Aug | J. Androl. | pmid:10452596 |
Gossypol--a new antifertility agent for males. | 1978 | Chin. Med. J. | pmid:104833 | |
Vranová J et al. | Inhibitory effect of gossypol on basal and luteinization factor-stimulated progesterone synthesis in porcine granulosa cells. | 1999 | Physiol Res | pmid:10534015 |
Balci A et al. | Gossypol induced apoptosis in the human promyelocytic leukemia cell line HL 60. | 1999 | Tohoku J. Exp. Med. | pmid:10622208 |
Dabrowski K et al. | Effects of diets containing gossypol on reproductive capacity of rainbow trout (Oncorhynchus mykiss). | 2000 | Biol. Reprod. | pmid:10642557 |
Taitzoglou IA et al. | Gossypol-induced inhibition of plasminogen activator activity in human and ovine acrosomal extract. | 1999 | Andrologia | pmid:10643510 |
Rinchard J et al. | Effects of gossypol on sperm viability and plasma sex steroid hormones in male sea lamprey, Petromyzon marinus. | 2000 | Toxicol. Lett. | pmid:10643862 |
Abe Y et al. | Altered vascular response to acetylcholine in conditions of endothelial damage in the isolated perfused rat stomach. | 2000 | J. Gastroenterol. | pmid:10680663 |