| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Cattle Diseases | D002418 | 24 associated lipids |
| Infertility, Male | D007248 | 11 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
Gossypol
Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
Cross Reference
Introduction
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Gossypol?
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Gossypol
PubChem Associated disorders and diseases
What pathways are associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Gossypol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Gossypol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Gossypol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Gossypol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Gossypol?
Xenograft Model
Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Gossypol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Mishra PJ et al. | Integrated Genomics Identifies miR-32/MCL-1 Pathway as a Critical Driver of Melanomagenesis: Implications for miR-Replacement and Combination Therapy. | 2016 | PLoS ONE | pmid:27846237 |
| Zhao R et al. | AT-101 enhances gefitinib sensitivity in non-small cell lung cancer with EGFR T790M mutations. | 2016 | BMC Cancer | pmid:27431492 |
| Zubair H et al. | Mobilization of Intracellular Copper by Gossypol and Apogossypolone Leads to Reactive Oxygen Species-Mediated Cell Death: Putative Anticancer Mechanism. | 2016 | Int J Mol Sci | pmid:27331811 |
| Ma D et al. | Genetic basis for glandular trichome formation in cotton. | 2016 | Nat Commun | pmid:26795254 |
| Zhang J et al. | Breeding Potential of Introgression Lines Developed from Interspecific Crossing between Upland Cotton (Gossypium hirsutum) and Gossypium barbadense: Heterosis, Combining Ability and Genetic Effects. | 2016 | PLoS ONE | pmid:26730964 |
| Antonietti P et al. | AT-101 simultaneously triggers apoptosis and a cytoprotective type of autophagy irrespective of expression levels and the subcellular localization of Bcl-xL and Bcl-2 in MCF7 cells. | 2016 | Biochim. Biophys. Acta | pmid:26721623 |
| Stein MN et al. | A Phase II Study of AT-101 to Overcome Bcl-2--Mediated Resistance to Androgen Deprivation Therapy in Patients With Newly Diagnosed Castration-Sensitive Metastatic Prostate Cancer. | 2016 | Clin Genitourin Cancer | pmid:26476589 |
| Baoleri X et al. | Combination of L-gossypol and low-concentration doxorubicin induces apoptosis in human synovial sarcoma cells. | 2015 | Mol Med Rep | pmid:26238307 |
| Li K et al. | Mulberry-like dual-drug complicated nanocarriers assembled with apogossypolone amphiphilic starch micelles and doxorubicin hyaluronic acid nanoparticles for tumor combination and targeted therapy. | 2015 | Biomaterials | pmid:25477180 |
| Quinn BA et al. | Pancreatic Cancer Combination Therapy Using a BH3 Mimetic and a Synthetic Tetracycline. | 2015 | Cancer Res. | pmid:26032425 |
| Zhang SD et al. | Isochamaejasmin induces apoptosis in leukemia cells through inhibiting Bcl-2 family proteins. | 2015 | Chin J Nat Med | pmid:26412425 |
| Bhatia C et al. | Towards a systematic analysis of human short-chain dehydrogenases/reductases (SDR): Ligand identification and structure-activity relationships. | 2015 | Chem. Biol. Interact. | pmid:25526675 |
| Câmara AC et al. | Toxicity of Gossypol from Cottonseed Cake to Sheep Ovarian Follicles. | 2015 | PLoS ONE | pmid:26600470 |
| Gong Y et al. | Valproic Acid Enhances the Anti-tumor Effect of (-)-gossypol to Burkitt Lymphoma Namalwa Cells. | 2015 | Biomed. Environ. Sci. | pmid:26582100 |
| Wu Y et al. | Influence of gossypol acetic acid on the growth of human adenoid cystic carcinoma ACC-M cells and the expression of DNA methyltransferase 1. | 2015 | Genet. Mol. Res. | pmid:26535659 |
| Zhao GX et al. | The BH3-mimetic gossypol and noncytotoxic doses of valproic acid induce apoptosis by suppressing cyclin-A2/Akt/FOXO3a signaling. | 2015 | Oncotarget | pmid:26517515 |
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| Tomoda K et al. | Examination of Gossypol-Pluronic Micelles as Potential Radiosensitizers. | 2015 | AAPS J | pmid:26246329 |
| Santana AT et al. | Mechanisms involved in reproductive damage caused by gossypol in rats and protective effects of vitamin E. | 2015 | Biol. Res. | pmid:26227499 |
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| He Z et al. | Chemical Composition of Defatted Cottonseed and Soy Meal Products. | 2015 | PLoS ONE | pmid:26079931 |
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| Pan R et al. | Inhibition of Mcl-1 with the pan-Bcl-2 family inhibitor (-)BI97D6 overcomes ABT-737 resistance in acute myeloid leukemia. | 2015 | Blood | pmid:26045609 |
| Maji S et al. | Mcl-1 is an important therapeutic target for oral squamous cell carcinomas. | 2015 | Oncotarget | pmid:26009874 |
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| Zeng QF et al. | The response of meat ducks from 15 to 35 d of age to gossypol from cottonseed meal. | 2015 | Poult. Sci. | pmid:25834247 |
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| Zhan W et al. | Inhibitory activity of apogossypol in human prostate cancer in vitro and in vivo. | 2015 | Mol Med Rep | pmid:25672487 |
| Zhang H et al. | Canonical Wnt signaling acts synergistically on BMP9-induced osteo/odontoblastic differentiation of stem cells of dental apical papilla (SCAPs). | 2015 | Biomaterials | pmid:25468367 |
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| Gadelha IC et al. | Gossypol promotes degeneration of ovarian follicles in rats. | 2014 | ScientificWorldJournal | pmid:25540815 |
| Jarzabek MA et al. | Interrogation of gossypol therapy in glioblastoma implementing cell line and patient-derived tumour models. | 2014 | Br. J. Cancer | pmid:25375271 |
| Sadahira K et al. | Gossypol induces apoptosis in multiple myeloma cells by inhibition of interleukin-6 signaling and Bcl-2/Mcl-1 pathway. | 2014 | Int. J. Oncol. | pmid:25231749 |
| Xu R et al. | Proteomic analysis of gossypol induces necrosis in multiple myeloma cells. | 2014 | Biomed Res Int | pmid:25197664 |
| Jin L et al. | Phosphoproteomic analysis of gossypol-induced apoptosis in ovarian cancer cell line, HOC1a. | 2014 | Biomed Res Int | pmid:25180175 |
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| Gao W et al. | Proteomic and virus-induced gene silencing (VIGS) Analyses reveal that gossypol, brassinosteroids, and jasmonic acid contribute to the resistance of cotton to Verticillium dahliae. | 2013 | Mol. Cell Proteomics | pmid:24019146 |
| Balakrishnan K et al. | Bax and Bak are required for apogossypolone, a BH3-mimetic, induced apoptosis in chronic lymphocytic leukemia cells. | 2013 | Leuk. Lymphoma | pmid:22866921 |
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| Pridgeon JW et al. | Attempt to develop live attenuated bacterial vaccines by selecting resistance to gossypol, proflavine hemisulfate, novobiocin, or ciprofloxacin. | 2013 | Vaccine | pmid:23499519 |
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| Yuan Y et al. | Gossypol and an HMT G9a inhibitor act in synergy to induce cell death in pancreatic cancer cells. | 2013 | Cell Death Dis | pmid:23807219 |
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| Zhong S et al. | (-)-Gossypol-enriched cottonseed oil inhibits proliferation and adipogenesis of human breast pre-adipocytes. | 2013 | Anticancer Res. | pmid:23482766 |
| Varadarajan S et al. | Sabutoclax (BI97C1) and BI112D1, putative inhibitors of MCL-1, induce mitochondrial fragmentation either upstream of or independent of apoptosis. | 2013 | Neoplasia | pmid:23633928 |
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