Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Ojha P et al. | Effect of antispermatogenic agents on cell marker enzymes of rat Sertoli cells in vitro. | 2006 | Contraception | pmid:16371305 |
Benedict CR et al. | The peroxidative coupling of hemigossypol to (+)- and (-)-gossypol in cottonseed extracts. | 2006 | Phytochemistry | pmid:16403543 |
Dale GL and Friese P | Bax activators potentiate coated-platelet formation. | 2006 | J. Thromb. Haemost. | pmid:16970802 |
Coward L et al. | Quantitative determination of apogossypol, a pro-apoptotic analog of gossypol, in mouse plasma using LC/MS/MS. | 2006 | J Pharm Biomed Anal | pmid:16859853 |
Cranston JJ et al. | Effects of feeding whole cottonseed and cottonseed products on performance and carcass characteristics of finishing beef cattle. | 2006 | J. Anim. Sci. | pmid:16864881 |
Zhang WJ et al. | Effect of selected fungi on the reduction of gossypol levels and nutritional value during solid substrate fermentation of cottonseed meal. | 2006 | J Zhejiang Univ Sci B | pmid:16909468 |
Zhang WJ et al. | Optimization of process parameters for reduction of gossypol levels in cottonseed meal by Candida tropicalis ZD-3 during solid substrate fermentation. | 2006 | Toxicon | pmid:16846625 |
Lei X et al. | Gossypol induces Bax/Bak-independent activation of apoptosis and cytochrome c release via a conformational change in Bcl-2. | 2006 | FASEB J. | pmid:16935937 |
Stipanovic RD et al. | Ratios of (+)- and (-)-gossypol in leaves, stems, and roots of selected accessions of Gossypium hirsutum var. marie galante (Watt) Hutchinson. | 2006 | J. Agric. Food Chem. | pmid:16506812 |
Yang G et al. | Molecular cloning and characterization of a novel lactate dehydrogenase gene from Clonorchis sinensis. | 2006 | Parasitol. Res. | pmid:16479375 |
Galvão KN et al. | Embryo survival from gossypol-fed heifers after transfer to lactating cows treated with human chorionic gonadotropin. | 2006 | J. Dairy Sci. | pmid:16702269 |
Stipanovic RD et al. | Effect of racemic and (+)- and (-)-gossypol on the survival and development of Helicoverpa zea larvae. | 2006 | J. Chem. Ecol. | pmid:16739016 |
Liu YX | Control of spermatogenesis in primate and prospect of male contraception. | 2005 Mar-Apr | Arch. Androl. | pmid:15804862 |
Lopez LM et al. | Nonhormonal drugs for contraception in men: a systematic review. | 2005 | Obstet Gynecol Surv | pmid:16250923 |
Dodou K et al. | Investigations on gossypol: past and present developments. | 2005 | Expert Opin Investig Drugs | pmid:16255680 |
Mohammad RM et al. | Nonpeptidic small-molecule inhibitor of Bcl-2 and Bcl-XL, (-)-Gossypol, enhances biological effect of genistein against BxPC-3 human pancreatic cancer cell line. | 2005 | Pancreas | pmid:16258364 |
Stipanovic RD et al. | Occurrence of (+)- and (-)-gossypol in wild species of cotton and in Gossypium hirsutum Var. marie-galante (Watt) Hutchinson. | 2005 | J. Agric. Food Chem. | pmid:16076104 |
Bauer JA et al. | Reversal of cisplatin resistance with a BH3 mimetic, (-)-gossypol, in head and neck cancer cells: role of wild-type p53 and Bcl-xL. | 2005 | Mol. Cancer Ther. | pmid:16020667 |
Mohammad RM et al. | Preclinical studies of a nonpeptidic small-molecule inhibitor of Bcl-2 and Bcl-X(L) [(-)-gossypol] against diffuse large cell lymphoma. | 2005 | Mol. Cancer Ther. | pmid:15657349 |
Uzal FA et al. | Gossypol toxicosis in a dog consequent to ingestion of cottonseed bedding. | 2005 | J. Vet. Diagn. Invest. | pmid:16475530 |