Gossypol

Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.

Cross Reference

Introduction

To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Gossypol?

Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Gossypol

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Adenocarcinoma D000230 166 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Cattle Diseases D002418 24 associated lipids
Infertility, Male D007248 11 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Body Weight D001835 333 associated lipids
Per page 10 20 50 100 | Total 52

PubChem Associated disorders and diseases

What pathways are associated with Gossypol

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Gossypol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Gossypol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Gossypol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Gossypol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Gossypol?

Xenograft Model

Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).

Transgenic Model

Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Gossypol

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Per page 10 20 50 100 | Total 1511
Authors Title Published Journal PubMed Link
Srivastava A et al. Studies on mechanism(s) of antifertility action of gossypol in rat and hamster. 1989 Contraception pmid:2469550
Moore GD et al. Inhibition of sperm migration, fertilization and implantation in rats by precoital intrauterine administration of gossypol or nonoxynol-9. 1988 Contraception pmid:2835205
Fu YF et al. Effects of gossypol on the activity of kidney (Na+ + K+)-ATPase and the functions of erythrocyte membrane. 1988 Contraception pmid:2836126
White IG et al. Studies of the mechanism of action of gossypol as a male antifertility agent. 1988 Contraception pmid:2836127
Hahn DW et al. Antifertility and endocrine activities of gossypol in rodents. 1981 Contraception pmid:7273769
Waller DP et al. Antifertility effects of gossypol and its impurities on male hamsters. 1981 Contraception pmid:7285581
Chang MC et al. Effects of Gossypol on the fertility of male rats, hamsters and rabbits. 1980 Contraception pmid:7428357
Sakesena SK et al. Gossypol: its toxicological and endocrinological effects in male rabbits. 1981 Contraception pmid:7297071
Tso WW and Lee CS Variations of gossypol sensitivity in boar spermatozoal electron transport chain segments. 1981 Contraception pmid:7318437
Tanphaichitr N and Fitzgerald LM Adverse effects of gossypol analogs on TM4 cell mitochondrial function. 1989 Contraception pmid:2752754
Tanphaichitr N et al. Inhibitory effects of gossypol analogs on human sperm motility. 1989 Contraception pmid:2752755
Ojha P et al. Effect of antispermatogenic agents on cell marker enzymes of rat Sertoli cells in vitro. 2006 Contraception pmid:16371305
Teng CS Biological activity in the repopulating rat spermatocyte after the withdrawal of gossypol treatment. V. Inhibition and recovery of microtubular dynein. 1995 Contraception pmid:7628207
International Symposium on Gossypol Research for Fertility Regulation. Wuhan, China, 15-17 October 1986. Representative papers. 1988 Contraception pmid:3370985
Zhong CQ et al. Study on sperm function in men long after cessation of gossypol treatment. 1990 Contraception pmid:2113849
Liu GZ et al. Effects of K salt or a potassium blocker on gossypol-related hypokalemia. 1988 Contraception pmid:3370986
Frick J et al. Clinical microdose study of gossypol: effect on sperm motility and renal function. 1988 Contraception pmid:3370988
Drayer DE and Reidenberg MM Gossypol and Na+, K+ ATPase from human erythrocytes. 1988 Contraception pmid:2848657
Xue SP et al. Evaluation of the renal tubulo-toxic effect of gossypol by urinary protein analysis with SDS-polyacrylamide gel electrophoresis. 1988 Contraception pmid:3370989
Beaudoin AR A developmental toxicity evaluation of gossypol. 1988 Contraception pmid:3370993
Benz C et al. Selective toxicity of gossypol against epithelial tumors and its detection by magnetic resonance spectroscopy. 1988 Contraception pmid:3370994
Matlin SA et al. Large-scale resolution of gossypol enantiomers for biological evaluation. 1988 Contraception pmid:3370995
Yang ZJ et al. Combined administration of low-dose gossypol acetic acid with desogestrel/mini-dose ethinylestradiol/testosterone undecanoate as an oral contraceptive for men. 2004 Contraception pmid:15325889
Lohiya NK et al. Limitations in developing gossypol acetic acid as a male contraceptive. 1990 Contraception pmid:2347196
Kumar M et al. Gossypol-induced hypokalemia and role of exogenous potassium salt supplementation when used as an antispermatogenic agent in male langur monkey. 1997 Contraception pmid:9408707
Wu DF and Reidenberg MM Stereoselective interaction between gossypol and rat plasma. 1990 Contraception pmid:2335102
Lin YC et al. Effect of gossypol on thyroid hormones in young female rats. 1990 Contraception pmid:2335106
Kim I et al. Inhibition of lactate dehydrogenase-X by imino-derivatives of gossypol:structure activity relationship. 1987 Contraception pmid:3608484
Sinha Hikim AP and Hoffer AP Quantitative analysis of germ cells and Leydig cells in rat made infertile with gossypol. 1987 Contraception pmid:3621939
Achedume AC et al. Biochemical studies of the effect of gossypol consumption on cholesterol and residual glucose in fed and protein-energy deficient rats. 1994 Contraception pmid:7813227
Teng CS Reversible changes in the content of cellular and microtubular tubulin in spermatogenic cells after gossypol treatment. 1997 Contraception pmid:9013060
Kainz P et al. The in vivo effect of gossypol on macromolecular synthesis in rat testis. 1985 Contraception pmid:2419026
Teng CS Biological activity in the repopulating rat spermatocyte after the withdrawal of gossypol treatment. IV. The activity for the modification of core histones. 1993 Contraception pmid:8403913
Polsky B et al. Inactivation of human immunodeficiency virus in vitro by gossypol. 1989 Contraception pmid:2473865
Bender HS et al. A histopathologic study of the effects of gossypol on the female rat. 1988 Contraception pmid:3197423
Nwoha PU The blood constituents of gossypol-treated, protein-malnourished Wistar rats. 1995 Contraception pmid:8605784
Nwoha PU and Aire TA The effects of gossypol and chloroquine interaction on serum electrolytes of protein-malnourished rats. 1995 Contraception pmid:8605785
Nwoha PU and Aire TA Reduced level of serum cholesterol in low protein-fed Wistar rats administered gossypol and chloroquine. 1995 Contraception pmid:8605786
Orhan G et al. The effect of the male contraceptive agent gossypol acetic acid on mouse bone marrow cells in vivo: micronuclei and mitotic index. 1993 Contraception pmid:8508667
Teng CS c-fos protein expression in apoptotic rat spermatocytes induced by gossypol. 1998 Contraception pmid:9649921
Wang C and Yeung RT Gossypol and hypokalaemia. 1985 Contraception pmid:3910352
Zhang SF et al. Biological activity in the repopulating rat spermatocyte after the withdrawal of gossypol treatment: I. The activity for DNA synthesis. 1989 Contraception pmid:2758843
Ye BK et al. Biological activity in the repopulating rat spermatocyte after the withdrawal of gossypol treatment: II. The activity for the synthesis of cellular and nuclear basic proteins. 1989 Contraception pmid:2758844
Wong PY et al. Gossypol does not affect testicular fluid secretion in rats. 1984 Contraception pmid:6744863
Wang JM et al. The entry of gossypol across the blood-testis barrier in rats. 1989 Contraception pmid:2721201
Wang Y et al. Antifertility effect of polyvinylpyrrolidone-gossypol and gossypol in male rats. 1985 Contraception pmid:4092462
Wu YM et al. Effects of gossypol on pituitary-ovarian endocrine function, ovulation and fertility in female hamsters. 1981 Contraception pmid:6796329
Pearce S et al. The viability of mouse Leydig cells in vitro following incubation with gossypol. 1985 Contraception pmid:4085245
Gu Y and Anderson NO Effects of gossypol on the estrous cycle and ovarian weight in the rat. 1985 Contraception pmid:4085249
Anuja MN et al. Spermatotoxicity of a protein isolated from the root of Achyranthes aspera: a comparative study with gossypol. 2010 Contraception pmid:20851234