Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Ivanov AA et al. | [Immunopharmacological analysis of secondary postradiation immunodeficiency]. | 1994 Jul-Oct | Radiats Biol Radioecol | pmid:7951873 |
Akingbemi BT and Aire TA | Haematological and serum biochemical changes in the rat due to protein malnutrition and gossypol-ethanol interactions. | 1994 | J. Comp. Pathol. | pmid:7884058 |
Benhaim P et al. | Induction of neutrophil Mac-1 integrin expression and superoxide production by the medicinal plant extract gossypol. | 1994 | Inflammation | pmid:7843790 |
Coyle T et al. | In vitro and in vivo cytotoxicity of gossypol against central nervous system tumor cell lines. | 1994 | J. Neurooncol. | pmid:7815102 |
Achedume AC et al. | Biochemical studies of the effect of gossypol consumption on cholesterol and residual glucose in fed and protein-energy deficient rats. | 1994 | Contraception | pmid:7813227 |
Abou-Donia MB | Physiological effects and metabolism of gossypol. | 1976 | Residue Rev | pmid:778955 |
Yuan YY et al. | Inhibition of rabbit sperm acrosomal enzymes by gossypol. | 1995 | Mol. Reprod. Dev. | pmid:7766416 |
Sakano T et al. | An experimental study of gastric mucosal blood flow in endotoxemia of the rat, with special reference to the vagus nerve and EDRF. | 1995 | J. Gastroenterol. | pmid:7719420 |
de Peyster A and Wang YY | Genetic toxicity studies of gossypol. | 1993 | Mutat. Res. | pmid:7692275 |
Teng CS | Biological activity in the repopulating rat spermatocyte after the withdrawal of gossypol treatment. V. Inhibition and recovery of microtubular dynein. | 1995 | Contraception | pmid:7628207 |
Gawai KR et al. | Changes in the activity of metabolic and non-metabolic liver enzymes in rats following co-administration of gossypol with phenobarbital. | 1995 | Pharmacol. Toxicol. | pmid:7617561 |
Velez de la Calle JF and Bujan L | [Male contraception]. | 1995 | Contracept Fertil Sex | pmid:7613573 |
Royer RE et al. | Synthesis and anti-HIV activity of 1,1'-dideoxygossypol and related compounds. | 1995 | J. Med. Chem. | pmid:7608907 |
Penrith ML et al. | Gossypol intoxication in pigs. | 1994 | J S Afr Vet Assoc | pmid:7602565 |
Willard ST et al. | Effects of free gossypol in the diet of pregnant and postpartum Brahman cows on calf development and cow performance. | 1995 | J. Anim. Sci. | pmid:7601784 |
Gilbert NE et al. | Antiproliferative activity of gossypol and gossypolone on human breast cancer cells. | 1995 | Life Sci. | pmid:7596222 |
Akingbemi BT et al. | The effects of protein malnutrition and experimental infection with Trypanosoma brucei on gossypol treatment in the rat: haematological and serum biochemical changes. | 1995 | J. Comp. Pathol. | pmid:7593758 |
Royer RE et al. | Comparison of the antiviral activities of 3'-azido-3'-deoxythymidine (AZT) and gossylic iminolactone (GIL) against clinical isolates of HIV-1. | 1995 | Pharmacol. Res. | pmid:7540302 |
Matlin SA | Prospects for pharmacological male contraception. | 1994 | Drugs | pmid:7533693 |
Bourinbaiar AS and Lee-Huang S | Comparative in vitro study of contraceptive agents with anti-HIV activity: gramicidin, nonoxynol-9, and gossypol. | 1994 | Contraception | pmid:7511493 |