Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Politzer WM | Long-term clinical remission of a patient with chronic lymphocytic leukemia using alternative treatment option: cottonseed oil (gossypol). | 2008 | Phytomedicine | pmid:18573644 |
Shaaban WF et al. | Reproductive toxicologic effects of gossypol on male rabbits: biochemical, enzymatic, and electrolytic properties of seminal plasma. | 2008 | Fertil. Steril. | pmid:17953964 |
Li ZM et al. | Synergistic cytotoxicity of Bcl-xL inhibitor, gossypol and chemotherapeutic agents in non-Hodgkin's lymphoma cells. | 2008 | Cancer Biol. Ther. | pmid:17938578 |
Jia L et al. | Comparison of pharmacokinetic and metabolic profiling among gossypol, apogossypol and apogossypol hexaacetate. | 2008 | Cancer Chemother. Pharmacol. | pmid:17356822 |
Paoluzzi L et al. | Targeting Bcl-2 family members with the BH3 mimetic AT-101 markedly enhances the therapeutic effects of chemotherapeutic agents in in vitro and in vivo models of B-cell lymphoma. | 2008 | Blood | pmid:18292288 |
Przybylski P et al. | CP/MAS spectroscopy in the determination of the tautomeric forms of gossypol, its Schiff bases and hydrazones in the solid state. | 2008 | Magn Reson Chem | pmid:18338327 |
Zha SW et al. | [Male antifertility drugs and cell apoptosis]. | 2008 | Zhonghua Nan Ke Xue | pmid:18297819 |
RodrÃguez-EnrÃquez S et al. | Energy metabolism transition in multi-cellular human tumor spheroids. | 2008 | J. Cell. Physiol. | pmid:18264981 |
Arnold AA et al. | Preclinical studies of Apogossypolone: a new nonpeptidic pan small-molecule inhibitor of Bcl-2, Bcl-XL and Mcl-1 proteins in Follicular Small Cleaved Cell Lymphoma model. | 2008 | Mol. Cancer | pmid:18275607 |
Sikora MJ et al. | Anti-oxidant treatment enhances anti-tumor cytotoxicity of (-)-gossypol. | 2008 | Cancer Biol. Ther. | pmid:18376141 |
Dowd MK and Pelitire SM | HPLC preparation of the chiral forms of 6-methoxy-gossypol and 6,6'-dimethoxy-gossypol. | 2008 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:18407810 |
Boonsri S et al. | Cytotoxic and antibacterial sesquiterpenes from Thespesia populnea. | 2008 | J. Nat. Prod. | pmid:18553924 |
Zhou DR et al. | Gossypol repressed the gap junctional intercellular communication between Sertoli cells by decreasing the expression of Connexin43. | 2008 | Toxicol In Vitro | pmid:18706992 |
Trischitta F and Faggio C | Gossypol affects ion transport in the isolated intestine of the seawater adapted eel, Anguilla anguilla. | 2008 | Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. | pmid:18606239 |
Etxebarria A et al. | Regulation of antiapoptotic MCL-1 function by gossypol: mechanistic insights from in vitro reconstituted systems. | 2008 | Biochem. Pharmacol. | pmid:18762177 |
Tang Y et al. | [Progress in small-molecule inhibitors of Bcl-2 family proteins]. | 2008 | Yao Xue Xue Bao | pmid:18819468 |
Gong YZ et al. | Cinnamyl-3,4-dihydroxy-alpha-cyanocinnamate and nordihydroguaiaretic acid inhibit human Kv1.5 currents independently of lipoxygenase. | 2008 | Eur. J. Pharmacol. | pmid:18930721 |
Sun J et al. | ApoG2 inhibits antiapoptotic Bcl-2 family proteins and induces mitochondria-dependent apoptosis in human lymphoma U937 cells. | 2008 | Anticancer Drugs | pmid:18827561 |
Janssen CO et al. | Interaction of kendomycin and semi-synthetic analogues with the anti-apoptotic protein Bcl-xl. | 2008 | Bioorg. Med. Chem. Lett. | pmid:18845435 |
Cui G et al. | Gossypol with methyltestosterone and ethinylestradiol male does not affect rat spermatogonial stem cell differentiation. | 2007 Mar-Apr | Arch. Androl. | pmid:17453689 |