| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Cattle Diseases | D002418 | 24 associated lipids |
| Infertility, Male | D007248 | 11 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
Gossypol
Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
Cross Reference
Introduction
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Gossypol?
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Mol. Cancer Ther. (4)
- Proc. Natl. Acad. Sci. U.S.A. (3)
- Am. J. Physiol. Lung Cell Mol. Physiol. (2)
- Others (13)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Gossypol
PubChem Associated disorders and diseases
What pathways are associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Gossypol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Gossypol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Gossypol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Gossypol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Gossypol?
Xenograft Model
Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Gossypol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Haspel HC et al. | Effect of gossypol on erythrocyte membrane function: specific inhibition of inorganic anion exchange and interaction with band 3. | 1985 | J. Pharmacol. Exp. Ther. | pmid:4032282 |
| Kimura K et al. | Inhibition by gossypol of phospholipid-sensitive Ca2+-dependent protein kinase from pig testis. | 1985 | Biochim. Biophys. Acta | pmid:3157405 |
| Berry CN et al. | Gossypol is a potent inhibitor of the NAD+-dependent dehydrogenase responsible for the inactivation of prostaglandins. | 1985 | Zhongguo Yao Li Xue Bao | pmid:3158161 |
| Li FY et al. | [The antiandrogen effect of gossypol and its influence on androgen receptor]. | 1985 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:3158419 |
| Wang YF | [Late effect of gossypol treatment in gynecological diseases--a clinical study of 72 cases]. | 1985 | Zhong Xi Yi Jie He Za Zhi | pmid:3158438 |
| Wang MZ et al. | [Determination of gossypol with high performance liquid chromatography]. | 1985 | Yao Xue Xue Bao | pmid:3834747 |
| Vongsorasak L and Svasti J | Inhibition of liquefaction and protein degradation in human semen by gossypol. | 1985 | Int. J. Androl. | pmid:3835162 |
| Rikihisa Y et al. | Histopathologic changes of uterus following gossypol treatment during early pregnancy in rats. | 1985 | Anat. Rec. | pmid:4073564 |
| Hamasaki Y and Tai HH | Gossypol, a potent inhibitor of arachidonate 5- and 12-lipoxygenases. | 1985 | Biochim. Biophys. Acta | pmid:3919771 |
| Wang Y et al. | Antifertility effect of polyvinylpyrrolidone-gossypol and gossypol in male rats. | 1985 | Contraception | pmid:4092462 |
| Wang MZ et al. | High-performance liquid chromatography with electrochemical detection of gossypol in human plasma. | 1985 | J. Chromatogr. | pmid:4066879 |
| Wang WH et al. | [Influence of salicylaldehyde and its analogs on the antispermatogenic effect of gossypol]. | 1985 | Yao Xue Xue Bao | pmid:4083027 |
| Pearce S et al. | The viability of mouse Leydig cells in vitro following incubation with gossypol. | 1985 | Contraception | pmid:4085245 |
| Gu Y and Anderson NO | Effects of gossypol on the estrous cycle and ovarian weight in the rat. | 1985 | Contraception | pmid:4085249 |
| Patton CS et al. | Heart failure caused by gossypol poisoning in two dogs. | 1985 | J. Am. Vet. Med. Assoc. | pmid:4086371 |
| Hoffer AP and Lisser SP | Recovery of normal testicular ultrastructure and sperm motility after cessation of gossypol treatment in rats. | 1984 Nov-Dec | J. Androl. | pmid:6511655 |
| Kim I and Waller DP | Specific inhibition of the testicular mitochondrial respiratory chain in vitro by gossypol. | 1984 Nov-Dec | J. Androl. | pmid:6511656 |
| SaÄitkulov AM et al. | [Biological characteristics of new interferon inducers created on a gossypol base]. | 1984 Nov-Dec | Vopr. Virusol. | pmid:6084903 |
| Kalla NR et al. | Studies on the male antifertility agent gossypol acetic acid. VI. Effect of gossypol acetic acid on the fertility of bonnet monkey. Macaca radiata. | 1984 May-Jun | Andrologia | pmid:6465549 |
| Gerez de Burgos NM et al. | Inhibition by gossypol of oxidoreductases from Trypanosoma cruzi. | 1984 | Biochem. Pharmacol. | pmid:6370265 |
| Qian SZ and Wang ZG | Gossypol: a potential antifertility agent for males. | 1984 | Annu. Rev. Pharmacol. Toxicol. | pmid:6375548 |
| Yuan JR | [Methods of extraction and purification of gossypol]. | 1984 | Shengzhi Yu Biyun | pmid:12339570 |
| de Peyster A et al. | Oxygen radical formation induced by gossypol in rat liver microsomes and human sperm. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6322752 |
| Pathak HK et al. | Gossypol, ouabain and vanadate on the isolated perfused rat kidney and Na, K-ATPase. | 1984 | Zhongguo Yao Li Xue Bao | pmid:6326465 |
| Zhang ZS et al. | [Use of technique of culturing cells in diffusion chamber in host-mediate for testing chromosomal effects of gossypol acetate on human lymphocytes]. | 1984 | Shengzhi Yu Biyun | pmid:12267337 |
| Alarcón B et al. | Screening for new compounds with antiherpes activity. | 1984 | Antiviral Res. | pmid:6517562 |
| Hamasaki Y et al. | [Rat basophilic leukemia-1 cell possesses 12-lipoxygenase and 5-lipoxygenase activities which are specifically inhibited by gossypol acetic acid]. | 1984 | Arerugi | pmid:6442854 |
| Gu ZW et al. | Studies on fertility control-the formation and antifertility effect of polyvinyl-pyrolidone-gossypol complex. | 1984 | Biomater Med Devices Artif Organs | pmid:6532483 |
| Engler SJ et al. | Absence of histopathology in somatic tissues of rats made infertile with gossypol. | 1984 | Arch. Androl. | pmid:6534283 |
| Zhu PD | [Electron microscopic observations on the effect of gossypol on the human endometrium]. | 1984 | Zhonghua Fu Chan Ke Za Zhi | pmid:6536444 |
| Bhargava SK | Semen characteristics of gossypol-treated langurs (Presbytis entellus entellus Dufresne). | 1984 | Arch. Androl. | pmid:6537746 |
| Zhang ZR et al. | [High performance liquid chromatography of gossypol]. | 1984 | Yao Xue Xue Bao | pmid:6544029 |
| Wang NG et al. | [Effect of gossypol acetic acid on early pregnancy in rats]. | 1984 | Yao Xue Xue Bao | pmid:6544547 |
| Wang NG et al. | [Effects of (-) and (+) gossypol on the fertility of male rats]. | 1984 | Yao Xue Xue Bao | pmid:6544566 |
| Admasu A and Chandravanshi BS | Spectrophotometric determination of total gossypol in cottonseeds and cottonseed meals. | 1984 | Anal. Chem. | pmid:6546479 |
| Jiang Y and Zhou TH | [Polarographic study on gossypol]. | 1984 | Yao Xue Xue Bao | pmid:6496091 |
| Zhou LF and Lei HP | [Effect of gossypol acetic acid on the uterus and ovary]. | 1984 | Yao Xue Xue Bao | pmid:6496095 |
| Tso WW | Gossypol inhibits Ehrlich ascites tumor cell proliferation. | 1984 | Cancer Lett. | pmid:6498805 |
| Ma XN and Back DJ | Inhibition of hepatic microsomal enzymes by gossypol in the rat. | 1984 | Contraception | pmid:6478834 |
| GÃ¥fvels M et al. | Toxic effects of the antifertility agent gossypol in male rats. | 1984 | Toxicology | pmid:6485000 |
| Rovan E et al. | Effect of gossypol on bull spermatozoa in vitro. | 1984 | Urol. Res. | pmid:6485187 |
| Wang NG et al. | [Antisteroidal and antigonadotrophic effects of gossypol acetic acid in rats]. | 1984 | Yao Xue Xue Bao | pmid:6464763 |
| Zu PD et al. | Electron microscopic observations of the effects of gossypol on the human endometrium. | 1984 | Am. J. Obstet. Gynecol. | pmid:6465231 |
| Whaley KJ et al. | Optically active gossypol as a circular dichroism probe of interactions with serum albumins. | 1984 | Biochim. Biophys. Acta | pmid:6466708 |
| Paz GF and Homonnai ZT | Effect of the antifertility agent, gossypol acetic acid, on the metabolism and testosterone secretion of isolated rat interstitial cells in vitro. | 1984 | Contraception | pmid:6467943 |
| Coutinho EM et al. | Antispermatogenic action of gossypol in men. | 1984 | Fertil. Steril. | pmid:6468676 |
| Reddy RM et al. | Pattern of ovarian and uterine carbohydrate metabolism during induced antiimplantation by (+)gossypol. | 1984 | Indian J. Exp. Biol. | pmid:6510968 |
| Tanphaichitr N et al. | Direct effect of gossypol on TR-ST cells: perturbation of rhodamine 123 accumulation in mitochondria. | 1984 | Biol. Reprod. | pmid:6518226 |
| Baker ME | Gossypol inhibits estrogen binding to rat alpha-fetoprotein. | 1984 | FEBS Lett. | pmid:6207049 |
| Hunt S and Mittwoch U | Effects of gossypol on sperm counts in two inbred strains of mice. | 1984 | J. Reprod. Fertil. | pmid:6694149 |
| Floridi A et al. | The effect of gossypol and Lonidamine on electron transport in Ehrlich ascites tumor mitochondria. | 1984 | Exp. Mol. Pathol. | pmid:6705894 |
| Gossypol prospects. | 1984 | Lancet | pmid:6144835 | |
| Wang Y and Rao PN | Effect of gossypol on DNA synthesis and cell cycle progression of mammalian cells in vitro. | 1984 | Cancer Res. | pmid:6690046 |
| Soufir JC et al. | Epididymal effects of gossypol. | 1984 | Lancet | pmid:6145995 |
| Penningroth SM | Pharmacological basis of therapeutics: gossypol, an oral male contraceptive? | 1984 | J Med Soc N J | pmid:6592366 |
| Tvermyr SM et al. | Glucose metabolism in rat germ cells: mechanism of action of gossypol. | 1984 | Ann. N. Y. Acad. Sci. | pmid:6598341 |
| Olgiati KL et al. | Gossypol modulation of nucleotide metabolizing enzymes in the reproductive tract of male rats. | 1984 | Biol. Reprod. | pmid:6095938 |
| Tuszynski GP and Cossu G | Differential cytotoxic effect of gossypol on human melanoma, colon carcinoma, and other tissue culture cell lines. | 1984 | Cancer Res. | pmid:6581864 |
| Haspel HC et al. | Cytocidal effect of gossypol on cultured murine erythroleukemia cells is prevented by serum protein. | 1984 | J. Pharmacol. Exp. Ther. | pmid:6584595 |
| Kim IC et al. | Comparative in vitro spermicidal effects of (+/-)-gossypol, (+)-gossypol, (-)-gossypol and gossypolone. | 1984 | Contraception | pmid:6509980 |
| Madzhidov UV | [T-suppressors in experimental adjuvant arthritis and immunosuppression]. | 1984 | Zh. Mikrobiol. Epidemiol. Immunobiol. | pmid:6230839 |
| Herrera J et al. | Modifications in the testis steroidogenic pathways in rats fed with cottonseed flour. | 1984 | Arch. Androl. | pmid:6236762 |
| Wang RL et al. | [Effect of gossypol acetic acid on the induction of sister chromatid exchange of spermatogonial cell in mice]. | 1984 | Zhongguo Yao Li Xue Bao | pmid:6240903 |
| Han ML et al. | [A comparative study on rapid and slow loading of gossypol in the treatment of gynecological diseases]. | 1984 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:6241066 |
| Wang RL et al. | [Effect of gossypol acetic acid on induction of sister chromatid exchange of spermatogonial cell in mice]. | 1984 | Zhongguo Yao Li Xue Bao | pmid:6242220 |
| Ali SF and El-Sewedy SM | Effect of gossypol on liver metabolic enzymes in male rats. | 1984 | Toxicol. Lett. | pmid:6084346 |
| Bi XF et al. | [Effects of potassium on the inhibitory effect of gossypol on Na,K-ATPase in vitro]. | 1984 | Zhongguo Yao Li Xue Bao | pmid:6087611 |
| Steiner M et al. | In vivo study of LDH isoenzyme activities in heart, liver and testis cytosols of gossypol-treated rats. | 1984 | Int. J. Androl. | pmid:6526516 |
| Breitbart H et al. | Effect of gossypol-acetic acid on calcium transport and ATPase activity in plasma membranes from ram and bull spermatozoa. | 1984 | Int. J. Androl. | pmid:6151940 |
| Olgiati KL et al. | Gossypol inhibition of adenylate cyclase. | 1984 | Arch. Biochem. Biophys. | pmid:6732240 |
| Hoffer AP and Hinton BT | Morphological evidence for a blood-epididymis barrier and the effects of gossypol on its integrity. | 1984 | Biol. Reprod. | pmid:6733204 |
| Oko R and Hrudka F | Comparison of the effects of gossypol, estradiol-17 beta and testosterone compensation on male rat reproductive organs. | 1984 | Biol. Reprod. | pmid:6733210 |
| Whaley KJ et al. | A circular dichroism study of (+) gossypol binding to proteins. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6743322 |
| Wong PY et al. | Gossypol does not affect testicular fluid secretion in rats. | 1984 | Contraception | pmid:6744863 |
| Reyes J et al. | Molecular mechanisms of gossypol action on lipid membranes. | 1984 | J. Biol. Chem. | pmid:6746663 |
| Marcelle GB et al. | Analysis of gossypol and gossypol-acetic acid by high-performance liquid chromatography. | 1984 | J Pharm Sci | pmid:6716251 |
| Nordenskjöld M and Lambert B | Gossypol induces DNA strand breaks in human fibroblasts and sister chromatid exchanges in human lymphocytes in vitro. | 1984 | J. Med. Genet. | pmid:6716412 |
| Tang F and Wong PY | Serum potassium and aldosterone levels in gossypol-treated rats. | 1984 | Int. J. Androl. | pmid:6724725 |
| Sattayasai N et al. | High-performance liquid chromatographic determination of gossypol in plasma. | 1984 | J. Chromatogr. | pmid:6725489 |
| Wang JM et al. | Effect of gossypol on testicular blood flow and testosterone production in rats. | 1984 | J. Reprod. Fertil. | pmid:6726673 |
| Demoulin A | [Male contraception]. | 1984 | Rev Med Liege | pmid:6729295 |
| Kalla NR et al. | Effect of gossypol on testicular testosterone production in vitro. | 1983 Sep-Oct | J. Androl. | pmid:6630052 |
| Zhuang LZ et al. | Effects of gossypol on rat Sertoli and Leydig cells in primary culture and established cell lines. | 1983 Sep-Oct | J. Androl. | pmid:6685120 |
| Weinbauer GF et al. | Toxicity of gossypol at antifertility dosages in male rats: statistical analysis of lethal rates and body weight responses. | 1983 May-Jun | Andrologia | pmid:6881556 |
| Waller DP et al. | Effect of (+)-gossypol on fertility in male hamsters. | 1983 Jul-Aug | J. Androl. | pmid:6618998 |
| Huang GZ et al. | [Etiological study of the burning sensation disease]. | 1983 | Acta Acad Med Wuhan | pmid:6621973 |
| Xue SP et al. | Subcellular site of antispermatogenic effect of gossypol and its possible molecular mechanism of action. | 1983 | Sci. Sin., Ser. B, Chem. Biol. Agric. Med. Earth Sci. | pmid:6623054 |
| Ratsula K et al. | Vaginal contraception with gossypol: a clinical study. | 1983 | Contraception | pmid:6684533 |
| Wong SM et al. | 14C-gossypol: optimum conditions for synthesis by cotton seedlings. | 1983 | Yao Xue Xue Bao | pmid:6687973 |
| El-Nahry FI et al. | Detoxification and nutritional evaluation of solvent extracted Egyptian cottonseed meal. | 1983 | Nahrung | pmid:6688656 |
| Herrera J et al. | Cottonseed flour effects on androgen testicular content and serum levels in rats. | 1983 | Arch. Androl. | pmid:6688944 |
| Stephens DT et al. | Mechanism of inhibition by gossypol of glycolysis and motility of monkey spermatozoa in vitro. | 1983 | J. Reprod. Fertil. | pmid:6631812 |
| Lei HP | [Prospect of gossypol as a contraceptive agents for men]. | 1983 | Yao Xue Xue Bao | pmid:6637482 |
| Gu ZP et al. | Morphological changes in the testes and epididymides of rats after gossypol. | 1983 | Zhongguo Yao Li Xue Bao | pmid:6223497 |
| Xu Y et al. | [Antagonism of antifertility effect of gossypol by aspirin]. | 1983 | Zhongguo Yao Li Xue Bao | pmid:6225300 |
| Qian SZ et al. | Antispermatogenic activity of gossypol in rats on low-potassium diet. | 1983 | Zhongguo Yao Li Xue Bao | pmid:6228118 |
| Wichmann K et al. | Effect of gossypol on the motility and metabolism of human spermatozoa. | 1983 | J. Reprod. Fertil. | pmid:6411909 |
| Eliasson R and Virji N | Effects of gossypol acetic acid on the activity of LDH-C4 from human and rabbit spermatozoa. | 1983 | Int. J. Androl. | pmid:6840877 |
| Tsui YC et al. | The effect of the male contraceptive agent Gossypol on human lymphocytes in vitro: traditional chromosome breakage, micronuclei, sister chromatid exchange, and cell kinetics. | 1983 | J. Med. Genet. | pmid:6842561 |
| Wong PY et al. | Lack of an effect of gossypol on the epididymis of the rat. | 1983 | Contraception | pmid:6851567 |