| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Cattle Diseases | D002418 | 24 associated lipids |
| Infertility, Male | D007248 | 11 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
Gossypol
Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
Cross Reference
Introduction
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Gossypol?
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Mol. Cancer Ther. (4)
- Proc. Natl. Acad. Sci. U.S.A. (3)
- Am. J. Physiol. Lung Cell Mol. Physiol. (2)
- Others (13)
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Gossypol
PubChem Associated disorders and diseases
What pathways are associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Gossypol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Gossypol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Gossypol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Gossypol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Gossypol?
Xenograft Model
Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with Gossypol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Song T et al. | 3-Thiomorpholin-8-oxo-8H-acenaphtho [1,2-b] pyrrole-9-carbonitrile (S1) derivatives as pan-Bcl-2-inhibitors of Bcl-2, Bcl-xL and Mcl-1. | 2013 | Bioorg. Med. Chem. | pmid:23206987 |
| Cheng P et al. | The novel BH-3 mimetic apogossypolone induces Beclin-1- and ROS-mediated autophagy in human hepatocellular carcinoma [corrected] cells. | 2013 | Cell Death Dis | pmid:23392177 |
| Ni Z et al. | Natural Bcl-2 inhibitor (-)- gossypol induces protective autophagy via reactive oxygen species-high mobility group box 1 pathway in Burkitt lymphoma. | 2013 | Leuk. Lymphoma | pmid:23398207 |
| Huo M et al. | Suppression of LPS-induced inflammatory responses by gossypol in RAW 264.7 cells and mouse models. | 2013 | Int. Immunopharmacol. | pmid:23352443 |
| Goff DJ et al. | A Pan-BCL2 inhibitor renders bone-marrow-resident human leukemia stem cells sensitive to tyrosine kinase inhibition. | 2013 | Cell Stem Cell | pmid:23333150 |
| Anderson MA et al. | BH3 mimetic therapy: an emerging and promising approach to treating chronic lymphocytic leukemia. | 2013 | Leuk. Lymphoma | pmid:23339446 |
| Kannan A et al. | Effect of feeding of calcium hydroxide-treated or vitamin E-supplemented cottonseed meal on plasma gossypol levels, blood parameters, and performance of Bikaneri lambs. | 2013 | Trop Anim Health Prod | pmid:23345064 |
| Ansari N et al. | Quantitative 3D cell-based assay performed with cellular spheroids and fluorescence microscopy. | 2013 | Methods Cell Biol. | pmid:23317907 |
| Senarisoy M et al. | Gossypol interferes with both type I and type II topoisomerase activities without generating strand breaks. | 2013 | Cell Biochem. Biophys. | pmid:23161103 |
| Karaca B et al. | Combination of AT-101/cisplatin overcomes chemoresistance by inducing apoptosis and modulating epigenetics in human ovarian cancer cells. | 2013 | Mol. Biol. Rep. | pmid:23269627 |
| Soderquist R et al. | Gossypol overcomes stroma-mediated resistance to the BCL2 inhibitor ABT-737 in chronic lymphocytic leukemia cells ex vivo. | 2013 | Leukemia | pmid:23640104 |
| Granchi C et al. | Small-molecule inhibitors of human LDH5. | 2013 | Future Med Chem | pmid:24175747 |
| Zhang Z et al. | Fragment-based design, synthesis, and biological evaluation of N-substituted-5-(4-isopropylthiophenol)-2-hydroxynicotinamide derivatives as novel Mcl-1 inhibitors. | 2013 | Eur J Med Chem | pmid:23314054 |
| Zhong S et al. | (-)-Gossypol-enriched cottonseed oil inhibits proliferation and adipogenesis of human breast pre-adipocytes. | 2013 | Anticancer Res. | pmid:23482766 |
| Varadarajan S et al. | Sabutoclax (BI97C1) and BI112D1, putative inhibitors of MCL-1, induce mitochondrial fragmentation either upstream of or independent of apoptosis. | 2013 | Neoplasia | pmid:23633928 |
| Semon B | Dietary intake of cottonseed toxins is hypothesized to be a partial cause of Alzheimer's disorder. | 2012 | Med. Hypotheses | pmid:22136946 |
| Pond GR et al. | Neutropenia as a potential pharmacodynamic marker for docetaxel-based chemotherapy in men with metastatic castration-resistant prostate cancer. | 2012 | Clin Genitourin Cancer | pmid:23000202 |
| Ilkevych NS et al. | Vibrational spectra, structure and antioxidant activity of gossypol imine derivatives. | 2012 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:22078080 |
| Sonpavde G et al. | Randomized phase II trial of docetaxel plus prednisone in combination with placebo or AT-101, an oral small molecule Bcl-2 family antagonist, as first-line therapy for metastatic castration-resistant prostate cancer. | 2012 | Ann. Oncol. | pmid:22112969 |
| Pond GR et al. | Evaluating the value of number of cycles of docetaxel and prednisone in men with metastatic castration-resistant prostate cancer. | 2012 | Eur. Urol. | pmid:21715086 |
| Azab B et al. | Enhanced delivery of mda-7/IL-24 using a serotype chimeric adenovirus (Ad.5/3) in combination with the Apogossypol derivative BI-97C1 (Sabutoclax) improves therapeutic efficacy in low CAR colorectal cancer cells. | 2012 | J. Cell. Physiol. | pmid:21780116 |
| Imai A et al. | Metronomic dosing of BH3 mimetic small molecule yields robust antiangiogenic and antitumor effects. | 2012 | Cancer Res. | pmid:22158856 |
| Rathore KS et al. | Ultra-low gossypol cottonseed: generational stability of the seed-specific, RNAi-mediated phenotype and resumption of terpenoid profile following seed germination. | 2012 | Plant Biotechnol. J. | pmid:21902797 |
| Mazumder S et al. | Mcl-1 Phosphorylation defines ABT-737 resistance that can be overcome by increased NOXA expression in leukemic B cells. | 2012 | Cancer Res. | pmid:22525702 |
| El-Mokadem MY et al. | Alleviation of reproductive toxicity of gossypol using selenium supplementation in rams. | 2012 | J. Anim. Sci. | pmid:22585803 |
| Cheng W et al. | [Effects of gossypol acetate on apoptosis in primary cultured cells from patients with lymphoid leukemia and its synergy with dexamethasone]. | 2012 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:22541072 |
| Zhang YS et al. | Gossypol exhibits a strong influence towards UDP-glucuronosyltransferase (UGT) 1A1, 1A9 and 2B7-mediated metabolism of xenobiotics and endogenous substances. | 2012 | Molecules | pmid:22543504 |
| Zubair H et al. | Apogossypolone, derivative of gossypol, mobilizes endogenous copper in human peripheral lymphocytes leading to oxidative DNA breakage. | 2012 | Eur J Pharm Sci | pmid:22554693 |
| Yang X et al. | Identification and proteomic analysis of a novel gossypol-degrading fungal strain. | 2012 | J. Sci. Food Agric. | pmid:22002592 |
| Mellon JE et al. | Inhibitory effects of gossypol, gossypolone, and apogossypolone on a collection of economically important filamentous fungi. | 2012 | J. Agric. Food Chem. | pmid:22324794 |
| Özdoğan M et al. | Effect of gossypol on blood serum parameters and small intestinal morphology of male broilers. | 2012 | J Anim Physiol Anim Nutr (Berl) | pmid:21261752 |
| Ionov M et al. | Stability and antioxidant activity of gossypol derivative immobilized on N-polyvinylpyrrolidone. | 2012 | Int. J. Biol. Macromol. | pmid:22910577 |
| Hedvat M et al. | Selected approaches for rational drug design and high throughput screening to identify anti-cancer molecules. | 2012 | Anticancer Agents Med Chem | pmid:22931411 |
| Varadarajan S et al. | A novel cellular stress response characterised by a rapid reorganisation of membranes of the endoplasmic reticulum. | 2012 | Cell Death Differ. | pmid:22955944 |
| Wang AP et al. | Effects of different sources and levels of dietary gossypol on gossypol residues in plasma and milk of lactating cows. | 2012 | J. Dairy Sci. | pmid:22916918 |
| Schuler MA | Insect P450s: mounted for battle in their war against toxins. | 2012 | Mol. Ecol. | pmid:22924794 |
| Yang J et al. | Synthesis and antiviral activities of novel gossypol derivatives. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22226654 |
| Jiang J et al. | Gossypol inhibits growth, invasiveness, and angiogenesis in human prostate cancer cells by modulating NF-κB/AP-1 dependent- and independent-signaling. | 2012 | Clin. Exp. Metastasis | pmid:22167622 |
| Chien CC et al. | The role of COX-2/PGE2 in gossypol-induced apoptosis of colorectal carcinoma cells. | 2012 | J. Cell. Physiol. | pmid:22170686 |
| Masood A et al. | Downregulation of BCL2 by AT-101 enhances the antileukaemic effect of lenalidomide both by an immune dependant and independent manner. | 2012 | Br. J. Haematol. | pmid:22171982 |
| Lian J et al. | Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation. | 2012 | Mol. Cancer Ther. | pmid:22188816 |
| Li HQ et al. | Structure-based design of rhodanine-based acylsulfonamide derivatives as antagonists of the anti-apoptotic Bcl-2 protein. | 2012 | Bioorg. Med. Chem. | pmid:22739087 |
| Ignatova M et al. | Quaternized chitosan-coated nanofibrous materials containing gossypol: preparation by electrospinning, characterization and antiproliferative activity towards HeLa cells. | 2012 | Int J Pharm | pmid:22728261 |
| Sun P et al. | Action of db-cAMP on the bystander effect and chemosensitivity through connexin 43 and Bcl-2-mediated pathways in medulloblastoma cells. | 2012 | Oncol. Rep. | pmid:22766741 |
| Lin H et al. | A validated HPLC assay for the determination of R-(-)-gossypol in human plasma and its application in clinical pharmacokinetic studies. | 2012 | J Pharm Biomed Anal | pmid:22483642 |
| Billard C | Development of Noxa-like BH3 mimetics for apoptosis-based therapeutic strategy in chronic lymphocytic leukemia. | 2012 | Mol. Cancer Res. | pmid:22466256 |
| An T et al. | Amino acid derivatives of the (-) enantiomer of gossypol are effective fusion inhibitors of human immunodeficiency virus type 1. | 2012 | Antiviral Res. | pmid:22426469 |
| Tao XY et al. | Gossypol-enhanced P450 gene pool contributes to cotton bollworm tolerance to a pyrethroid insecticide. | 2012 | Mol. Ecol. | pmid:22515600 |
| Wagner TA et al. | Hemigossypol, a constituent in developing glanded cottonseed (Gossypium hirsutum). | 2012 | J. Agric. Food Chem. | pmid:22369216 |
| Kisim A et al. | Pretreatment with AT-101 enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis of breast cancer cells by inducing death receptors 4 and 5 protein levels. | 2012 | J. Cancer Res. Clin. Oncol. | pmid:22411600 |
| Bodur C and Basaga H | Bcl-2 inhibitors: emerging drugs in cancer therapy. | 2012 | Curr. Med. Chem. | pmid:22414090 |
| Hsiao WT et al. | Involvement of Smac, p53, and caspase pathways in induction of apoptosis by gossypol in human retinoblastoma cells. | 2012 | Mol. Vis. | pmid:22876131 |
| Wong FY et al. | Combination therapy with gossypol reveals synergism against gemcitabine resistance in cancer cells with high BCL-2 expression. | 2012 | PLoS ONE | pmid:23226540 |
| Sarwar Gilani G et al. | Impact of antinutritional factors in food proteins on the digestibility of protein and the bioavailability of amino acids and on protein quality. | 2012 | Br. J. Nutr. | pmid:23107545 |
| Vshivkov S et al. | Capillary electrophoresis to quantitate gossypol enantiomers in cotton flower petals and seed. | 2012 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:23122406 |
| Zbidah M et al. | Gossypol-induced suicidal erythrocyte death. | 2012 | Toxicology | pmid:23041711 |
| Thakur A et al. | Pan-Bcl-2 inhibitor AT-101 enhances tumor cell killing by EGFR targeted T cells. | 2012 | PLoS ONE | pmid:23185240 |
| Jackson RS et al. | Sabutoclax, a Mcl-1 antagonist, inhibits tumorigenesis in transgenic mouse and human xenograft models of prostate cancer. | 2012 | Neoplasia | pmid:22904682 |
| Hu W et al. | Proapoptotic protein Smac mediates apoptosis in cisplatin-resistant ovarian cancer cells when treated with the anti-tumor agent AT101. | 2012 | J. Biol. Chem. | pmid:22052903 |
| Shen Y and Ye D | Re: Gregory R. Pond, Andrew J. Armstrong, Brian A. Wood, et al. Evaluating the value of number of cycles of docetaxel and prednisone in men with metastatic castration-resistant prostate cancer. Eur Urol 2012;61:363-9. | 2012 | Eur. Urol. | pmid:21824719 |
| Wang Y et al. | Small molecule inhibition of the steroid receptor coactivators, SRC-3 and SRC-1. | 2011 | Mol. Endocrinol. | pmid:22053001 |
| Ready N et al. | Double-blind, placebo-controlled, randomized phase 2 study of the proapoptotic agent AT-101 plus docetaxel, in second-line non-small cell lung cancer. | 2011 | J Thorac Oncol | pmid:21289522 |
| Zhou DR et al. | [Gossypol decreases the expression of connexin 43 in Sertoli cells]. | 2011 | Zhonghua Nan Ke Xue | pmid:22141269 |
| Williams JL et al. | Fitness cost of resistance to Bt cotton linked with increased gossypol content in pink bollworm larvae. | 2011 | PLoS ONE | pmid:21738799 |
| Chang Q et al. | Drug synergistic antifertility effect of combined administration of low-dose gossypol with steroid hormones in rats. | 2011 | Chin. Med. J. | pmid:21740776 |
| Gunassekaran GR et al. | In vitro and in vivo studies on antitumor effects of gossypol on human stomach adenocarcinoma (AGS) cell line and MNNG induced experimental gastric cancer. | 2011 | Biochem. Biophys. Res. Commun. | pmid:21782799 |
| Yin J et al. | Novel O-glycosidic gossypol isomers and their bioactivities. | 2011 | Carbohydr. Res. | pmid:21788013 |
| Ouyang DY et al. | Valproic acid synergistically enhances the cytotoxicity of gossypol in DU145 prostate cancer cells: an iTRTAQ-based quantitative proteomic analysis. | 2011 | J Proteomics | pmid:21726675 |
| Li H et al. | Liposomes containing (-)-gossypol-enriched cottonseed oil suppress Bcl-2 and Bcl-xL expression in breast cancer cells. | 2011 | Pharm. Res. | pmid:21710341 |
| Dash R et al. | Apogossypol derivative BI-97C1 (Sabutoclax) targeting Mcl-1 sensitizes prostate cancer cells to mda-7/IL-24-mediated toxicity. | 2011 | Proc. Natl. Acad. Sci. U.S.A. | pmid:21555592 |
| Pang X et al. | (-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis. | 2011 | Mol. Cancer Ther. | pmid:21372225 |
| Guo Z et al. | [Gossypol acetic acid induces DNA double-strand breaks in human mucoepidermoid carcinoma cell MEC-1]. | 2011 | Sheng Li Xue Bao | pmid:21505732 |
| Ma X et al. | Environmental inhibitors of 11β-hydroxysteroid dehydrogenase type 2. | 2011 | Toxicology | pmid:21515335 |
| Mao YB et al. | Cotton plants expressing CYP6AE14 double-stranded RNA show enhanced resistance to bollworms. | 2011 | Transgenic Res. | pmid:20953975 |
| Moon DO et al. | Gossypol decreases tumor necrosis factor-α-induced intercellular adhesion molecule-1 expression via suppression of NF-κB activity. | 2011 | Food Chem. Toxicol. | pmid:21223991 |
| Mellon JE et al. | Inhibitory effects of gossypol-related compounds on growth of Aspergillus flavus. | 2011 | Lett. Appl. Microbiol. | pmid:21291481 |
| Le TT et al. | Evidence for a trianion intermediate in the metalation of 4-hydroxy-6,7-dimethoxy-8-methyl-2-naphthoic acid. Methodology and application to racemic 5,5'-didesisopropyl-5,5'-dialkylapogossypol derivatives. | 2011 | J. Org. Chem. | pmid:21174400 |
| Hu ZY et al. | Apogossypolone targets mitochondria and light enhances its anticancer activity by stimulating generation of singlet oxygen and reactive oxygen species. | 2011 | Chin J Cancer | pmid:21192843 |
| Baggstrom MQ et al. | A phase II study of AT-101 (Gossypol) in chemotherapy-sensitive recurrent extensive-stage small cell lung cancer. | 2011 | J Thorac Oncol | pmid:21918390 |
| Lu Z et al. | Mirabamides E-H, HIV-inhibitory depsipeptides from the sponge Stelletta clavosa. | 2011 | J. Nat. Prod. | pmid:21280591 |
| Zhang P et al. | Suppression of jasmonic acid-dependent defense in cotton plant by the mealybug Phenacoccus solenopsis. | 2011 | PLoS ONE | pmid:21818315 |
| Lian J et al. | A natural BH3 mimetic induces autophagy in apoptosis-resistant prostate cancer via modulating Bcl-2-Beclin1 interaction at endoplasmic reticulum. | 2011 | Cell Death Differ. | pmid:20577262 |
| Spagnuolo C et al. | Quercetin downregulates Mcl-1 by acting on mRNA stability and protein degradation. | 2011 | Br. J. Cancer | pmid:21750559 |
| Amm HM et al. | Mechanisms of drug sensitization to TRA-8, an agonistic death receptor 5 antibody, involve modulation of the intrinsic apoptotic pathway in human breast cancer cells. | 2011 | Mol. Cancer Res. | pmid:21357440 |
| Granchi C et al. | Discovery of N-hydroxyindole-based inhibitors of human lactate dehydrogenase isoform A (LDH-A) as starvation agents against cancer cells. | 2011 | J. Med. Chem. | pmid:21332213 |
| Celorio-Mancera Mde L et al. | Transcriptional responses underlying the hormetic and detrimental effects of the plant secondary metabolite gossypol on the generalist herbivore Helicoverpa armigera. | 2011 | BMC Genomics | pmid:22111916 |
| Akagunduz O et al. | Radiosensitization of hormone-refractory prostate cancer cells by gossypol treatment. | 2010 Oct-Dec | J BUON | pmid:21229643 |
| Tiliabaev KZ et al. | [Synthesis, structures, and acute toxicity of gossypol nonsymmetrical aldehyde derivatives]. | 2010 May-Jun | Bioorg. Khim. | pmid:20644599 |
| Fulda S | Modulation of apoptosis by natural products for cancer therapy. | 2010 | Planta Med. | pmid:20486070 |
| Ionov M et al. | The interaction of PVP complexes of gossypol and its derivatives with an artificial membrane lipid matrix. | 2010 | Cell. Mol. Biol. Lett. | pmid:19936629 |
| Blevins S et al. | Effects of silymarin on gossypol toxicosis in divergent lines of chickens. | 2010 | Poult. Sci. | pmid:20709972 |
| Yan F et al. | A novel water-soluble gossypol derivative increases chemotherapeutic sensitivity and promotes growth inhibition in colon cancer. | 2010 | J. Med. Chem. | pmid:20684596 |
| Wu G et al. | Responses of three successive generations of beet armyworm, Spodoptera exigua, fed exclusively on different levels of gossypol in cotton leaves. | 2010 | J. Insect Sci. | pmid:21067414 |
| Wei J et al. | Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins. | 2010 | J. Med. Chem. | pmid:21033669 |
| ZHU Y et al. | Involvement of Bcl-2, Src, and ERα in gossypol-mediated growth inhibition and apoptosis in human uterine leiomyoma and myometrial cells. | 2010 | Acta Pharmacol. Sin. | pmid:21102482 |
| Barelier S et al. | Fragment-based deconstruction of Bcl-xL inhibitors. | 2010 | J. Med. Chem. | pmid:20192224 |
| Le A et al. | Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression. | 2010 | Proc. Natl. Acad. Sci. U.S.A. | pmid:20133848 |
| Zhang XQ et al. | Inhibition of proliferation of prostate cancer cell line, PC-3, in vitro and in vivo using (-)-gossypol. | 2010 | Asian J. Androl. | pmid:20081872 |
| Liu YX | Temperature control of spermatogenesis and prospect of male contraception. | 2010 | Front Biosci (Schol Ed) | pmid:20036980 |
| Wang H et al. | Inhibition of calcineurin by quercetin in vitro and in Jurkat cells. | 2010 | J. Biochem. | pmid:19880376 |